Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 494
- +68 vs. Q3 2025
- Shares held
- 170.2M
- +2.78M (+1.7%) vs. Q3 2025
- Total value
- $13.5B
- +$2.50B (+22.8%) vs. Q3 2025
- New holders
- 112
- 167 more added
- Sold out
- 44
- 142 more reduced
11 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Huntington National Bank | 695 | $55.0K | 0.00% | +41+6.3% | Added |
| Elequin Capital LP | 711 | $56.2K | 0.01% | +711 | New |
| Meeder Asset Management Inc | 716 | $56.6K | 0.00% | +3+0.4% | Added |
| Clear Street Markets LLC | 748 | $59.2K | 0.01% | +748 | New |
| SRS Capital Advisors, Inc. | 774 | $61.2K | 0.00% | +774 | New |
| MAI Capital Management | 900 | $71.2K | 0.00% | +633+237.1% | Added |
| Allworth Financial LP | 920 | $72.8K | 0.00% | +80+9.5% | Added |
| IFP Advisors, Inc | 1,014 | $80.2K | 0.00% | −56−5.2% | Reduced |
| Sunbelt Securities, Inc. | 1,014 | $80.2K | 0.01% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 1,069 | $84.6K | 0.00% | 00.0% | Unchanged |
| Bayforest Capital Ltd | 1,091 | $86.3K | 0.06% | +937+608.4% | Added |
| EverSource Wealth Advisors, LLC | 1,137 | $89.9K | 0.00% | +310+37.5% | Added |
| Farther Finance Advisors, LLC | 1,199 | $94.9K | 0.00% | +633+111.8% | Added |
| International Assets Investment Management, LLC | 1,217 | $96.3K | 0.01% | −6,990−85.2% | Reduced |
| Root Financial Partners, LLC | 1,339 | $105.9K | 0.01% | −1−0.1% | Reduced |
| Employees Retirement System of Texas | 1,354 | $107.0K | 0.00% | +1,354 | New |
| Smartleaf Asset Management LLC | 1,388 | $109.6K | 0.00% | +1,284+1,234.6% | Added |
| Danske Bank A/S | 1,400 | $110.8K | 0.00% | 00.0% | Unchanged |
| Versant Capital Management, Inc | 1,496 | $118.3K | 0.01% | +31+2.1% | Added |
| Twin Lakes Capital Management, LLC | 1,500 | $118.7K | 0.05% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 1,713 | $135.5K | 0.00% | +815+90.8% | Added |
| GAMMA Investing LLC | 1,733 | $137.1K | 0.01% | +392+29.2% | Added |
| Global Retirement Partners, LLC | 1,876 | $148.4K | 0.00% | +1,853+8,056.5% | Added |
| Parallel Advisors, LLC | 1,882 | $148.9K | 0.00% | +5+0.3% | Added |
| Signaturefd, LLC | 2,041 | $161.5K | 0.00% | +38+1.9% | Added |
| Larson Financial Group LLC | 2,340 | $185.1K | 0.01% | +1,230+110.8% | Added |
| Ancora Advisors, LLC | 2,342 | $185.3K | 0.00% | +205+9.6% | Added |
| Motley Fool Asset Management LLC | 2,630 | $208.1K | 0.01% | +2,630 | New |
| PharVision Advisers, LLC | 2,661 | $210.5K | 0.11% | −926−25.8% | Reduced |
| IFG Advisory, LLC | 2,678 | $211.9K | 0.01% | +2,678 | New |
| Kerntke Otto McGlone Wealth Management Group | 2,695 | $213.2K | 0.15% | +2,695 | New |
| Montis Financial, LLC | 2,700 | $213.6K | 0.04% | +2,700 | New |
| Clearbridge Investments, LLC | 2,715 | $214.8K | 0.00% | +2,715 | New |
| Rockefeller Capital Management L.P. | 2,726 | $215.7K | 0.00% | +523+23.7% | Added |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 2,750 | $219.1K | 0.00% | −2,657−49.1% | Reduced |
| Campbell & CO Investment Adviser LLC | 2,784 | $220.2K | 0.01% | +2,784 | New |
| Advisors Asset Management, Inc. | 2,835 | $224.3K | 0.00% | −2,619−48.0% | Reduced |
| Axxcess Wealth Management, LLC | 2,877 | $227.6K | 0.00% | +2,877 | New |
| Impact Partnership Wealth, LLC | 2,905 | $229.8K | 0.03% | +2,905 | New |
| HB Wealth Management, LLC | 2,922 | $231.2K | 0.00% | +2,922 | New |
| Norden Group LLC | 2,935 | $232.2K | 0.02% | +2,935 | New |
| Cambridge Investment Research Advisors, Inc. | 2,957 | $234.0K | 0.00% | +2,957 | New |
| National Asset Management, Inc. | 2,975 | $235.3K | 0.01% | +2,975 | New |
| Argent Trust Co | 3,018 | $238.8K | 0.01% | +3,018 | New |
| Venturi Wealth Management, LLC | 3,061 | $242.2K | 0.01% | +3,061 | New |
| Crossmark Global Holdings, Inc. | 3,102 | $245.4K | 0.00% | +3,102 | New |
| Raab & Moskowitz Asset Management LLC | 3,115 | $246.4K | 0.05% | 00.0% | Unchanged |
| Westfield Capital Management Co LP | 3,157 | $249.8K | 0.00% | +64+2.1% | Added |
