Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2026
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 515
- +21 vs. Q1 2026
- Shares held
- 179.7M
- +7.19M (+4.2%) vs. Q1 2026
- Total value
- $14.3B
- +$1.30B (+10.0%) vs. Q1 2026
- New holders
- 67
- 199 more added
- Sold out
- 46
- 162 more reduced
3 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Artisan Partners Limited Partnership | 2,640,024 | $209.3M | 0.34% | +581,716+28.3% | Added |
| JPMorgan Chase & Co | 2,671,717 | $216.2M | 0.01% | +308,150+13.0% | Added |
| Price T Rowe Associates Inc | 3,184,500 | $252.5M | 0.03% | +159,249+5.3% | Added |
| Geode Capital Management, LLC | 3,584,024 | $294.8M | 0.02% | −400,308−10.0% | Reduced |
| T. Rowe Price Investment Management, Inc. | 3,959,372 | $313.9M | 0.21% | −2,199,655−35.7% | Reduced |
| State Street Corp | 4,334,848 | $343.7M | 0.01% | +339,284+8.5% | Added |
| Royal Bank of Canada | 6,182,479 | $490.2M | 0.08% | +2,380,664+62.6% | Added |
| Two Sigma Investments, LP | 6,252,342 | $495.7M | 0.37% | +394,713+6.7% | Added |
| Vanguard Capital Management LLC | 7,211,497 | $571.8M | 0.01% | +93,167+1.3% | Added |
| Wellington Management Group LLP | 7,651,415 | $606.7M | 0.10% | +1,259,599+19.7% | Added |
| Vanguard Portfolio Management LLC | 7,859,529 | $623.2M | 0.03% | +50,627+0.6% | Added |
| BlackRock, Inc. | 10,704,660 | $848.8M | 0.01% | +262,184+2.5% | Added |
| Capital World Investors | 21,669,226 | $1.72B | 0.20% | +482,857+2.3% | Added |
| FMR LLC | 24,631,956 | $1.95B | 0.08% | +75,319+0.3% | Added |
| Coppell Advisory Solutions LLC | 26 | – | – | +26 | New |
| Zurich Insurance Group Ltd | 0 | $0 | 0.00% | −239,645−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −127,038−100.0% | Sold out |
| Integral Health Asset Management, LLC | 0 | $0 | 0.00% | −125,000−100.0% | Sold out |
| Winton Group Ltd | 0 | $0 | 0.00% | −106,532−100.0% | Sold out |
| Lisanti Capital Growth, LLC | 0 | $0 | 0.00% | −75,699−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −48,244−100.0% | Sold out |
| West Michigan Advisors, LLC | 0 | $0 | 0.00% | −44,614−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −29,658−100.0% | Sold out |
| StemPoint Capital LP | 0 | $0 | 0.00% | −26,385−100.0% | Sold out |
| Florida Financial Advisors, LLC | 0 | $0 | 0.00% | −25,886−100.0% | Sold out |
| EAM Investors, LLC | 0 | $0 | 0.00% | −20,608−100.0% | Sold out |
| Readystate Asset Management LP | 0 | $0 | 0.00% | −20,436−100.0% | Sold out |
| Landscape Capital Management, L.L.C. | 0 | $0 | 0.00% | −20,146−100.0% | Sold out |
| Legato Capital Management LLC | 0 | $0 | 0.00% | −19,840−100.0% | Sold out |
| Highland Capital Management, LLC | 0 | $0 | 0.00% | −12,819−100.0% | Sold out |
| Capstone Capital Management Ltd | 0 | $0 | 0.00% | −21,447−100.0% | Sold out |
| Aigen Investment Management, LP | 0 | $0 | 0.00% | −8,790−100.0% | Sold out |
| Ground Swell Capital, LLC | 0 | $0 | 0.00% | −7,285−100.0% | Sold out |
| Principal Financial Group Inc | 0 | $0 | 0.00% | −7,019−100.0% | Sold out |
| Cynosure Management, LLC | 0 | $0 | 0.00% | −5,614−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −5,342−100.0% | Sold out |
| Lighthouse Investment Partners, LLC | 0 | $0 | 0.00% | −4,970−100.0% | Sold out |
| Farallon Capital Management, L.L.C. | 0 | $0 | 0.00% | −4,800−100.0% | Sold out |
| Vise Technologies, Inc. | 0 | $0 | 0.00% | −4,305−100.0% | Sold out |
| Inspire Advisors, LLC | 0 | $0 | 0.00% | −4,120−100.0% | Sold out |
| Optas, LLC | 0 | $0 | 0.00% | −4,034−100.0% | Sold out |
| Congress Asset Management Co | 0 | $0 | 0.00% | −3,946−100.0% | Sold out |
| EntryPoint Capital, LLC | 0 | $0 | 0.00% | −2,963−100.0% | Sold out |
| Fideuram Asset Management (Ireland) dac | 0 | $0 | 0.00% | −2,213−100.0% | Sold out |
| Advisors Asset Management, Inc. | 0 | $0 | 0.00% | −1,878−100.0% | Sold out |
| Stephens Inc | 0 | $0 | 0.00% | −26,761−100.0% | Sold out |
| MAI Capital Management | 0 | $0 | 0.00% | −940−100.0% | Sold out |
| Root Financial Partners, LLC | 0 | $0 | 0.00% | −681−100.0% | Sold out |
| Quadrant Capital Group LLC | 0 | $0 | 0.00% | −616−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −604−100.0% | Sold out |
| Bayforest Capital Ltd | 0 | $0 | 0.00% | −413−100.0% | Sold out |
| RWM Asset Management, LLC | 0 | $0 | 0.00% | −375−100.0% | Sold out |
| Employees Retirement System of Texas | 0 | $0 | 0.00% | −378−100.0% | Sold out |
| Sound Income Strategies, LLC | 0 | $0 | 0.00% | −300−100.0% | Sold out |
| Twin Peaks Wealth Advisors, LLC | 0 | $0 | 0.00% | −215−100.0% | Sold out |
| Elequin Capital LP | 0 | $0 | 0.00% | −208−100.0% | Sold out |
| Wealth Preservation Advisors, LLC | 0 | $0 | 0.00% | −150−100.0% | Sold out |
| Clear Investment Research, LLC | 0 | $0 | 0.00% | −71−100.0% | Sold out |
| Crewe Advisors LLC | 0 | $0 | 0.00% | −48−100.0% | Sold out |
| Aspect Partners, LLC | 0 | $0 | 0.00% | −20−100.0% | Sold out |
| Dunhill Financial, LLC | 0 | $0 | 0.00% | −2−100.0% | Sold out |
| Janus Henderson Group PLC | – | – | – | – | Not filed |
| CWM, LLC | – | – | – | – | Not filed |
| Sunbelt Securities, Inc. | – | – | – | – | Not filed |