Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 344
- −6 vs. Q4 2024
- Shares held
- 166.7M
- +6.69M (+4.2%) vs. Q4 2024
- Total value
- $5.03B
- −$564.9M (−10.1%) vs. Q4 2024
- New holders
- 54
- 102 more added
- Sold out
- 60
- 123 more reduced
6 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| SummitTX Capital, L.P. | 35,103 | $1.06M | 0.05% | +35,103 | New |
| Creative Planning | 36,122 | $1.09M | 0.00% | −10,681−22.8% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 36,509 | $1.10M | 0.00% | +187+0.5% | Added |
| Capital Counsel LLC | 37,080 | $1.12M | 0.05% | 00.0% | Unchanged |
| Grandfield & Dodd, LLC | 37,761 | $1.14M | 0.07% | +1,874+5.2% | Added |
| Prelude Capital Management, LLC | 37,772 | $1.14M | 0.11% | +22,177+142.2% | Added |
| Blair William & Co | 38,381 | $1.16M | 0.00% | −1,501−3.8% | Reduced |
| Arizona State Retirement System | 40,687 | $1.23M | 0.01% | −460−1.1% | Reduced |
| Point72 (DIFC) Ltd | 41,347 | $1.25M | 0.12% | +41,347 | New |
| Guggenheim Capital LLC | 41,414 | $1.25M | 0.01% | +6,041+17.1% | Added |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.27M | 0.16% | 00.0% | Unchanged |
| Raiffeisen Bank International AG | 41,754 | $1.30M | 0.02% | +40,000+2,280.5% | Added |
| Handelsbanken Fonder AB | 43,211 | $1.30M | 0.01% | −600−1.4% | Reduced |
| Great West Life Assurance Co | 43,853 | $1.33M | 0.00% | +4,639+11.8% | Added |
| Readystate Asset Management LP | 46,394 | $1.40M | 0.07% | +46,394 | New |
| Schroder Investment Management Group | 45,950 | $1.43M | 0.00% | −54,709−54.4% | Reduced |
| Public Employees Retirement System of Ohio | 48,177 | $1.45M | 0.01% | −5,571−10.4% | Reduced |
| Verition Fund Management LLC | 52,287 | $1.58M | 0.01% | −147,897−73.9% | Reduced |
| Erste Asset Management GmbH | 51,300 | $1.60M | 0.02% | 00.0% | Unchanged |
| Jane Street Group, LLC | 54,117 | $1.63M | 0.00% | −110,517−67.1% | Reduced |
| Ensign Peak Advisors, Inc | 55,100 | $1.66M | 0.00% | +1,780+3.3% | Added |
| Davenport & Co LLC | 56,393 | $1.70M | 0.01% | −6,347−10.1% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 57,549 | $1.74M | 0.02% | +854+1.5% | Added |
| Capital Fund Management S.A. | 58,014 | $1.75M | 0.02% | +58,014 | New |
| Skandinaviska Enskilda Banken AB (publ) | 59,626 | $1.80M | 0.01% | 00.0% | Unchanged |
| Avidity Partners Management LP | 60,000 | $1.81M | 0.37% | +60,000 | New |
| State of New Jersey Common Pension Fund D | 60,662 | $1.83M | 0.01% | −2,544−4.0% | Reduced |
| Lazard Asset Management LLC | 60,758 | $1.83M | 0.00% | +54,201+826.6% | Added |
| Voya Investment Management LLC | 63,767 | $1.92M | 0.00% | −28,764−31.1% | Reduced |
| Sphera Funds Management Ltd. | 63,821 | $1.93M | 0.47% | 00.0% | Unchanged |
| Simplex Trading, LLC | 64,581 | $1.95M | 0.07% | +64,581 | New |
| Janus Henderson Group PLC | 63,877 | $1.99M | 0.00% | 00.0% | Unchanged |
| Granite Investment Partners, LLC | 68,434 | $2.06M | 0.10% | −5,432−7.4% | Reduced |
| SEI Investments Co | 71,558 | $2.16M | 0.00% | +1,467+2.1% | Added |
| Treasurer of the State of North Carolina | 71,593 | $2.16M | 0.01% | +2,790+4.1% | Added |
| Susquehanna International Group, LLP | 71,811 | $2.17M | 0.00% | +45,747+175.5% | Added |
| HSBC Holdings PLC | 74,833 | $2.22M | 0.00% | −8,222−9.9% | Reduced |
| New York State Common Retirement Fund | 78,261 | $2.36M | 0.00% | −6,000−7.1% | Reduced |
| Rhenman & Partners Asset Management AB | 81,000 | $2.44M | 0.28% | −131,500−61.9% | Reduced |
| Jump Financial, LLC | 81,321 | $2.45M | 0.04% | +41,584+104.6% | Added |
| Manufacturers Life Insurance Company, The | 83,440 | $2.52M | 0.00% | −202,839−70.9% | Reduced |
| Deutsche Bank AG | 84,810 | $2.56M | 0.00% | −7,091−7.7% | Reduced |
| Nicola Wealth Management Ltd. | 87,000 | $2.62M | 0.26% | 00.0% | Unchanged |
| UBS Oconnor LLC | 90,779 | $2.74M | 0.07% | +30,199+49.8% | Added |
| Walleye Capital LLC | 94,990 | $2.87M | 0.03% | +78,735+484.4% | Added |
| DCF Advisers, LLC | 95,000 | $2.87M | 1.54% | +12,118+14.6% | Added |
| DekaBank Deutsche Girozentrale | 93,807 | $2.87M | 0.01% | 00.0% | Unchanged |
| PDT Partners, LLC | 96,056 | $2.90M | 0.21% | +67,062+231.3% | Added |
| Alliancebernstein L.P. | 100,749 | $3.04M | 0.00% | +48,613+93.2% | Added |
