Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Definium Therapeutics, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 248
- +42 vs. Q4 2025
- Shares held
- 78.1M
- +12.8M (+19.6%) vs. Q4 2025
- Total value
- $1.47B
- +$600.8M (+68.7%) vs. Q4 2025
- New holders
- 69
- 82 more added
- Sold out
- 27
- 53 more reduced
3 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 8,480,230 | $160.3M | 0.00% | +206,954+2.5% | Added |
| Driehaus Capital Management LLC | 5,911,889 | $111.7M | 0.82% | −625,313−9.6% | Reduced |
| Avoro Capital Advisors LLC | 5,000,000 | $94.5M | 0.93% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 3,556,041 | $67.2M | 0.03% | +1,144,345+47.4% | Added |
| Deep Track Capital, LP | 3,000,000 | $56.7M | 1.17% | +1,323,460+78.9% | Added |
| Geode Capital Management, LLC | 2,495,399 | $47.2M | 0.00% | +162,461+7.0% | Added |
| State Street Corp | 2,471,873 | $46.7M | 0.00% | +103,807+4.4% | Added |
| Octagon Capital Advisors LP | 2,440,000 | $46.1M | 5.10% | +210,000+9.4% | Added |
| Commodore Capital LP | 2,000,000 | $37.8M | 2.19% | 00.0% | Unchanged |
| FMR LLC | 1,809,610 | $34.2M | 0.00% | +1,647,557+1,016.7% | Added |
| Trails Edge Capital Partners, LP | 1,738,110 | $32.9M | 7.73% | −830,000−32.3% | Reduced |
| Goldman Sachs Group Inc | 1,675,411 | $31.7M | 0.00% | +750,079+81.1% | Added |
| ArrowMark Colorado Holdings LLC | 1,594,717 | $30.1M | 0.80% | +1,594,717 | New |
| Citadel Advisors LLC | 1,333,442 | $25.2M | 0.02% | +1,123,498+535.1% | Added |
| Wellington Management Group LLP | 1,304,749 | $24.7M | 0.00% | +84,082+6.9% | Added |
| Candriam Luxembourg S.C.A. | 1,293,629 | $24.4M | 0.13% | +322,411+33.2% | Added |
| Balyasny Asset Management LLC | 1,274,221 | $24.1M | 0.05% | −33,894−2.6% | Reduced |
| Two Sigma Investments, LP | 1,201,610 | $22.7M | 0.02% | +776,403+182.6% | Added |
| Marshall Wace, LLP | 1,200,825 | $22.7M | 0.02% | −1,774,877−59.6% | Reduced |
| Adage Capital Partners GP, L.L.C. | 1,150,000 | $21.7M | 0.03% | 00.0% | Unchanged |
| Vanguard Capital Management LLC | 1,096,978 | $20.7M | 0.00% | +1,096,978 | New |
| Holocene Advisors, LP | 1,091,967 | $20.6M | 0.05% | +1,091,967 | New |
| AWM Investment Company, Inc. | 1,076,893 | $20.4M | 2.25% | −313,769−22.6% | Reduced |
| Catalio Capital Management, LP | 1,037,984 | $19.6M | 4.10% | +1,037,984 | New |
| Ameriprise Financial Inc | 966,608 | $18.3M | 0.00% | +462,367+91.7% | Added |
| Siren, L.L.C. | 919,493 | $17.4M | 0.48% | +119,493+14.9% | Added |
| Vanguard Portfolio Management LLC | 872,665 | $16.5M | 0.00% | +872,665 | New |
| Millennium Management LLC | 846,896 | $16.0M | 0.01% | −536,279−38.8% | Reduced |
| Charles Schwab Investment Management Inc | 808,715 | $15.3M | 0.00% | +1,466+0.2% | Added |
