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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 3 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

13F holders, Q3 2026

Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Q3 2026 data is still coming in (13F filing deadline: Nov 16, 2026), so these numbers are incomplete.

Institutional holders
3
0 vs. Q2 2026
Shares held
2.06K
+387 (+23.2%) vs. Q2 2026
Total value
$91.8K
−$40.6K (−30.6%) vs. Q2 2026
New holders
0
2 more added
Sold out
0
1 more reduced

512 institutions that held it in Q2 2026 haven't filed for Q3 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holders
Q1 2021: 365 institutionsQ2 2021: 338 institutionsQ3 2021: 326 institutionsQ4 2021: 341 institutionsQ1 2022: 333 institutionsQ2 2022: 351 institutionsQ3 2022: 350 institutionsQ4 2022: 339 institutionsQ1 2023: 315 institutionsQ2 2023: 305 institutionsQ3 2023: 312 institutionsQ4 2023: 365 institutionsQ1 2024: 361 institutionsQ2 2024: 357 institutionsQ3 2024: 354 institutionsQ4 2024: 356 institutionsQ1 2025: 344 institutionsQ2 2025: 363 institutionsQ3 2025: 437 institutionsQ4 2025: 494 institutionsQ1 2026: 497 institutionsQ2 2026: 515 institutions
Value held
Q1 2021: $5.55BQ2 2021: $4.96BQ3 2021: $4.08BQ4 2021: $3.75BQ1 2022: $4.63BQ2 2022: $4.61BQ3 2022: $5.59BQ4 2022: $4.93BQ1 2023: $4.69BQ2 2023: $5.60BQ3 2023: $6.35BQ4 2023: $7.21BQ1 2024: $6.17BQ2 2024: $6.83BQ3 2024: $6.31BQ4 2024: $5.61BQ1 2025: $5.03BQ2 2025: $6.67BQ3 2025: $11.0BQ4 2025: $13.5BQ1 2026: $13.0BQ2 2026: $14.3B
Institutions holding IONS and their total value by quarter
QuarterHoldersValue
Q2 2026515$14.3B
Q1 2026497$13.0B
Q4 2025494$13.5B
Q3 2025437$11.0B
Q2 2025363$6.67B
Q1 2025344$5.03B
Q4 2024356$5.61B
Q3 2024354$6.31B
Q2 2024357$6.83B
Q1 2024361$6.17B
Q4 2023365$7.21B
Q3 2023312$6.35B
Q2 2023305$5.60B
Q1 2023315$4.69B
Q4 2022339$4.93B
Q3 2022350$5.59B
Q2 2022351$4.61B
Q1 2022333$4.63B
Q4 2021341$3.75B
Q3 2021326$4.08B
Q2 2021338$4.96B
Q1 2021365$5.55B

Institutions, Q3 2026

Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2026.

