Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 437
- +78 vs. Q2 2025
- Shares held
- 168.2M
- −221.1K (−0.1%) vs. Q2 2025
- Total value
- $11.0B
- +$4.36B (+65.5%) vs. Q2 2025
- New holders
- 115
- 136 more added
- Sold out
- 37
- 116 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Treasurer of the State of North Carolina | 69,862 | $4.57M | 0.01% | −2,725−3.8% | Reduced |
| Erste Asset Management GmbH | 71,800 | $4.61M | 0.04% | +20,500+40.0% | Added |
| Hillsdale Investment Management Inc. | 70,900 | $4.64M | 0.14% | +70,900 | New |
| First Trust Advisors LP | 75,224 | $4.92M | 0.00% | +18,705+33.1% | Added |
| Russell Investments Group, Ltd. | 77,293 | $5.06M | 0.01% | +68,028+734.2% | Added |
| Great Point Partners LLC | 80,000 | $5.23M | 2.19% | −420,000−84.0% | Reduced |
| Nicola Wealth Management Ltd. | 87,000 | $5.69M | 0.51% | 00.0% | Unchanged |
| Standard Life Aberdeen plc | 87,924 | $5.75M | 0.01% | −318,770−78.4% | Reduced |
| Deutsche Bank AG | 88,803 | $5.81M | 0.00% | +3,525+4.1% | Added |
| DekaBank Deutsche Girozentrale | 93,807 | $5.99M | 0.01% | 00.0% | Unchanged |
| Lisanti Capital Growth, LLC | 92,124 | $6.03M | 1.47% | +92,124 | New |
| Susquehanna Portfolio Strategies, LLC | 95,960 | $6.28M | 0.10% | +3,060+3.3% | Added |
| J. Goldman & Co LP | 96,198 | $6.29M | 0.24% | −51,484−34.9% | Reduced |
| State of Wisconsin Investment Board | 96,837 | $6.34M | 0.01% | +143+0.1% | Added |
| Manufacturers Life Insurance Company, The | 98,023 | $6.41M | 0.01% | +14,637+17.6% | Added |
| Simplex Trading, LLC | 100,206 | $6.55M | 0.14% | +60,568+152.8% | Added |
| Amundi | 101,531 | $7.01M | 0.00% | +101,531 | New |
| DCF Advisers, LLC | 108,413 | $7.09M | 2.69% | +16,663+18.2% | Added |
| Acadian Asset Management LLC | 110,444 | $7.21M | 0.01% | +110,444 | New |
| Voya Investment Management LLC | 111,589 | $7.30M | 0.01% | +47,072+73.0% | Added |
| Van Eck Associates Corp | 111,819 | $7.32M | 0.01% | +38,202+51.9% | Added |
| Nikko Asset Management Americas, Inc. | 114,592 | $7.49M | 0.07% | −25,147−18.0% | Reduced |
| Neuberger Berman Group LLC | 114,743 | $7.51M | 0.01% | +120+0.1% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 114,772 | $7.51M | 0.00% | −24,967−17.9% | Reduced |
| Healthcare of Ontario Pension Plan Trust Fund | 116,000 | $7.59M | 0.01% | 00.0% | Unchanged |
| BLB&B Advisors, LLC | 118,600 | $7.76M | 0.33% | −32,950−21.7% | Reduced |
| SEI Investments Co | 119,028 | $7.79M | 0.01% | +20,680+21.0% | Added |
| Kennedy Capital Management, Inc. | 122,766 | $8.03M | 0.18% | −9,279−7.0% | Reduced |
| Rafferty Asset Management, LLC | 125,773 | $8.23M | 0.03% | −18,997−13.1% | Reduced |
| Exome Asset Management LLC | 131,016 | $8.57M | 5.66% | +9,900+8.2% | Added |
| ADAR1 Capital Management, LLC | 133,818 | $8.75M | 0.87% | −14,643−9.9% | Reduced |
