Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 209
- +20 vs. Q3 2025
- Shares held
- 67.9M
- +28.3M (+71.7%) vs. Q3 2025
- Total value
- $908.7M
- +$442.6M (+95.0%) vs. Q3 2025
- New holders
- 50
- 92 more added
- Sold out
- 30
- 31 more reduced
7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 8,273,276 | $110.8M | 0.00% | +2,337,719+39.4% | Added |
| Driehaus Capital Management LLC | 6,537,202 | $87.5M | 0.59% | +3,427,291+110.2% | Added |
| Avoro Capital Advisors LLC | 5,000,000 | $67.0M | 0.66% | +5,000,000 | New |
| Marshall Wace, LLP | 2,975,702 | $39.8M | 0.04% | +593,722+24.9% | Added |
| Vanguard Group Inc | 2,591,901 | $34.7M | 0.00% | +579,027+28.8% | Added |
| Trails Edge Capital Partners, LP | 2,568,110 | $34.4M | 8.50% | +2,568,110 | New |
| Janus Henderson Group PLC | 2,411,696 | $32.3M | 0.01% | +2,383,696+8,513.2% | Added |
| State Street Corp | 2,368,066 | $31.7M | 0.00% | +443,173+23.0% | Added |
| Geode Capital Management, LLC | 2,332,938 | $31.2M | 0.00% | +508,237+27.9% | Added |
| Octagon Capital Advisors LP | 2,230,000 | $29.9M | 3.74% | +100,000+4.7% | Added |
| Blackstone Group Inc. | 2,059,805 | $27.6M | 0.12% | −716,756−25.8% | Reduced |
| Commodore Capital LP | 2,000,000 | $26.8M | 1.78% | −1,225,000−38.0% | Reduced |
| Deep Track Capital, LP | 1,676,540 | $22.4M | 0.51% | +176,540+11.8% | Added |
| AWM Investment Company, Inc. | 1,390,662 | $18.6M | 1.80% | +175,000+14.4% | Added |
| Millennium Management LLC | 1,383,175 | $18.5M | 0.01% | +1,084,970+363.8% | Added |
| Balyasny Asset Management LLC | 1,308,115 | $17.5M | 0.03% | +1,308,115 | New |
| OrbiMed Advisors LLC | 1,226,700 | $16.4M | 0.34% | +858,876+233.5% | Added |
| Wellington Management Group LLP | 1,220,667 | $16.3M | 0.00% | +964,301+376.1% | Added |
| Adage Capital Partners GP, L.L.C. | 1,150,000 | $15.4M | 0.02% | +850,000+283.3% | Added |
| Candriam Luxembourg S.C.A. | 971,218 | $13.0M | 0.06% | +971,218 | New |
| Goldman Sachs Group Inc | 925,332 | $12.4M | 0.00% | +374,702+68.0% | Added |
| Charles Schwab Investment Management Inc | 807,249 | $10.8M | 0.00% | +173,547+27.4% | Added |
| Siren, L.L.C. | 800,000 | $10.7M | 0.32% | +800,000 | New |
| Rosalind Advisors, Inc. | 750,000 | $10.0M | 3.85% | 00.0% | Unchanged |
| Northern Trust Corp | 734,660 | $9.84M | 0.00% | +106,122+16.9% | Added |
| UBS Group AG | 683,802 | $9.16M | 0.00% | +131,993+23.9% | Added |
| Vestal Point Capital, LP | 637,000 | $8.53M | 0.31% | +637,000 | New |
| Boxer Capital Management, LLC | 598,500 | $8.01M | 1.75% | +435,000+266.1% | Added |
| Jane Street Group, LLC | 536,002 | $7.18M | 0.01% | +261,154+95.0% | Added |
| Ameriprise Financial Inc | 504,241 | $6.75M | 0.00% | +504,241 | New |
| Susquehanna International Group, LLP | 477,112 | $6.39M | 0.01% | +459,839+2,662.2% | Added |
| Two Sigma Investments, LP | 425,207 | $5.69M | 0.01% | +128,764+43.4% | Added |
| Superstring Capital Management LP | 425,202 | $5.69M | 3.05% | +425,202 | New |
| Deutsche Bank AG | 398,269 | $5.33M | 0.00% | +343,109+622.0% | Added |
| Morgan Stanley | 366,695 | $4.91M | 0.00% | −128,923−26.0% | Reduced |
| Integral Health Asset Management, LLC | 350,000 | $4.69M | 0.24% | +350,000 | New |
| RTW Investments, LP | 300,000 | $4.02M | 0.04% | +300,000 | New |
| Bank of New York Mellon Corp | 298,660 | $4.00M | 0.00% | +69,629+30.4% | Added |
| D. E. Shaw & Co., Inc. | 293,722 | $3.93M | 0.00% | +77,388+35.8% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 278,720 | $3.73M | 0.01% | +278,720 | New |
| Nuveen, LLC | 276,454 | $3.70M | 0.00% | +42,950+18.4% | Added |
| Ensign Peak Advisors, Inc | 262,000 | $3.51M | 0.01% | +262,000 | New |
| Seven Grand Managers, LLC | 225,000 | $3.01M | 0.23% | +225,000 | New |
| Citadel Advisors LLC | 209,944 | $2.81M | 0.00% | −129,494−38.1% | Reduced |
| Barclays PLC | 183,623 | $2.46M | 0.00% | +33,018+21.9% | Added |
| Point72 Asset Management, L.P. | 180,441 | $2.42M | 0.00% | −43,859−19.6% | Reduced |
| Royce & Associates LP | 164,041 | $2.20M | 0.02% | +83,017+102.5% | Added |
| FMR LLC | 162,053 | $2.17M | 0.00% | +146,495+941.6% | Added |
