Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 437
- +78 vs. Q2 2025
- Shares held
- 168.2M
- −221.1K (−0.1%) vs. Q2 2025
- Total value
- $11.0B
- +$4.36B (+65.5%) vs. Q2 2025
- New holders
- 115
- 136 more added
- Sold out
- 37
- 116 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| denkapparat Operations GmbH | 9,968 | $652.1K | 0.42% | +9,968 | New |
| Cypress Capital, LLC | 10,000 | $654.2K | 0.19% | 00.0% | Unchanged |
| Gsa Capital Partners LLP | 10,172 | $665.0K | 0.06% | +10,172 | New |
| Jefferies Financial Group Inc. | 10,169 | $665.3K | 0.01% | −12,212−54.6% | Reduced |
| Baader Bank INC | 10,228 | $668.4K | 0.06% | +10,228 | New |
| Capstone Investment Advisors, LLC | 10,402 | $680.5K | 0.01% | +10,402 | New |
| Suvretta Capital Management, LLC | 10,800 | $706.5K | 0.02% | 00.0% | Unchanged |
| Plancorp, LLC | 11,208 | $733.2K | 0.02% | 00.0% | Unchanged |
| Blueshift Asset Management, LLC | 11,460 | $749.7K | 0.23% | +11,460 | New |
| Allianz Asset Management GmbH | 11,500 | $752.3K | 0.00% | +11,500 | New |
| Vident Advisory, LLC | 11,551 | $755.7K | 0.01% | −449−3.7% | Reduced |
| JustInvest LLC | 12,090 | $790.9K | 0.01% | +18+0.1% | Added |
| The PNC Financial Services Group, Inc. | 12,113 | $792.4K | 0.00% | +702+6.2% | Added |
| Amalgamated Bank | 12,195 | $798.0K | 0.01% | +669+5.8% | Added |
| NEOS Investment Management LLC | 12,306 | $805.1K | 0.01% | −15,855−56.3% | Reduced |
| Tema ETFs LLC | 12,306 | $805.1K | 0.07% | −15,855−56.3% | Reduced |
| Virtus Investment Advisers, Inc. | 12,476 | $816.2K | 0.23% | 00.0% | Unchanged |
| Horizon Kinetics Asset Management LLC | 12,476 | $816.2K | 0.01% | +524+4.4% | Added |
| Wiley Bros.-Aintree Capital, LLC | 12,663 | $828.4K | 0.01% | +905+7.7% | Added |
| Northwestern Mutual Wealth Management Co | 12,782 | $836.2K | 0.00% | +538+4.4% | Added |
| Annis Gardner Whiting Capital Advisors, LLC | 12,801 | $837.4K | 0.17% | 00.0% | Unchanged |
| Westmount Partners, LLC | 12,961 | $852.8K | 0.22% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 13,349 | $873.0K | 0.00% | −593−4.3% | Reduced |
| Fieldview Capital Management, LLC | 13,523 | $884.7K | 0.14% | −3,783−21.9% | Reduced |
| Aigen Investment Management, LP | 13,578 | $888.3K | 0.14% | +5,280+63.6% | Added |
| Bleakley Financial Group, LLC | 13,878 | $907.9K | 0.02% | −4,251−23.4% | Reduced |
| Brown Advisory Inc | 14,026 | $917.6K | 0.00% | +1,835+15.1% | Added |
| Dynasty Wealth Management, LLC | 14,341 | $938.2K | 0.01% | +14,341 | New |
| Significant Wealth Partners LLC | 14,967 | $979.1K | 0.48% | −537−3.5% | Reduced |
| Davy Global Fund Management Ltd | 15,284 | $999.9K | 0.07% | +2,021+15.2% | Added |
| Public Employees Retirement Association of Colorado | 15,589 | $1.02M | 0.00% | 00.0% | Unchanged |
| Diversified Trust Co | 15,633 | $1.02M | 0.02% | +15,633 | New |
| Point72 (DIFC) Ltd | 15,698 | $1.03M | 0.07% | +7,611+94.1% | Added |
| North Star Asset Management Inc | 16,610 | $1.09M | 0.04% | 00.0% | Unchanged |
| Graham Capital Management, L.P. | 17,163 | $1.12M | 0.04% | −3,772−18.0% | Reduced |
| Legato Capital Management LLC | 17,300 | $1.13M | 0.12% | +17,300 | New |
| Exchange Traded Concepts, LLC | 18,070 | $1.18M | 0.01% | +9,268+105.3% | Added |
| Victory Capital Management Inc | 18,211 | $1.19M | 0.00% | −305−1.6% | Reduced |
| Dana Investment Advisors, Inc. | 18,818 | $1.23M | 0.04% | +18,818 | New |
| Resolute Capital Asset Partners LLC | 20,000 | $1.31M | 0.68% | +20,000 | New |
| Nicollet Investment Management, Inc. | 20,408 | $1.33M | 0.44% | −339−1.6% | Reduced |
| Xponance, Inc. | 21,450 | $1.40M | 0.01% | −1,304−5.7% | Reduced |
| Atika Capital Management LLC | 21,500 | $1.41M | 0.12% | +21,500 | New |
| BlueCrest Capital Management Ltd | 23,370 | $1.53M | 0.09% | +23,370 | New |
| Teachers Retirement System of the State of Kentucky | 24,083 | $1.58M | 0.01% | 00.0% | Unchanged |
| Mariner, LLC | 24,227 | $1.58M | 0.00% | −12,687−34.4% | Reduced |
| LPL Financial LLC | 24,463 | $1.60M | 0.00% | −409−1.6% | Reduced |
| Daiwa Securities Group Inc. | 24,701 | $1.62M | 0.01% | −1,440−5.5% | Reduced |
