Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 363
- +21 vs. Q1 2025
- Shares held
- 168.9M
- +2.14M (+1.3%) vs. Q1 2025
- Total value
- $6.67B
- +$1.64B (+32.6%) vs. Q1 2025
- New holders
- 80
- 121 more added
- Sold out
- 59
- 109 more reduced
2 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Swiss National Bank | 288,600 | $11.4M | 0.01% | +13,300+4.8% | Added |
| Point72 Asset Management, L.P. | 292,647 | $11.6M | 0.03% | +5,443+1.9% | Added |
| Sovran Advisors, LLC | 321,913 | $13.3M | 1.39% | −6,991−2.1% | Reduced |
| Citigroup Inc | 340,977 | $13.5M | 0.01% | −85,503−20.0% | Reduced |
| Artisan Partners Limited Partnership | 354,962 | $14.0M | 0.02% | +151,784+74.7% | Added |
| Ameriprise Financial Inc | 368,119 | $14.5M | 0.00% | +7,931+2.2% | Added |
| JPMorgan Chase & Co | 394,978 | $15.6M | 0.00% | −26,533−6.3% | Reduced |
| Great Lakes Advisors, LLC | 399,646 | $15.8M | 0.13% | +399,646 | New |
| Legal & General Group Plc | 404,366 | $16.0M | 0.00% | +65,904+19.5% | Added |
| Standard Life Aberdeen plc | 406,694 | $16.2M | 0.03% | −39,503−8.9% | Reduced |
| GW&K Investment Management, LLC | 448,830 | $17.7M | 0.16% | +266,521+146.2% | Added |
| Schonfeld Strategic Advisors LLC | 449,206 | $17.7M | 0.13% | −111,153−19.8% | Reduced |
| C WorldWide Group Holding A/S | 450,000 | $17.8M | 0.24% | +50,000+12.5% | Added |
| Norges Bank | 450,254 | $17.8M | 0.00% | −407,974−47.5% | Reduced |
| American Century Companies Inc | 472,749 | $18.7M | 0.01% | +355,981+304.9% | Added |
| Bank of Montreal | 483,289 | $19.1M | 0.01% | −299,546−38.3% | Reduced |
| Pinnacle Associates Ltd | 494,539 | $19.5M | 0.28% | −113,978−18.7% | Reduced |
| Great Point Partners LLC | 500,000 | $19.8M | 12.84% | +250,000+100.0% | Added |
| Vestal Point Capital, LP | 500,000 | $19.8M | 1.04% | +500,000 | New |
| Massachusetts Financial Services Co | 519,184 | $20.5M | 0.01% | +519,184 | New |
| Bank of New York Mellon Corp | 527,188 | $20.8M | 0.00% | −17,445−3.2% | Reduced |
| AXA S.A. | 566,883 | $22.4M | 0.06% | +397+0.1% | Added |
| Barclays PLC | 583,266 | $23.0M | 0.01% | +229,329+64.8% | Added |
| Eversept Partners, LP | 588,900 | $23.3M | 2.34% | +71,879+13.9% | Added |
| Pictet Asset Management Holding SA | 608,640 | $24.2M | 0.02% | −9,910−1.6% | Reduced |
| Teacher Retirement System of Texas | 668,273 | $26.4M | 0.11% | +167,822+33.5% | Added |
| Groupama Asset Managment | 660,957 | $26.8M | 0.44% | +91,746+16.1% | Added |
| Candriam Luxembourg S.C.A. | 724,740 | $28.6M | 0.17% | −268,964−27.1% | Reduced |
| Woodline Partners LP | 732,813 | $29.0M | 0.15% | +732,813 | New |
| Hudson Bay Capital Management LP | 750,000 | $29.6M | 0.19% | −299,900−28.6% | Reduced |
| Balyasny Asset Management LLC | 768,648 | $30.4M | 0.07% | +768,648 | New |
| Goldman Sachs Group Inc | 777,940 | $30.7M | 0.00% | +125,422+19.2% | Added |
| UBS Asset Management Americas Inc | 791,072 | $31.3M | 0.01% | +131,637+20.0% | Added |
| Royal Bank of Canada | 799,912 | $31.6M | 0.01% | +183,831+29.8% | Added |
| Northern Trust Corp | 814,250 | $32.2M | 0.00% | −20,597−2.5% | Reduced |
| Voloridge Investment Management, LLC | 854,634 | $33.8M | 0.12% | +477,430+126.6% | Added |
| ARK Investment Management LLCSuperinvestorARK Invest | 900,318 | $35.6M | 0.26% | −100,209−10.0% | Reduced |
| Bank of America Corp | 995,890 | $39.3M | 0.00% | +228,458+29.8% | Added |
| Polar Capital Holdings Plc | 1,000,000 | $39.5M | 0.21% | +1,000,000 | New |
| TD Asset Management Inc | 1,104,690 | $43.6M | 0.04% | +4,224+0.4% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,350,879 | $53.4M | 0.13% | +154,487+12.9% | Added |
| Morgan Stanley | 1,362,209 | $53.8M | 0.00% | +218,028+19.1% | Added |
| Macquarie Group Ltd | 1,434,073 | $56.7M | 0.07% | −233,121−14.0% | Reduced |
| Charles Schwab Investment Management Inc | 1,487,818 | $58.8M | 0.01% | +44,189+3.1% | Added |
| Citadel Advisors LLC | 1,494,981 | $59.1M | 0.05% | −1,985,081−57.0% | Reduced |
| UBS Group AG | 1,529,323 | $60.4M | 0.01% | −361,279−19.1% | Reduced |
