Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q2 2026
Institutional positions in Definium Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 362
- +119 vs. Q1 2026
- Shares held
- 114.8M
- +40.3M (+54.1%) vs. Q1 2026
- Total value
- $5.35B
- +$3.94B (+280.1%) vs. Q1 2026
- New holders
- 148
- 117 more added
- Sold out
- 29
- 64 more reduced
5 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 11,232,834 | $528.4M | 0.01% | +2,752,604+32.5% | Added |
| Avoro Capital Advisors LLC | 7,188,888 | $338.2M | 3.04% | +2,188,888+43.8% | Added |
| Driehaus Capital Management LLC | 6,845,276 | $322.0M | 1.87% | +933,387+15.8% | Added |
| Jupiter Topco LLC | 5,615,645 | $264.0M | 0.11% | +5,615,645 | New |
| Capital World Investors | 5,367,723 | $252.5M | 0.03% | +5,367,723 | New |
| FMR LLC | 4,752,921 | $223.6M | 0.01% | +2,943,311+162.6% | Added |
| Price T Rowe Associates Inc | 4,652,032 | $218.8M | 0.02% | +4,582,031+6,545.7% | Added |
| Geode Capital Management, LLC | 3,644,813 | $171.5M | 0.01% | +1,149,414+46.1% | Added |
| State Street Corp | 3,065,390 | $144.2M | 0.00% | +593,517+24.0% | Added |
| Capital International Investors | 2,963,410 | $139.4M | 0.03% | +2,963,410 | New |
| Octagon Capital Advisors LP | 2,950,000 | $138.8M | 12.74% | +510,000+20.9% | Added |
| Wellington Management Group LLP | 2,949,734 | $138.8M | 0.02% | +1,644,985+126.1% | Added |
| Deep Track Capital, LP | 2,750,000 | $129.4M | 1.91% | −250,000−8.3% | Reduced |
| Commodore Capital LP | 2,000,000 | $94.1M | 5.60% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 1,800,852 | $84.7M | 0.01% | +125,441+7.5% | Added |
| Citadel Advisors LLC | 1,688,587 | $79.4M | 0.05% | +355,145+26.6% | Added |
| Vanguard Portfolio Management LLC | 1,648,426 | $77.5M | 0.00% | +775,761+88.9% | Added |
| Ra Capital Management, L.P. | 1,500,000 | $70.6M | 0.61% | +1,500,000 | New |
| Vanguard Capital Management LLC | 1,486,454 | $69.9M | 0.00% | +389,476+35.5% | Added |
| Siren, L.L.C. | 1,419,493 | $66.8M | 1.36% | +500,000+54.4% | Added |
| Marshall Wace, LLP | 1,298,946 | $61.1M | 0.05% | +98,121+8.2% | Added |
| Northern Trust Corp | 1,169,238 | $55.0M | 0.01% | +370,251+46.3% | Added |
| Ameriprise Financial Inc | 1,148,363 | $54.0M | 0.01% | +181,755+18.8% | Added |
| Nuveen, LLC | 1,105,314 | $52.0M | 0.01% | +407,184+58.3% | Added |
| Charles Schwab Investment Management Inc | 1,083,576 | $51.0M | 0.01% | +274,861+34.0% | Added |
| Woodline Partners LP | 1,003,641 | $47.2M | 0.15% | +250,849+33.3% | Added |
| Adage Capital Partners GP, L.L.C. | 1,000,000 | $47.0M | 0.07% | −150,000−13.0% | Reduced |
| Boxer Capital Management, LLC | 998,500 | $47.0M | 3.54% | +400,000+66.8% | Added |
| Two Sigma Investments, LP | 921,818 | $43.4M | 0.03% | −279,792−23.3% | Reduced |