| Bayesian Capital Management, LP | 24,715 | $1.62M | 0.33% | +8,115+48.9% | Added |
| Bamco Inc | 25,000 | $1.64M | 0.00% | +25,000 | New |
| Engineers Gate Manager LP | 25,779 | $1.69M | 0.02% | −7,339−22.2% | Reduced |
| Calamos Advisors LLC | 25,863 | $1.69M | 0.01% | +25,863 | New |
| Profund Advisors LLC | 25,932 | $1.70M | 0.06% | −2,927−10.1% | Reduced |
| Landscape Capital Management, L.L.C. | 26,562 | $1.74M | 0.11% | +26,562 | New |
| Wolverine Trading, LLC | 27,585 | $1.77M | 0.04% | +27,585 | New |
| Envestnet Asset Management Inc | 27,509 | $1.80M | 0.00% | +13,965+103.1% | Added |
| Ensign Peak Advisors, Inc | 27,595 | $1.81M | 0.00% | −25,725−48.2% | Reduced |
| China Universal Asset Management Co., Ltd. | 27,939 | $1.83M | 0.15% | −4,027−12.6% | Reduced |
| Granite Investment Partners, LLC | 28,033 | $1.83M | 0.10% | −15,148−35.1% | Reduced |
| Twin Tree Management, LP | 28,575 | $1.87M | 0.09% | +28,575 | New |
| KLP Kapitalforvaltning AS | 31,500 | $2.06M | 0.01% | 00.0% | Unchanged |
| Gotham Asset Management, LLC | 32,152 | $2.10M | 0.01% | +17,873+125.2% | Added |
| Entropy Technologies, LP | 32,925 | $2.15M | 0.16% | +3,473+11.8% | Added |
| Pathstone Holdings, LLC | 33,602 | $2.20M | 0.01% | +2,843+9.2% | Added |
| Blair William & Co | 34,371 | $2.25M | 0.01% | −3,520−9.3% | Reduced |
| Guggenheim Capital LLC | 35,357 | $2.31M | 0.02% | −5,500−13.5% | Reduced |
| Stanley-Laman Group, Ltd. | 35,774 | $2.34M | 0.33% | +35,774 | New |
| Quantinno Capital Management LP | 36,115 | $2.36M | 0.01% | +18,573+105.9% | Added |
| Future Fund LLC | 36,156 | $2.37M | 0.83% | +6,561+22.2% | Added |
| One Capital Management, LLC | 36,426 | $2.38M | 0.08% | +6,561+22.0% | Added |
| Verition Fund Management LLC | 37,196 | $2.43M | 0.01% | −195,491−84.0% | Reduced |
| Prelude Capital Management, LLC | 37,293 | $2.44M | 0.19% | −2,130−5.4% | Reduced |
| LMR Partners LLP | 37,600 | $2.46M | 0.03% | +37,600 | New |
| Grandfield & Dodd, LLC | 37,675 | $2.46M | 0.14% | +445+1.2% | Added |
| NJ State Employees Deferred Compensation Plan | 42,000 | $2.75M | 0.30% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 42,217 | $2.76M | 0.00% | +42,217 | New |
| Fred Alger Management, LLC | 42,401 | $2.77M | 0.01% | +32,937+348.0% | Added |
| Bridgewater Associates, LP | 43,578 | $2.85M | 0.01% | +43,578 | New |
| Arizona State Retirement System | 44,731 | $2.93M | 0.02% | +691+1.6% | Added |
| HSBC Holdings PLC | 45,456 | $2.95M | 0.00% | −62,838−58.0% | Reduced |
| Great West Life Assurance Co | 46,128 | $2.96M | 0.00% | −373−0.8% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 45,220 | $2.96M | 0.01% | +1,605+3.7% | Added |
| Dark Forest Capital Management LP | 46,092 | $3.02M | 0.11% | +46,092 | New |
| Point72 Hong Kong Ltd | 47,517 | $3.11M | 0.14% | +47,517 | New |
| Public Employees Retirement System of Ohio | 48,545 | $3.18M | 0.01% | +301+0.6% | Added |
| Cubist Systematic Strategies, LLC | 48,654 | $3.18M | 0.04% | +48,654 | New |
| Raiffeisen Bank International AG | 50,000 | $3.21M | 0.04% | −6,754−11.9% | Reduced |
| Capital Counsel LLC | 49,605 | $3.25M | 0.12% | −600−1.2% | Reduced |
| Creative Planning | 51,474 | $3.37M | 0.00% | −1,815−3.4% | Reduced |
| Handelsbanken Fonder AB | 51,911 | $3.40M | 0.01% | +8,700+20.1% | Added |
| EAM Investors, LLC | 54,977 | $3.54M | 0.41% | +54,977 | New |
| Alliancebernstein L.P. | 54,262 | $3.55M | 0.00% | +2,205+4.2% | Added |
| PDT Partners, LLC | 54,365 | $3.56M | 0.22% | 00.0% | Unchanged |
| Alpine Global Management, LLC | 55,900 | $3.66M | 0.75% | +30,463+119.8% | Added |
| State of New Jersey Common Pension Fund D | 59,817 | $3.91M | 0.01% | +899+1.5% | Added |
| Artia Global Partners LP | 60,176 | $3.94M | 0.69% | +60,176 | New |
| Davenport & Co LLC | 62,563 | $4.09M | 0.02% | −2,280−3.5% | Reduced |
| Lazard Asset Management LLC | 63,791 | $4.17M | 0.01% | +3,042+5.0% | Added |
| Janus Henderson Group PLC | 63,877 | $4.18M | 0.00% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 69,324 | $4.54M | 0.04% | +9,601+16.1% | Added |