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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 3 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

13F holders, Q3 2026

Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Q3 2026 data is still coming in (13F filing deadline: Nov 16, 2026), so these numbers are incomplete.

Institutional holders
3
0 vs. Q2 2026
Shares held
2.06K
+387 (+23.2%) vs. Q2 2026
Total value
$91.8K
−$40.6K (−30.6%) vs. Q2 2026
New holders
0
2 more added
Sold out
0
1 more reduced

512 institutions that held it in Q2 2026 haven't filed for Q3 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holders
Q1 2021: 365 institutionsQ2 2021: 338 institutionsQ3 2021: 326 institutionsQ4 2021: 341 institutionsQ1 2022: 333 institutionsQ2 2022: 351 institutionsQ3 2022: 350 institutionsQ4 2022: 339 institutionsQ1 2023: 315 institutionsQ2 2023: 305 institutionsQ3 2023: 312 institutionsQ4 2023: 365 institutionsQ1 2024: 361 institutionsQ2 2024: 357 institutionsQ3 2024: 354 institutionsQ4 2024: 356 institutionsQ1 2025: 344 institutionsQ2 2025: 363 institutionsQ3 2025: 437 institutionsQ4 2025: 494 institutionsQ1 2026: 497 institutionsQ2 2026: 515 institutions
Value held
Q1 2021: $5.55BQ2 2021: $4.96BQ3 2021: $4.08BQ4 2021: $3.75BQ1 2022: $4.63BQ2 2022: $4.61BQ3 2022: $5.59BQ4 2022: $4.93BQ1 2023: $4.69BQ2 2023: $5.60BQ3 2023: $6.35BQ4 2023: $7.21BQ1 2024: $6.17BQ2 2024: $6.83BQ3 2024: $6.31BQ4 2024: $5.61BQ1 2025: $5.03BQ2 2025: $6.67BQ3 2025: $11.0BQ4 2025: $13.5BQ1 2026: $13.0BQ2 2026: $14.3B
Institutions holding IONS and their total value by quarter
QuarterHoldersValue
Q2 2026515$14.3B
Q1 2026497$13.0B
Q4 2025494$13.5B
Q3 2025437$11.0B
Q2 2025363$6.67B
Q1 2025344$5.03B
Q4 2024356$5.61B
Q3 2024354$6.31B
Q2 2024357$6.83B
Q1 2024361$6.17B
Q4 2023365$7.21B
Q3 2023312$6.35B
Q2 2023305$5.60B
Q1 2023315$4.69B
Q4 2022339$4.93B
Q3 2022350$5.59B
Q2 2022351$4.61B
Q1 2022333$4.63B
Q4 2021341$3.75B
Q3 2021326$4.08B
Q2 2021338$4.96B
Q1 2021365$5.55B

Institutions, Q3 2026

Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2026.

