Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2022
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 150
- +16 vs. Q1 2022
- Shares held
- 67.1M
- −737.9K (−1.1%) vs. Q1 2022
- Total value
- $302.8M
- −$195.8M (−39.3%) vs. Q1 2022
- New holders
- 28
- 40 more added
- Sold out
- 12
- 58 more reduced
5 institutions that held it in Q1 2022 haven't filed for Q2 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2022
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Swiss National Bank | 160,750 | $725.0K | 0.00% | 00.0% | Unchanged |
| Allianz Asset Management GmbH | 179,225 | $808.0K | 0.00% | +15,240+9.3% | Added |
| JPMorgan Chase & Co | 184,165 | $830.0K | 0.00% | −534,475−74.4% | Reduced |
| Acadian Asset Management LLC | 185,296 | $836.0K | 0.00% | −313,626−62.9% | Reduced |
| Cubist Systematic Strategies, LLC | 190,479 | $859.0K | 0.01% | +28,996+18.0% | Added |
| Wellington Management Group LLP | 196,342 | $886.0K | 0.00% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 199,977 | $902.0K | 0.00% | +5,780+3.0% | Added |
| Jane Street Group, LLC | 208,597 | $941.0K | 0.00% | −208,246−50.0% | Reduced |
| Jupiter Asset Management Ltd | 224,603 | $1.01M | 0.01% | +224,603 | New |
| UBS Oconnor LLC | 227,599 | $1.03M | 0.01% | +227,599 | New |
| Qube Research & Technologies Ltd | 242,997 | $1.10M | 0.01% | +242,997 | New |
| HighVista Strategies LLC | 250,377 | $1.13M | 0.68% | +250,377 | New |
| Birchview Capital, LP | 269,332 | $1.22M | 0.88% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 281,936 | $1.27M | 0.00% | +807+0.3% | Added |
| Bank of New York Mellon Corp | 286,381 | $1.29M | 0.00% | −10,519−3.5% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 286,659 | $1.29M | 0.08% | −99,178−25.7% | Reduced |
| UBS Group AG | 317,535 | $1.43M | 0.00% | −200,925−38.8% | Reduced |
| Macquarie Group Ltd | 382,041 | $1.72M | 0.00% | 00.0% | Unchanged |
| Voloridge Investment Management, LLC | 389,164 | $1.75M | 0.01% | −287,670−42.5% | Reduced |
| Citadel Advisors LLC | 408,349 | $1.84M | 0.00% | −446,168−52.2% | Reduced |
| Renaissance Technologies LLC | 454,800 | $2.05M | 0.00% | +239,700+111.4% | Added |
| Rafferty Asset Management, LLC | 459,409 | $2.07M | 0.02% | −349,530−43.2% | Reduced |
| Citigroup Inc | 469,019 | $2.12M | 0.00% | +341,239+267.1% | Added |
| Bank of America Corp | 479,418 | $2.16M | 0.00% | −636,812−57.1% | Reduced |
| Lombard Odier Asset Management (Switzerland) SA | 513,802 | $2.32M | 0.20% | −262,251−33.8% | Reduced |
| BNP Paribas Arbitrage, SA | 584,288 | $2.64M | 0.01% | +575,738+6,733.8% | Added |
| Deutsche Bank AG | 594,488 | $2.68M | 0.00% | −4,948−0.8% | Reduced |
| Millennium Management LLC | 605,383 | $2.73M | 0.00% | −647,490−51.7% | Reduced |
| Frontier Capital Management Co LLC | 632,506 | $2.85M | 0.03% | −646,789−50.6% | Reduced |
| ExodusPoint Capital Management, LP | 645,985 | $2.91M | 0.04% | +626,498+3,215.0% | Added |
| Altium Capital Management LP | 700,000 | $3.16M | 1.34% | +55,000+8.5% | Added |
| Northern Trust Corp | 768,098 | $3.46M | 0.00% | +3,763+0.5% | Added |
| Two Sigma Advisers, LP | 986,000 | $4.45M | 0.01% | +210,700+27.2% | Added |
| Two Sigma Investments, LP | 1,023,752 | $4.62M | 0.02% | −94,173−8.4% | Reduced |
| Iron Triangle Partners LP | 1,100,000 | $4.96M | 0.80% | −900,000−45.0% | Reduced |
| Candriam Luxembourg S.C.A. | 1,235,724 | $5.57M | 0.05% | −99,302−7.4% | Reduced |
| Rice Hall James & Associates, LLC | 1,315,834 | $5.93M | 0.29% | −29,095−2.2% | Reduced |
| Geode Capital Management, LLC | 1,326,319 | $5.98M | 0.00% | −11,569−0.9% | Reduced |
| Goldman Sachs Group Inc | 1,446,402 | $6.52M | 0.00% | +547,496+60.9% | Added |
| C WorldWide Group Holding A/S | 1,500,000 | $6.76M | 0.08% | 00.0% | Unchanged |
| Jacobs Levy Equity Management, Inc | 1,527,040 | $6.89M | 0.05% | +863,528+130.1% | Added |
| Walleye Capital LLC | 1,745,415 | $7.87M | 0.23% | +1,662,337+2,000.9% | Added |
| Nuveen Asset Management, LLC | 1,895,378 | $8.55M | 0.00% | +76,330+4.2% | Added |
| Commodore Capital LP | 1,935,609 | $8.73M | 1.85% | −1,625,443−45.6% | Reduced |
| Morgan Stanley | 2,386,698 | $10.8M | 0.00% | −425,865−15.1% | Reduced |
| Vanguard Group Inc | 4,221,980 | $19.0M | 0.00% | +261,272+6.6% | Added |
| Rubric Capital Management LP | 4,400,000 | $19.8M | 1.04% | +792,557+22.0% | Added |
| Palo Alto Investors LP | 5,621,533 | $25.4M | 2.21% | 00.0% | Unchanged |
| BlackRock Inc. | 8,122,849 | $36.6M | 0.00% | +195,231+2.5% | Added |
| State Street Corp | 10,362,009 | $46.7M | 0.00% | −604,692−5.5% | Reduced |
| Victory Capital Management Inc | 0 | $0 | 0.00% | −197,570−100.0% | Sold out |
| ClariVest Asset Management LLC | 0 | $0 | 0.00% | −59,600−100.0% | Sold out |
| Capital Fund Management S.A. | 0 | $0 | 0.00% | −44,154−100.0% | Sold out |
| Walleye Trading LLC | 0 | $0 | 0.00% | −26,482−100.0% | Sold out |
| Dimensional Fund Advisors LP | 0 | $0 | 0.00% | −23,570−100.0% | Sold out |
| Blueshift Asset Management, LLC | 0 | $0 | 0.00% | −22,229−100.0% | Sold out |
| BIT Capital GmbH | 0 | $0 | 0.00% | −13,000−100.0% | Sold out |
| Future Financial Wealth Managment LLC | 0 | $0 | 0.00% | −900−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −830−100.0% | Sold out |
| Jefferies Group LLC | 0 | $0 | 0.00% | −100−100.0% | Sold out |
| American Portfolios Advisors | 0 | $0 | 0.00% | −83−100.0% | Sold out |
| Aaron Wealth Advisors | 0 | $0 | 0.00% | −2,837−100.0% | Sold out |
| Parametric Portfolio Associates LLC | – | – | – | – | Not filed |
| Susquehanna Fundamental Investments, LLC | – | – | – | – | Not filed |
| IndexIQ Advisors LLC | – | – | – | – | Not filed |
| Golden State Equity Partners | – | – | – | – | Not filed |
| Amalgamated Financial Corp. | – | – | – | – | Not filed |