Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2024
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 356
- +9 vs. Q3 2024
- Shares held
- 160.5M
- +3.10M (+2.0%) vs. Q3 2024
- Total value
- $5.61B
- −$692.3M (−11.0%) vs. Q3 2024
- New holders
- 58
- 119 more added
- Sold out
- 49
- 121 more reduced
7 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Advisor Group Holdings, Inc. | 3,986 | $99.0K | 0.00% | −12,386−75.7% | Reduced |
| Sterling Capital Management LLC | 3,010 | $105.2K | 0.00% | −35−1.1% | Reduced |
| Venturi Wealth Management, LLC | 3,061 | $107.0K | 0.01% | +3,061 | New |
| Steward Partners Investment Advisory, LLC | 3,074 | $107.5K | 0.00% | +1,019+49.6% | Added |
| GF Fund Management Co. Ltd. | 3,315 | $115.9K | 0.00% | +3,315 | New |
| Ci Investments Inc. | 4,090 | $143.0K | 0.00% | +710+21.0% | Added |
| US Bancorp | 4,220 | $147.5K | 0.00% | −1,510−26.4% | Reduced |
| Sandia Investment Management LP | 5,000 | $174.8K | 0.33% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 5,262 | $189.0K | 0.00% | −26−0.5% | Reduced |
| Caption Management, LLC | 5,417 | $189.4K | 0.01% | −21,183−79.6% | Reduced |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 5,654 | $196.8K | 0.00% | +69+1.2% | Added |
| Stevens Capital Management LP | 5,860 | $205.0K | 0.08% | +5,860 | New |
| Vontobel Holding Ltd. | 5,865 | $205.0K | 0.00% | +363+6.6% | Added |
| Quarry LP | 6,000 | $209.8K | 0.04% | +6,000 | New |
| Advisors Asset Management, Inc. | 6,070 | $212.2K | 0.00% | −70−1.1% | Reduced |
| M&T Bank Corp | 6,096 | $213.6K | 0.00% | −2,800−31.5% | Reduced |
| Castle Rock Wealth Management, LLC | 6,972 | $216.4K | 0.05% | 00.0% | Unchanged |
| Gotham Asset Management, LLC | 6,260 | $218.8K | 0.00% | −20.0% | Reduced |
| EntryPoint Capital, LLC | 6,382 | $223.1K | 0.09% | +6,382 | New |
| KBC Group NV | 6,484 | $227.0K | 0.00% | +2,676+70.3% | Added |
| Lazard Asset Management LLC | 6,557 | $228.0K | 0.00% | −16,366−71.4% | Reduced |
| Silvercrest Asset Management Group LLC | 6,617 | $231.3K | 0.00% | +6,617 | New |
| Everence Capital Management Inc | 6,770 | $237.0K | 0.02% | +6,770 | New |
| Truist Financial Corp | 6,847 | $239.4K | 0.00% | −501−6.8% | Reduced |
| Tanaka Capital Management Inc | 6,892 | $241.0K | 0.55% | −7,620−52.5% | Reduced |
| Clearstead Advisors, LLC | 7,185 | $251.2K | 0.00% | −1,100−13.3% | Reduced |
| Sectoral Asset Management Inc | 7,200 | $251.7K | 0.17% | −2,240−23.7% | Reduced |
| Comerica Bank | 7,393 | $258.5K | 0.00% | −222−2.9% | Reduced |
| ProShare Advisors LLC | 7,480 | $261.5K | 0.00% | −1,160−13.4% | Reduced |
| AlphaCentric Advisors LLC | 7,614 | $266.2K | 0.27% | +7,614 | New |
| Cambridge Investment Research Advisors, Inc. | 7,765 | $271.0K | 0.00% | −1,973−20.3% | Reduced |
| Colony Group, LLC | 8,055 | $281.6K | 0.00% | +2,359+41.4% | Added |
| International Assets Investment Management, LLC | 8,207 | $284.7K | 0.02% | −320,565−97.5% | Reduced |
| Maryland State Retirement & Pension System | 8,284 | $289.6K | 0.01% | 00.0% | Unchanged |
| Man Group plc | 8,315 | $290.7K | 0.00% | −587,948−98.6% | Reduced |
| Utah Retirement Systems | 8,400 | $293.7K | 0.00% | 00.0% | Unchanged |
| Teza Capital Management LLC | 8,525 | $298.0K | 0.05% | −2,075−19.6% | Reduced |
| Wolverine Trading, LLC | 8,847 | $308.9K | 0.01% | −2,764−23.8% | Reduced |
| MetLife Investment Management | 9,160 | $320.2K | 0.00% | −203−2.2% | Reduced |
| Jones Financial Companies LLLP | 9,338 | $326.5K | 0.00% | +2,614+38.9% | Added |
| Y-Intercept (Hong Kong) Ltd | 9,407 | $328.9K | 0.02% | −10,734−53.3% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 9,450 | $330.0K | 0.00% | +1,625+20.8% | Added |
| Virtus ETF Advisers LLC | 9,448 | $330.3K | 0.13% | +1,439+18.0% | Added |
| Torno Capital, LLC | 9,500 | $332.1K | 0.07% | +4,500+90.0% | Added |
| Fifth Third Bancorp | 9,531 | $333.2K | 0.00% | −41−0.4% | Reduced |
| Janney Montgomery Scott LLC | 9,840 | $344.0K | 0.00% | −1,454−12.9% | Reduced |
| Walleye Trading LLC | 9,920 | $346.8K | 0.01% | +6,307+174.6% | Added |
| Cypress Capital, LLC | 10,000 | $349.6K | 0.10% | 00.0% | Unchanged |