| Lombard Odier Asset Management (Europe) Ltd | – | $8.96M | 0.46% | – | New |
| State Board of Administration of Florida Retirement System | 143,534 | $9.39M | 0.02% | −10,361−6.7% | Reduced |
| California State Teachers Retirement System | 145,112 | $9.49M | 0.01% | +80.0% | Added |
| Natixis | 145,286 | $9.50M | 0.05% | +145,286 | New |
| ExodusPoint Capital Management, LP | 152,125 | $9.95M | 0.14% | +152,125 | New |
| Skandinaviska Enskilda Banken AB (publ) | 155,790 | $10.2M | 0.04% | +96,164+161.3% | Added |
| Citigroup Inc | 155,853 | $10.2M | 0.01% | −185,124−54.3% | Reduced |
| Edmond de Rothschild Holding S.A. | 156,690 | $10.3M | 0.16% | −40,910−20.7% | Reduced |
| Aquatic Capital Management LLC | 159,045 | $10.4M | 0.19% | +959+0.6% | Added |
| Capricorn Fund Managers Ltd | 162,800 | $10.7M | 3.58% | +162,800 | New |
| Boothbay Fund Management, LLC | 163,462 | $10.7M | 0.28% | +163,462 | New |
| Sicart Associates LLC | 164,318 | $10.7M | 2.91% | −20,978−11.3% | Reduced |
| New York State Common Retirement Fund | 168,222 | $11.0M | 0.01% | +81,250+93.4% | Added |
| Sonora Investment Management Group, LLC | 169,808 | $11.1M | 0.79% | +6,636+4.1% | Added |
| Sovran Advisors, LLC | 150,856 | $11.2M | 0.99% | −171,057−53.1% | Reduced |
| Cinctive Capital Management LP | 173,819 | $11.4M | 0.57% | +173,819 | New |
| Rhumbline Advisers | 182,061 | $11.9M | 0.01% | +462+0.3% | Added |
| Great Lakes Advisors, LLC | 186,950 | $12.2M | 0.10% | −212,696−53.2% | Reduced |
| Tocqueville Asset Management L.P. | 193,045 | $12.6M | 0.18% | +5,700+3.0% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 197,434 | $12.9M | 0.02% | +47,595+31.8% | Added |
| Schonfeld Strategic Advisors LLC | 200,839 | $13.1M | 0.09% | −248,367−55.3% | Reduced |
| Stifel Financial Corp | 202,628 | $13.3M | 0.01% | +6,271+3.2% | Added |
| Trexquant Investment LP | 215,121 | $14.1M | 0.15% | +86,252+66.9% | Added |
| California Public Employees Retirement System | 215,845 | $14.1M | 0.01% | +13,852+6.9% | Added |
| Orion Investment Co | 224,705 | $14.7M | 4.70% | +7,335+3.4% | Added |
| Jain Global LLC | 225,739 | $14.8M | 0.19% | +218,544+3,037.4% | Added |
| Raymond James Financial Inc | 240,424 | $15.7M | 0.01% | +29,832+14.2% | Added |
| Privium Fund Management B.V. | 248,894 | $16.3M | 2.93% | −18,700−7.0% | Reduced |
| Algert Global LLC | 252,281 | $16.5M | 0.28% | +214,191+562.3% | Added |
| GW&K Investment Management, LLC | 264,007 | $17.3M | 0.15% | −184,823−41.2% | Reduced |
| Sector Gamma AS | 270,963 | $17.7M | 4.40% | −14,879−5.2% | Reduced |
| Wells Fargo & Company | 285,293 | $18.7M | 0.00% | +75,436+35.9% | Added |
| Swiss National Bank | 293,100 | $19.2M | 0.01% | +4,500+1.6% | Added |
| Rhenman & Partners Asset Management AB | 310,000 | $20.3M | 2.24% | +128,000+70.3% | Added |
