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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 3 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

13F holders, Q3 2026

Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Q3 2026 data is still coming in (13F filing deadline: Nov 16, 2026), so these numbers are incomplete.

Institutional holders
3
0 vs. Q2 2026
Shares held
2.06K
+387 (+23.2%) vs. Q2 2026
Total value
$91.8K
−$40.6K (−30.6%) vs. Q2 2026
New holders
0
2 more added
Sold out
0
1 more reduced

512 institutions that held it in Q2 2026 haven't filed for Q3 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holders
Q1 2021: 365 institutionsQ2 2021: 338 institutionsQ3 2021: 326 institutionsQ4 2021: 341 institutionsQ1 2022: 333 institutionsQ2 2022: 351 institutionsQ3 2022: 350 institutionsQ4 2022: 339 institutionsQ1 2023: 315 institutionsQ2 2023: 305 institutionsQ3 2023: 312 institutionsQ4 2023: 365 institutionsQ1 2024: 361 institutionsQ2 2024: 357 institutionsQ3 2024: 354 institutionsQ4 2024: 356 institutionsQ1 2025: 344 institutionsQ2 2025: 363 institutionsQ3 2025: 437 institutionsQ4 2025: 494 institutionsQ1 2026: 497 institutionsQ2 2026: 515 institutions
Value held
Q1 2021: $5.55BQ2 2021: $4.96BQ3 2021: $4.08BQ4 2021: $3.75BQ1 2022: $4.63BQ2 2022: $4.61BQ3 2022: $5.59BQ4 2022: $4.93BQ1 2023: $4.69BQ2 2023: $5.60BQ3 2023: $6.35BQ4 2023: $7.21BQ1 2024: $6.17BQ2 2024: $6.83BQ3 2024: $6.31BQ4 2024: $5.61BQ1 2025: $5.03BQ2 2025: $6.67BQ3 2025: $11.0BQ4 2025: $13.5BQ1 2026: $13.0BQ2 2026: $14.3B
Institutions holding IONS and their total value by quarter
QuarterHoldersValue
Q2 2026515$14.3B
Q1 2026497$13.0B
Q4 2025494$13.5B
Q3 2025437$11.0B
Q2 2025363$6.67B
Q1 2025344$5.03B
Q4 2024356$5.61B
Q3 2024354$6.31B
Q2 2024357$6.83B
Q1 2024361$6.17B
Q4 2023365$7.21B
Q3 2023312$6.35B
Q2 2023305$5.60B
Q1 2023315$4.69B
Q4 2022339$4.93B
Q3 2022350$5.59B
Q2 2022351$4.61B
Q1 2022333$4.63B
Q4 2021341$3.75B
Q3 2021326$4.08B
Q2 2021338$4.96B
Q1 2021365$5.55B

Institutions, Q3 2026

Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2026.

