Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Protagonist Therapeutics, Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 275
- +3 vs. Q2 2025
- Shares held
- 70.7M
- −267.3K (−0.4%) vs. Q2 2025
- Total value
- $4.70B
- +$772.8M (+19.7%) vs. Q2 2025
- New holders
- 42
- 84 more added
- Sold out
- 39
- 109 more reduced
2 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Crossmark Global Holdings, Inc. | 3,966 | $263.5K | 0.00% | −99−2.4% | Reduced |
| Bank of Montreal | 3,864 | $256.7K | 0.00% | −5,714−59.7% | Reduced |
| Tower Research Capital LLC (TRC) | 3,801 | $252.5K | 0.01% | −1,538−28.8% | Reduced |
| Velan Capital Investment Management LP | 3,700 | $245.8K | 0.23% | 00.0% | Unchanged |
| FORA Capital, LLC | 3,685 | $244.8K | 0.04% | +3,685 | New |
| Wealth Enhancement Advisory Services, LLC | 3,511 | $229.9K | 0.00% | +3,511 | New |
| Verdence Capital Advisors LLC | 3,038 | $228.6K | 0.01% | +3,038 | New |
| Captrust Financial Advisors | 3,312 | $220.0K | 0.00% | +3,312 | New |
| Quantbot Technologies LP | 3,303 | $219.4K | 0.01% | +3,303 | New |
| JustInvest LLC | 3,298 | $219.1K | 0.00% | +3,298 | New |
| ISAM Funds (UK) Ltd | 3,118 | $207.1K | 0.04% | +3,118 | New |
| Fox Run Management, L.L.C. | 3,103 | $206.1K | 0.03% | +3,103 | New |
| Rockefeller Capital Management L.P. | 2,980 | $198.0K | 0.00% | +2,980 | New |
| NBC Securities, Inc. | 2,958 | $196.5K | 0.02% | +393+15.3% | Added |
| The PNC Financial Services Group, Inc. | 2,738 | $181.9K | 0.00% | +324+13.4% | Added |
| Mirae Asset Global Investments Co., Ltd. | 2,405 | $159.8K | 0.00% | +11+0.5% | Added |
| Virtus Investment Advisers, Inc. | 2,020 | $134.2K | 0.04% | +350+21.0% | Added |
| GAMMA Investing LLC | 1,648 | $109.5K | 0.01% | +571+53.0% | Added |
| Quest Partners LLC | 1,618 | $107.5K | 0.01% | +1,618 | New |
| KBC Group NV | 1,574 | $105.0K | 0.00% | 00.0% | Unchanged |
| Smartleaf Asset Management LLC | 1,403 | $91.4K | 0.01% | +146+11.6% | Added |
| Advisor Group Holdings, Inc. | 1,391 | $91.0K | 0.00% | +206+17.4% | Added |
| Quadrant Capital Group LLC | 1,352 | $89.8K | 0.00% | +1,352 | New |
| GF Fund Management Co. Ltd. | 1,338 | $88.9K | 0.00% | −188−12.3% | Reduced |
| Covestor Ltd | 990 | $66.0K | 0.04% | −755−43.3% | Reduced |
| Wexford Capital LP | 941 | $62.5K | 0.02% | −2,374−71.6% | Reduced |
| Abich Financial Wealth Management LLC | 932 | $61.9K | 0.02% | +932 | New |
| Truvestments Capital LLC | 722 | $48.0K | 0.01% | +72+11.1% | Added |
| CWM, LLC | 556 | $37.0K | 0.00% | −53−8.7% | Reduced |
| EverSource Wealth Advisors, LLC | 540 | $35.9K | 0.00% | +314+138.9% | Added |
| Salomon & Ludwin, LLC | 442 | $28.7K | 0.00% | +442 | New |
| Global Retirement Partners, LLC | 316 | $21.0K | 0.00% | 00.0% | Unchanged |
| Fifth Third Bancorp | 307 | $20.4K | 0.00% | +96+45.5% | Added |
| Hantz Financial Services, Inc. | 295 | $20.0K | 0.00% | +152+106.3% | Added |
| Assetmark, Inc | 280 | $18.6K | 0.00% | −10−3.4% | Reduced |
| Umb Bank N A | 258 | $17.1K | 0.00% | +59+29.6% | Added |
| Allworth Financial LP | 247 | $16.4K | 0.00% | +130+111.1% | Added |
| Rise Advisors, LLC | 224 | $14.9K | 0.01% | 00.0% | Unchanged |
| Clearstead Advisors, LLC | 200 | $13.3K | 0.00% | +90+81.8% | Added |
| Daiwa Securities Group Inc. | 190 | $13.0K | 0.00% | −25−11.6% | Reduced |
| Optiver Holding B.V. | 169 | $11.2K | 0.00% | +169 | New |
| Larson Financial Group LLC | 154 | $10.2K | 0.00% | +128+492.3% | Added |
| Signaturefd, LLC | 149 | $9.90K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 141 | $9.37K | 0.00% | −2−1.4% | Reduced |
| Farther Finance Advisors, LLC | 141 | $9.37K | 0.00% | +48+51.6% | Added |
| Massmutual Trust Co FSB | 119 | $7.91K | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 102 | $6.78K | 0.00% | +5+5.2% | Added |
