Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 363
- +21 vs. Q1 2025
- Shares held
- 168.9M
- +2.14M (+1.3%) vs. Q1 2025
- Total value
- $6.67B
- +$1.64B (+32.6%) vs. Q1 2025
- New holders
- 80
- 121 more added
- Sold out
- 59
- 109 more reduced
2 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Daiwa Securities Group Inc. | 26,141 | $1.03M | 0.00% | +4,000+18.1% | Added |
| NEOS Investment Management LLC | 28,161 | $1.11M | 0.01% | +3,020+12.0% | Added |
| Tema ETFs LLC | 28,161 | $1.11M | 0.30% | +3,020+12.0% | Added |
| Profund Advisors LLC | 28,859 | $1.14M | 0.04% | −6,028−17.3% | Reduced |
| Entropy Technologies, LP | 29,452 | $1.16M | 0.09% | +29,452 | New |
| Future Fund LLC | 29,595 | $1.17M | 0.52% | +29,595 | New |
| One Capital Management, LLC | 29,865 | $1.18M | 0.04% | +29,865 | New |
| Pathstone Holdings, LLC | 30,759 | $1.22M | 0.00% | −3,613−10.5% | Reduced |
| Capital Fund Management S.A. | 31,219 | $1.23M | 0.01% | −26,795−46.2% | Reduced |
| KLP Kapitalforvaltning AS | 31,500 | $1.24M | 0.01% | +4,100+15.0% | Added |
| China Universal Asset Management Co., Ltd. | 31,966 | $1.26M | 0.12% | +80+0.3% | Added |
| Nomura Holdings Inc | 32,161 | $1.27M | 0.01% | −204,265−86.4% | Reduced |
| Brevan Howard Capital Management LP | 32,732 | $1.29M | 0.01% | +9,759+42.5% | Added |
| Engineers Gate Manager LP | 33,118 | $1.31M | 0.02% | +33,118 | New |
| Mariner, LLC | 36,914 | $1.46M | 0.00% | +3,431+10.2% | Added |
| Grandfield & Dodd, LLC | 37,230 | $1.47M | 0.09% | −531−1.4% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 37,649 | $1.49M | 0.04% | +37,649 | New |
| Blair William & Co | 37,891 | $1.50M | 0.00% | −490−1.3% | Reduced |
| Algert Global LLC | 38,090 | $1.50M | 0.03% | +38,090 | New |
| Prelude Capital Management, LLC | 39,423 | $1.56M | 0.15% | +1,651+4.4% | Added |
| Simplex Trading, LLC | 39,638 | $1.57M | 0.04% | −24,943−38.6% | Reduced |
| Guggenheim Capital LLC | 40,857 | $1.61M | 0.01% | −557−1.3% | Reduced |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.66M | 0.20% | 00.0% | Unchanged |
| Granite Investment Partners, LLC | 43,181 | $1.71M | 0.08% | −25,253−36.9% | Reduced |
| Handelsbanken Fonder AB | 43,211 | $1.71M | 0.01% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,615 | $1.72M | 0.00% | +7,106+19.5% | Added |
| Arizona State Retirement System | 44,040 | $1.74M | 0.01% | +3,353+8.2% | Added |
| Schroder Investment Management Group | 45,950 | $1.82M | 0.00% | 00.0% | Unchanged |
| Great West Life Assurance Co | 46,501 | $1.84M | 0.00% | +2,648+6.0% | Added |
| Public Employees Retirement System of Ohio | 48,244 | $1.91M | 0.01% | +67+0.1% | Added |
| Capital Counsel LLC | 50,205 | $1.98M | 0.08% | +13,125+35.4% | Added |
| Erste Asset Management GmbH | 51,300 | $2.04M | 0.02% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 52,057 | $2.06M | 0.00% | −48,692−48.3% | Reduced |
| Creative Planning | 53,289 | $2.11M | 0.00% | +17,167+47.5% | Added |
| Ensign Peak Advisors, Inc | 53,320 | $2.11M | 0.00% | −1,780−3.2% | Reduced |
| PDT Partners, LLC | 54,365 | $2.15M | 0.12% | −41,691−43.4% | Reduced |
| First Trust Advisors LP | 56,519 | $2.23M | 0.00% | +56,519 | New |
| Raiffeisen Bank International AG | 56,754 | $2.27M | 0.03% | +15,000+35.9% | Added |
| State of New Jersey Common Pension Fund D | 58,918 | $2.33M | 0.01% | −1,744−2.9% | Reduced |
| Skandinaviska Enskilda Banken AB (publ) | 59,626 | $2.36M | 0.01% | 00.0% | Unchanged |
| Police & Firemen's Retirement System of New Jersey | 59,723 | $2.36M | 0.02% | +2,174+3.8% | Added |
| Lazard Asset Management LLC | 60,749 | $2.40M | 0.00% | −90.0% | Reduced |
| Janus Henderson Group PLC | 63,877 | $2.52M | 0.00% | 00.0% | Unchanged |
| Voya Investment Management LLC | 64,517 | $2.55M | 0.00% | +750+1.2% | Added |
| Davenport & Co LLC | 64,843 | $2.56M | 0.01% | +8,450+15.0% | Added |
| Walleye Capital LLC | 66,482 | $2.63M | 0.02% | −28,508−30.0% | Reduced |
| Treasurer of the State of North Carolina | 72,587 | $2.87M | 0.01% | +994+1.4% | Added |
| Van Eck Associates Corp | 73,617 | $2.91M | 0.00% | +71,460+3,312.9% | Added |
| Worldquant Millennium Advisors LLC | 74,438 | $2.94M | 0.01% | +74,438 | New |
