Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Definium Therapeutics, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 196
- +15 vs. Q2 2025
- Shares held
- 39.7M
- −2.05M (−4.9%) vs. Q2 2025
- Total value
- $468.6M
- +$197.6M (+72.9%) vs. Q2 2025
- New holders
- 39
- 56 more added
- Sold out
- 24
- 48 more reduced
2 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 5,935,557 | $70.0M | 0.00% | +133,418+2.3% | Added |
| Commodore Capital LP | 3,225,000 | $38.0M | 1.86% | −1,775,000−35.5% | Reduced |
| Driehaus Capital Management LLC | 3,109,911 | $36.7M | 0.26% | +17,253+0.6% | Added |
| Blackstone Group Inc. | 2,776,561 | $32.7M | 0.14% | −810,918−22.6% | Reduced |
| Marshall Wace, LLP | 2,381,980 | $28.1M | 0.03% | −1,039,244−30.4% | Reduced |
| Octagon Capital Advisors LP | 2,130,000 | $25.1M | 3.92% | 00.0% | Unchanged |
| Vanguard Group Inc | 2,012,874 | $23.7M | 0.00% | +198,878+11.0% | Added |
| State Street Corp | 1,924,893 | $22.7M | 0.00% | +119,000+6.6% | Added |
| Geode Capital Management, LLC | 1,824,701 | $21.5M | 0.00% | +91,247+5.3% | Added |
| Deep Track Capital, LP | 1,500,000 | $17.7M | 0.49% | −1,000,000−40.0% | Reduced |
| AWM Investment Company, Inc. | 1,215,662 | $14.3M | 1.34% | 00.0% | Unchanged |
| Rosalind Advisors, Inc. | 750,000 | $8.84M | 3.21% | +330,000+78.6% | Added |
| Charles Schwab Investment Management Inc | 633,702 | $7.47M | 0.00% | +35,490+5.9% | Added |
| Northern Trust Corp | 628,538 | $7.41M | 0.00% | +29,296+4.9% | Added |
| Tang Capital Management LLC | 600,200 | $7.08M | 0.27% | 00.0% | Unchanged |
| UBS Group AG | 551,809 | $6.51M | 0.00% | +37,364+7.3% | Added |
| Goldman Sachs Group Inc | 550,630 | $6.49M | 0.00% | +447,783+435.4% | Added |
| Morgan Stanley | 495,618 | $5.84M | 0.00% | −192,913−28.0% | Reduced |
| OrbiMed Advisors LLC | 367,824 | $4.34M | 0.10% | +367,824 | New |
| Ally Bridge Group (NY) LLC | 361,444 | $4.26M | 3.57% | −364,728−50.2% | Reduced |
| Citadel Advisors LLC | 339,438 | $4.00M | 0.00% | +160,834+90.1% | Added |
| Adage Capital Partners GP, L.L.C. | 300,000 | $3.54M | 0.01% | +300,000 | New |
| Millennium Management LLC | 298,205 | $3.52M | 0.00% | +114,805+62.6% | Added |
| Two Sigma Investments, LP | 296,443 | $3.50M | 0.01% | +239,965+424.9% | Added |
| Jane Street Group, LLC | 274,848 | $3.24M | 0.00% | +146,533+114.2% | Added |
| Wellington Management Group LLP | 256,366 | $3.02M | 0.00% | −5,587−2.1% | Reduced |
| Nuveen, LLC | 233,504 | $2.75M | 0.00% | −6,338−2.6% | Reduced |
| Bank of New York Mellon Corp | 229,031 | $2.70M | 0.00% | −11,708−4.9% | Reduced |
| Point72 Asset Management, L.P. | 224,300 | $2.64M | 0.01% | +224,300 | New |
| D. E. Shaw & Co., Inc. | 216,334 | $2.55M | 0.00% | +157,570+268.1% | Added |
| Boxer Capital Management, LLC | 163,500 | $1.93M | 0.61% | +163,500 | New |
| CenterBook Partners LP | 159,421 | $1.88M | 0.09% | +159,421 | New |
| Barclays PLC | 150,605 | $1.78M | 0.00% | −24,628−14.1% | Reduced |
| AdvisorShares Investments LLC | 121,664 | $1.43M | 0.23% | +12,071+11.0% | Added |
| UBS Asset Management Americas Inc | 117,239 | $1.38M | 0.00% | +75,110+178.3% | Added |
| Swiss National Bank | 117,100 | $1.38M | 0.00% | +2,000+1.7% | Added |
| Rhumbline Advisers | 112,118 | $1.32M | 0.00% | −3,178−2.8% | Reduced |
| Cubist Systematic Strategies, LLC | 108,214 | $1.28M | 0.02% | +108,214 | New |
| Diadema Partners LP | 105,891 | $1.25M | 0.87% | −52,645−33.2% | Reduced |
| Data Collective IV GP, LLC | 100,350 | $1.18M | 1.74% | 00.0% | Unchanged |
| Bank of America Corp | 84,011 | $990.5K | 0.00% | −35,203−29.5% | Reduced |
| Two Sigma Advisers, LP | 81,483 | $960.7K | 0.00% | +81,483 | New |
| Royce & Associates LP | 81,024 | $955.3K | 0.01% | +81,024 | New |
| StemPoint Capital LP | 76,875 | $906.4K | 0.18% | −13,977−15.4% | Reduced |
| LPL Financial LLC | 75,947 | $895.4K | 0.00% | +7,458+10.9% | Added |
| PFM Health Sciences, LP | 75,138 | $885.9K | 0.08% | +75,138 | New |
| Alliancebernstein L.P. | 74,830 | $882.2K | 0.00% | 00.0% | Unchanged |
| Boothbay Fund Management, LLC | 67,984 | $801.5K | 0.02% | +50,000+278.0% | Added |
