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Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q4 2024

Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
174
+18 vs. Q3 2024
Shares held
41.5M
−7.96M (−16.1%) vs. Q3 2024
Total value
$288.9M
+$7.36M (+2.6%) vs. Q3 2024
New holders
37
60 more added
Sold out
19
33 more reduced

2 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2024: 174 institutions
Q1 2021: 8 institutionsQ2 2021: 156 institutionsQ3 2021: 175 institutionsQ4 2021: 176 institutionsQ1 2022: 159 institutionsQ2 2022: 156 institutionsQ3 2022: 101 institutionsQ4 2022: 104 institutionsQ1 2023: 89 institutionsQ2 2023: 84 institutionsQ3 2023: 93 institutionsQ4 2023: 104 institutionsQ1 2024: 135 institutionsQ2 2024: 152 institutionsQ3 2024: 158 institutionsQ4 2024: 174 institutionsQ1 2025: 191 institutionsQ2 2025: 183 institutionsQ3 2025: 196 institutionsQ4 2025: 209 institutionsQ1 2026: 248 institutionsQ2 2026: 362 institutions
Value heldQ4 2024: $288.9M
Q1 2021: $932.0KQ2 2021: $131.0MQ3 2021: $104.8MQ4 2021: $72.0MQ1 2022: $53.6MQ2 2022: $15.1MQ3 2022: $20.5MQ4 2022: $11.1MQ1 2023: $12.6MQ2 2023: $13.9MQ3 2023: $12.1MQ4 2023: $17.9MQ1 2024: $327.2MQ2 2024: $299.3MQ3 2024: $281.6MQ4 2024: $288.9MQ1 2025: $240.5MQ2 2025: $271.0MQ3 2025: $468.6MQ4 2025: $908.7MQ1 2026: $1.47BQ2 2026: $5.35B
Institutions holding DFTX and their total value by quarter
QuarterHoldersValue
Q2 2026362$5.35B
Q1 2026248$1.47B
Q4 2025209$908.7M
Q3 2025196$468.6M
Q2 2025183$271.0M
Q1 2025191$240.5M
Q4 2024174$288.9M
Q3 2024158$281.6M
Q2 2024152$299.3M
Q1 2024135$327.2M
Q4 2023104$17.9M
Q3 202393$12.1M
Q2 202384$13.9M
Q1 202389$12.6M
Q4 2022104$11.1M
Q3 2022101$20.5M
Q2 2022156$15.1M
Q1 2022159$53.6M
Q4 2021176$72.0M
Q3 2021175$104.8M
Q2 2021156$131.0M
Q1 20218$932.0K

Institutions, Q4 2024

Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2024.

