Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q4 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 155
- +9 vs. Q3 2022
- Shares held
- 98.4M
- +31.8M (+47.7%) vs. Q3 2022
- Total value
- $334.4M
- −$29.2M (−8.0%) vs. Q3 2022
- New holders
- 32
- 63 more added
- Sold out
- 23
- 40 more reduced
1 institution that held it in Q3 2022 haven't filed for Q4 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q4 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q3 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| DAFNA Capital Management LLC | 192,678 | $655.1K | 0.18% | +192,678 | New |
| Charles Schwab Investment Management Inc | 206,831 | $703.2K | 0.00% | +6,330+3.2% | Added |
| Wellington Management Group LLP | 228,619 | $777.3K | 0.00% | −16,515−6.7% | Reduced |
| Putnam Investments LLC | 242,620 | $824.9K | 0.00% | +242,620 | New |
| Susquehanna International Group, LLP | 255,193 | $867.7K | 0.00% | −136,724−34.9% | Reduced |
| Swiss National Bank | 259,150 | $881.1K | 0.00% | +89,700+52.9% | Added |
| Two Sigma Investments, LP | 265,308 | $902.0K | 0.00% | +36,973+16.2% | Added |
| Birchview Capital, LP | 291,332 | $991.0K | 0.70% | +22,000+8.2% | Added |
| D. E. Shaw & Co., Inc. | 307,959 | $1.05M | 0.00% | +164,153+114.1% | Added |
| Millennium Management LLC | 351,543 | $1.20M | 0.00% | +88,857+33.8% | Added |
| Macquarie Group Ltd | 380,000 | $1.29M | 0.00% | −1,465−0.4% | Reduced |
| BNP Paribas Arbitrage, SA | 423,620 | $1.44M | 0.00% | −338,900−44.4% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 432,278 | $1.47M | 0.01% | +276,845+178.1% | Added |
| Bank of New York Mellon Corp | 432,881 | $1.47M | 0.00% | +133,890+44.8% | Added |
| Alyeska Investment Group, L.P. | 481,696 | $1.64M | 0.02% | +481,696 | New |
| Monashee Investment Management LLC | 481,696 | $1.64M | 0.70% | +481,696 | New |
| Cubist Systematic Strategies, LLC | 490,010 | $1.67M | 0.01% | +401,646+454.5% | Added |
| Tejara Capital Ltd | 501,562 | $1.71M | 0.99% | +501,562 | New |
| Citigroup Inc | 508,593 | $1.73M | 0.00% | −98,803−16.3% | Reduced |
| UBS Group AG | 523,259 | $1.78M | 0.00% | +410,713+364.9% | Added |
| Qube Research & Technologies Ltd | 523,788 | $1.78M | 0.01% | +523,788 | New |
| Deutsche Bank AG | 594,326 | $2.02M | 0.00% | +509+0.1% | Added |
| Affinity Asset Advisors, LLC | 661,264 | $2.25M | 1.03% | +661,264 | New |
| Rafferty Asset Management, LLC | 696,666 | $2.37M | 0.02% | +28,662+4.3% | Added |
| Two Sigma Advisers, LP | 703,200 | $2.39M | 0.01% | −128,100−15.4% | Reduced |
| Northern Trust Corp | 745,733 | $2.54M | 0.00% | −8,046−1.1% | Reduced |
| Adage Capital Partners GP, L.L.C. | 770,713 | $2.62M | 0.01% | +770,713 | New |
| Acadian Asset Management LLC | 845,744 | $2.87M | 0.01% | −4,832−0.6% | Reduced |
| Ally Bridge Group (NY) LLC | 896,618 | $3.05M | 2.97% | −631,962−41.3% | Reduced |
| Barclays PLC | 1,046,712 | $3.56M | 0.00% | +591,248+129.8% | Added |
| Goldman Sachs Group Inc | 1,056,633 | $3.59M | 0.00% | −298,543−22.0% | Reduced |
| ExodusPoint Capital Management, LP | 1,106,132 | $3.76M | 0.06% | +398,852+56.4% | Added |
| CVI Holdings, LLC | 1,252,408 | $4.26M | 0.54% | +1,252,408 | New |
| Opaleye Management Inc. | 1,206,841 | $4.28M | 1.49% | +1,206,841 | New |
| Morgan Stanley | 1,289,437 | $4.38M | 0.00% | +209,556+19.4% | Added |
