Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q1 2022
Institutional positions in Ionis Pharmaceuticals Inc as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 333
- −3 vs. Q4 2021
- Shares held
- 125.0M
- +1.76M (+1.4%) vs. Q4 2021
- Total value
- $4.63B
- +$876.1M (+23.4%) vs. Q4 2021
- New holders
- 47
- 107 more added
- Sold out
- 50
- 109 more reduced
5 institutions that held it in Q4 2021 haven't filed for Q1 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q1 2022
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q4 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Jane Street Group, LLC | 27,791 | $1.03M | 0.00% | −24,759−47.1% | Reduced |
| Grandfield & Dodd, LLC | 28,001 | $1.04M | 0.07% | +1,230+4.6% | Added |
| MML Investors Services, LLC | 28,122 | $1.04M | 0.01% | +2,905+11.5% | Added |
| First Foundation Advisors | 29,130 | $1.08M | 0.04% | +1,158+4.1% | Added |
| Tudor Investment Corp Et Al | 29,525 | $1.09M | 0.03% | −148,861−83.4% | Reduced |
| Principal Financial Group Inc | 30,211 | $1.12M | 0.00% | −1,544−4.9% | Reduced |
| Truist Financial Corp | 31,270 | $1.16M | 0.00% | +333+1.1% | Added |
| Amalgamated Bank | 31,934 | $1.18M | 0.01% | +2,610+8.9% | Added |
| Amalgamated Financial Corp. | 31,934 | $1.18M | 0.01% | +31,934 | New |
| Macquarie Group Ltd | 32,006 | $1.19M | 0.00% | −543−1.7% | Reduced |
| Employees Retirement System of Texas | 32,409 | $1.20M | 0.01% | 00.0% | Unchanged |
| Deutsche Bank AG | 33,362 | $1.24M | 0.00% | +19,275+136.8% | Added |
| Arizona State Retirement System | 34,354 | $1.27M | 0.01% | +164+0.5% | Added |
| Ergoteles LLC | 38,000 | $1.41M | 0.05% | +30,045+377.7% | Added |
| Gotham Asset Management, LLC | 38,427 | $1.42M | 0.04% | +38,427 | New |
| Janney Montgomery Scott LLC | 38,614 | $1.43M | 0.01% | +2,190+6.0% | Added |
| Capital Counsel LLC | 41,010 | $1.52M | 0.07% | +430+1.1% | Added |
| NJ State Employees Deferred Compensation Plan | 42,000 | $1.55M | 0.21% | 00.0% | Unchanged |
| Koss-Olinger Consulting, LLC | 44,120 | $1.63M | 0.26% | +14,959+51.3% | Added |
| Capital Fund Management S.A. | 44,719 | $1.66M | 0.04% | +16,611+59.1% | Added |
| Trexquant Investment LP | 47,762 | $1.77M | 0.08% | +13,859+40.9% | Added |
| Erste Asset Management GmbH | 51,300 | $1.83M | 0.03% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 49,726 | $1.84M | 0.00% | −154,529−75.7% | Reduced |
| Raymond James Financial Services Advisors, Inc. | 50,585 | $1.87M | 0.00% | +1,604+3.3% | Added |
| Treasurer of the State of North Carolina | 51,671 | $1.91M | 0.01% | +825+1.6% | Added |
| Schonfeld Strategic Advisors LLC | 55,543 | $2.06M | 0.02% | +55,543 | New |
| Eaton Vance Management | 56,565 | $2.10M | 0.00% | +28,873+104.3% | Added |
| AlphaCrest Capital Management LLC | 58,292 | $2.16M | 0.12% | +5,385+10.2% | Added |
| Alliancebernstein L.P. | 61,939 | $2.29M | 0.00% | −41,275−40.0% | Reduced |
