Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2021
Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 176
- +7 vs. Q3 2021
- Shares held
- 51.9M
- +7.33M (+16.4%) vs. Q3 2021
- Total value
- $72.0M
- −$32.6M (−31.1%) vs. Q3 2021
- New holders
- 37
- 54 more added
- Sold out
- 30
- 35 more reduced
6 institutions that held it in Q3 2021 haven't filed for Q4 2021 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock Inc. | 17,065,574 | $23.6M | 0.00% | +383,577+2.3% | Added |
| State Street Corp | 5,728,738 | $7.91M | 0.00% | +94,650+1.7% | Added |
| Geode Capital Management, LLC | 2,908,735 | $4.01M | 0.00% | −4,298−0.1% | Reduced |
| Northern Trust Corp | 2,539,207 | $3.50M | 0.00% | −50,110−1.9% | Reduced |
| Morgan Stanley | 2,399,883 | $3.31M | 0.00% | +2,205,055+1,131.8% | Added |
| Vanguard Group Inc | 1,974,999 | $2.73M | 0.00% | +99,591+5.3% | Added |
| Data Collective IV GP, LLC | 1,505,248 | $2.60M | 0.35% | +1,505,248 | New |
| Citadel Advisors LLC | 1,660,750 | $2.29M | 0.00% | +1,390,655+514.9% | Added |
| Busey Wealth Management | 1,248,201 | $1.72M | 0.07% | +431,267+52.8% | Added |
| Two Sigma Investments, LP | 1,123,766 | $1.55M | 0.00% | +790,860+237.6% | Added |
| Millennium Management LLC | 1,076,153 | $1.49M | 0.00% | −316,206−22.7% | Reduced |
| Susquehanna International Group, LLP | 1,053,838 | $1.45M | 0.00% | −7,348−0.7% | Reduced |
| Bank of New York Mellon Corp | 919,642 | $1.27M | 0.00% | +33,807+3.8% | Added |
| Swiss National Bank | 772,800 | $1.05M | 0.00% | +56,300+7.9% | Added |
| Charles Schwab Investment Management Inc | 749,388 | $1.03M | 0.00% | +12,328+1.7% | Added |
| Group One Trading, L.P. | 475,859 | $657.0K | 0.01% | +328,202+222.3% | Added |
| AdvisorShares Investments LLC | 417,522 | $576.0K | 0.07% | +265,004+173.8% | Added |
| LPL Financial LLC | 387,205 | $534.0K | 0.00% | +343,320+782.3% | Added |
| Deutsche Bank AG | 331,718 | $458.0K | 0.00% | +17,089+5.4% | Added |
| Rhumbline Advisers | 309,943 | $428.0K | 0.00% | +2,739+0.9% | Added |
| Alliancebernstein L.P. | 290,700 | $401.0K | 0.00% | −45,200−13.5% | Reduced |
| Penserra Capital Management LLC | 242,116 | $334.0K | 0.01% | +46,096+23.5% | Added |
| Goldman Sachs Group Inc | 228,702 | $316.0K | 0.00% | −787,312−77.5% | Reduced |
| Credit Suisse AG | 215,090 | $297.0K | 0.00% | −22,241−9.4% | Reduced |
| Parametric Portfolio Associates LLC | 214,152 | $296.0K | 0.00% | +88,272+70.1% | Added |
| New York State Common Retirement Fund | 206,258 | $285.0K | 0.00% | −665−0.3% | Reduced |
| Wells Fargo & Company | 201,729 | $279.0K | 0.00% | +175,536+670.2% | Added |
| Cresset Asset Management, LLC | 201,100 | $278.0K | 0.00% | +201,100 | New |
| California State Teachers Retirement System | 188,069 | $260.0K | 0.00% | −626−0.3% | Reduced |
| American International Group, Inc. | 184,914 | $255.0K | 0.00% | −5,531−2.9% | Reduced |
| Manufacturers Life Insurance Company, The | 177,756 | $245.0K | 0.00% | +1,710+1.0% | Added |
| National Bank of Canada | 177,053 | $244.0K | 0.00% | +177,053 | New |
| Jane Street Group, LLC | 175,205 | $241.0K | 0.00% | +124,170+243.3% | Added |
| tru Independence LLC | 167,293 | $232.0K | 0.06% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 167,211 | $231.0K | 0.00% | −3,311−1.9% | Reduced |
| Commonwealth Equity Services, LLC | 166,202 | $229.0K | 0.00% | +16,240+10.8% | Added |
| Bank of Montreal | 146,730 | $216.0K | 0.00% | −22,882−13.5% | Reduced |
| Bank of America Corp | 155,458 | $214.0K | 0.00% | +118,264+318.0% | Added |
| Invesco Ltd. | 146,994 | $203.0K | 0.00% | −52,638−26.4% | Reduced |
| Royal Bank of Canada | 143,677 | $199.0K | 0.00% | +47,664+49.6% | Added |
| BIT Capital GmbH | 140,000 | $193.2K | 0.01% | 00.0% | Unchanged |
| MetLife Investment Management | 138,319 | $190.9K | 0.00% | +46,054+49.9% | Added |
| Voya Investment Management LLC | 134,563 | $186.0K | 0.00% | +171+0.1% | Added |
| Man Group plc | 109,400 | $151.0K | 0.00% | +109,400 | New |
| UBS Group AG | 106,831 | $147.0K | 0.00% | +105,784+10,103.5% | Added |
| Ikarian Capital, LLC | 100,000 | $138.0K | 0.04% | +100,000 | New |
