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Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q2 2022

Institutional positions in Definium Therapeutics, Inc. as of Jun 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
156
−1 vs. Q1 2022
Shares held
22.9M
−25.5M (−52.7%) vs. Q1 2022
Total value
$15.1M
−$38.5M (−71.8%) vs. Q1 2022
New holders
49
26 more added
Sold out
50
42 more reduced

2 institutions that held it in Q1 2022 haven't filed for Q2 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2022: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2022: 156 institutions
Q1 2021: 8 institutionsQ2 2021: 156 institutionsQ3 2021: 175 institutionsQ4 2021: 176 institutionsQ1 2022: 159 institutionsQ2 2022: 156 institutionsQ3 2022: 101 institutionsQ4 2022: 104 institutionsQ1 2023: 89 institutionsQ2 2023: 84 institutionsQ3 2023: 93 institutionsQ4 2023: 104 institutionsQ1 2024: 135 institutionsQ2 2024: 152 institutionsQ3 2024: 158 institutionsQ4 2024: 174 institutionsQ1 2025: 191 institutionsQ2 2025: 183 institutionsQ3 2025: 196 institutionsQ4 2025: 209 institutionsQ1 2026: 248 institutionsQ2 2026: 362 institutions
Value heldQ2 2022: $15.1M
Q1 2021: $932.0KQ2 2021: $131.0MQ3 2021: $104.8MQ4 2021: $72.0MQ1 2022: $53.6MQ2 2022: $15.1MQ3 2022: $20.5MQ4 2022: $11.1MQ1 2023: $12.6MQ2 2023: $13.9MQ3 2023: $12.1MQ4 2023: $17.9MQ1 2024: $327.2MQ2 2024: $299.3MQ3 2024: $281.6MQ4 2024: $288.9MQ1 2025: $240.5MQ2 2025: $271.0MQ3 2025: $468.6MQ4 2025: $908.7MQ1 2026: $1.47BQ2 2026: $5.35B
Institutions holding DFTX and their total value by quarter
QuarterHoldersValue
Q2 2026362$5.35B
Q1 2026248$1.47B
Q4 2025209$908.7M
Q3 2025196$468.6M
Q2 2025183$271.0M
Q1 2025191$240.5M
Q4 2024174$288.9M
Q3 2024158$281.6M
Q2 2024152$299.3M
Q1 2024135$327.2M
Q4 2023104$17.9M
Q3 202393$12.1M
Q2 202384$13.9M
Q1 202389$12.6M
Q4 2022104$11.1M
Q3 2022101$20.5M
Q2 2022156$15.1M
Q1 2022159$53.6M
Q4 2021176$72.0M
Q3 2021175$104.8M
Q2 2021156$131.0M
Q1 20218$932.0K

Institutions, Q2 2022

Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q1 2022.

