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Protagonist Therapeutics, Inc

PTGX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001377121

In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q2 2021

Institutional positions in Protagonist Therapeutics, Inc as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
139
+12 vs. Q1 2021
Shares held
48.2M
+3.82M (+8.6%) vs. Q1 2021
Total value
$2.16B
+$1.01B (+88.1%) vs. Q1 2021
New holders
27
60 more added
Sold out
15
36 more reduced

Compare with Q1 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2021: 139 institutions
Q1 2021: 127 institutionsQ2 2021: 139 institutionsQ3 2021: 132 institutionsQ4 2021: 149 institutionsQ1 2022: 140 institutionsQ2 2022: 131 institutionsQ3 2022: 133 institutionsQ4 2022: 137 institutionsQ1 2023: 138 institutionsQ2 2023: 167 institutionsQ3 2023: 144 institutionsQ4 2023: 157 institutionsQ1 2024: 185 institutionsQ2 2024: 188 institutionsQ3 2024: 240 institutionsQ4 2024: 241 institutionsQ1 2025: 275 institutionsQ2 2025: 274 institutionsQ3 2025: 275 institutionsQ4 2025: 319 institutionsQ1 2026: 322 institutionsQ2 2026: 346 institutions
Value heldQ2 2021: $2.16B
Q1 2021: $1.15BQ2 2021: $2.16BQ3 2021: $820.8MQ4 2021: $1.68BQ1 2022: $1.19BQ2 2022: $422.1MQ3 2022: $398.9MQ4 2022: $533.3MQ1 2023: $1.22BQ2 2023: $1.57BQ3 2023: $945.9MQ4 2023: $1.32BQ1 2024: $1.73BQ2 2024: $2.05BQ3 2024: $2.78BQ4 2024: $2.44BQ1 2025: $3.15BQ2 2025: $3.92BQ3 2025: $4.70BQ4 2025: $6.18BQ1 2026: $8.31BQ2 2026: $9.30B
Institutions holding PTGX and their total value by quarter
QuarterHoldersValue
Q2 2026346$9.30B
Q1 2026322$8.31B
Q4 2025319$6.18B
Q3 2025275$4.70B
Q2 2025274$3.92B
Q1 2025275$3.15B
Q4 2024241$2.44B
Q3 2024240$2.78B
Q2 2024188$2.05B
Q1 2024185$1.73B
Q4 2023157$1.32B
Q3 2023144$945.9M
Q2 2023167$1.57B
Q1 2023138$1.22B
Q4 2022137$533.3M
Q3 2022133$398.9M
Q2 2022131$422.1M
Q1 2022140$1.19B
Q4 2021149$1.68B
Q3 2021132$820.8M
Q2 2021139$2.16B
Q1 2021127$1.15B

Institutions, Q2 2021

Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q1 2021.

Institutions holding PTGX in Q2 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Bank of New York Mellon Corp146,330$6.57M0.00%+12,735+9.5%Added
International Biotechnology Trust PLC152,000$6.81M1.82%00.0%Unchanged
Pinz Capital Management, LP196,000$8.80M2.65%+196,000New
Commodore Capital LP210,600$9.45M3.29%−139,000−39.8%Reduced
D. E. Shaw & Co., Inc.248,235$11.1M0.01%+47,255+23.5%Added
Two Sigma Advisers, LP256,075$11.5M0.03%−90,600−26.1%Reduced
Charles Schwab Investment Management Inc281,378$12.6M0.00%+19,791+7.6%Added
Altium Capital Management LP282,445$12.7M2.94%+44,091+18.5%Added
Sphera Funds Management Ltd.302,965$13.6M1.29%+100,831+49.9%Added
Opaleye Management Inc.330,222$14.8M2.46%+33,222+11.2%Added
Laurion Capital Management LP337,109$15.1M0.24%+189,704+128.7%Added
Tri Locum Partners LP341,650$15.3M6.42%+84,564+32.9%Added
Rothschild & Co Asset Management US Inc.388,228$17.4M0.21%−46,021−10.6%Reduced
Goldman Sachs Group Inc391,943$17.6M0.00%−22,191−5.4%Reduced
Citadel Advisors LLC403,208$18.1M0.02%+204,990+103.4%Added
JPMorgan Chase & Co433,428$19.5M0.00%−151,469−25.9%Reduced
Northern Trust Corp444,585$20.0M0.00%+29,072+7.0%Added
Sofinnova Investments, Inc.449,082$20.2M1.22%−205,818−31.4%Reduced
Baker Bros. Advisors LP455,276$20.4M0.09%−980,916−68.3%Reduced
Loomis Sayles & Co L P536,920$24.1M0.03%+536,920New
Adage Capital Partners GP, L.L.C.550,045$24.7M0.05%−50,000−8.3%Reduced
Novo Holdings A/S600,010$26.9M1.19%−267,714−30.9%Reduced
Geode Capital Management, LLC713,838$32.0M0.00%+68,159+10.6%Added
Obermeyer Wood Investment Counsel, LLLP761,018$34.2M1.90%+374,946+97.1%Added
Dimensional Fund Advisors LP791,016$35.5M0.01%+134,915+20.6%Added
Deutsche Bank AG821,722$36.9M0.02%+796,161+3,114.7%Added
Victory Capital Management Inc845,199$37.9M0.04%+845,199New
Price T Rowe Associates Inc986,254$44.3M0.00%+72,664+8.0%Added
Point72 Asset Management, L.P.1,155,200$51.8M0.26%+212,900+22.6%Added
Deerfield Management Company, L.P. (Series C)1,362,790$61.2M1.09%+104,000+8.3%Added
State Street Corp1,454,620$65.3M0.00%−258,063−15.1%Reduced
Vanguard Group Inc2,288,034$102.7M0.00%+147,487+6.9%Added
Farallon Capital Management, L.L.C.2,329,680$104.6M0.50%−95,320−3.9%Reduced
Johnson & Johnson Innovation - JJDC, Inc.2,449,183$109.9M11.24%00.0%Unchanged
BlackRock Inc.3,040,541$136.5M0.00%+38,912+1.3%Added
Consonance Capital Management LP3,446,874$154.7M18.62%+737,165+27.2%Added
RTW Investments, LP3,507,390$157.4M2.38%00.0%Unchanged
BVF Inc3,754,095$168.5M6.31%−205,356−5.2%Reduced
FMR LLC7,116,383$319.4M0.03%+545,156+8.3%Added
Marshall Wace, LLP0$00.00%−86,691−100.0%Sold out
Artal Group S.A.0$00.00%−75,000−100.0%Sold out
California Public Employees Retirement System0$00.00%−67,400−100.0%Sold out
Canada Pension Plan Investment Board0$00.00%−55,000−100.0%Sold out
Los Angeles Capital Management LLC0$00.00%−47,387−100.0%Sold out
Marshall Wace North America L.P.0$00.00%−44,385−100.0%Sold out
Atom Investors LP0$00.00%−30,542−100.0%Sold out
Ameriprise Financial Inc0$00.00%−28,488−100.0%Sold out
Qube Research & Technologies Ltd0$00.00%−13,465−100.0%Sold out
Trexquant Investment LP0$00.00%−10,522−100.0%Sold out
Athanor Capital, LP0$00.00%−8,748−100.0%Sold out
Dynamic Technology Lab Private Ltd0$00.00%−8,202−100.0%Sold out
Pacer Advisors, Inc.0$00.00%−1,780−100.0%Sold out
Sowell Financial Services LLC0$00.00%−1,000−100.0%Sold out
Quantbot Technologies LP0$00.00%−954−100.0%Sold out