| OrbiMed Advisors LLC | 804,000 | $15.2M | 0.35% | −422,700−34.5% | Reduced |
| Northern Trust Corp | 798,987 | $15.1M | 0.00% | +64,327+8.8% | Added |
| Bank of New York Mellon Corp | 752,922 | $14.2M | 0.00% | +454,262+152.1% | Added |
| Woodline Partners LP | 752,792 | $14.2M | 0.05% | +602,222+400.0% | Added |
| Nuveen, LLC | 698,130 | $13.2M | 0.00% | +421,676+152.5% | Added |
| Eventide Asset Management, LLC | 686,162 | $13.0M | 0.21% | +686,162 | New |
| Boxer Capital Management, LLC | 598,500 | $11.3M | 1.49% | 00.0% | Unchanged |
| Vanguard Fiduciary Trust Co | 575,937 | $10.9M | 0.00% | +575,937 | New |
| Ensign Peak Advisors, Inc | 546,783 | $10.3M | 0.02% | +284,783+108.7% | Added |
| Blackstone Group Inc. | 508,668 | $9.61M | 0.04% | −1,551,137−75.3% | Reduced |
| UBS Group AG | 493,977 | $9.34M | 0.00% | −189,825−27.8% | Reduced |
| Morgan Stanley | 438,573 | $8.29M | 0.00% | +71,878+19.6% | Added |
| Qube Research & Technologies Ltd | 426,055 | $8.05M | 0.01% | +426,055 | New |
| Deutsche Bank AG | 411,834 | $7.78M | 0.00% | +13,565+3.4% | Added |
| Integral Health Asset Management, LLC | 400,000 | $7.56M | 0.40% | +50,000+14.3% | Added |
| Tri Locum Partners LP | 369,588 | $6.99M | 0.98% | +369,588 | New |
| Superstring Capital Management LP | 351,461 | $6.64M | 4.75% | −73,741−17.3% | Reduced |
| Sofinnova Investments, Inc. | 344,166 | $6.50M | 0.33% | +344,166 | New |
| Patient Square Capital LP | 331,000 | $6.26M | 1.11% | +331,000 | New |
| StemPoint Capital LP | 325,483 | $6.15M | 1.18% | +325,483 | New |
| RTW Investments, LP | 300,000 | $5.67M | 0.06% | 00.0% | Unchanged |
| BIT Capital GmbH | 277,511 | $5.24M | 0.29% | +277,511 | New |
| D. E. Shaw & Co., Inc. | 271,717 | $5.14M | 0.00% | −22,005−7.5% | Reduced |
| Jane Street Group, LLC | 260,241 | $4.92M | 0.01% | −275,761−51.4% | Reduced |
| JPMorgan Chase & Co | 264,545 | $4.63M | 0.00% | +110,823+72.1% | Added |
| Royce & Associates LP | 234,051 | $4.42M | 0.04% | +70,010+42.7% | Added |
| Seven Grand Managers, LLC | 225,000 | $4.25M | 0.28% | 00.0% | Unchanged |
| Brevan Howard Capital Management LP | 211,488 | $4.00M | 0.04% | +200,374+1,802.9% | Added |
| PFM Health Sciences, LP | 205,317 | $3.88M | 0.41% | +205,317 | New |
| Polygon Management Ltd. | 199,994 | $3.78M | 0.74% | +199,994 | New |
| HighVista Strategies LLC | 185,856 | $3.51M | 0.97% | +185,856 | New |
| Point72 Asset Management, L.P. | 175,490 | $3.32M | 0.01% | −4,951−2.7% | Reduced |
| Eversept Partners, LP | 160,723 | $3.04M | 0.20% | +160,723 | New |
| Swiss National Bank | 158,400 | $2.99M | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 158,345 | $2.99M | 0.00% | +47,878+43.3% | Added |
| Soviero Asset Management, LP | 140,000 | $2.65M | 1.49% | −10,000−6.7% | Reduced |