| Woodline Partners LP | 1,324,884 | $4.50M | 0.06% | −188,375−12.4% | Reduced |
| Geode Capital Management, LLC | 1,377,128 | $4.68M | 0.00% | +46,693+3.5% | Added |
| JPMorgan Chase & Co | 1,482,164 | $5.04M | 0.00% | +1,302,937+727.0% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $5.10M | 0.07% | 00.0% | Unchanged |
| Bank of America Corp | 1,511,166 | $5.14M | 0.00% | +779,302+106.5% | Added |
| Candriam Luxembourg S.C.A. | 1,535,026 | $5.22M | 0.04% | +200,000+15.0% | Added |
| Nuveen Asset Management, LLC | 1,593,710 | $5.42M | 0.00% | −377,338−19.1% | Reduced |
| Iron Triangle Partners LP | 1,926,782 | $6.55M | 1.17% | +1,926,782 | New |
| Commodore Capital LP | 1,935,609 | $6.58M | 0.99% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 1,991,613 | $6.77M | 0.03% | +1,988,113+56,803.2% | Added |
| Marshall Wace, LLP | 2,210,223 | $7.51M | 0.02% | +2,051,086+1,288.9% | Added |
| Jacobs Levy Equity Management, Inc | 2,249,399 | $7.65M | 0.05% | +666,875+42.1% | Added |
| Citadel Advisors LLC | 3,713,153 | $12.3M | 0.01% | +1,903,507+105.2% | Added |
| Armistice Capital, LLC | 3,853,565 | $13.1M | 0.35% | +3,853,565 | New |
| Vanguard Group Inc | 5,197,502 | $17.7M | 0.00% | +384,103+8.0% | Added |
| Palo Alto Investors LP | 5,655,676 | $19.2M | 1.64% | +34,143+0.6% | Added |
| State Street Corp | 8,287,036 | $28.2M | 0.00% | −723,303−8.0% | Reduced |
| Rubric Capital Management LP | 8,294,621 | $28.2M | 1.23% | +4,304,495+107.9% | Added |
| BlackRock Inc. | 8,508,237 | $28.9M | 0.00% | +595,283+7.5% | Added |
| Avidity Partners Management LP | 9,633,911 | $32.8M | 0.77% | +9,633,911 | New |
| Rice Hall James & Associates, LLC | 0 | $0 | 0.00% | −909,083−100.0% | Sold out |
| Altium Capital Management LP | 0 | $0 | 0.00% | −750,000−100.0% | Sold out |
| Frontier Capital Management Co LLC | 0 | $0 | 0.00% | −629,154−100.0% | Sold out |
| Lombard Odier Asset Management (Switzerland) SA | 0 | $0 | 0.00% | −479,124−100.0% | Sold out |
| UBS Oconnor LLC | 0 | $0 | 0.00% | −271,219−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −119,526−100.0% | Sold out |
| Walleye Trading LLC | 0 | $0 | 0.00% | −59,480−100.0% | Sold out |
| Ensign Peak Advisors, Inc | 0 | $0 | 0.00% | −43,380−100.0% | Sold out |
| GFG Capital, LLC | 0 | $0 | 0.00% | −41,400−100.0% | Sold out |
| CSS LLC | 0 | $0 | 0.00% | −33,128−100.0% | Sold out |
| Mirae Asset Global Investments Co., Ltd. | 0 | $0 | 0.00% | −32,197−100.0% | Sold out |
| Dynamic Technology Lab Private Ltd | 0 | $0 | 0.00% | −22,469−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −18,857−100.0% | Sold out |
| Qtron Investments LLC | 0 | $0 | 0.00% | −18,330−100.0% | Sold out |
| Mariner, LLC | 0 | $0 | 0.00% | −16,705−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −15,214−100.0% | Sold out |
| First Republic Investment Management, Inc. | 0 | $0 | 0.00% | −12,012−100.0% | Sold out |
| American Trust | 0 | $0 | 0.00% | −11,715−100.0% | Sold out |
| Commonwealth Equity Services, LLC | 0 | $0 | 0.00% | −10,165−100.0% | Sold out |
| US Bancorp | 0 | $0 | 0.00% | −3,989−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −761−100.0% | Sold out |
| Signaturefd, LLC | 0 | $0 | 0.00% | −607−100.0% | Sold out |
| Lindbrook Capital, LLC | 0 | $0 | 0.00% | −48−100.0% | Sold out |
| Jefferies Group LLC | – | – | – | – | Not filed |