Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2025
Institutional positions in Definium Therapeutics, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 191
- +18 vs. Q4 2024
- Shares held
- 41.2M
- −58.8K (−0.1%) vs. Q4 2024
- Total value
- $240.5M
- −$46.4M (−16.2%) vs. Q4 2024
- New holders
- 39
- 50 more added
- Sold out
- 21
- 46 more reduced
1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 5,715,713 | $33.4M | 0.00% | −354,340−5.8% | Reduced |
| Commodore Capital LP | 4,525,000 | $26.5M | 1.95% | +216,575+5.0% | Added |
| Blackstone Group Inc. | 3,587,479 | $21.0M | 0.09% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 3,351,405 | $19.6M | 0.19% | −24,802−0.7% | Reduced |
| Octagon Capital Advisors LP | 3,018,000 | $17.7M | 3.84% | 00.0% | Unchanged |
| Marshall Wace, LLP | 2,593,157 | $15.2M | 0.02% | +91,766+3.7% | Added |
| Deep Track Capital, LP | 2,500,000 | $14.6M | 0.47% | −316,594−11.2% | Reduced |
| State Street Corp | 1,842,214 | $10.8M | 0.00% | +60,715+3.4% | Added |
| Vanguard Group Inc | 1,766,547 | $10.3M | 0.00% | −144,278−7.6% | Reduced |
| Geode Capital Management, LLC | 1,666,791 | $9.75M | 0.00% | −56,297−3.3% | Reduced |
| AWM Investment Company, Inc. | 1,208,162 | $7.07M | 0.97% | +15,000+1.3% | Added |
| Woodline Partners LP | 1,005,198 | $5.88M | 0.04% | 00.0% | Unchanged |
| Morgan Stanley | 659,892 | $3.86M | 0.00% | +163,240+32.9% | Added |
| Northern Trust Corp | 642,783 | $3.76M | 0.00% | −42,053−6.1% | Reduced |
| Charles Schwab Investment Management Inc | 563,304 | $3.30M | 0.00% | −30,052−5.1% | Reduced |
| Rosalind Advisors, Inc. | 420,000 | $2.46M | 1.20% | +420,000 | New |
| Citadel Advisors LLC | 413,390 | $2.42M | 0.00% | +291,630+239.5% | Added |
| Tang Capital Management LLC | 400,200 | $2.34M | 0.13% | +200,200+100.1% | Added |
| Ally Bridge Group (NY) LLC | 390,143 | $2.28M | 2.06% | +59,868+18.1% | Added |
| Susquehanna International Group, LLP | 345,204 | $2.02M | 0.00% | +146,784+74.0% | Added |
| Nuveen, LLC | 266,051 | $1.56M | 0.00% | +266,051 | New |
| Wellington Management Group LLP | 225,928 | $1.32M | 0.00% | +31,437+16.2% | Added |
| Bank of New York Mellon Corp | 200,197 | $1.17M | 0.00% | +760.0% | Added |
| Goldman Sachs Group Inc | 192,195 | $1.12M | 0.00% | −104,611−35.2% | Reduced |
| Balyasny Asset Management LLC | 169,558 | $991.9K | 0.00% | +169,558 | New |
| Barclays PLC | 119,573 | $699.5K | 0.00% | −35,861−23.1% | Reduced |
| AdvisorShares Investments LLC | 119,593 | $662.5K | 0.13% | +15,884+15.3% | Added |
| Rhumbline Advisers | 108,457 | $634.5K | 0.00% | +7,762+7.7% | Added |
| UBS Group AG | 108,026 | $632.0K | 0.00% | −6,412−5.6% | Reduced |
| Swiss National Bank | 106,600 | $623.6K | 0.00% | −13,300−11.1% | Reduced |
| Data Collective IV GP, LLC | 100,350 | $587.0K | 0.68% | 00.0% | Unchanged |
| Bank of America Corp | 88,222 | $516.1K | 0.00% | −184,707−67.7% | Reduced |
| Alliancebernstein L.P. | 75,580 | $442.1K | 0.00% | +7,650+11.3% | Added |
| Jane Street Group, LLC | 73,989 | $432.8K | 0.00% | +57,432+346.9% | Added |
| Citigroup Inc | 71,175 | $416.4K | 0.00% | −5,733−7.5% | Reduced |
| Oppenheimer & Co Inc | 71,115 | $416.0K | 0.01% | +5,574+8.5% | Added |
| LPL Financial LLC | 67,433 | $394.5K | 0.00% | +5,099+8.2% | Added |
| Royal Bank of Canada | 65,237 | $382.0K | 0.00% | +6,148+10.4% | Added |
| Creative Planning | 64,442 | $377.0K | 0.00% | +64,442 | New |
| D. E. Shaw & Co., Inc. | 63,249 | $370.0K | 0.00% | +63,249 | New |
| Ikarian Capital, LLC | 62,691 | $366.7K | 0.12% | 00.0% | Unchanged |
| Deutsche Bank AG | 59,226 | $346.5K | 0.00% | −12,369−17.3% | Reduced |
| Two Sigma Investments, LP | 59,222 | $346.4K | 0.00% | −121,071−67.2% | Reduced |
| California State Teachers Retirement System | 58,498 | $342.2K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 57,293 | $335.2K | 0.00% | −1,144−2.0% | Reduced |
| Intech Investment Management LLC | 54,990 | $321.7K | 0.00% | +25,428+86.0% | Added |
| Scotia Capital Inc. | 53,975 | $314.8K | 0.00% | +200.0% | Added |
| Kestra Private Wealth Services, LLC | 50,206 | $293.7K | 0.00% | −1,000−2.0% | Reduced |