| Syon Capital LLC | 10,119 | $353.8K | 0.03% | +10,119 | New |
| Landscape Capital Management, L.L.C. | 10,270 | $359.0K | 0.04% | −15,165−59.6% | Reduced |
| Wiley Bros.-Aintree Capital, LLC | 10,317 | $359.1K | 0.00% | +711+7.4% | Added |
| Amalgamated Bank | 10,292 | $360.0K | 0.00% | +335+3.4% | Added |
| Harbor Advisors LLC | 10,500 | $367.1K | 0.06% | +5,000+90.9% | Added |
| Annis Gardner Whiting Capital Advisors, LLC | 10,736 | $375.3K | 0.11% | +800+8.1% | Added |
| Suvretta Capital Management, LLC | 10,800 | $377.6K | 0.01% | 00.0% | Unchanged |
| Significant Wealth Partners LLC | 10,905 | $381.2K | 0.20% | +10,905 | New |
| The PNC Financial Services Group, Inc. | 10,994 | $384.4K | 0.00% | +1,101+11.1% | Added |
| Amundi | 11,374 | $387.9K | 0.00% | −116,925−91.1% | Reduced |
| Plancorp, LLC | 11,128 | $389.0K | 0.02% | −158−1.4% | Reduced |
| Northwestern Mutual Wealth Management Co | 11,327 | $396.0K | 0.00% | +64+0.6% | Added |
| Essential Planning, LLC. | 11,440 | $428.1K | 0.00% | +11,440 | New |
| JustInvest LLC | 12,271 | $429.0K | 0.01% | +3,867+46.0% | Added |
| Horizon Kinetics Asset Management LLC | 12,476 | $436.2K | 0.01% | +524+4.4% | Added |
| Brown Advisory Inc | 12,730 | $445.0K | 0.00% | −16−0.1% | Reduced |
| Stratos Wealth Partners, LTD. | 12,813 | $447.9K | 0.01% | +25+0.2% | Added |
| Franklin Resources Inc | 13,301 | $465.0K | 0.00% | +3,146+31.0% | Added |
| Westmount Partners, LLC | 13,462 | $470.6K | 0.14% | 00.0% | Unchanged |
| Commerce Bank | 13,584 | $474.9K | 0.00% | −63,969−82.5% | Reduced |
| Principal Financial Group Inc | 13,616 | $476.0K | 0.00% | +504+3.8% | Added |
| North Star Asset Management Inc | 13,640 | $476.9K | 0.02% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 14,157 | $494.9K | 0.01% | +9,856+229.2% | Added |
| Natixis Advisors, L.P. | 14,313 | $500.0K | 0.00% | −6,767−32.1% | Reduced |
| Inceptionr LLC | 14,390 | $503.1K | 0.11% | +14,390 | New |
| Public Employees Retirement Association of Colorado | 15,589 | $545.0K | 0.00% | 00.0% | Unchanged |
| Prelude Capital Management, LLC | 15,595 | $545.2K | 0.05% | +15,595 | New |
| Campbell & CO Investment Adviser LLC | 15,681 | $548.2K | 0.04% | +15,681 | New |
| Walleye Capital LLC | 16,255 | $568.3K | 0.01% | −107,861−86.9% | Reduced |
| Natixis | 16,626 | $581.2K | 0.00% | +16,626 | New |
| E Fund Management Co., Ltd. | 16,868 | $589.7K | 0.03% | +4,116+32.3% | Added |
| Bleakley Financial Group, LLC | 16,942 | $592.3K | 0.02% | +264+1.6% | Added |
| NBT Bank N A | 17,050 | $596.1K | 0.04% | 00.0% | Unchanged |
| Toroso Investments, LLC | 17,407 | $608.5K | 0.00% | −1,501−7.9% | Reduced |
| Aigen Investment Management, LP | 17,723 | $619.6K | 0.11% | +6,111+52.6% | Added |
| Victory Capital Management Inc | 18,004 | $629.4K | 0.00% | −346−1.9% | Reduced |
| Xponance, Inc. | 19,339 | $676.1K | 0.01% | +318+1.7% | Added |
| Nicollet Investment Management, Inc. | 19,786 | $692.0K | 0.24% | −616−3.0% | Reduced |
| Canada Pension Plan Investment Board | 19,900 | $695.7K | 0.00% | +8,700+77.7% | Added |
| Brevan Howard Capital Management LP | 21,366 | $747.0K | 0.02% | −7,113−25.0% | Reduced |
| Bridgefront Capital, LLC | 21,802 | $762.2K | 0.26% | +10,606+94.7% | Added |
| Commonwealth Equity Services, LLC | 21,826 | $763.0K | 0.00% | +373+1.7% | Added |
| Jefferies Financial Group Inc. | 22,381 | $782.4K | 0.01% | −30,400−57.6% | Reduced |
| D. E. Shaw & Co., Inc. | 23,123 | $808.4K | 0.00% | −121,968−84.1% | Reduced |
| SG Americas Securities, LLC | 23,927 | $836.0K | 0.00% | +16,508+222.5% | Added |
| Castle Hook Partners LP | 23,940 | $836.9K | 0.02% | 00.0% | Unchanged |
| Teachers Retirement System of the State of Kentucky | 24,083 | $842.0K | 0.01% | 00.0% | Unchanged |
| XTX Topco Ltd | 25,362 | $886.7K | 0.07% | +8,557+50.9% | Added |
| Pathstone Holdings, LLC | 26,058 | $911.0K | 0.00% | −1,749−6.3% | Reduced |
| Susquehanna International Group, LLP | 26,064 | $911.2K | 0.00% | −31,175−54.5% | Reduced |
| BlueCrest Capital Management Ltd | 26,200 | $916.0K | 0.05% | +26,200 | New |
| Mariner, LLC | 27,661 | $967.0K | 0.00% | +4,534+19.6% | Added |