Institutions holding IONS in Q3 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Everence Capital Management Inc––––Not filed
Nykredit A/S––––Not filed
Janney Montgomery Scott LLC––––Not filed
MCF Advisors LLC––––Not filed
Cypress Capital, LLC––––Not filed
Cerity Partners LLC––––Not filed
Frank, Rimerman Advisors LLC––––Not filed
Regions Financial Corp––––Not filed
Robeco Institutional Asset Management B.V.––––Not filed
E Fund Management Co., Ltd.––––Not filed
Tema ETFs LLC––––Not filed
ProShare Advisors LLC––––Not filed
VARCOV Co.––––Not filed
Coldstream Capital Management Inc––––Not filed
Resources Investment Advisors, LLC.––––Not filed
R Squared Ltd––––Not filed
Captrust Financial Advisors––––Not filed
Granite Investment Partners, LLC––––Not filed
CIBC Asset Management Inc––––Not filed
Moisand Fitzgerald Tamayo, LLC––––Not filed
AlphaCore Capital LLC––––Not filed
Vontobel Holding Ltd.––––Not filed
Wedmont Private Capital––––Not filed
GWM Advisors LLC––––Not filed
Quantbot Technologies LP––––Not filed
Azzad Asset Management Inc––––Not filed
North Dakota State Investment Board––––Not filed
Atria Investments LLC––––Not filed
Gateway Investment Advisers LLC––––Not filed
Mirae Asset Global ETFs Holdings Ltd.––––Not filed
Blueshift Asset Management, LLC––––Not filed
Credit Agricole S A––––Not filed
Yorktown Management & Research Co Inc––––Not filed
Kestra Advisory Services, LLC––––Not filed
Intrust Bank NA––––Not filed
Checchi Capital Advisers, LLC––––Not filed
Westfield Capital Management Co LP––––Not filed
Prospera Financial Services Inc––––Not filed
HighTower Advisors, LLC––––Not filed
Wealth Enhancement Advisory Services, LLC––––Not filed
Prime Capital Investment Advisors, LLC––––Not filed
Sanctuary Advisors, LLC––––Not filed
Susquehanna Portfolio Strategies, LLC––––Not filed
Qsemble Capital Management, LP––––Not filed
Susquehanna International Group, LLP––––Not filed
Rockefeller Capital Management L.P.––––Not filed
Pinnacle Wealth Planning Services, Inc.––––Not filed
Bridgefront Capital, LLC––––Not filed
Anb Bank––––Not filed
Eurizon Capital SGR S.p.A.––––Not filed
Park Avenue Securities LLC––––Not filed
Berkshire Asset Management LLC––––Not filed
Crossmark Global Holdings, Inc.––––Not filed
MML Investors Services, LLC––––Not filed
Sequoia Financial Advisors, LLC––––Not filed
Everhart Financial Group, Inc.––––Not filed
GF Fund Management Co. Ltd.––––Not filed
Perigon Wealth Management, LLC––––Not filed
New York Life Investment Management LLC––––Not filed
Victrix Investment Advisors––––Not filed
Mitchell & Pahl Private Wealth, LLC––––Not filed
Nwam LLC––––Not filed
Raab & Moskowitz Asset Management LLC––––Not filed
QRG Capital Management, Inc.––––Not filed
M&G Plc––––Not filed
Venturi Wealth Management, LLC––––Not filed
HB Wealth Management, LLC––––Not filed
Argent Trust Co––––Not filed
Larson Financial Group LLC––––Not filed
National Asset Management, Inc.––––Not filed
AlphaGrep UK Ltd––––Not filed
Integrated Wealth Concepts LLC––––Not filed
University of Texas/Texas Am Investment Managment Co––––Not filed
Cambria Investment Management, L.P.––––Not filed
Voleon Capital Management LP––––Not filed
Montis Financial, LLC––––Not filed
Norden Group LLC––––Not filed
IFG Advisory, LLC––––Not filed
Kerntke Otto McGlone Wealth Management Group––––Not filed
Mitsubishi UFJ Kokusai Asset Management Co., Ltd.––––Not filed
Mesirow Financial Investment Management, Inc.––––Not filed
Steward Partners Investment Advisory, LLC––––Not filed
Global Retirement Partners, LLC––––Not filed
Ancora Advisors, LLC––––Not filed
GAMMA Investing LLC––––Not filed
State of Wyoming––––Not filed
Signaturefd, LLC––––Not filed
Caption Management, LLC––––Not filed
Parallel Advisors, LLC––––Not filed
Smartleaf Asset Management LLC––––Not filed
Harbor Investment Advisory, LLC––––Not filed
Sterling Capital Management LLC––––Not filed
Graticule Asia Macro Advisors LLC––––Not filed
International Assets Investment Management, LLC––––Not filed
Farther Finance Advisors, LLC––––Not filed
IMA Wealth, Inc.––––Not filed
SRS Capital Advisors, Inc.––––Not filed
IFP Advisors, Inc––––Not filed
AdvisorNet Financial, Inc––––Not filed
Tripletail Wealth Management, LLC––––Not filed