| DRW Securities, LLC | 50,000 | $292.5K | 0.02% | +50,000 | New |
| MetLife Investment Management | 49,196 | $287.8K | 0.00% | −466−0.9% | Reduced |
| Cerity Partners LLC | 48,485 | $283.6K | 0.00% | +48,485 | New |
| Simplex Trading, LLC | 47,856 | $279.0K | 0.01% | +37,628+367.9% | Added |
| JPMorgan Chase & Co | 46,145 | $269.9K | 0.00% | −2,013−4.2% | Reduced |
| UBS Asset Management Americas Inc | 45,621 | $266.9K | 0.00% | −39,423−46.4% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 43,550 | $254.8K | 0.00% | −2,140−4.7% | Reduced |
| Fore Capital, LLC | 40,000 | $234.0K | 0.28% | +2,461+6.6% | Added |
| Invesco Ltd. | 39,100 | $228.7K | 0.00% | −2,300−5.6% | Reduced |
| Wells Fargo & Company | 37,416 | $218.9K | 0.00% | −2,558−6.4% | Reduced |
| Moloney Securities Asset Management, LLC | 36,011 | $210.7K | 0.03% | −80,500−69.1% | Reduced |
| Corebridge Financial, Inc. | 35,986 | $210.5K | 0.00% | −4,078−10.2% | Reduced |
| Janney Montgomery Scott LLC | 34,685 | $203.0K | 0.00% | +34,685 | New |
| Caxton Corp | 34,073 | $199.3K | 3.92% | 00.0% | Unchanged |
| Clough Capital Partners L P | 33,900 | $198.3K | 0.03% | 00.0% | Unchanged |
| Virtu Financial LLC | 32,836 | $192.0K | 0.01% | +32,836 | New |
| Price T Rowe Associates Inc | 30,945 | $182.0K | 0.00% | −368−1.2% | Reduced |
| Janus Henderson Group PLC | 28,000 | $173.5K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 29,544 | $172.8K | 0.01% | −6,595−18.2% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 28,867 | $168.9K | 0.00% | +1,669+6.1% | Added |
| Rathbone Brothers plc | 28,200 | $165.0K | 0.00% | +8,000+39.6% | Added |
| Manufacturers Life Insurance Company, The | 27,364 | $160.1K | 0.00% | +256+0.9% | Added |
| Algert Global LLC | 24,770 | $144.9K | 0.00% | +24,770 | New |
| Massar Capital Management, LP | 24,583 | $143.8K | 0.17% | +24,583 | New |
| Squarepoint Ops LLC | 23,471 | $137.3K | 0.00% | −18,497−44.1% | Reduced |
| Virtus Investment Advisers, Inc. | 23,388 | $136.8K | 0.04% | +23,388 | New |
| EntryPoint Capital, LLC | 22,708 | $132.8K | 0.06% | +22,708 | New |
| Palumbo Wealth Management LLC | 22,628 | $132.4K | 0.04% | +22,628 | New |
| Federation des caisses Desjardins du Quebec | 22,422 | $131.2K | 0.00% | +1,000+4.7% | Added |
| Voya Investment Management LLC | 21,115 | $123.5K | 0.00% | −2,551−10.8% | Reduced |
| Mitchell McLeod Pugh & Williams Inc | 20,000 | $117.0K | 0.02% | 00.0% | Unchanged |
| Mercer Global Advisors Inc | 19,580 | $114.5K | 0.00% | +3,580+22.4% | Added |
| ProShare Advisors LLC | 19,209 | $112.4K | 0.00% | −6,958−26.6% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 18,554 | $108.5K | 0.00% | +4,080+28.2% | Added |
| Raymond James Financial Inc | 18,479 | $108.1K | 0.00% | +2,475+15.5% | Added |
| Commonwealth Equity Services, LLC | 18,292 | $107.0K | 0.00% | −3,200−14.9% | Reduced |
| Boothbay Fund Management, LLC | 17,984 | $105.2K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 17,523 | $102.5K | 0.00% | +7,277+71.0% | Added |
| Profund Advisors LLC | 17,509 | $102.4K | 0.00% | +5,216+42.4% | Added |
| New York State Common Retirement Fund | 17,100 | $100.0K | 0.00% | 00.0% | Unchanged |
| Gruss & Co., LLC | 16,939 | $99.1K | 0.43% | +16,939 | New |
| HRT Financial LP | 16,703 | $97.0K | 0.00% | +16,703 | New |
| Sequoia Financial Advisors, LLC | 16,579 | $97.0K | 0.00% | 00.0% | Unchanged |
| CIBC World Markets Corp | 16,299 | $95.3K | 0.00% | +16,299 | New |
| Arizona State Retirement System | 15,776 | $92.3K | 0.00% | −1,864−10.6% | Reduced |
| Bank of Montreal | 15,105 | $88.4K | 0.00% | +4,438+41.6% | Added |
| Ameriprise Financial Inc | 15,048 | $88.0K | 0.00% | +2,443+19.4% | Added |
| Teacher Retirement System of Texas | 14,860 | $86.9K | 0.00% | −3,345−18.4% | Reduced |
| China Universal Asset Management Co., Ltd. | 14,709 | $86.0K | 0.01% | −840−5.4% | Reduced |
| Bailard, Inc. | 14,600 | $85.4K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 14,412 | $84.3K | 0.00% | −10,497−42.1% | Reduced |
| Wolverine Trading, LLC | 13,236 | $81.9K | 0.00% | −8,170−38.2% | Reduced |