Institutions holding IONS in Q3 2026
InstitutionSharesValue% of portfolioChange in sharesAction
EverSource Wealth Advisors, LLC––––Not filed
Huntington National Bank––––Not filed
Los Angeles Capital Management LLC––––Not filed
Pacer Advisors, Inc.––––Not filed
Archer Investment Corp––––Not filed
Nisa Investment Advisors, LLC––––Not filed
Harbour Investments, Inc.––––Not filed
Silvant Capital Management LLC––––Not filed
Allworth Financial LP––––Not filed
Mather Group, LLC.––––Not filed
Cassaday & Co Wealth Management LLC––––Not filed
ORG Wealth Partners, LLC––––Not filed
Golden State Wealth Management, LLC––––Not filed
CoreCap Advisors, LLC––––Not filed
Brown Brothers Harriman & Co––––Not filed
Salomon & Ludwin, LLC––––Not filed
Wellington-Altus USA Inc.––––Not filed
Eastern Bank––––Not filed
Capital Advisors, Ltd. LLC––––Not filed
Global X Japan Co., Ltd.––––Not filed
NBC Securities, Inc.––––Not filed
Nomura Asset Management Co Ltd––––Not filed
Steigerwald, Gordon & Koch Inc.––––Not filed
E Fund Management (Hong Kong) Co., Ltd.––––Not filed
SMA Capital LLC––––Not filed
MTM Investment Management, LLC––––Not filed
Parkside Financial Bank & Trust––––Not filed
Trust Co––––Not filed
Caitong International Asset Management Co., Ltd––––Not filed
Umb Bank N A––––Not filed
Harvest Fund Management Co., Ltd––––Not filed
Westside Investment Management, Inc.––––Not filed
FIL Ltd––––Not filed
Cedar Mountain Advisors, LLC––––Not filed
Zions Bancorporation, National Association––––Not filed
Global Trust Asset Management, LLC––––Not filed
Owl Creek Wealth Partners LLC––––Not filed
Covestor Ltd––––Not filed
MH & Associates Securities Management Corp––––Not filed
Atlantic Union Bankshares Corp––––Not filed
LifeSteps Financial, Inc.––––Not filed
Aster Capital Management (DIFC) Ltd––––Not filed
Tower Research Capital LLC (TRC)––––Not filed
United Financial Planning Group LLC––––Not filed
Strategic Wealth Partners, Ltd.––––Not filed
Silver Grove Financial Group, Inc.––––Not filed
SBI Securities Co., Ltd.––––Not filed
Bogart Wealth, LLC––––Not filed
Action Point Financial Planning, LLC––––Not filed
LRI Investments, LLC––––Not filed
Quent Capital, LLC––––Not filed
WPG Advisers, LLC––––Not filed
Spire Wealth Management––––Not filed
Danske Bank A/S––––Not filed
Main Street Group, LTD––––Not filed
TD Private Client Wealth LLC––––Not filed
Basecamp Wealth Advisors LLC––––Not filed
Massmutual Trust Co FSB––––Not filed
Bessemer Group Inc––––Not filed
Keating Financial Advisory Services, Inc.––––Not filed
Ameriflex Group, Inc.––––Not filed
Orion Capital Management LLC––––Not filed
Rossby Financial, LCC––––Not filed
Leonteq Securities AG––––Not filed
Meeder Asset Management Inc––––Not filed
Truvestments Capital LLC––––Not filed
Private Wealth Management Group, LLC––––Not filed
First Horizon Corp––––Not filed
Bell Investment Advisors, Inc––––Not filed
Hilton Head Capital Partners, LLC––––Not filed
Triumph Capital Management––––Not filed
TD Waterhouse Canada Inc.––––Not filed
Sachetta, LLC––––Not filed
Highline Wealth Partners LLC––––Not filed
Hantz Financial Services, Inc.––––Not filed
Cromwell Holdings LLC––––Not filed
Principia Wealth Advisory, LLC––––Not filed
Quarry LP––––Not filed
Cheviot Value Management, LLC––––Not filed
Raffa Wealth Management, LLC––––Not filed
Horizon Investments, LLC––––Not filed
Bruce G. Allen Investments, LLC––––Not filed
Bryn Mawr Trust Co––––Not filed
TFC Financial Management––––Not filed
Transamerica Financial Advisors, Inc.––––Not filed
NBT Bank N A––––Not filed
Clearstead Advisors, LLC––––Not filed
Fortitude Family Office, LLC––––Not filed
Quaker Wealth Management, LLC––––Not filed
MJT & Associates Financial Advisory Group, Inc.––––Not filed
Whipplewood Advisors, LLC––––Not filed
Cornerstone Financial Management LLC––––Not filed
South State Corp.––––Not filed
Mascoma Wealth Management LLC––––Not filed
Cape Investment Advisory, Inc.––––Not filed
Rothschild Investment LLC––––Not filed
Signature Equity Partners, LLC––––Not filed
Valley National Advisers Inc––––Not filed
Hughes Financial Services, LLC––––Not filed
True Wealth Design, LLC––––Not filed