| Voya Investment Management LLC | 64,265 | $2.38M | 0.00% | −1,243−1.9% | Reduced |
| Guggenheim Capital LLC | 68,237 | $2.53M | 0.02% | −4,741−6.5% | Reduced |
| Rhenman & Partners Asset Management AB | 71,000 | $2.63M | 0.26% | −4,000−5.3% | Reduced |
| Manufacturers Life Insurance Company, The | 75,298 | $2.69M | 0.00% | +75,298 | New |
| PFS Investments Inc. | 75,061 | $2.78M | 0.05% | −1,118−1.5% | Reduced |
| Public Employees Retirement System of Ohio | 77,666 | $2.88M | 0.01% | −6,995−8.3% | Reduced |
| PDT Partners, LLC | 80,070 | $2.97M | 0.26% | +12,373+18.3% | Added |
| Citigroup Inc | 81,336 | $3.01M | 0.00% | −104,711−56.3% | Reduced |
| Allianz Asset Management GmbH | 81,830 | $3.03M | 0.00% | 00.0% | Unchanged |
| Davenport & Co LLC | 83,863 | $3.11M | 0.02% | −800−0.9% | Reduced |
| AXA S.A. | 86,300 | $3.20M | 0.01% | −1,600−1.8% | Reduced |
| Allspring Global Investments Holdings, LLC | 87,285 | $3.23M | 0.00% | −11,289−11.5% | Reduced |
| State of New Jersey Common Pension Fund D | 88,879 | $3.29M | 0.01% | −6,355−6.7% | Reduced |
| International Biotechnology Trust PLC | 154,088 | $3.30M | 1.45% | −201,000−56.6% | Reduced |
| Envestnet Asset Management Inc | 90,871 | $3.37M | 0.00% | −421−0.5% | Reduced |
| BNP Paribas Arbitrage, SA | 90,936 | $3.37M | 0.01% | −215,317−70.3% | Reduced |
| LPL Financial LLC | 94,553 | $3.50M | 0.00% | +5,887+6.6% | Added |
| Cubist Systematic Strategies, LLC | 95,530 | $3.54M | 0.03% | −201,652−67.9% | Reduced |
| Bard Financial Services, Inc. | 99,020 | $3.67M | 0.30% | +57,500+138.5% | Added |
| Gateway Investment Advisers LLC | 99,129 | $3.67M | 0.04% | +14,026+16.5% | Added |
| HRT Financial LP | 109,376 | $4.05M | 0.03% | +109,376 | New |
| Jump Financial, LLC | 109,827 | $4.07M | 0.17% | −10,673−8.9% | Reduced |
| State of Wisconsin Investment Board | 114,451 | $4.24M | 0.01% | +97,397+571.1% | Added |
| DekaBank Deutsche Girozentrale | 124,776 | $4.45M | 0.01% | +15,300+14.0% | Added |
| Peregrine Capital Management LLC | 130,320 | $4.83M | 0.11% | −9,401−6.7% | Reduced |
| Rhumbline Advisers | 133,560 | $4.95M | 0.01% | −6,189−4.4% | Reduced |
| Renaissance Technologies LLC | 134,914 | $5.00M | 0.01% | −95,900−41.5% | Reduced |
| Invesco Ltd. | 139,992 | $5.18M | 0.00% | +7,750+5.9% | Added |
| Alps Advisors Inc | 145,615 | $5.39M | 0.06% | −17,809−10.9% | Reduced |
| New York State Common Retirement Fund | 146,800 | $5.44M | 0.01% | −7,000−4.6% | Reduced |
| BLB&B Advisors, LLC | 149,745 | $5.55M | 0.37% | −1,190−0.8% | Reduced |
| Private Advisor Group, LLC | 156,968 | $5.81M | 0.04% | +41,226+35.6% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 157,193 | $5.82M | 0.03% | +44,668+39.7% | Added |
| Sonora Investment Management Group, LLC | 157,261 | $5.83M | 0.66% | +471+0.3% | Added |
| Eversept Partners, LP | 158,806 | $5.88M | 0.54% | −225,983−58.7% | Reduced |
| Legal & General Group Plc | 162,318 | $6.01M | 0.00% | +3,974+2.5% | Added |