| Neuberger Berman Group LLC | 102,473 | $3.09M | 0.00% | +5,842+6.0% | Added |
| State of Wisconsin Investment Board | 108,316 | $3.27M | 0.01% | +7,085+7.0% | Added |
| American Century Companies Inc | 116,768 | $3.52M | 0.00% | +116,768 | New |
| Edmond de Rothschild Holding S.A. | 124,200 | $3.75M | 0.07% | +124,200 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 129,273 | $3.90M | 0.02% | +3,884+3.1% | Added |
| California State Teachers Retirement System | 132,238 | $3.99M | 0.00% | −1,664−1.2% | Reduced |
| Exome Asset Management LLC | 135,616 | $4.09M | 3.66% | +74,249+121.0% | Added |
| Nikko Asset Management Americas, Inc. | 142,433 | $4.30M | 0.06% | −14,224−9.1% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 142,433 | $4.30M | 0.00% | −14,224−9.1% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 143,870 | $4.34M | 0.01% | +143,870 | New |
| Raymond James Financial Inc | 148,690 | $4.49M | 0.00% | +43,071+40.8% | Added |
| Tang Capital Management LLC | 150,000 | $4.53M | 0.25% | 00.0% | Unchanged |
| Kennedy Capital Management, Inc. | 150,424 | $4.54M | 0.11% | −72,854−32.6% | Reduced |
| BLB&B Advisors, LLC | 152,200 | $4.59M | 0.23% | +150+0.1% | Added |
| State Board of Administration of Florida Retirement System | 152,315 | $4.60M | 0.01% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 153,514 | $4.63M | 0.01% | −52,000−25.3% | Reduced |
| Sonora Investment Management Group, LLC | 154,147 | $4.65M | 0.37% | +5,371+3.6% | Added |
| Aquatic Capital Management LLC | 156,157 | $4.71M | 0.12% | −73,859−32.1% | Reduced |
| Susquehanna Fundamental Investments, LLC | 158,609 | $4.79M | 0.08% | −54,406−25.5% | Reduced |
| Rafferty Asset Management, LLC | 176,248 | $5.32M | 0.02% | −61,089−25.7% | Reduced |
| GW&K Investment Management, LLC | 182,309 | $5.50M | 0.05% | −4,911−2.6% | Reduced |
| Sicart Associates LLC | 185,646 | $5.60M | 1.94% | −175−0.1% | Reduced |
| Tocqueville Asset Management L.P. | 187,395 | $5.65M | 0.09% | −164,745−46.8% | Reduced |
| Rhumbline Advisers | 188,216 | $5.68M | 0.01% | −3,677−1.9% | Reduced |
| California Public Employees Retirement System | 191,004 | $5.76M | 0.00% | −1,126−0.6% | Reduced |
| Stifel Financial Corp | 200,942 | $6.06M | 0.01% | −10,551−5.0% | Reduced |
| Artisan Partners Limited Partnership | 203,178 | $6.13M | 0.01% | −49,457−19.6% | Reduced |
| Orion Investment Co | 215,290 | $6.50M | 2.67% | −710−0.3% | Reduced |
| Nomura Holdings Inc | 236,426 | $7.13M | 0.04% | −120,829−33.8% | Reduced |
| CI Private Wealth, LLC | 237,133 | $7.15M | 0.01% | −2,030−0.8% | Reduced |
| Great Point Partners LLC | 250,000 | $7.54M | 4.10% | −255,007−50.5% | Reduced |
| Wells Fargo & Company | 256,233 | $7.73M | 0.00% | −74,776−22.6% | Reduced |
| Privium Fund Management B.V. | 267,594 | $8.07M | 2.10% | +800+0.3% | Added |
| Swiss National Bank | 275,300 | $8.31M | 0.01% | −3,900−1.4% | Reduced |
| Sector Gamma AS | 285,842 | $8.62M | 2.76% | +50,000+21.2% | Added |
| Point72 Asset Management, L.P. | 287,204 | $8.66M | 0.02% | +287,204 | New |
| Squarepoint Ops LLC | 305,373 | $9.21M | 0.02% | +138,905+83.4% | Added |
| J. Goldman & Co LP | 307,770 | $9.29M | 0.33% | −299,729−49.3% | Reduced |
| BNP Paribas Arbitrage, SA | 308,293 | $9.30M | 0.01% | +53,772+21.1% | Added |
| Nuveen, LLC | 308,777 | $9.32M | 0.00% | +308,777 | New |
| Sovran Advisors, LLC | 328,904 | $9.34M | 1.21% | +157,092+91.4% | Added |
| Legal & General Group Plc | 338,462 | $10.2M | 0.00% | +170,382+101.4% | Added |
| Barclays PLC | 353,937 | $10.7M | 0.00% | −242,135−40.6% | Reduced |
| Baker Bros. Advisors LP | 357,915 | $10.8M | 0.12% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 360,188 | $10.9M | 0.00% | −27,260−7.0% | Reduced |
| Voloridge Investment Management, LLC | 377,204 | $11.4M | 0.04% | +60,261+19.0% | Added |
| C WorldWide Group Holding A/S | 400,000 | $12.1M | 0.15% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 421,511 | $12.7M | 0.00% | +5,592+1.3% | Added |
| Citigroup Inc | 426,480 | $12.9M | 0.01% | +257,325+152.1% | Added |
| Standard Life Aberdeen plc | 446,197 | $13.5M | 0.03% | +44,696+11.1% | Added |
| Teacher Retirement System of Texas | 500,451 | $15.1M | 0.06% | +434,659+660.7% | Added |