Institutions holding IONS in Q3 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Planning Strategies Inc.12$5360.00%+4+50.0%Added
CX Institutional46$2.00K0.00%−157−77.3%Reduced
Versant Capital Management, Inc2,000$89.3K0.01%+540+37.0%Added
FMR LLC––––Not filed
Capital World Investors––––Not filed
BlackRock, Inc.––––Not filed
Vanguard Portfolio Management LLC––––Not filed
Wellington Management Group LLP––––Not filed
Vanguard Capital Management LLC––––Not filed
Two Sigma Investments, LP––––Not filed
Royal Bank of Canada––––Not filed
State Street Corp––––Not filed
T. Rowe Price Investment Management, Inc.––––Not filed
Geode Capital Management, LLC––––Not filed
Price T Rowe Associates Inc––––Not filed
JPMorgan Chase & Co––––Not filed
Artisan Partners Limited Partnership––––Not filed
Tweedy, Browne Co LLC––––Not filed
Deep Track Capital, LP––––Not filed
Goldman Sachs Group Inc––––Not filed
Baker Bros. Advisors LP––––Not filed
Deerfield Management Company, L.P. (Series C)––––Not filed
American Century Companies Inc––––Not filed
Franklin Resources Inc––––Not filed
Charles Schwab Investment Management Inc––––Not filed
Barclays PLC––––Not filed
Pictet Asset Management Holding SA––––Not filed
UBS Asset Management Americas Inc––––Not filed
Polar Capital Holdings Plc––––Not filed
Alyeska Investment Group, L.P.––––Not filed
Nomura Asset Management International Inc.––––Not filed
Morgan Stanley––––Not filed
Invesco Ltd.––––Not filed
Vanguard Fiduciary Trust Co––––Not filed
Bellevue Group AG––––Not filed
Groupama Asset Managment––––Not filed
Northern Trust Corp––––Not filed
Capital International Investors––––Not filed
Davern Capital Partners, LP––––Not filed
Bank of America Corp––––Not filed
Summit Partners Public Asset Management, LLC––––Not filed
GW&K Investment Management, LLC––––Not filed
BNP PARIBAS ASSET MANAGEMENT Holding S.A.––––Not filed
Nuveen, LLC––––Not filed
Connor, Clark & Lunn Investment Management Ltd.––––Not filed
Eversept Partners, LP––––Not filed
Voloridge Investment Management, LLC––––Not filed
Massachusetts Financial Services Co––––Not filed
Neuberger Berman Group LLC––––Not filed
Arrowstreet Capital, Limited Partnership––––Not filed
UBS Group AG––––Not filed
TimesSquare Capital Management, LLC––––Not filed
Eventide Asset Management, LLC––––Not filed
Perceptive Advisors LLC––––Not filed
Renaissance Technologies LLC––––Not filed
Bank of New York Mellon Corp––––Not filed
Teacher Retirement System of Texas––––Not filed
Boone Capital Management LLC––––Not filed
Jane Street Group, LLC––––Not filed
New York State Common Retirement Fund––––Not filed
BNP Paribas Arbitrage, SA––––Not filed
Candriam Luxembourg S.C.A.––––Not filed
First Trust Advisors LP––––Not filed
Pinnacle Associates Ltd––––Not filed
Nomura Holdings Inc––––Not filed
Handelsbanken Fonder AB––––Not filed
C WorldWide Group Holding A/S––––Not filed
TD Asset Management Inc––––Not filed
Freestone Grove Partners LP––––Not filed
Qube Research & Technologies Ltd––––Not filed
Capital Research Global Investors––––Not filed
Capital Fund Management S.A.––––Not filed
Alliancebernstein L.P.––––Not filed
Carmignac Gestion––––Not filed
Privium Fund Management B.V.––––Not filed
Swiss National Bank––––Not filed
Jump Financial, LLC––––Not filed
ARK Investment Management LLCSuperinvestorARK Invest––––Not filed
Legal & General Group Plc––––Not filed
D. E. Shaw & Co., Inc.––––Not filed
Millennium Management LLC––––Not filed
Davenport & Co LLC––––Not filed
Standard Life Aberdeen plc––––Not filed
California Public Employees Retirement System––––Not filed
Tocqueville Asset Management L.P.––––Not filed
Raymond James Financial Inc––––Not filed
Citadel Advisors LLC––––Not filed
Universal- Beteiligungs- und Servicegesellschaft mbH––––Not filed
Wells Fargo & Company––––Not filed
Empowered Funds, LLC––––Not filed
Orion Investment Co––––Not filed
Life Cycle Investment Partners Ltd––––Not filed
Algert Global LLC––––Not filed
Stifel Financial Corp––––Not filed
CI Private Wealth, LLC––––Not filed
Eagle Health Investments LP––––Not filed
HSBC Holdings PLC––––Not filed
Sector Gamma AS––––Not filed
California State Teachers Retirement System––––Not filed
Polymer Capital Management (HK) LTD––––Not filed