| Ergoteles LLC | 98,829 | $136.0K | 0.01% | +50,721+105.4% | Added |
| Citigroup Inc | 94,316 | $129.0K | 0.00% | +53,789+132.7% | Added |
| Scotia Capital Inc. | 87,608 | $120.0K | 0.00% | +4,461+5.4% | Added |
| STRS Ohio | 79,800 | $110.0K | 0.00% | 00.0% | Unchanged |
| Audent Global Asset Management, LLC | 78,000 | $108.0K | 0.05% | +78,000 | New |
| Metropolitan Life Insurance Co | 77,352 | $106.7K | 0.00% | +6,407+9.0% | Added |
| ProShare Advisors LLC | 76,012 | $105.0K | 0.00% | +31,421+70.5% | Added |
| Gofen & Glossberg LLC | 72,500 | $100.0K | 0.00% | 00.0% | Unchanged |
| HSBC Holdings PLC | 38,229 | $93.0K | 0.00% | +10,114+36.0% | Added |
| Ground Swell Capital, LLC | 63,698 | $88.0K | 0.51% | +63,698 | New |
| SG Americas Securities, LLC | 62,146 | $86.0K | 0.00% | −78,877−55.9% | Reduced |
| Principal Financial Group Inc | 59,189 | $82.0K | 0.00% | −13,812−18.9% | Reduced |
| Alpine Global Management, LLC | 59,690 | $82.0K | 0.01% | +59,690 | New |
| HighTower Advisors, LLC | 59,228 | $81.0K | 0.00% | −52,975−47.2% | Reduced |
| Creative Planning | 58,080 | $80.0K | 0.00% | −18,152−23.8% | Reduced |
| XTX Topco Ltd | 57,608 | $79.0K | 0.04% | +57,608 | New |
| Legal & General Group Plc | 54,490 | $78.0K | 0.00% | +802+1.5% | Added |
| Two Sigma Advisers, LP | 56,400 | $78.0K | 0.00% | +56,400 | New |
| Parallax Volatility Advisers, L.P. | 53,563 | $74.0K | 0.00% | +53,563 | New |
| State Board of Administration of Florida Retirement System | 48,230 | $66.0K | 0.00% | +100+0.2% | Added |
| Stifel Financial Corp | 46,240 | $64.0K | 0.00% | +1,260+2.8% | Added |
| Toronto Dominion Bank | 40,923 | $56.0K | 0.00% | +1,100+2.8% | Added |
| First Republic Investment Management, Inc. | 37,500 | $52.0K | 0.00% | −4,837−11.4% | Reduced |
| Shell Asset Management Co | 37,982 | $52.0K | 0.00% | +9,169+31.8% | Added |
| Jaffetilchin Investment Partners, LLC | 36,855 | $51.0K | 0.00% | 00.0% | Unchanged |
| Wedbush Securities Inc | 36,000 | $50.0K | 0.00% | +13,500+60.0% | Added |
| Two Sigma Securities, LLC | 36,347 | $50.0K | 0.01% | +36,347 | New |
| Wolverine Trading, LLC | 33,479 | $48.0K | 0.00% | +6,085+22.2% | Added |
| Squarepoint Ops LLC | 34,795 | $48.0K | 0.00% | +23,379+204.8% | Added |
| Stratos Wealth Partners, LTD. | 33,604 | $46.0K | 0.00% | 00.0% | Unchanged |
| Csenge Advisory Group | 12,112 | $42.0K | 0.00% | −2,500−17.1% | Reduced |
| American Portfolios Advisors | 30,000 | $41.4K | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 30,001 | $41.0K | 0.00% | −29,999−50.0% | Reduced |
| Cutler Group LP | 29,889 | $41.0K | 0.00% | −1,132−3.6% | Reduced |
| Simplex Trading, LLC | 28,219 | $38.0K | 0.00% | −170,247−85.8% | Reduced |
| IHT Wealth Management, LLC | 27,500 | $38.0K | 0.00% | −2,500−8.3% | Reduced |
| Pictet Asset Management SA | 27,463 | $38.0K | 0.00% | 00.0% | Unchanged |
| Private Advisor Group, LLC | 25,710 | $36.0K | 0.00% | −34,794−57.5% | Reduced |
| Ameritas Investment Partners, Inc. | 25,253 | $35.0K | 0.00% | 00.0% | Unchanged |
| Conservest Capital Advisors, Inc. | 23,695 | $33.0K | 0.00% | +251+1.1% | Added |
| Bayesian Capital Management, LP | 23,578 | $33.0K | 0.01% | +23,578 | New |
| Price T Rowe Associates Inc | 22,986 | $32.0K | 0.00% | −5,800−20.1% | Reduced |
| K.J. Harrison & Partners Inc | 21,500 | $30.0K | 0.00% | 00.0% | Unchanged |
| Prudential Financial Inc | 20,240 | $28.0K | 0.00% | −2,510−11.0% | Reduced |
| Fisher Asset Management, LLC | 20,125 | $28.0K | 0.00% | +20,125 | New |
| Regions Financial Corp | 20,000 | $28.0K | 0.00% | +20,000 | New |
| CWM, LLC | 19,642 | $27.0K | 0.00% | +19,642 | New |
| Mackenzie Financial Corp | 19,191 | $26.0K | 0.00% | +277+1.5% | Added |
| HRT Financial LP | 17,743 | $24.0K | 0.00% | +17,743 | New |
| Xponance, Inc. | 16,486 | $23.0K | 0.00% | +117+0.7% | Added |
| Federation des caisses Desjardins du Quebec | 16,559 | $22.8K | 0.00% | −100−0.6% | Reduced |
| Close Asset Management Ltd | 16,000 | $22.0K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 13,400 | $21.8K | 0.00% | +13,400 | New |
| CIBC World Markets Inc. | 15,546 | $21.0K | 0.00% | +175+1.1% | Added |