| GF Fund Management Co. Ltd. | 3,183 | $251.8K | 0.00% | −246−7.2% | Reduced |
| Anb Bank | 3,193 | $252.6K | 0.10% | −38−1.2% | Reduced |
| Tower Research Capital LLC (TRC) | 3,263 | $258.1K | 0.01% | +218+7.2% | Added |
| MML Investors Services, LLC | 3,264 | $258.2K | 0.00% | +3,264 | New |
| Eurizon Capital SGR S.p.A. | 3,314 | $261.4K | 0.00% | +3,314 | New |
| Nwam LLC | 3,238 | $262.3K | 0.01% | 00.0% | Unchanged |
| Principal Financial Group Inc | 3,339 | $264.1K | 0.00% | −1,446−30.2% | Reduced |
| Mitchell & Pahl Private Wealth, LLC | 3,379 | $267.3K | 0.11% | −193−5.4% | Reduced |
| Everhart Financial Group, Inc. | 3,465 | $274.1K | 0.03% | +3,465 | New |
| Marex Group plc | 3,524 | $278.8K | 0.00% | −3,198−47.6% | Reduced |
| Park Avenue Securities LLC | 3,571 | $283.0K | 0.00% | +3,571 | New |
| Avanza Fonder AB | 3,596 | $284.5K | 0.01% | +3,596 | New |
| Berkshire Asset Management LLC | 3,630 | $287.2K | 0.01% | +16+0.4% | Added |
| Tudor Investment Corp Et Al | 3,661 | $289.6K | 0.00% | +3,661 | New |
| Cambria Investment Management, L.P. | 3,684 | $291.4K | 0.02% | +3,684 | New |
| Group One Trading, L.P. | 3,778 | $298.9K | 0.01% | −1,018−21.2% | Reduced |
| STRS Ohio | 3,788 | $299.7K | 0.00% | +72+1.9% | Added |
| Pinnacle Wealth Planning Services, Inc. | 3,864 | $305.7K | 0.03% | −1,249−24.4% | Reduced |
| Mackenzie Financial Corp | 3,891 | $306.7K | 0.00% | +303+8.4% | Added |
| Prime Capital Investment Advisors, LLC | 3,981 | $314.9K | 0.00% | +47+1.2% | Added |
| Comerica Bank | 3,997 | $316.2K | 0.00% | +1,810+82.8% | Added |
| Janney Montgomery Scott LLC | 4,177 | $330.0K | 0.00% | +4,177 | New |
| Bank of Nova Scotia | 4,189 | $331.4K | 0.00% | +680+19.4% | Added |
| Checchi Capital Advisers, LLC | 4,272 | $338.0K | 0.02% | +39+0.9% | Added |
| Voleon Capital Management LP | 4,288 | $339.2K | 0.01% | +1,228+40.1% | Added |
| Vise Technologies, Inc. | 4,305 | $340.6K | 0.01% | +4,305 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 4,334 | $342.3K | 0.00% | −2,097−32.6% | Reduced |
| AE Wealth Management LLC | 4,403 | $348.3K | 0.00% | +4,403 | New |
| Credit Agricole S A | 4,410 | $348.9K | 0.00% | −300−6.4% | Reduced |
| Kestra Advisory Services, LLC | 4,451 | $352.1K | 0.00% | −521−10.5% | Reduced |
| Sanctuary Advisors, LLC | 4,502 | $356.2K | 0.00% | +865+23.8% | Added |
| Skopos Labs, Inc. | 4,669 | $373.4K | 0.02% | +4,669 | New |
| Prospera Financial Services Inc | 4,759 | $376.5K | 0.01% | +178+3.9% | Added |
| Farallon Capital Management, L.L.C. | 4,800 | $379.7K | 0.00% | 00.0% | Unchanged |
| Granite Investment Partners, LLC | 4,806 | $380.2K | 0.02% | −23,227−82.9% | Reduced |
| Harvest Fund Management Co., Ltd | 4,816 | $381.0K | 0.01% | +3,070+175.8% | Added |
| Inspire Advisors, LLC | 4,851 | $383.8K | 0.04% | +4,851 | New |
| GWM Advisors LLC | 4,938 | $390.6K | 0.00% | +116+2.4% | Added |
| Moisand Fitzgerald Tamayo, LLC | 5,000 | $395.6K | 0.04% | 00.0% | Unchanged |
| Resources Investment Advisors, LLC. | 5,006 | $396.0K | 0.00% | +1,418+39.5% | Added |
| CIBC Asset Management Inc | 5,017 | $396.9K | 0.00% | +409+8.9% | Added |
| CWM, LLC | 5,049 | $399.0K | 0.00% | +2,561+102.9% | Added |
| HighTower Advisors, LLC | 5,122 | $405.2K | 0.00% | −336−6.2% | Reduced |
| US Bancorp | 5,141 | $406.7K | 0.00% | +437+9.3% | Added |
| Vontobel Holding Ltd. | 5,240 | $414.5K | 0.00% | +5,240 | New |
| Captrust Financial Advisors | 5,293 | $418.7K | 0.00% | +5,293 | New |
| Dymon Asia Capital (Singapore) Pte. Ltd. | 5,350 | $423.2K | 0.09% | +5,350 | New |
| North Dakota State Investment Board | 5,480 | $433.5K | 0.02% | +5,480 | New |
| Mercer Global Advisors Inc | 5,554 | $439.4K | 0.00% | +1,807+48.2% | Added |
| Atria Investments LLC | 5,655 | $447.4K | 0.01% | −1,375−19.6% | Reduced |
| Frank, Rimerman Advisors LLC | 5,781 | $457.3K | 0.03% | +16+0.3% | Added |
| Wedmont Private Capital | 5,536 | $460.4K | 0.02% | +173+3.2% | Added |