Institutions holding DFTX in Q2 2022
InstitutionSharesValue% of portfolioChange in sharesAction
Millennium Management LLC5,075,110$3.25M0.00%+4,638,774+1,063.1%Added
Data Collective IV GP, LLC1,505,248$1.23M1.02%00.0%Unchanged
Citadel Advisors LLC1,741,833$1.11M0.00%+541,759+45.1%Added
Busey Wealth Management1,248,201$799.0K0.04%00.0%Unchanged
Ergoteles LLC1,087,598$696.0K0.02%+1,087,598New
State Street Corp962,810$616.0K0.00%−5,182,693−84.3%Reduced
Swiss National Bank848,400$539.0K0.00%−102,700−10.8%Reduced
LPL Financial LLC774,711$496.0K0.00%+774,711New
AdvisorShares Investments LLC750,151$480.0K0.13%+100,983+15.6%Added
Morgan Stanley728,900$468.0K0.00%−1,245,399−63.1%Reduced
Susquehanna International Group, LLP632,746$405.0K0.00%−51,208−7.5%Reduced
Group One Trading, L.P.566,863$363.0K0.01%+31,658+5.9%Added
Merit Financial Group, LLC532,387$341.0K0.01%+532,387New
Cubist Systematic Strategies, LLC511,780$328.0K0.00%+511,780New
Penserra Capital Management LLC441,865$282.0K0.01%−38,988−8.1%Reduced
Two Sigma Investments, LP372,832$239.0K0.00%−304,948−45.0%Reduced
Credit Suisse AG319,740$204.0K0.00%+40,687+14.6%Added
Goldman Sachs Group Inc261,290$167.0K0.00%−86,487−24.9%Reduced
Bank of Montreal148,513$150.0K0.00%+1,680+1.1%Added
Man Group plc–$148.0K0.00%––
Vanguard Group Inc230,252$147.0K0.00%−1,672,898−87.9%Reduced
Commonwealth Equity Services, LLC225,971$144.0K0.00%+40,346+21.7%Added
BlackRock Inc.208,091$133.0K0.00%−16,226,119−98.7%Reduced
The PNC Financial Services Group, Inc.203,035$130.0K0.00%+203,035New
Geode Capital Management, LLC201,145$129.0K0.00%−2,621,537−92.9%Reduced
Jane Street Group, LLC203,002$129.0K0.00%−94,786−31.8%Reduced
Deutsche Bank AG178,535$115.0K0.00%−187,757−51.3%Reduced
HRT Financial LP173,838$111.0K0.00%+161,728+1,335.5%Added
Fore Capital, LLC160,000$102.0K0.26%+60,000+60.0%Added
Y-Intercept (Hong Kong) Ltd147,092$94.0K0.01%+147,092New
Laurion Capital Management LP132,327$85.0K0.00%+132,327New
Ikarian Capital, LLC105,958$68.0K0.03%00.0%Unchanged
Bank of America Corp106,081$68.0K0.00%+58,618+123.5%Added
Parallax Volatility Advisers, L.P.100,107$64.0K0.00%+206+0.2%Added
Scotia Capital Inc.91,545$58.0K0.00%+7,762+9.3%Added
Audent Global Asset Management, LLC78,000$50.0K0.04%00.0%Unchanged
Gofen & Glossberg LLC72,500$46.0K0.00%00.0%Unchanged
Balyasny Asset Management LLC66,300$42.0K0.00%+66,300New
Royal Bank of Canada64,922$41.0K0.00%−27,721−29.9%Reduced
Exchange Traded Concepts, LLC59,592$38.0K0.00%+46,039+339.7%Added
Creative Planning53,156$34.0K0.00%−2,339−4.2%Reduced
Toronto Dominion Bank46,523$30.0K0.00%+1,000+2.2%Added
Legal & General Group Plc44,895$29.0K0.00%−39,659−46.9%Reduced
Bank of New York Mellon Corp42,788$28.0K0.00%−893,600−95.4%Reduced
Quantum Private Wealth, LLC45,040$28.0K0.02%+45,040New
Squarepoint Ops LLC41,688$27.0K0.00%−36,444−46.6%Reduced
Accurate Wealth Management, LLC40,240$26.0K0.01%+5,900+17.2%Added
Shell Asset Management Co37,982$24.0K0.00%00.0%Unchanged
