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Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q1 2025

Institutional positions in Definium Therapeutics, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
191
+18 vs. Q4 2024
Shares held
41.2M
−58.8K (−0.1%) vs. Q4 2024
Total value
$240.5M
−$46.4M (−16.2%) vs. Q4 2024
New holders
39
50 more added
Sold out
21
46 more reduced

1 institution that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q4 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2025: 191 institutions
Q1 2021: 8 institutionsQ2 2021: 156 institutionsQ3 2021: 175 institutionsQ4 2021: 176 institutionsQ1 2022: 159 institutionsQ2 2022: 156 institutionsQ3 2022: 101 institutionsQ4 2022: 104 institutionsQ1 2023: 89 institutionsQ2 2023: 84 institutionsQ3 2023: 93 institutionsQ4 2023: 104 institutionsQ1 2024: 135 institutionsQ2 2024: 152 institutionsQ3 2024: 158 institutionsQ4 2024: 174 institutionsQ1 2025: 191 institutionsQ2 2025: 183 institutionsQ3 2025: 196 institutionsQ4 2025: 209 institutionsQ1 2026: 248 institutionsQ2 2026: 362 institutions
Value heldQ1 2025: $240.5M
Q1 2021: $932.0KQ2 2021: $131.0MQ3 2021: $104.8MQ4 2021: $72.0MQ1 2022: $53.6MQ2 2022: $15.1MQ3 2022: $20.5MQ4 2022: $11.1MQ1 2023: $12.6MQ2 2023: $13.9MQ3 2023: $12.1MQ4 2023: $17.9MQ1 2024: $327.2MQ2 2024: $299.3MQ3 2024: $281.6MQ4 2024: $288.9MQ1 2025: $240.5MQ2 2025: $271.0MQ3 2025: $468.6MQ4 2025: $908.7MQ1 2026: $1.47BQ2 2026: $5.35B
Institutions holding DFTX and their total value by quarter
QuarterHoldersValue
Q2 2026362$5.35B
Q1 2026248$1.47B
Q4 2025209$908.7M
Q3 2025196$468.6M
Q2 2025183$271.0M
Q1 2025191$240.5M
Q4 2024174$288.9M
Q3 2024158$281.6M
Q2 2024152$299.3M
Q1 2024135$327.2M
Q4 2023104$17.9M
Q3 202393$12.1M
Q2 202384$13.9M
Q1 202389$12.6M
Q4 2022104$11.1M
Q3 2022101$20.5M
Q2 2022156$15.1M
Q1 2022159$53.6M
Q4 2021176$72.0M
Q3 2021175$104.8M
Q2 2021156$131.0M
Q1 20218$932.0K

Institutions, Q1 2025

Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q4 2024.