| Tocqueville Asset Management L.P. | 167,505 | $6.20M | 0.09% | −2,900−1.7% | Reduced |
| California State Teachers Retirement System | 168,362 | $6.24M | 0.01% | −15,642−8.5% | Reduced |
| State Board of Administration of Florida Retirement System | 170,728 | $6.32M | 0.01% | −2,532−1.5% | Reduced |
| Sio Capital Management, LLC | 175,568 | $6.50M | 2.62% | −146,998−45.6% | Reduced |
| Tekla Capital Management LLC | 175,680 | $6.51M | 0.23% | 00.0% | Unchanged |
| Rafferty Asset Management, LLC | 178,794 | $6.62M | 0.04% | −10,845−5.7% | Reduced |
| Privium Fund Management B.V. | 180,107 | $6.67M | 1.50% | −450,092−71.4% | Reduced |
| Credit Suisse AG | 180,626 | $6.69M | 0.01% | +3,859+2.2% | Added |
| Sector Gamma AS | 188,439 | $6.98M | 1.52% | −21,098−10.1% | Reduced |
| Voloridge Investment Management, LLC | 189,556 | $7.02M | 0.04% | −77,289−29.0% | Reduced |
| Millennium Management LLC | 191,191 | $7.08M | 0.01% | −1,431,947−88.2% | Reduced |
| Woodline Partners LP | 192,651 | $7.14M | 0.12% | −218,803−53.2% | Reduced |
| Majedie Asset Management Ltd | 195,492 | $7.22M | 0.59% | +19,984+11.4% | Added |
| Tang Capital Management LLC | 200,000 | $7.41M | 1.50% | +200,000 | New |
| UBS Group AG | 201,201 | $7.45M | 0.00% | +7,612+3.9% | Added |
| Pictet Asset Management SA | 206,141 | $7.63M | 0.01% | +23,054+12.6% | Added |
| UBS Asset Management Americas Inc | 206,906 | $7.66M | 0.00% | +23,154+12.6% | Added |
| Altrinsic Global Advisors LLC | 208,158 | $7.71M | 0.27% | −191,234−47.9% | Reduced |
| Hudson Bay Capital Management LP | 210,000 | $7.78M | 0.11% | −95,000−31.1% | Reduced |
| Morningstar Investment Services LLC | 222,681 | $8.00M | 0.09% | +3,249+1.5% | Added |
| Parametric Portfolio Associates LLC | 230,804 | $8.55M | 0.00% | +5,698+2.5% | Added |
| Raymond James & Associates | 256,726 | $9.51M | 0.01% | −1,259−0.5% | Reduced |
| Bank of Montreal | 268,497 | $9.58M | 0.01% | +39,090+17.0% | Added |
| Russell Investments Group, Ltd. | 284,130 | $10.5M | 0.02% | +89,985+46.3% | Added |
| California Public Employees Retirement System | 294,815 | $10.9M | 0.01% | +10,391+3.7% | Added |
| Nuveen Asset Management, LLC | 315,819 | $11.0M | 0.00% | −35,657−10.1% | Reduced |
| Swiss National Bank | 300,500 | $11.1M | 0.01% | +21,200+7.6% | Added |
| Dowling & Yahnke LLC | 302,571 | $11.2M | 0.49% | +1500.0% | Added |
| Sicart Associates LLC | 304,782 | $11.3M | 2.92% | +22,251+7.9% | Added |
| Barclays PLC | 316,350 | $11.7M | 0.01% | −13,588−4.1% | Reduced |
| Stifel Financial Corp | 340,566 | $12.6M | 0.02% | −17,382−4.9% | Reduced |
| Baillie Gifford & Co | 348,863 | $12.9M | 0.01% | +33,043+10.5% | Added |
| Dimensional Fund Advisors LP | 353,481 | $13.1M | 0.00% | −33,210−8.6% | Reduced |
| Assenagon Asset Management S.A. | 357,896 | $13.3M | 0.04% | +309,495+639.4% | Added |
| Nomura Holdings Inc | 394,154 | $15.3M | 0.12% | +21,674+5.8% | Added |