| Ikarian Capital, LLC | 62,691 | $739.1K | 0.17% | 00.0% | Unchanged |
| Wolverine Trading, LLC | 60,250 | $725.4K | 0.01% | +60,250 | New |
| HRT Financial LP | 57,565 | $678.0K | 0.00% | +57,565 | New |
| California State Teachers Retirement System | 57,291 | $675.5K | 0.00% | +30.0% | Added |
| Wells Fargo & Company | 56,495 | $666.1K | 0.00% | +8,778+18.4% | Added |
| Gsa Capital Partners LLP | 55,489 | $654.0K | 0.05% | +55,489 | New |
| Deutsche Bank AG | 55,160 | $650.3K | 0.00% | +7,171+14.9% | Added |
| Legal & General Group Plc | 55,019 | $648.7K | 0.00% | −1,684−3.0% | Reduced |
| Scotia Capital Inc. | 53,931 | $636.1K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 51,759 | $611.0K | 0.00% | −45,370−46.7% | Reduced |
| Fox Run Management, L.L.C. | 51,692 | $609.4K | 0.10% | +51,692 | New |
| Kestra Private Wealth Services, LLC | 50,140 | $591.2K | 0.01% | 00.0% | Unchanged |
| Cerity Partners LLC | 49,650 | $585.4K | 0.00% | 00.0% | Unchanged |
| MetLife Investment Management | 49,196 | $580.0K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 48,378 | $570.4K | 0.00% | +45,000+1,332.1% | Added |
| JPMorgan Chase & Co | 43,182 | $509.1K | 0.00% | −5,305−10.9% | Reduced |
| Price T Rowe Associates Inc | 41,205 | $486.0K | 0.00% | +4,874+13.4% | Added |
| Simplex Trading, LLC | 41,165 | $485.0K | 0.01% | −46,786−53.2% | Reduced |
| Invesco Ltd. | 40,129 | $473.1K | 0.00% | +1,666+4.3% | Added |
| Quantinno Capital Management LP | 35,742 | $421.4K | 0.00% | +18,588+108.4% | Added |
| Schonfeld Strategic Advisors LLC | 35,510 | $418.7K | 0.00% | +35,510 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 35,397 | $417.3K | 0.00% | −5,864−14.2% | Reduced |
| Fore Capital, LLC | 35,000 | $412.6K | 0.52% | 00.0% | Unchanged |
| Palumbo Wealth Management LLC | 32,929 | $388.2K | 0.12% | +8,886+37.0% | Added |
| Virtu Financial LLC | 32,184 | $379.0K | 0.02% | +32,184 | New |
| Blair William & Co | 31,905 | $376.2K | 0.00% | +9,687+43.6% | Added |
| DRW Securities, LLC | 30,727 | $360.9K | 0.02% | −38,699−55.7% | Reduced |
| Rathbone Brothers plc | 30,200 | $356.1K | 0.00% | +2,000+7.1% | Added |
| Janus Henderson Group PLC | 28,000 | $329.8K | 0.00% | 00.0% | Unchanged |
| Intech Investment Management LLC | 27,134 | $319.9K | 0.00% | −10,552−28.0% | Reduced |
| Caxton Corp | 27,011 | $318.5K | 1.39% | −7,062−20.7% | Reduced |
| Sender Co & Partners, Inc. | 25,906 | $305.4K | 0.12% | +25,906 | New |
| Manufacturers Life Insurance Company, The | 25,318 | $298.5K | 0.00% | −2,250−8.2% | Reduced |
| Persistent Asset Partners Ltd | 24,282 | $286.3K | 0.21% | −12,360−33.7% | Reduced |
| Scientech Research LLC | 24,239 | $285.8K | 0.10% | +24,239 | New |
| Moloney Securities Asset Management, LLC | 23,511 | $277.2K | 0.03% | −8,000−25.4% | Reduced |
| Citigroup Inc | 23,463 | $276.6K | 0.00% | −13,870−37.2% | Reduced |
| Federation des caisses Desjardins du Quebec | 21,992 | $259.3K | 0.00% | +570+2.7% | Added |
| Mercer Global Advisors Inc | 21,931 | $258.6K | 0.00% | +2,079+10.5% | Added |
| AQR Capital Management LLC | 21,596 | $254.6K | 0.00% | +1,838+9.3% | Added |
| Police & Firemen's Retirement System of New Jersey | 21,033 | $248.0K | 0.00% | +2,479+13.4% | Added |
| Profund Advisors LLC | 18,666 | $220.1K | 0.01% | +4,959+36.2% | Added |
| Mariner, LLC | 18,084 | $213.2K | 0.00% | +6,041+50.2% | Added |
| Arizona State Retirement System | 17,867 | $210.7K | 0.00% | +286+1.6% | Added |
| Raymond James Financial Inc | 17,792 | $209.8K | 0.00% | +763+4.5% | Added |
| Susquehanna International Group, LLP | 17,273 | $203.6K | 0.00% | −152,052−89.8% | Reduced |
| Sequoia Financial Advisors, LLC | 17,132 | $202.0K | 0.00% | +553+3.3% | Added |
| New York State Common Retirement Fund | 17,100 | $201.6K | 0.00% | 00.0% | Unchanged |
| Gotham Asset Management, LLC | 17,002 | $200.5K | 0.00% | +2,924+20.8% | Added |
| Omers Administration Corp | 16,600 | $195.7K | 0.00% | +16,600 | New |
| Cetera Investment Advisers | 16,242 | $191.5K | 0.00% | +16,242 | New |
| ProShare Advisors LLC | 15,592 | $183.8K | 0.00% | −2,676−14.6% | Reduced |