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Ionis Pharmaceuticals Inc

IONS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000874015

In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 3 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.

13F holders, Q3 2026

Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Q3 2026 data is still coming in (13F filing deadline: Nov 16, 2026), so these numbers are incomplete.

Institutional holders
3
0 vs. Q2 2026
Shares held
2.06K
+387 (+23.2%) vs. Q2 2026
Total value
$91.8K
−$40.6K (−30.6%) vs. Q2 2026
New holders
0
2 more added
Sold out
0
1 more reduced

512 institutions that held it in Q2 2026 haven't filed for Q3 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2026: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holders
Q1 2021: 365 institutionsQ2 2021: 338 institutionsQ3 2021: 326 institutionsQ4 2021: 341 institutionsQ1 2022: 333 institutionsQ2 2022: 351 institutionsQ3 2022: 350 institutionsQ4 2022: 339 institutionsQ1 2023: 315 institutionsQ2 2023: 305 institutionsQ3 2023: 312 institutionsQ4 2023: 365 institutionsQ1 2024: 361 institutionsQ2 2024: 357 institutionsQ3 2024: 354 institutionsQ4 2024: 356 institutionsQ1 2025: 344 institutionsQ2 2025: 363 institutionsQ3 2025: 437 institutionsQ4 2025: 494 institutionsQ1 2026: 497 institutionsQ2 2026: 515 institutions
Value held
Q1 2021: $5.55BQ2 2021: $4.96BQ3 2021: $4.08BQ4 2021: $3.75BQ1 2022: $4.63BQ2 2022: $4.61BQ3 2022: $5.59BQ4 2022: $4.93BQ1 2023: $4.69BQ2 2023: $5.60BQ3 2023: $6.35BQ4 2023: $7.21BQ1 2024: $6.17BQ2 2024: $6.83BQ3 2024: $6.31BQ4 2024: $5.61BQ1 2025: $5.03BQ2 2025: $6.67BQ3 2025: $11.0BQ4 2025: $13.5BQ1 2026: $13.0BQ2 2026: $14.3B
Institutions holding IONS and their total value by quarter
QuarterHoldersValue
Q2 2026515$14.3B
Q1 2026497$13.0B
Q4 2025494$13.5B
Q3 2025437$11.0B
Q2 2025363$6.67B
Q1 2025344$5.03B
Q4 2024356$5.61B
Q3 2024354$6.31B
Q2 2024357$6.83B
Q1 2024361$6.17B
Q4 2023365$7.21B
Q3 2023312$6.35B
Q2 2023305$5.60B
Q1 2023315$4.69B
Q4 2022339$4.93B
Q3 2022350$5.59B
Q2 2022351$4.61B
Q1 2022333$4.63B
Q4 2021341$3.75B
Q3 2021326$4.08B
Q2 2021338$4.96B
Q1 2021365$5.55B

Institutions, Q3 2026

Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2026.