| Danske Bank A/S | 100 | $6.64K | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 92 | $6.11K | 0.00% | +92 | New |
| MAI Capital Management | 86 | $5.71K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 85 | $5.65K | 0.00% | −25−22.7% | Reduced |
| Aster Capital Management (DIFC) Ltd | 83 | $5.51K | 0.00% | +83 | New |
| Brown Brothers Harriman & Co | 81 | $5.38K | 0.00% | 00.0% | Unchanged |
| Bell Investment Advisors, Inc | 81 | $5.38K | 0.00% | 00.0% | Unchanged |
| WPG Advisers, LLC | 78 | $5.18K | 0.00% | 00.0% | Unchanged |
| Annis Gardner Whiting Capital Advisors, LLC | 76 | $5.05K | 0.00% | 00.0% | Unchanged |
| Raffa Wealth Management, LLC | 60 | $3.99K | 0.00% | 00.0% | Unchanged |
| Wealthspire Advisors, LLC | 48 | $3.19K | 0.00% | +48 | New |
| Parkside Financial Bank & Trust | 45 | $2.99K | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 39 | $2.59K | 0.00% | 00.0% | Unchanged |
| Wolff Wiese Magana LLC | 35 | $2.33K | 0.00% | 00.0% | Unchanged |
| Farmers & Merchants Investments Inc | 35 | $2.33K | 0.00% | 00.0% | Unchanged |
| Bare Financial Services, Inc | 34 | $2.26K | 0.00% | +11+47.8% | Added |
| Principal Securities, Inc. | 32 | $2.13K | 0.00% | −4−11.1% | Reduced |
| Picton Mahoney Asset Management | 25 | $2.00K | 0.00% | 00.0% | Unchanged |
| Marquette Asset Management, LLC | 28 | $1.86K | 0.00% | +28 | New |
| Versant Capital Management, Inc | 27 | $1.79K | 0.00% | −2−6.9% | Reduced |
| Montag A & Associates Inc | 25 | $1.66K | 0.00% | +25 | New |
| Atlantic Trust, LLC | 21 | $1.40K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 20 | $1.35K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 9 | $598 | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 9 | $598 | 0.00% | +9 | New |
| Abound Wealth Management | 4 | $266 | 0.00% | 00.0% | Unchanged |
| Kilter Group LLC | 4 | $266 | 0.00% | 00.0% | Unchanged |
| DecisionPoint Financial, LLC | 4 | $256 | 0.00% | 00.0% | Unchanged |
| Holocene Advisors, LP | 0 | $0 | 0.00% | −530,326−100.0% | Sold out |
| Jupiter Asset Management Ltd | 0 | $0 | 0.00% | −405,644−100.0% | Sold out |
| Eversept Partners, LP | 0 | $0 | 0.00% | −277,316−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −173,134−100.0% | Sold out |
| Capitolis Liquid Global Markets LLC | 0 | $0 | 0.00% | −116,100−100.0% | Sold out |
| Checkpoint Capital L.P. | 0 | $0 | 0.00% | −81,311−100.0% | Sold out |
| EAM Global Investors LLC | 0 | $0 | 0.00% | −69,726−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −68,983−100.0% | Sold out |
| Natixis | 0 | $0 | 0.00% | −42,040−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −42,000−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −36,018−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −34,013−100.0% | Sold out |
| Massachusetts Financial Services Co | 0 | $0 | 0.00% | −32,123−100.0% | Sold out |
| Horizon Investments, LLC | 0 | $0 | 0.00% | −22,470−100.0% | Sold out |
| Fieldview Capital Management, LLC | 0 | $0 | 0.00% | −20,381−100.0% | Sold out |
| Arrowstreet Capital, Limited Partnership | 0 | $0 | 0.00% | −17,856−100.0% | Sold out |
| UBS Oconnor LLC | 0 | $0 | 0.00% | −14,523−100.0% | Sold out |
| Precision Wealth Strategies, LLC | 0 | $0 | 0.00% | −14,339−100.0% | Sold out |
| Algert Global LLC | 0 | $0 | 0.00% | −13,055−100.0% | Sold out |
| Harvest Investment Services, LLC | 0 | $0 | 0.00% | −13,029−100.0% | Sold out |
| Options Solutions, LLC | 0 | $0 | 0.00% | −10,226−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −9,452−100.0% | Sold out |
| Nomura Holdings Inc | 0 | $0 | 0.00% | −7,416−100.0% | Sold out |
| Bryce Point Capital, LLC | 0 | $0 | 0.00% | −6,200−100.0% | Sold out |
| Mitsubishi UFJ Trust & Banking Corp | 0 | $0 | 0.00% | −5,975−100.0% | Sold out |