| Two Sigma Investments, LP | 1,788,367 | $70.7M | 0.13% | +102,514+6.1% | Added |
| BVF Inc | 1,913,385 | $75.6M | 2.70% | 00.0% | Unchanged |
| Millennium Management LLC | 2,649,527 | $104.7M | 0.09% | +2,014,157+317.0% | Added |
| Two Sigma Advisers, LP | 2,667,611 | $105.4M | 0.22% | +575,600+27.5% | Added |
| Geode Capital Management, LLC | 2,891,095 | $114.2M | 0.01% | +48,141+1.7% | Added |
| Tweedy, Browne Co LLC | 2,891,948 | $114.3M | 10.60% | −91,570−3.1% | Reduced |
| Price T Rowe Associates Inc | 3,126,073 | $123.5M | 0.01% | −138,961−4.3% | Reduced |
| Adage Capital Partners GP, L.L.C. | 3,800,000 | $150.1M | 0.25% | +2,724,400+253.3% | Added |
| State Street Corp | 4,530,398 | $179.0M | 0.01% | −314,735−6.5% | Reduced |
| Deep Track Capital, LP | 4,891,544 | $193.3M | 6.21% | +327,337+7.2% | Added |
| Wellington Management Group LLP | 6,345,776 | $250.7M | 0.05% | −2,070,645−24.6% | Reduced |
| Bellevue Group AG | 7,853,198 | $310.3M | 6.84% | 00.0% | Unchanged |
| BlackRock, Inc. | 10,896,937 | $430.5M | 0.01% | −367,505−3.3% | Reduced |
| Capital World Investors | 12,540,188 | $495.5M | 0.07% | +178,194+1.4% | Added |
| T. Rowe Price Investment Management, Inc. | 16,048,721 | $634.1M | 0.40% | −126,812−0.8% | Reduced |
| Vanguard Group Inc | 16,714,846 | $660.4M | 0.01% | +330,912+2.0% | Added |
| FMR LLC | 23,642,990 | $934.1M | 0.05% | +29,405+0.1% | Added |
| OrbiMed Advisors LLC | 0 | $0 | 0.00% | −2,540,136−100.0% | Sold out |
| Camber Capital Management LP | 0 | $0 | 0.00% | −725,000−100.0% | Sold out |
| Baker Bros. Advisors LP | 0 | $0 | 0.00% | −357,915−100.0% | Sold out |
| Susquehanna Fundamental Investments, LLC | 0 | $0 | 0.00% | −158,609−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −71,811−100.0% | Sold out |
| Sphera Funds Management Ltd. | 0 | $0 | 0.00% | −63,821−100.0% | Sold out |
| Avidity Partners Management LP | 0 | $0 | 0.00% | −60,000−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −54,117−100.0% | Sold out |
| Readystate Asset Management LP | 0 | $0 | 0.00% | −46,394−100.0% | Sold out |
| Allostery Investments LP | 0 | $0 | 0.00% | −35,000−100.0% | Sold out |
| Private Advisor Group, LLC | 0 | $0 | 0.00% | −34,531−100.0% | Sold out |
| Liontrust Investment Partners LLP | 0 | $0 | 0.00% | −30,390−100.0% | Sold out |
| Axq Capital, LP | 0 | $0 | 0.00% | −30,104−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −26,261−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −25,824−100.0% | Sold out |
| BlueCrest Capital Management Ltd | 0 | $0 | 0.00% | −24,800−100.0% | Sold out |
| Castle Hook Partners LP | 0 | $0 | 0.00% | −23,940−100.0% | Sold out |
| Toroso Investments, LLC | 0 | $0 | 0.00% | −21,833−100.0% | Sold out |
| Bridgefront Capital, LLC | 0 | $0 | 0.00% | −20,528−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −20,050−100.0% | Sold out |
| NBT Bank N A | 0 | $0 | 0.00% | −17,050−100.0% | Sold out |
| Virginia Retirement Systems Et Al | 0 | $0 | 0.00% | −16,522−100.0% | Sold out |
| Twinbeech Capital LP | 0 | $0 | 0.00% | −15,938−100.0% | Sold out |
| Point72 Hong Kong Ltd | 0 | $0 | 0.00% | −12,862−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −12,404−100.0% | Sold out |
| Intech Investment Management LLC | 0 | $0 | 0.00% | −12,207−100.0% | Sold out |
| SIH Partners, LLLP | 0 | $0 | 0.00% | −11,999−100.0% | Sold out |
| FORA Capital, LLC | 0 | $0 | 0.00% | −11,570−100.0% | Sold out |
| Twin Tree Management, LP | 0 | $0 | 0.00% | −11,385−100.0% | Sold out |
| Capula Management Ltd | 0 | $0 | 0.00% | −10,382−100.0% | Sold out |
| Walleye Trading LLC | 0 | $0 | 0.00% | −9,361−100.0% | Sold out |
| Amundi | 0 | $0 | 0.00% | −3,873−100.0% | Sold out |
| Quarry LP | 0 | $0 | 0.00% | −3,000−100.0% | Sold out |
| Corebridge Financial, Inc. | 0 | $0 | 0.00% | −2,657−100.0% | Sold out |
| Sandia Investment Management LP | 0 | $0 | 0.00% | −2,500−100.0% | Sold out |
| Coldstream Capital Management Inc | 0 | $0 | 0.00% | −2,345−100.0% | Sold out |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | $0 | 0.00% | −2,082−100.0% | Sold out |