Institutions holding DFTX in Q4 2024
InstitutionSharesValue% of portfolioChange in sharesAction
TSFG, LLC24$00.00%00.0%Unchanged
Huntington National Bank1$10.00%00.0%Unchanged
Coppell Advisory Solutions LLC1$70.00%00.0%Unchanged
Signaturefd, LLC2$140.00%00.0%Unchanged
Rothschild Investment LLC3$210.00%00.0%Unchanged
Hexagon Capital Partners LLC4$280.00%00.0%Unchanged
CoreCap Advisors, LLC5$350.00%−10−66.7%Reduced
NBT Bank N A6$420.00%00.0%Unchanged
Belmont Capital, LLC6$420.00%00.0%Unchanged
Strategic Investment Solutions, Inc.6$420.00%00.0%Unchanged
Glen Eagle Advisors, LLC6$420.00%00.0%Unchanged
CNB Bank10$700.00%00.0%Unchanged
MAI Capital Management10$700.00%+10New
Ameriflex Group, Inc.13$880.00%+13New
EverSource Wealth Advisors, LLC13$900.00%+13New
IFP Advisors, Inc0$1110.00%−1,000−100.0%Reduced
Parallel Advisors, LLC19$1320.00%−700−97.4%Reduced
Robbins Farley LLC28$1950.00%00.0%Unchanged
Chesapeake Asset Management LLC33$2290.00%00.0%Unchanged
TruNorth Capital Management, LLC33$2300.00%00.0%Unchanged
Plante Moran Financial Advisors, LLC36$2510.00%00.0%Unchanged
Anfield Capital Management, LLC36$2510.00%00.0%Unchanged
Louisbourg Investments Inc.52$3620.00%00.0%Unchanged
Tradewinds Capital Management, LLC53$3690.00%00.0%Unchanged
Fifth Third Bancorp59$4110.00%00.0%Unchanged
Activest Wealth Management66$4590.00%00.0%Unchanged
Kohmann Bosshard Financial Services, LLC66$4590.00%+66New
Allworth Financial LP69$4840.00%+3+4.5%Added
Sterling Capital Management LLC74$5150.00%00.0%Unchanged
Cornerstone Planning Group LLC77$5310.00%00.0%Unchanged
HighMark Wealth Management LLC100$6960.00%+22+28.2%Added
GAMMA Investing LLC106$7380.00%−77−42.1%Reduced
GWM Advisors LLC148$1.03K0.00%00.0%Unchanged
SBI Securities Co., Ltd.196$1.36K0.00%+196New
Nisa Investment Advisors, LLC204$1.42K0.00%+204New
Continuum Advisory, LLC239$1.66K0.00%00.0%Unchanged
SRS Capital Advisors, Inc.276$1.92K0.00%+248+885.7%Added
Daiwa Securities Group Inc.242$2.00K0.00%+242New
Harbour Investments, Inc.356$2.48K0.00%−100−21.9%Reduced
Tortoise Investment Management, LLC400$2.78K0.00%00.0%Unchanged
NVWM, LLC416$2.90K0.00%00.0%Unchanged
CIBC Private Wealth Group, LLC423$2.99K0.00%00.0%Unchanged
R Squared Ltd450$3.13K0.00%+450New
Northwestern Mutual Wealth Management Co468$3.26K0.00%+69+17.3%Added
Nelson, Van Denburg & Campbell Wealth Management Group, LLC533$3.71K0.00%+135+33.9%Added
Venturi Wealth Management, LLC721$5.02K0.00%00.0%Unchanged
Steward Partners Investment Advisory, LLC900$6.26K0.00%+400+80.0%Added
Farther Finance Advisors, LLC901$6.27K0.00%−20−2.2%Reduced
Spire Wealth Management1,040$7.24K0.00%+1,040New
Bullock Wealth Management Group1,194$8.31K0.00%00.0%Unchanged
CWM, LLC1,468$10.0K0.00%−37−2.5%Reduced
GF Fund Management Co. Ltd.1,540$10.7K0.00%+1,540New
National Bank of Canada1,547$10.8K0.00%+77+5.2%Added
Crewe Advisors LLC1,999$13.9K0.00%00.0%Unchanged
Tower Research Capital LLC (TRC)2,150$15.0K0.00%−1,895−46.8%Reduced
Russell Investments Group, Ltd.2,166$15.1K0.00%+1,354+166.7%Added
Mirae Asset Global Investments Co., Ltd.2,444$16.7K0.00%+2,444New
Amalgamated Bank2,491$17.0K0.00%00.0%Unchanged
EMC Capital Management2,575$18.0K0.01%+2,575New
TD Waterhouse Canada Inc.4,335$30.1K0.00%00.0%Unchanged
Diadema Partners LP4,710$32.8K0.04%+4,710New
Ameritas Investment Partners, Inc.7,053$49.1K0.00%00.0%Unchanged
Hollencrest Capital Management7,216$50.2K0.00%+7,150+10,833.3%Added
Militia Capital Partners, LP7,400$51.5K0.02%+7,400New
PEAK6 LLC8,095$56.3K0.00%+8,095New
North Star Investment Management Corp.9,401$65.4K0.00%00.0%Unchanged
Diversify Wealth Management, LLC10,000$69.3K0.01%00.0%Unchanged
King Wealth10,000$70.0K0.01%+10,000New
Virtus ETF Advisers LLC10,127$70.5K0.03%+10,127New
Sharpepoint LLC10,165$70.7K0.06%+10,165New
Simplex Trading, LLC10,228$71.0K0.00%+10,228New
Advisor Group Holdings, Inc.10,246$71.2K0.00%+2,270+28.5%Added
KLP Kapitalforvaltning AS10,400$72.4K0.00%+10,400New
SEI Investments Co10,415$72.5K0.00%00.0%Unchanged
BNP Paribas Arbitrage, SA10,631$74.0K0.00%+10,631New
Bank of Montreal10,667$74.2K0.00%+10,667New
Stoneridge Investment Partners LLC10,759$75.0K0.03%−5,603−34.2%Reduced
Avantax Advisory Services, Inc.11,179$77.8K0.00%+11,179New
Sanctuary Advisors, LLC11,002$78.4K0.00%−5,000−31.2%Reduced
Profund Advisors LLC12,293$85.6K0.00%−8,550−41.0%Reduced
Ameriprise Financial Inc12,605$87.7K0.00%+12,605New
HighTower Advisors, LLC13,029$90.7K0.00%+50+0.4%Added
Foundations Investment Advisors, LLC13,100$91.2K0.00%+13,100New
SLT Holdings LLC13,100$91.2K0.09%+13,100New
Wealth Enhancement Advisory Services, LLC13,550$94.3K0.00%+3,350+32.8%Added
Corton Capital Inc.14,416$100.3K0.06%+14,416New
Police & Firemen's Retirement System of New Jersey14,474$100.7K0.00%+14,474New
Bailard, Inc.14,600$101.6K0.00%−9,500−39.4%Reduced
Diametric Capital, LP15,450$107.5K0.07%+15,450New
China Universal Asset Management Co., Ltd.15,549$108.2K0.01%+15,549New
Mercer Global Advisors Inc16,000$111.4K0.00%−520−3.1%Reduced
Raymond James Financial Inc16,004$111.4K0.00%+16,004New
Jane Street Group, LLC16,557$115.2K0.00%−14,164−46.1%Reduced
Sequoia Financial Advisors, LLC16,579$115.4K0.00%+10.0%Added
New York State Common Retirement Fund17,100$119.0K0.00%00.0%Unchanged
Arizona State Retirement System17,640$122.8K0.00%+70+0.4%Added
Boothbay Fund Management, LLC17,984$125.2K0.00%+210+1.2%Added
Teacher Retirement System of Texas18,205$127.0K0.00%+2,915+19.1%Added
Mitchell McLeod Pugh & Williams Inc20,000$139.2K0.03%00.0%Unchanged
Rathbone Brothers plc20,200$140.6K0.00%00.0%Unchanged