| Balyasny Asset Management LLC | 897,658 | $42.2M | 0.08% | −376,563−29.6% | Reduced |
| Vanguard Fiduciary Trust Co | 827,693 | $38.9M | 0.01% | +251,756+43.7% | Added |
| Holocene Advisors, LP | 796,574 | $37.5M | 0.09% | −295,393−27.1% | Reduced |
| AWM Investment Company, Inc. | 784,800 | $36.9M | 3.20% | −292,093−27.1% | Reduced |
| Bank of New York Mellon Corp | 777,271 | $36.6M | 0.01% | +24,349+3.2% | Added |
| Polar Capital Holdings Plc | 777,253 | $36.6M | 0.10% | +777,253 | New |
| Alliancebernstein L.P. | 1,803,287 | $34.1M | 0.01% | +1,711,584+1,866.4% | Added |
| Eventide Asset Management, LLC | 710,000 | $33.4M | 0.45% | +23,838+3.5% | Added |
| Neuberger Berman Group LLC | 687,539 | $32.3M | 0.02% | +554,170+415.5% | Added |
| Qube Research & Technologies Ltd | 682,901 | $32.1M | 0.04% | +256,846+60.3% | Added |
| Candriam Luxembourg S.C.A. | 614,425 | $28.9M | 0.13% | −679,204−52.5% | Reduced |
| ArrowMark Colorado Holdings LLC | 564,069 | $26.5M | 1.10% | −1,030,648−64.6% | Reduced |
| Catalio Capital Management, LP | 562,672 | $26.5M | 4.97% | −475,312−45.8% | Reduced |
| Blackstone Group Inc. | 561,612 | $26.4M | 0.09% | +52,944+10.4% | Added |
| Integral Health Asset Management, LLC | 550,000 | $25.9M | 1.06% | +150,000+37.5% | Added |
| Bamco Inc | 520,108 | $24.5M | 0.04% | +520,108 | New |
| UBS Group AG | 499,467 | $23.5M | 0.00% | +5,490+1.1% | Added |
| Franklin Resources Inc | 486,219 | $22.9M | 0.00% | +486,219 | New |
| Point72 Asset Management, L.P. | 483,980 | $22.8M | 0.03% | +308,490+175.8% | Added |
| Ensign Peak Advisors, Inc | 466,106 | $21.9M | 0.04% | −80,677−14.8% | Reduced |
| Morgan Stanley | 454,912 | $21.4M | 0.00% | +16,339+3.7% | Added |
| Great Point Partners LLC | 425,000 | $20.0M | 4.71% | +425,000 | New |
| RTW Investments, LP | 400,000 | $18.8M | 0.16% | +100,000+33.3% | Added |
| Cormorant Asset Management, LP | 400,000 | $18.8M | 0.96% | +400,000 | New |
| Silverarc Capital Management, LLC | 400,000 | $18.8M | 2.09% | +400,000 | New |
| Assetmark, Inc | 396,542 | $18.7M | 0.03% | +396,542 | New |
| OrbiMed Advisors LLC | 365,400 | $17.2M | 0.33% | −438,600−54.6% | Reduced |
| Duquesne Family Office LLCSuperinvestorDuquesne Family Office | 356,600 | $16.8M | 0.39% | +356,600 | New |
| D. E. Shaw & Co., Inc. | 315,410 | $14.8M | 0.01% | +43,693+16.1% | Added |
| Polygon Management Ltd. | 286,990 | $13.5M | 2.20% | +86,996+43.5% | Added |
| Millennium Management LLC | 266,076 | $12.5M | 0.01% | −580,820−68.6% | Reduced |
| JPMorgan Chase & Co | 265,955 | $12.4M | 0.00% | +1,410+0.5% | Added |
| Sofinnova Investments, Inc. | 255,903 | $12.0M | 0.64% | −88,263−25.6% | Reduced |
| PFM Health Sciences, LP | 249,020 | $11.7M | 1.02% | +43,703+21.3% | Added |
| HighVista Strategies LLC | 242,884 | $11.4M | 2.60% | +57,028+30.7% | Added |
