Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2024
Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 174
- +18 vs. Q3 2024
- Shares held
- 41.5M
- −7.96M (−16.1%) vs. Q3 2024
- Total value
- $288.9M
- +$7.36M (+2.6%) vs. Q3 2024
- New holders
- 37
- 60 more added
- Sold out
- 19
- 33 more reduced
2 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 6,070,053 | $42.2M | 0.00% | +406,020+7.2% | Added |
| Commodore Capital LP | 4,308,425 | $30.0M | 2.20% | −3,691,575−46.1% | Reduced |
| Blackstone Group Inc. | 3,587,479 | $25.0M | 0.12% | −325,000−8.3% | Reduced |
| Driehaus Capital Management LLC | 3,376,207 | $23.5M | 0.19% | −517,920−13.3% | Reduced |
| Octagon Capital Advisors LP | 3,018,000 | $21.0M | 3.58% | 00.0% | Unchanged |
| Deep Track Capital, LP | 2,816,594 | $19.6M | 0.73% | −4,248,505−60.1% | Reduced |
| Marshall Wace, LLP | 2,501,391 | $17.4M | 0.02% | +213,526+9.3% | Added |
| Vanguard Group Inc | 1,910,825 | $13.3M | 0.00% | −37,482−1.9% | Reduced |
| State Street Corp | 1,781,499 | $12.4M | 0.00% | −33,330−1.8% | Reduced |
| Geode Capital Management, LLC | 1,723,088 | $12.0M | 0.00% | +45,386+2.7% | Added |
| AWM Investment Company, Inc. | 1,193,162 | $8.30M | 1.01% | +340,162+39.9% | Added |
| Woodline Partners LP | 1,005,198 | $7.00M | 0.05% | +2,654+0.3% | Added |
| Tri Locum Partners LP | 820,793 | $5.71M | 1.18% | −842,160−50.6% | Reduced |
| Northern Trust Corp | 684,836 | $4.77M | 0.00% | +76,559+12.6% | Added |
| Charles Schwab Investment Management Inc | 593,356 | $4.13M | 0.00% | −9,188−1.5% | Reduced |
| Morgan Stanley | 496,652 | $3.46M | 0.00% | +141,033+39.7% | Added |
| Ally Bridge Group (NY) LLC | 330,275 | $2.30M | 1.97% | −458,233−58.1% | Reduced |
| Goldman Sachs Group Inc | 296,806 | $2.07M | 0.00% | +126,857+74.6% | Added |
| Nuveen Asset Management, LLC | 286,334 | $1.99M | 0.00% | +8,856+3.2% | Added |
| Bank of America Corp | 272,929 | $1.90M | 0.00% | −39,662−12.7% | Reduced |
| Bank of New York Mellon Corp | 200,121 | $1.39M | 0.00% | +10,338+5.4% | Added |
| Tang Capital Management LLC | 200,000 | $1.39M | 0.09% | +200,000 | New |
| Susquehanna International Group, LLP | 198,420 | $1.38M | 0.00% | +198,420 | New |
| Wellington Management Group LLP | 194,491 | $1.35M | 0.00% | +8,769+4.7% | Added |
| Millennium Management LLC | 185,721 | $1.29M | 0.00% | +106,511+134.5% | Added |
| Two Sigma Investments, LP | 180,293 | $1.25M | 0.00% | −98,746−35.4% | Reduced |
| Barclays PLC | 155,434 | $1.08M | 0.00% | +19,336+14.2% | Added |
| Allostery Investments LP | 130,000 | $904.8K | 1.78% | +130,000 | New |
| Citadel Advisors LLC | 121,760 | $847.5K | 0.00% | +78,917+184.2% | Added |
| Swiss National Bank | 119,900 | $834.5K | 0.00% | 00.0% | Unchanged |
| Moloney Securities Asset Management, LLC | 116,511 | $810.9K | 0.11% | +1,000+0.9% | Added |
| UBS Group AG | 114,438 | $796.5K | 0.00% | −13,860−10.8% | Reduced |
| AdvisorShares Investments LLC | 103,709 | $721.8K | 0.14% | −5,457−5.0% | Reduced |
| Rhumbline Advisers | 100,695 | $700.8K | 0.00% | +4,868+5.1% | Added |
| Data Collective IV GP, LLC | 100,350 | $698.4K | 0.31% | 00.0% | Unchanged |
| UBS Asset Management Americas Inc | 85,044 | $591.9K | 0.00% | +14,691+20.9% | Added |
| Citigroup Inc | 76,908 | $535.3K | 0.00% | −7,588−9.0% | Reduced |
| Deutsche Bank AG | 71,595 | $498.3K | 0.00% | +24,716+52.7% | Added |
| Alliancebernstein L.P. | 67,930 | $472.8K | 0.00% | −7,400−9.8% | Reduced |
| Oppenheimer & Co Inc | 65,541 | $456.2K | 0.01% | +13,160+25.1% | Added |
| BIT Capital GmbH | 63,405 | $441.3K | 0.04% | +63,405 | New |
| Ikarian Capital, LLC | 62,691 | $436.3K | 0.12% | +210+0.3% | Added |
| LPL Financial LLC | 62,334 | $433.8K | 0.00% | +14,439+30.1% | Added |
| Royal Bank of Canada | 59,089 | $410.0K | 0.00% | +2,401+4.2% | Added |
| California State Teachers Retirement System | 58,498 | $407.1K | 0.00% | +140.0% | Added |
| Legal & General Group Plc | 58,437 | $406.7K | 0.00% | +762+1.3% | Added |
| Scotia Capital Inc. | 53,955 | $375.6K | 0.00% | +40.0% | Added |
| Kestra Private Wealth Services, LLC | 51,206 | $356.4K | 0.01% | −133−0.3% | Reduced |