| Neuberger Berman Group LLC | 133,369 | $2.52M | 0.00% | +133,369 | New |
| Squarepoint Ops LLC | 125,522 | $2.37M | 0.01% | +80,120+176.5% | Added |
| Rosalind Advisors, Inc. | 125,000 | $2.36M | 0.97% | −625,000−83.3% | Reduced |
| Rhumbline Advisers | 119,972 | $2.27M | 0.00% | +9,225+8.3% | Added |
| Russell Investments Group, Ltd. | 119,464 | $2.26M | 0.00% | +110,599+1,247.6% | Added |
| ExodusPoint Capital Management, LP | 104,915 | $1.98M | 0.02% | +85,967+453.7% | Added |
| Data Collective IV GP, LLC | 100,350 | $1.90M | 3.39% | 00.0% | Unchanged |
| Burkehill Global Management, LP | 100,000 | $1.89M | 0.09% | 00.0% | Unchanged |
| Seven Fleet Capital Management LP | 99,887 | $1.89M | 0.59% | +99,887 | New |
| Royal Bank of Canada | 97,192 | $1.84M | 0.00% | +3,566+3.8% | Added |
| Fred Alger Management, LLC | 92,165 | $1.74M | 0.01% | +92,165 | New |
| Alliancebernstein L.P. | 91,703 | $1.73M | 0.00% | +16,866+22.5% | Added |
| AdvisorShares Investments LLC | 91,301 | $1.73M | 0.31% | −11,537−11.2% | Reduced |
| HRT Financial LP | 89,141 | $1.68M | 0.00% | +62,859+239.2% | Added |
| Invesco Ltd. | 88,121 | $1.67M | 0.00% | +34,739+65.1% | Added |
| Group One Trading, L.P. | 87,832 | $1.66M | 0.05% | +87,832 | New |
| Susquehanna International Group, LLP | 81,456 | $1.54M | 0.00% | −395,656−82.9% | Reduced |
| LPL Financial LLC | 78,271 | $1.48M | 0.00% | +1,035+1.3% | Added |
| Price T Rowe Associates Inc | 70,001 | $1.32M | 0.00% | +17,771+34.0% | Added |
| Platinum Investment Management Ltd | 70,000 | $1.32M | 0.33% | 00.0% | Unchanged |
| Legal & General Group Plc | 59,799 | $1.13M | 0.00% | −7,176−10.7% | Reduced |
| Ikarian Capital, LLC | 58,803 | $1.11M | 0.16% | 00.0% | Unchanged |
| AQR Capital Management LLC | 57,094 | $1.08M | 0.00% | −1,204−2.1% | Reduced |
| Rockefeller Capital Management L.P. | 55,206 | $1.04M | 0.00% | +54,855+15,628.2% | Added |
| MetLife Investment Management | 54,261 | $1.03M | 0.01% | +1,681+3.2% | Added |
| Vanguard Asset Management, Ltd | 54,018 | $1.02M | 0.00% | +54,018 | New |
| Blair William & Co | 53,695 | $1.01M | 0.00% | +53,695 | New |
| Kestra Private Wealth Services, LLC | 50,588 | $956.1K | 0.01% | +448+0.9% | Added |
| State of Wisconsin Investment Board | 50,420 | $952.9K | 0.00% | −8,182−14.0% | Reduced |
| Nisa Investment Advisors, LLC | 48,903 | $924.3K | 0.00% | +525+1.1% | Added |
| Vanguard Global Advisers, LLC | 48,044 | $908.0K | 0.00% | +48,044 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 46,193 | $873.0K | 0.00% | +2,457+5.6% | Added |
| Allstate Corp | 45,366 | $857.4K | 0.01% | +45,366 | New |
| CenterBook Partners LP | 42,829 | $809.5K | 0.04% | −95,986−69.1% | Reduced |
| Twinbeech Capital LP | 42,100 | $795.7K | 0.08% | +42,100 | New |