| Trexquant Investment LP | 233,199 | $11.0M | 0.07% | +233,199 | New |
| Seven Grand Managers, LLC | 225,000 | $10.6M | 0.43% | 00.0% | Unchanged |
| Swiss National Bank | 221,200 | $10.4M | 0.01% | +62,800+39.6% | Added |
| Eversept Partners, LP | 217,185 | $10.2M | 0.56% | +56,462+35.1% | Added |
| UBS Asset Management Americas Inc | 211,183 | $9.93M | 0.00% | +208,770+8,651.9% | Added |
| TD Asset Management Inc | 209,460 | $9.85M | 0.01% | +209,460 | New |
| Royce & Associates LP | 208,551 | $9.81M | 0.08% | −25,500−10.9% | Reduced |
| SEB Asset Management AB | 208,254 | $9.80M | 0.04% | +208,254 | New |
| Superstring Capital Management LP | 188,282 | $8.86M | 5.59% | −163,179−46.4% | Reduced |
| Emerald Advisers, LLC | 178,751 | $8.41M | 0.20% | +178,751 | New |
| Standard Life Aberdeen plc | 175,000 | $8.23M | 0.01% | +175,000 | New |
| Bank of America Corp | 164,575 | $7.74M | 0.00% | +6,230+3.9% | Added |
| Tri Locum Partners LP | 162,996 | $7.67M | 0.94% | −206,592−55.9% | Reduced |
| Rhumbline Advisers | 158,096 | $7.44M | 0.01% | +38,124+31.8% | Added |
| Brevan Howard Capital Management LP | 156,812 | $7.38M | 0.10% | −54,676−25.9% | Reduced |
| Russell Investments Group, Ltd. | 153,477 | $7.22M | 0.01% | +34,013+28.5% | Added |
| LMR Partners LLP | 150,200 | $7.07M | 0.05% | +150,200 | New |
| Seven Fleet Capital Management LP | 148,647 | $6.99M | 1.15% | +48,760+48.8% | Added |
| Manufacturers Life Insurance Company, The | 146,368 | $6.89M | 0.01% | +119,964+454.3% | Added |
| Rock Springs Capital Management LP | 143,187 | $6.74M | 0.33% | +143,187 | New |
| Deutsche Bank AG | 142,947 | $6.72M | 0.00% | −268,887−65.3% | Reduced |
| SummitTX Capital, L.P. | 142,489 | $6.70M | 0.18% | +142,489 | New |
| StemPoint Capital LP | 137,124 | $6.45M | 1.12% | −188,359−57.9% | Reduced |
| AQR Capital Management LLC | 134,152 | $6.31M | 0.00% | +77,058+135.0% | Added |
| California State Teachers Retirement System | 128,346 | $6.04M | 0.01% | +128,346 | New |
| BIT Capital GmbH | 128,131 | $6.03M | 0.21% | −149,380−53.8% | Reduced |
| Fred Alger Management, LLC | 125,256 | $5.89M | 0.02% | +33,091+35.9% | Added |
| Wells Fargo & Company | 122,033 | $5.74M | 0.00% | +82,060+205.3% | Added |
| Atika Capital Management LLC | 122,000 | $5.74M | 0.57% | +122,000 | New |
| AdvisorShares Investments LLC | 121,381 | $5.71M | 0.69% | +30,080+32.9% | Added |
| Emerald Mutual Fund Advisers Trust | 121,249 | $5.70M | 0.20% | +121,249 | New |
| EAM Investors, LLC | 120,928 | $5.69M | 0.51% | +120,928 | New |
| Schonfeld Strategic Advisors LLC | 119,610 | $5.63M | 0.03% | +109,198+1,048.8% | Added |
| HSBC Holdings PLC | 117,482 | $5.53M | 0.00% | +117,482 | New |
| Alps Advisors Inc | 110,388 | $5.19M | 0.02% | +110,388 | New |
| Data Collective IV GP, LLC | 100,350 | $4.72M | 6.01% | 00.0% | Unchanged |