| MetLife Investment Management | 49,662 | $345.6K | 0.00% | +7,113+16.7% | Added |
| JPMorgan Chase & Co | 48,158 | $335.2K | 0.00% | +11,163+30.2% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 45,690 | $318.0K | 0.00% | +6,182+15.6% | Added |
| Squarepoint Ops LLC | 41,968 | $292.1K | 0.00% | −38,153−47.6% | Reduced |
| Invesco Ltd. | 41,400 | $288.1K | 0.00% | +4,564+12.4% | Added |
| Corebridge Financial, Inc. | 40,064 | $278.8K | 0.00% | +1,569+4.1% | Added |
| Wells Fargo & Company | 39,974 | $278.2K | 0.00% | +15,269+61.8% | Added |
| Fore Capital, LLC | 37,539 | $261.3K | 0.32% | +7,539+25.1% | Added |
| XTX Topco Ltd | 36,139 | $251.5K | 0.02% | −23,083−39.0% | Reduced |
| Caxton Corp | 34,073 | $237.1K | 1.43% | 00.0% | Unchanged |
| Clough Capital Partners L P | 33,900 | $235.9K | 0.03% | +33,900 | New |
| Price T Rowe Associates Inc | 31,313 | $218.0K | 0.00% | +8,361+36.4% | Added |
| Intech Investment Management LLC | 29,562 | $205.8K | 0.00% | +6,089+25.9% | Added |
| Janus Henderson Group PLC | 28,000 | $194.6K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 27,198 | $189.3K | 0.00% | +4,972+22.4% | Added |
| Manufacturers Life Insurance Company, The | 27,108 | $188.7K | 0.00% | +503+1.9% | Added |
| ProShare Advisors LLC | 26,167 | $182.1K | 0.00% | +12,562+92.3% | Added |
| AQR Capital Management LLC | 25,137 | $175.0K | 0.00% | +2,364+10.4% | Added |
| ADAR1 Capital Management, LLC | 25,000 | $174.0K | 0.04% | +25,000 | New |
| FMR LLC | 24,909 | $173.4K | 0.00% | +12,767+105.1% | Added |
| Two Sigma Advisers, LP | 24,650 | $171.6K | 0.00% | +5,400+28.1% | Added |
| SG Americas Securities, LLC | 24,406 | $170.0K | 0.00% | +8,004+48.8% | Added |
| Voya Investment Management LLC | 23,666 | $164.7K | 0.00% | −637−2.6% | Reduced |
| Commonwealth Equity Services, LLC | 21,492 | $150.0K | 0.00% | +1,928+9.9% | Added |
| Federation des caisses Desjardins du Quebec | 21,422 | $149.1K | 0.00% | +1,500+7.5% | Added |
| Wolverine Trading, LLC | 21,406 | $143.4K | 0.00% | +4,055+23.4% | Added |
| Rathbone Brothers plc | 20,200 | $140.6K | 0.00% | 00.0% | Unchanged |
| Mitchell McLeod Pugh & Williams Inc | 20,000 | $139.2K | 0.03% | 00.0% | Unchanged |
| Teacher Retirement System of Texas | 18,205 | $127.0K | 0.00% | +2,915+19.1% | Added |
| Boothbay Fund Management, LLC | 17,984 | $125.2K | 0.00% | +210+1.2% | Added |
| Arizona State Retirement System | 17,640 | $122.8K | 0.00% | +70+0.4% | Added |
| New York State Common Retirement Fund | 17,100 | $119.0K | 0.00% | 00.0% | Unchanged |
| Sequoia Financial Advisors, LLC | 16,579 | $115.4K | 0.00% | +10.0% | Added |
| Jane Street Group, LLC | 16,557 | $115.2K | 0.00% | −14,164−46.1% | Reduced |
| Raymond James Financial Inc | 16,004 | $111.4K | 0.00% | +16,004 | New |
| Mercer Global Advisors Inc | 16,000 | $111.4K | 0.00% | −520−3.1% | Reduced |
| China Universal Asset Management Co., Ltd. | 15,549 | $108.2K | 0.01% | +15,549 | New |
| Diametric Capital, LP | 15,450 | $107.5K | 0.07% | +15,450 | New |
| Bailard, Inc. | 14,600 | $101.6K | 0.00% | −9,500−39.4% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 14,474 | $100.7K | 0.00% | +14,474 | New |
| Corton Capital Inc. | 14,416 | $100.3K | 0.06% | +14,416 | New |
| Wealth Enhancement Advisory Services, LLC | 13,550 | $94.3K | 0.00% | +3,350+32.8% | Added |
| Foundations Investment Advisors, LLC | 13,100 | $91.2K | 0.00% | +13,100 | New |
| SLT Holdings LLC | 13,100 | $91.2K | 0.09% | +13,100 | New |
| HighTower Advisors, LLC | 13,029 | $90.7K | 0.00% | +50+0.4% | Added |
| Ameriprise Financial Inc | 12,605 | $87.7K | 0.00% | +12,605 | New |
| Profund Advisors LLC | 12,293 | $85.6K | 0.00% | −8,550−41.0% | Reduced |
| Sanctuary Advisors, LLC | 11,002 | $78.4K | 0.00% | −5,000−31.2% | Reduced |
| Avantax Advisory Services, Inc. | 11,179 | $77.8K | 0.00% | +11,179 | New |
| Stoneridge Investment Partners LLC | 10,759 | $75.0K | 0.03% | −5,603−34.2% | Reduced |
| Bank of Montreal | 10,667 | $74.2K | 0.00% | +10,667 | New |
| BNP Paribas Arbitrage, SA | 10,631 | $74.0K | 0.00% | +10,631 | New |