Ionis Pharmaceuticals Inc
IONS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000874015
In the last 90 days, Ionis Pharmaceuticals Inc insiders filed 1 open-market purchase and 4 sales; 515 institutions reported holding it in 13F filings for Q2 2026, worth $14.3B in total; ARK Invest is the only superinvestor holding it.
13F holders, Q4 2021
Institutional positions in Ionis Pharmaceuticals Inc as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 341
- +20 vs. Q3 2021
- Shares held
- 123.2M
- +1.71M (+1.4%) vs. Q3 2021
- Total value
- $3.75B
- −$326.3M (−8.0%) vs. Q3 2021
- New holders
- 59
- 106 more added
- Sold out
- 39
- 119 more reduced
5 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting IONS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 515 | $14.3B |
| Q1 2026 | 497 | $13.0B |
| Q4 2025 | 494 | $13.5B |
| Q3 2025 | 437 | $11.0B |
| Q2 2025 | 363 | $6.67B |
| Q1 2025 | 344 | $5.03B |
| Q4 2024 | 356 | $5.61B |
| Q3 2024 | 354 | $6.31B |
| Q2 2024 | 357 | $6.83B |
| Q1 2024 | 361 | $6.17B |
| Q4 2023 | 365 | $7.21B |
| Q3 2023 | 312 | $6.35B |
| Q2 2023 | 305 | $5.60B |
| Q1 2023 | 315 | $4.69B |
| Q4 2022 | 339 | $4.93B |
| Q3 2022 | 350 | $5.59B |
| Q2 2022 | 351 | $4.61B |
| Q1 2022 | 333 | $4.63B |
| Q4 2021 | 341 | $3.75B |
| Q3 2021 | 326 | $4.08B |
| Q2 2021 | 338 | $4.96B |
| Q1 2021 | 365 | $5.55B |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Ionis Pharmaceuticals Inc; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Stifel Financial Corp | 357,948 | $10.9M | 0.01% | −18,271−4.9% | Reduced |
| Nomura Holdings Inc | 372,480 | $11.3M | 0.07% | −4,268−1.1% | Reduced |
| Eversept Partners, LP | 384,789 | $11.7M | 0.97% | −65,712−14.6% | Reduced |
| Dimensional Fund Advisors LP | 386,691 | $11.8M | 0.00% | +30,852+8.7% | Added |
| Altrinsic Global Advisors LLC | 399,392 | $12.2M | 0.39% | −45,495−10.2% | Reduced |
| Woodline Partners LP | 411,454 | $12.5M | 0.18% | +5,993+1.5% | Added |
| Morgan Stanley | 464,885 | $14.1M | 0.00% | −33,051−6.6% | Reduced |
| Royal Bank of Canada | 480,648 | $14.6M | 0.00% | −8,913−1.8% | Reduced |
| Two Sigma Advisers, LP | 497,411 | $15.1M | 0.04% | +65,200+15.1% | Added |
| Pinnacle Associates Ltd | 541,044 | $16.5M | 0.28% | −2,182−0.4% | Reduced |
| Bank of New York Mellon Corp | 556,577 | $16.9M | 0.00% | −3,989−0.7% | Reduced |
| Goldman Sachs Group Inc | 589,298 | $17.9M | 0.00% | −12,538−2.1% | Reduced |
| Nikko Asset Management Americas, Inc. | 605,902 | $17.9M | 0.09% | −69,399−10.3% | Reduced |
| Two Sigma Investments, LP | 594,885 | $18.1M | 0.04% | +280,751+89.4% | Added |
| Bank of Nova Scotia | 601,883 | $18.3M | 0.03% | +589,568+4,787.4% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 605,902 | $18.4M | 0.01% | −79,758−11.6% | Reduced |
| Bank of America Corp | 612,835 | $18.6M | 0.00% | −97,282−13.7% | Reduced |
| Privium Fund Management B.V. | 630,199 | $19.2M | 3.83% | +630,199 | New |
| Northern Trust Corp | 660,890 | $20.1M | 0.00% | +5,469+0.8% | Added |
| TD Asset Management Inc | 743,164 | $22.6M | 0.02% | +321,200+76.1% | Added |
| Wells Fargo & Company | 810,966 | $24.7M | 0.01% | −42,404−5.0% | Reduced |
| Norges Bank | 831,219 | $25.3M | 0.01% | −315,699−27.5% | Reduced |
| Candriam Luxembourg S.C.A. | 936,635 | $28.5M | 0.18% | +210,276+28.9% | Added |
| Charles Schwab Investment Management Inc | 1,093,439 | $33.3M | 0.01% | +23,707+2.2% | Added |
| Swedbank AB | 1,117,339 | $34.1M | 0.06% | 00.0% | Unchanged |
| Citadel Advisors LLC | 1,221,571 | $37.2M | 0.04% | +171,714+16.4% | Added |
| JPMorgan Chase & Co | 1,268,652 | $38.6M | 0.00% | −1,147,661−47.5% | Reduced |
| Camber Capital Management LP | 1,390,000 | $42.3M | 1.63% | −1,110,000−44.4% | Reduced |
| Jacobs Levy Equity Management, Inc | 1,407,388 | $42.8M | 0.29% | +216,152+18.1% | Added |
| Thrivent Financial for Lutherans | 1,533,999 | $46.7M | 0.09% | +146,235+10.5% | Added |
| Millennium Management LLC | 1,623,138 | $49.4M | 0.05% | +1,340,284+473.8% | Added |