Institutions holding DFTX in Q1 2025
InstitutionSharesValue% of portfolioChange in sharesAction
TSFG, LLC24$00.00%00.0%Unchanged
Huntington National Bank1$10.00%00.0%Unchanged
Signaturefd, LLC2$120.00%00.0%Unchanged
Rothschild Investment LLC3$180.00%00.0%Unchanged
Hexagon Capital Partners LLC4$230.00%00.0%Unchanged
CoreCap Advisors, LLC5$290.00%00.0%Unchanged
NBT Bank N A6$350.00%00.0%Unchanged
Belmont Capital, LLC6$350.00%00.0%Unchanged
Strategic Investment Solutions, Inc.6$350.00%00.0%Unchanged
MAI Capital Management10$590.00%00.0%Unchanged
CNB Bank10$590.00%00.0%Unchanged
Boston Private Wealth LLC11$640.00%+11New
Ameriflex Group, Inc.13$760.00%00.0%Unchanged
Harbor Investment Advisory, LLC13$760.00%+13New
Coldstream Capital Management Inc16$940.00%+16New
Parallel Advisors, LLC19$1110.00%00.0%Unchanged
Robbins Farley LLC28$1640.00%00.0%Unchanged
TruNorth Capital Management, LLC33$1930.00%00.0%Unchanged
Chesapeake Asset Management LLC33$1930.00%00.0%Unchanged
Plante Moran Financial Advisors, LLC36$2110.00%00.0%Unchanged
Anfield Capital Management, LLC36$2110.00%00.0%Unchanged
TD Capital Management LLC39$2280.00%+39New
Louisbourg Investments Inc.52$3040.00%00.0%Unchanged
Tradewinds Capital Management, LLC53$3110.00%00.0%Unchanged
EverSource Wealth Advisors, LLC56$3280.00%+43+330.8%Added
Fifth Third Bancorp59$3450.00%00.0%Unchanged
Activest Wealth Management66$3860.00%00.0%Unchanged
Allworth Financial LP69$4440.00%00.0%Unchanged
Sterling Capital Management LLC87$5090.00%+13+17.6%Added
Northwestern Mutual Wealth Management Co100$5850.00%−368−78.6%Reduced
HighMark Wealth Management LLC100$5850.00%00.0%Unchanged
Pandora Wealth, Inc.131$7660.00%+131New
GWM Advisors LLC142$8310.00%−6−4.1%Reduced
Daiwa Securities Group Inc.242$1.00K0.00%00.0%Unchanged
Atlantic Edge Private Wealth Management, LLC193$1.13K0.00%+193New
Continuum Advisory, LLC239$1.40K0.00%00.0%Unchanged
SRS Capital Advisors, Inc.264$1.54K0.00%−12−4.3%Reduced
SBI Securities Co., Ltd.306$1.79K0.00%+110+56.1%Added
CarsonAllaria Wealth Management, Ltd.325$1.90K0.00%+325New
CIBC Private Wealth Group, LLC423$2.07K0.00%00.0%Unchanged
Harbour Investments, Inc.356$2.08K0.00%00.0%Unchanged
Skopos Labs, Inc.382$2.23K0.00%+382New
Tortoise Investment Management, LLC400$2.34K0.00%00.0%Unchanged
NVWM, LLC416$2.43K0.00%00.0%Unchanged
NBC Securities, Inc.600$3.00K0.00%+600New
Caitong International Asset Management Co., Ltd559$3.27K0.00%+559New
Massmutual Trust Co FSB567$3.32K0.00%+567New
GAMMA Investing LLC693$4.05K0.00%+587+553.8%Added
Farther Finance Advisors, LLC994$5.51K0.00%+93+10.3%Added
Steward Partners Investment Advisory, LLC1,000$5.85K0.00%+100+11.1%Added
Stone House Investment Management, LLC1,000$5.85K0.00%+1,000New
IFP Advisors, Inc984$5.94K0.00%+984Added
Bullock Wealth Management Group1,194$6.62K0.00%00.0%Unchanged
Versant Capital Management, Inc1,137$6.65K0.00%+1,137New
National Bank of Canada1,421$8.31K0.00%−126−8.1%Reduced
Russell Investments Group, Ltd.1,814$10.6K0.00%−352−16.3%Reduced
GF Fund Management Co. Ltd.1,877$11.0K0.00%+337+21.9%Added
Crewe Advisors LLC1,999$11.7K0.00%00.0%Unchanged
EMC Capital Management2,575$14.0K0.01%00.0%Unchanged
Nisa Investment Advisors, LLC2,433$14.2K0.00%+2,229+1,092.6%Added
Kestra Advisory Services, LLC2,532$14.8K0.00%+2,532New
Mirae Asset Global Investments Co., Ltd.2,454$15.2K0.00%+10+0.4%Added
Amalgamated Bank2,781$16.0K0.00%+290+11.6%Added
CWM, LLC2,663$16.0K0.00%+1,195+81.4%Added
Walleye Trading LLC2,910$17.0K0.00%+2,910New
Larson Financial Group LLC2,932$17.2K0.00%+2,932New
TD Waterhouse Canada Inc.4,996$27.5K0.00%+661+15.2%Added
BNP Paribas Arbitrage, SA5,397$31.6K0.00%−5,234−49.2%Reduced
Ameritas Investment Partners, Inc.7,053$41.3K0.00%00.0%Unchanged
Hollencrest Capital Management7,216$42.2K0.00%00.0%Unchanged
Capital Advisors Inc50,000$50.0K0.00%+50,000New
North Star Investment Management Corp.9,401$55.0K0.00%00.0%Unchanged
King Wealth10,000$59.0K0.01%00.0%Unchanged
KLP Kapitalforvaltning AS10,400$60.8K0.00%00.0%Unchanged
SEI Investments Co10,415$60.9K0.00%00.0%Unchanged
Black Swift Group, LLC10,713$62.7K0.01%+10,713New
Stoneridge Investment Partners LLC10,759$63.0K0.05%00.0%Unchanged
Diversify Wealth Management, LLC10,000$63.0K0.00%00.0%Unchanged
Sharpepoint LLC10,165$64.0K0.06%00.0%Unchanged
Sanctuary Advisors, LLC11,332$66.3K0.00%+330+3.0%Added
Tower Research Capital LLC (TRC)11,368$66.5K0.00%+9,218+428.7%Added
Change Path, LLC11,455$67.0K0.00%+11,455New
Avantax Advisory Services, Inc.11,597$67.8K0.00%+418+3.7%Added
AQR Capital Management LLC12,250$71.7K0.00%−12,887−51.3%Reduced
Blair William & Co12,500$73.1K0.00%+12,500New
HighTower Advisors, LLC12,676$74.2K0.00%−353−2.7%Reduced
PEAK6 LLC13,002$76.1K0.00%+4,907+60.6%Added
Diametric Capital, LP13,370$78.2K0.09%−2,080−13.5%Reduced
Wealth Enhancement Advisory Services, LLC13,538$79.2K0.00%−12−0.1%Reduced
Rafferty Asset Management, LLC13,773$80.6K0.00%+13,773New
Clear Street Markets LLC13,911$81.4K0.06%+13,911New
Wolverine Trading, LLC13,236$81.9K0.00%−8,170−38.2%Reduced
FMR LLC14,412$84.3K0.00%−10,497−42.1%Reduced
Bailard, Inc.14,600$85.4K0.00%00.0%Unchanged
China Universal Asset Management Co., Ltd.14,709$86.0K0.01%−840−5.4%Reduced
Teacher Retirement System of Texas14,860$86.9K0.00%−3,345−18.4%Reduced
Ameriprise Financial Inc15,048$88.0K0.00%+2,443+19.4%Added
Bank of Montreal15,105$88.4K0.00%+4,438+41.6%Added
Arizona State Retirement System15,776$92.3K0.00%−1,864−10.6%Reduced
CIBC World Markets Corp16,299$95.3K0.00%+16,299New