Institutions holding IONS in Q3 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Deutsche Bank AG––––Not filed
ADAR1 Capital Management, LLC––––Not filed
Rhumbline Advisers––––Not filed
Sicart Associates LLC––––Not filed
HRT Financial LP––––Not filed
Vanguard Asset Management, Ltd––––Not filed
CSS LLC––––Not filed
DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main––––Not filed
Adage Capital Partners GP, L.L.C.––––Not filed
Colony Group, LLC––––Not filed
Hudson Bay Capital Management LP––––Not filed
Artia Global Partners LP––––Not filed
Fisher Asset Management, LLC––––Not filed
HealthInvest Partners AB––––Not filed
Lazard Asset Management LLC––––Not filed
State Board of Administration of Florida Retirement System––––Not filed
SEI Investments Co––––Not filed
EFG International AG––––Not filed
Gotham Asset Management, LLC––––Not filed
Manufacturers Life Insurance Company, The––––Not filed
Braidwell LP––––Not filed
Norges Bank––––Not filed
SEB Asset Management AB––––Not filed
Edmond de Rothschild Holding S.A.––––Not filed
Squarepoint Ops LLC––––Not filed
Kennedy Capital Management, Inc.––––Not filed
Envestnet Asset Management Inc––––Not filed
Polygon Management Ltd.––––Not filed
Swedbank AB––––Not filed
State of Wisconsin Investment Board––––Not filed
Public Employees Retirement Association of Colorado––––Not filed
CenterBook Partners LP––––Not filed
Exome Asset Management LLC––––Not filed
Citigroup Inc––––Not filed
DekaBank Deutsche Girozentrale––––Not filed
Dimensional Fund Advisors LP––––Not filed
Russell Investments Group, Ltd.––––Not filed
Fred Alger Management, LLC––––Not filed
China Universal Asset Management Co., Ltd.––––Not filed
Police & Firemen's Retirement System of New Jersey––––Not filed
SG Americas Securities, LLC––––Not filed
Erste Asset Management GmbH––––Not filed
Future Fund LLC––––Not filed
Hillsdale Investment Management Inc.––––Not filed
Treasurer of the State of North Carolina––––Not filed
Bank of Nova Scotia––––Not filed
Jupiter Topco LLC––––Not filed
Ameriprise Financial Inc––––Not filed
Y-Intercept (Hong Kong) Ltd––––Not filed
Great Lakes Advisors, LLC––––Not filed
Voya Investment Management LLC––––Not filed
Victory Capital Management Inc––––Not filed
Vanguard Global Advisers, LLC––––Not filed
Zurcher Kantonalbank (Zurich Cantonalbank)––––Not filed
Quantinno Capital Management LP––––Not filed
Van Eck Associates Corp––––Not filed
Thrivent Financial for Lutherans––––Not filed
Panagora Asset Management Inc––––Not filed
Stanley-Laman Group, Ltd.––––Not filed
XTX Topco Ltd––––Not filed
Schroder Investment Management Group––––Not filed
Rhenman & Partners Asset Management AB––––Not filed
Sovran Advisors, LLC––––Not filed
Edgestream Partners, L.P.––––Not filed
One Capital Management, LLC––––Not filed
Fideuram - Intesa Sanpaolo Private Banking S.P.A.––––Not filed
Nicola Wealth Management Ltd.––––Not filed
KBC Group NV––––Not filed
State of New Jersey Common Pension Fund D––––Not filed
Creative Planning––––Not filed
Campbell & CO Investment Adviser LLC––––Not filed
Capital Counsel LLC––––Not filed
Toroso Investments, LLC––––Not filed
Worldquant Millennium Advisors LLC––––Not filed
Jones Financial Companies LLLP––––Not filed
Sumitomo Mitsui Trust Holdings, Inc.––––Not filed
Nikko Asset Management Americas, Inc.––––Not filed
Public Employees Retirement System of Ohio––––Not filed
Natixis Advisors, L.P.––––Not filed
Arizona State Retirement System––––Not filed
Aquatic Capital Management LLC––––Not filed
Guggenheim Capital LLC––––Not filed
Assenagon Asset Management S.A.––––Not filed
J. Goldman & Co LP––––Not filed
Jefferies Financial Group Inc.––––Not filed
Exchange Traded Concepts, LLC––––Not filed
Vanguard Investments Australia, Ltd.––––Not filed
STRS Ohio––––Not filed
Rafferty Asset Management, LLC––––Not filed
DCF Advisers, LLC––––Not filed
Grandfield & Dodd, LLC––––Not filed
KLP Kapitalforvaltning AS––––Not filed
Entropy Technologies, LP––––Not filed
DeepCurrents Investment Group LLC––––Not filed
ExodusPoint Capital Management, LP––––Not filed
Raiffeisen Bank International AG––––Not filed
Prudential Financial Inc––––Not filed
Pathstone Holdings, LLC––––Not filed
Canada Pension Plan Investment Board––––Not filed
Jain Global LLC––––Not filed