| Swiss National Bank | 158,400 | $2.12M | 0.00% | +41,300+35.3% | Added |
| JPMorgan Chase & Co | 153,722 | $2.06M | 0.00% | +110,540+256.0% | Added |
| Woodline Partners LP | 150,570 | $2.02M | 0.01% | +150,570 | New |
| Soviero Asset Management, LP | 150,000 | $2.01M | 1.05% | +150,000 | New |
| CenterBook Partners LP | 138,815 | $1.86M | 0.09% | −20,606−12.9% | Reduced |
| Verition Fund Management LLC | 132,263 | $1.77M | 0.01% | +132,263 | New |
| Rhumbline Advisers | 110,747 | $1.48M | 0.00% | −1,371−1.2% | Reduced |
| Bank of America Corp | 110,467 | $1.48M | 0.00% | +26,456+31.5% | Added |
| Wells Fargo & Company | 107,057 | $1.43M | 0.00% | +50,562+89.5% | Added |
| AdvisorShares Investments LLC | 102,838 | $1.38M | 0.23% | −18,826−15.5% | Reduced |
| Data Collective IV GP, LLC | 100,350 | $1.34M | 2.30% | 00.0% | Unchanged |
| Burkehill Global Management, LP | 100,000 | $1.34M | 0.09% | +100,000 | New |
| Royal Bank of Canada | 93,626 | $1.25M | 0.00% | +41,867+80.9% | Added |
| LPL Financial LLC | 77,236 | $1.03M | 0.00% | +1,289+1.7% | Added |
| Alliancebernstein L.P. | 74,837 | $1.00M | 0.00% | +70.0% | Added |
| Platinum Investment Management Ltd | 70,000 | $937.3K | 0.22% | +70,000 | New |
| Legal & General Group Plc | 66,975 | $896.8K | 0.00% | +11,956+21.7% | Added |
| Two Sigma Advisers, LP | 65,281 | $874.1K | 0.00% | −16,202−19.9% | Reduced |
| Ikarian Capital, LLC | 58,803 | $787.4K | 0.10% | −3,888−6.2% | Reduced |
| State of Wisconsin Investment Board | 58,602 | $784.7K | 0.00% | +58,602 | New |
| California State Teachers Retirement System | 58,383 | $781.7K | 0.00% | +1,092+1.9% | Added |
| AQR Capital Management LLC | 58,298 | $780.6K | 0.00% | +36,702+169.9% | Added |
| Jennison Associates LLC | 53,785 | $720.2K | 0.00% | +53,785 | New |
| Invesco Ltd. | 53,382 | $714.8K | 0.00% | +13,253+33.0% | Added |
| MetLife Investment Management | 52,580 | $704.0K | 0.00% | +3,384+6.9% | Added |
| Gsa Capital Partners LLP | 52,255 | $700.0K | 0.06% | −3,234−5.8% | Reduced |
| Price T Rowe Associates Inc | 52,230 | $700.0K | 0.00% | +11,025+26.8% | Added |
| Kestra Private Wealth Services, LLC | 50,140 | $671.4K | 0.01% | 00.0% | Unchanged |
| Scotia Capital Inc. | 49,677 | $663.7K | 0.00% | −4,254−7.9% | Reduced |
| Nisa Investment Advisors, LLC | 48,378 | $647.8K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 48,226 | $645.7K | 0.02% | +7,061+17.2% | Added |
| Squarepoint Ops LLC | 45,402 | $607.9K | 0.00% | +45,402 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 43,736 | $585.6K | 0.00% | +8,339+23.6% | Added |
| Citigroup Inc | 41,463 | $555.2K | 0.00% | +18,000+76.7% | Added |
| Quantinno Capital Management LP | 39,324 | $526.5K | 0.00% | +3,582+10.0% | Added |
| Palumbo Wealth Management LLC | 39,002 | $522.2K | 0.13% | +6,073+18.4% | Added |
| PSP Research LLC | 34,841 | $466.5K | 0.41% | +34,841 | New |
| Scientech Research LLC | 31,699 | $424.4K | 0.27% | +7,460+30.8% | Added |
| Fox Run Management, L.L.C. | 30,708 | $411.2K | 0.06% | −20,984−40.6% | Reduced |
| Dark Forest Capital Management LP | 30,661 | $410.6K | 0.02% | +30,661 | New |
| Schonfeld Strategic Advisors LLC | 30,456 | $407.8K | 0.00% | −5,054−14.2% | Reduced |
| Rathbone Brothers plc | 30,200 | $404.4K | 0.00% | 00.0% | Unchanged |
| Intech Investment Management LLC | 29,655 | $397.1K | 0.00% | +2,521+9.3% | Added |
| New York State Common Retirement Fund | 29,600 | $396.3K | 0.00% | +12,500+73.1% | Added |
| Manufacturers Life Insurance Company, The | 28,322 | $379.2K | 0.00% | +3,004+11.9% | Added |
| HRT Financial LP | 26,282 | $351.0K | 0.00% | −31,283−54.3% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 25,207 | $337.5K | 0.00% | +4,174+19.8% | Added |
| Dynamic Technology Lab Private Ltd | 22,964 | $308.0K | 0.07% | +12,612+121.8% | Added |
| BNP Paribas Arbitrage, SA | 22,383 | $299.7K | 0.00% | +7,063+46.1% | Added |
| Arizona State Retirement System | 22,242 | $297.8K | 0.00% | +4,375+24.5% | Added |
| Profund Advisors LLC | 21,989 | $294.4K | 0.01% | +3,323+17.8% | Added |
| ProShare Advisors LLC | 21,539 | $288.4K | 0.00% | +5,947+38.1% | Added |