Jaffetilchin Investment Partners, LLC36,855$24.0K0.00%+36,855New
Public Employees Retirement Association of Colorado28,200$23.0K0.00%+28,200New
Wedbush Securities Inc36,000$23.0K0.00%+36,000New
Private Advisor Group, LLC36,063$23.0K0.00%+36,063New
tru Independence LLC32,293$21.0K0.01%−135,000−80.7%Reduced
HSBC Holdings PLC31,802$20.0K0.00%−11,279−26.2%Reduced
Alpine Global Management, LLC31,750$20.0K0.01%00.0%Unchanged
American Portfolios Advisors30,000$19.2K0.00%00.0%Unchanged
Huntington National Bank30,001$19.0K0.00%00.0%Unchanged
Miracle Mile Advisors, LLC30,000$19.0K0.00%+30,000New
Crewe Advisors LLC29,985$19.0K0.00%+29,985New
Strategic Blueprint, LLC28,000$18.0K0.00%+12,000+75.0%Added
CWM, LLC28,779$18.0K0.00%+28,779New
National Bank of Canada26,760$17.0K0.00%−6,750−20.1%Reduced
UBS Group AG26,946$17.0K0.00%+5,615+26.3%Added
Parallel Advisors, LLC27,172$17.0K0.00%+27,172New
Barclays PLC22,806$15.0K0.00%−29,475−56.4%Reduced
K.J. Harrison & Partners Inc21,500$14.0K0.00%00.0%Unchanged
Crestwood Advisors Group LLC22,000$14.0K0.00%+22,000New
Cutler Group LP21,081$13.0K0.00%−12,308−36.9%Reduced
Glenmede Trust Co NA21,585$13.0K0.00%00.0%Unchanged
Fisher Asset Management, LLC20,000$13.0K0.00%−500−2.4%Reduced
IFP Advisors, Inc15,494$13.0K0.00%−14,215−47.8%Reduced
Advisor Group Holdings, Inc.20,501$13.0K0.00%+12,870+168.7%Added
InterOcean Capital Group, LLC20,014$13.0K0.00%+20,014New
Regions Financial Corp19,000$12.0K0.00%−1,000−5.0%Reduced
CIBC World Markets Inc.18,226$12.0K0.00%+20+0.1%Added
Raymond James & Associates18,095$12.0K0.00%+1,063+6.2%Added
Tower Research Capital LLC (TRC)18,539$12.0K0.00%+9,418+103.3%Added
Two Sigma Advisers, LP16,500$11.0K0.00%−35,500−68.3%Reduced
Invesco Ltd.15,600$10.0K0.00%−118,267−88.3%Reduced
Fulton Breakefield Broenniman LLC15,000$10.0K0.00%−2,750−15.5%Reduced
Veritable, L.P.15,100$10.0K0.00%00.0%Unchanged
Federation des caisses Desjardins du Quebec14,824$9.48K0.00%−1,735−10.5%Reduced
Endowment Wealth Management, Inc.13,913$9.00K0.01%+1,500+12.1%Added
North Star Investment Management Corp.14,100$9.00K0.00%+14,100New
Valeo Financial Advisors, LLC14,023$9.00K0.00%+14,023New
Financial Advocates Investment Management14,535$9.00K0.00%+14,535New
Delta Investment Management, LLC14,268$9.00K0.00%+14,268New
Sawtooth Solutions, LLC12,322$8.00K0.00%−993−7.5%Reduced
FMR LLC12,086$8.00K0.00%−938−7.2%Reduced
Oppenheimer & Co Inc12,812$8.00K0.00%−13−0.1%Reduced
Pacitti Group Inc.12,600$8.00K0.01%00.0%Unchanged
VisionPoint Advisory Group, LLC12,500$8.00K0.00%+2,500+25.0%Added
Captrust Financial Advisors12,548$8.00K0.00%+8,770+232.1%Added
Sandy Spring Bank12,152$8.00K0.00%+12,152New
Western Wealth Management, LLC12,000$8.00K0.00%+12,000New
Two Sigma Securities, LLC10,637$7.00K0.00%−8,132−43.3%Reduced
Ausdal Financial Partners, Inc.11,070$7.00K0.00%−1,900−14.6%Reduced
United Capital Financial Advisers, LLC11,628$7.00K0.00%−71−0.6%Reduced
Apollon Wealth Management, LLC11,427$7.00K0.00%00.0%Unchanged
NorthRock Partners, LLC10,702$7.00K0.00%−48−0.4%Reduced