| UBS Oconnor LLC | 81,251 | $3.21M | 0.09% | −9,528−10.5% | Reduced |
| Marex Group plc | 83,361 | $3.29M | 0.06% | +83,361 | New |
| Manufacturers Life Insurance Company, The | 83,386 | $3.29M | 0.00% | −54−0.1% | Reduced |
| Deutsche Bank AG | 85,278 | $3.37M | 0.00% | +468+0.6% | Added |
| New York State Common Retirement Fund | 86,972 | $3.44M | 0.00% | +8,711+11.1% | Added |
| Nicola Wealth Management Ltd. | 87,000 | $3.44M | 0.32% | 00.0% | Unchanged |
| DCF Advisers, LLC | 91,750 | $3.63M | 1.74% | −3,250−3.4% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 92,900 | $3.67M | 0.08% | +92,900 | New |
| DekaBank Deutsche Girozentrale | 93,807 | $3.72M | 0.01% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 96,694 | $3.82M | 0.01% | −11,622−10.7% | Reduced |
| Superstring Capital Management LP | 98,267 | $3.88M | 4.84% | +98,267 | New |
| SEI Investments Co | 98,348 | $3.89M | 0.00% | +26,790+37.4% | Added |
| HSBC Holdings PLC | 108,294 | $4.29M | 0.00% | +33,461+44.7% | Added |
| Neuberger Berman Group LLC | 114,623 | $4.53M | 0.00% | +12,150+11.9% | Added |
| Healthcare of Ontario Pension Plan Trust Fund | 116,000 | $4.58M | 0.01% | +116,000 | New |
| Exome Asset Management LLC | 121,116 | $4.79M | 3.95% | −14,500−10.7% | Reduced |
| Trexquant Investment LP | 128,869 | $5.09M | 0.06% | +128,869 | New |
| Kennedy Capital Management, Inc. | 132,045 | $5.22M | 0.12% | −18,379−12.2% | Reduced |
| Squarepoint Ops LLC | 134,395 | $5.31M | 0.01% | −170,978−56.0% | Reduced |
| Nikko Asset Management Americas, Inc. | 139,739 | $5.52M | 0.06% | −2,694−1.9% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 139,739 | $5.52M | 0.00% | −2,694−1.9% | Reduced |
| Rafferty Asset Management, LLC | 144,770 | $5.72M | 0.02% | −31,478−17.9% | Reduced |
| California State Teachers Retirement System | 145,104 | $5.73M | 0.01% | +12,866+9.7% | Added |
| J. Goldman & Co LP | 147,682 | $5.83M | 0.18% | −160,088−52.0% | Reduced |
| ADAR1 Capital Management, LLC | 148,461 | $5.87M | 0.95% | +148,461 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 149,839 | $5.92M | 0.01% | +5,969+4.1% | Added |
| Tang Capital Management LLC | 150,000 | $5.93M | 0.30% | 00.0% | Unchanged |
| BLB&B Advisors, LLC | 151,550 | $5.99M | 0.28% | −650−0.4% | Reduced |
| State Board of Administration of Florida Retirement System | 153,895 | $6.08M | 0.01% | +1,580+1.0% | Added |
| Aquatic Capital Management LLC | 158,086 | $6.25M | 0.13% | +1,929+1.2% | Added |
| Alyeska Investment Group, L.P. | 159,008 | $6.28M | 0.02% | +159,008 | New |
| Sonora Investment Management Group, LLC | 163,172 | $6.45M | 0.48% | +9,025+5.9% | Added |
| BNP Paribas Arbitrage, SA | 177,762 | $7.02M | 0.01% | −130,531−42.3% | Reduced |
| Rhumbline Advisers | 181,599 | $7.17M | 0.01% | −6,617−3.5% | Reduced |
| Rhenman & Partners Asset Management AB | 182,000 | $7.19M | 0.91% | +101,000+124.7% | Added |
| Sicart Associates LLC | 185,296 | $7.32M | 2.56% | −350−0.2% | Reduced |
| Tocqueville Asset Management L.P. | 187,345 | $7.40M | 0.11% | −500.0% | Reduced |
| Stifel Financial Corp | 196,357 | $7.76M | 0.01% | −4,585−2.3% | Reduced |
| Edmond de Rothschild Holding S.A. | 197,600 | $7.81M | 0.12% | +73,400+59.1% | Added |
| California Public Employees Retirement System | 201,993 | $7.98M | 0.01% | +10,989+5.8% | Added |
| Wells Fargo & Company | 209,857 | $8.29M | 0.00% | −46,376−18.1% | Reduced |
| Raymond James Financial Inc | 210,592 | $8.32M | 0.00% | +61,902+41.6% | Added |
| Orion Investment Co | 217,370 | $8.59M | 3.06% | +2,080+1.0% | Added |
| Verition Fund Management LLC | 232,687 | $9.19M | 0.05% | +180,400+345.0% | Added |
| CI Private Wealth, LLC | 237,840 | $9.40M | 0.01% | +707+0.3% | Added |
| Nuveen, LLC | 245,085 | $9.68M | 0.00% | −63,692−20.6% | Reduced |
| Invesco Ltd. | 256,235 | $10.1M | 0.00% | −618,599−70.7% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 265,793 | $10.5M | 0.04% | +136,520+105.6% | Added |
| Privium Fund Management B.V. | 267,594 | $10.7M | 2.31% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 270,714 | $10.7M | 0.01% | +117,200+76.3% | Added |
| Sector Gamma AS | 285,842 | $11.3M | 3.69% | 00.0% | Unchanged |