| First Trust Advisors LP | 1,680,012 | $51.1M | 0.05% | −5370.0% | Reduced |
| Geode Capital Management, LLC | 1,825,226 | $55.5M | 0.01% | +52,459+3.0% | Added |
| State Street Corp | 3,906,375 | $118.9M | 0.01% | +385,061+10.9% | Added |
| Clearbridge Investments, LLC | 5,882,982 | $179.0M | 0.12% | −1,444,340−19.7% | Reduced |
| ARK Investment Management LLCSuperinvestorARK Invest | 7,083,256 | $215.5M | 0.65% | −1,428,128−16.8% | Reduced |
| BlackRock Inc. | 8,539,282 | $259.8M | 0.01% | +419,429+5.2% | Added |
| Bellevue Group AG | 10,355,123 | $315.1M | 3.25% | +1,007,197+10.8% | Added |
| Vanguard Group Inc | 12,007,076 | $365.4M | 0.01% | +207,067+1.8% | Added |
| Price T Rowe Associates Inc | 12,490,280 | $380.1M | 0.03% | +752,959+6.4% | Added |
| FMR LLC | 21,181,502 | $644.6M | 0.05% | +9,3480.0% | Added |
| American Century Companies Inc | 0 | $0 | 0.00% | −199,346−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −128,087−100.0% | Sold out |
| Sabby Management, LLC | 0 | $0 | 0.00% | −84,600−100.0% | Sold out |
| Arrowstreet Capital, Limited Partnership | 0 | $0 | 0.00% | −41,100−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −22,512−100.0% | Sold out |
| Sphera Funds Management Ltd. | 0 | $0 | 0.00% | −22,000−100.0% | Sold out |
| Emerald Advisers, LLC | 0 | $0 | 0.00% | −16,815−100.0% | Sold out |
| AGF Investments LLC | 0 | $0 | 0.00% | −15,936−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −15,470−100.0% | Sold out |
| JustInvest LLC | 0 | $0 | 0.00% | −13,544−100.0% | Sold out |
| HAP Trading, LLC | 0 | $0 | 0.00% | −11,877−100.0% | Sold out |
| Mackenzie Financial Corp | 0 | $0 | 0.00% | −9,783−100.0% | Sold out |
| FDx Advisors, Inc. | 0 | $0 | 0.00% | −7,507−100.0% | Sold out |
| Mitchell & Pahl Private Wealth, LLC | 0 | $0 | 0.00% | −6,888−100.0% | Sold out |
| Mirae Asset Global Investments Co., Ltd. | 0 | $0 | 0.00% | −6,599−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −5,763−100.0% | Sold out |
| Global Retirement Partners, LLC | 0 | $0 | 0.00% | −5,784−100.0% | Sold out |
| Agf Investments Inc. | 0 | $0 | 0.00% | −4,800−100.0% | Sold out |
| Advisors Asset Management, Inc. | 0 | $0 | 0.00% | −3,164−100.0% | Sold out |
| Walled Lake Planning & Wealth Management, LLC | 0 | $0 | 0.00% | −1,900−100.0% | Sold out |
| Cedar Wealth Management, LLC | 0 | $0 | 0.00% | −1,370−100.0% | Sold out |
| Antonetti Capital Management LLC | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Consolidated Planning Corp | 0 | $0 | 0.00% | −777−100.0% | Sold out |
| Firestone Capital Management | 0 | $0 | 0.00% | −250−100.0% | Sold out |
| O'Shaughnessy Asset Management, LLC | 0 | $0 | 0.00% | −243−100.0% | Sold out |
| Federation des caisses Desjardins du Quebec | 0 | $0 | 0.00% | −200−100.0% | Sold out |
| Eagle Bay Advisors LLC | 0 | $0 | 0.00% | −150−100.0% | Sold out |
| IAG Wealth Partners, LLC | 0 | $0 | 0.00% | −135−100.0% | Sold out |
| Whittier Trust Co | 0 | $0 | 0.00% | −100−100.0% | Sold out |
| JFS Wealth Advisors, LLC | 0 | $0 | 0.00% | −75−100.0% | Sold out |
| Zions Bancorporation, N.A. | 0 | $0 | 0.00% | −83−100.0% | Sold out |
| Mitsubishi UFJ Trust & Banking Corp | 0 | $0 | 0.00% | −50−100.0% | Sold out |
| PSI Advisors, LLC | 0 | $0 | 0.00% | −50−100.0% | Sold out |
| Covington Capital Management | 0 | $0 | 0.00% | −23−100.0% | Sold out |
| Stonebridge Capital Advisors LLC | 0 | $0 | 0.00% | −29−100.0% | Sold out |
| Liberty Wealth Management LLC | 0 | $0 | 0.00% | −44−100.0% | Sold out |
| Meridian Wealth Partners, LLC | 0 | $0 | 0.00% | −23−100.0% | Sold out |
| TD Private Client Wealth LLC | 0 | $0 | 0.00% | −11−100.0% | Sold out |
| Meeder Asset Management Inc | 0 | $0 | 0.00% | −14−100.0% | Sold out |
| Sonora Investment Management, LLC | – | – | – | – | Not filed |
| Alexandria Capital, LLC | – | – | – | – | Not filed |
| Optimal Asset Management, Inc. | – | – | – | – | Not filed |
| Berman Capital Advisors, LLC | – | – | – | – | Not filed |
| Heritage Wealth Management, LLC | – | – | – | – | Not filed |