| Alyeska Investment Group, L.P. | 311,258 | $20.4M | 0.06% | +152,250+95.7% | Added |
| Assenagon Asset Management S.A. | 312,297 | $20.4M | 0.03% | +294,643+1,669.0% | Added |
| Legal & General Group Plc | 319,565 | $20.9M | 0.00% | −84,801−21.0% | Reduced |
| Man Group plc | 333,820 | $21.8M | 0.04% | +324,851+3,621.9% | Added |
| Jane Street Group, LLC | 365,070 | $23.9M | 0.03% | +365,070 | New |
| BNP Paribas Arbitrage, SA | 383,226 | $25.1M | 0.02% | +205,464+115.6% | Added |
| Squarepoint Ops LLC | 383,792 | $25.1M | 0.05% | +249,397+185.6% | Added |
| AXA Investment Managers S.A. | 406,451 | $26.6M | 0.07% | +406,451 | New |
| Ikarian Capital, LLC | 415,163 | $27.2M | 6.15% | +415,163 | New |
| Nuveen, LLC | 415,618 | $27.2M | 0.01% | +170,533+69.6% | Added |
| Boone Capital Management LLC | 417,833 | $27.3M | 8.96% | +417,833 | New |
| Susquehanna International Group, LLP | 420,950 | $27.5M | 0.04% | +420,950 | New |
| C WorldWide Group Holding A/S | 426,000 | $27.9M | 0.43% | −24,000−5.3% | Reduced |
| Teacher Retirement System of Texas | 473,945 | $31.0M | 0.12% | −194,328−29.1% | Reduced |
| Pinnacle Associates Ltd | 481,751 | $31.5M | 0.42% | −12,788−2.6% | Reduced |
| Renaissance Technologies LLC | 486,714 | $31.8M | 0.04% | +216,000+79.8% | Added |
| Hudson Bay Capital Management LP | 515,000 | $33.7M | 0.20% | −235,000−31.3% | Reduced |
| Invesco Ltd. | 519,070 | $34.0M | 0.01% | +262,835+102.6% | Added |
| Bank of New York Mellon Corp | 532,114 | $34.8M | 0.01% | +4,926+0.9% | Added |
| Eversept Partners, LP | 538,661 | $35.2M | 2.70% | −50,239−8.5% | Reduced |
| JPMorgan Chase & Co | 544,468 | $35.6M | 0.00% | +149,490+37.8% | Added |
| Tang Capital Management LLC | 550,000 | $36.0M | 1.39% | +400,000+266.7% | Added |
| Baker Bros. Advisors LP | 566,798 | $37.1M | 0.27% | +566,798 | New |
| Groupama Asset Managment | 561,777 | $37.4M | 0.55% | −99,180−15.0% | Reduced |
| Candriam Luxembourg S.C.A. | 611,237 | $40.0M | 0.21% | −113,503−15.7% | Reduced |
| Arrowstreet Capital, Limited Partnership | 630,136 | $41.2M | 0.03% | +630,136 | New |
| D. E. Shaw & Co., Inc. | 630,938 | $41.3M | 0.03% | +630,938 | New |
| ARK Investment Management LLCSuperinvestorARK Invest | 631,215 | $41.3M | 0.25% | −269,103−29.9% | Reduced |
| Barclays PLC | 714,048 | $46.7M | 0.02% | +130,782+22.4% | Added |
| Nomura Holdings Inc | 733,398 | $48.0M | 0.22% | +701,237+2,180.4% | Added |
| Bank of Montreal | 747,402 | $48.9M | 0.02% | +264,113+54.6% | Added |
| Summit Partners Public Asset Management, LLC | 750,000 | $49.1M | 1.60% | +750,000 | New |
| Balyasny Asset Management LLC | 760,111 | $49.7M | 0.10% | −8,537−1.1% | Reduced |
| Ameriprise Financial Inc | 765,822 | $50.1M | 0.01% | +397,703+108.0% | Added |
| Goldman Sachs Group Inc | 777,570 | $50.9M | 0.01% | −3700.0% | Reduced |