Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 209
- +20 vs. Q3 2025
- Shares held
- 67.9M
- +28.3M (+71.7%) vs. Q3 2025
- Total value
- $908.7M
- +$442.6M (+95.0%) vs. Q3 2025
- New holders
- 50
- 92 more added
- Sold out
- 30
- 31 more reduced
7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Virtus Investment Advisers, Inc. | 21,198 | $283.8K | 0.08% | +5,611+36.0% | Added |
| Raymond James Financial Inc | 21,121 | $282.8K | 0.00% | +3,329+18.7% | Added |
| Concurrent Investment Advisors, LLC | 20,397 | $273.1K | 0.00% | +20,397 | New |
| Mercer Global Advisors Inc | 20,392 | $273.0K | 0.00% | −1,539−7.0% | Reduced |
| EntryPoint Capital, LLC | 20,219 | $270.7K | 0.11% | +20,219 | New |
| Mariner, LLC | 20,166 | $270.7K | 0.00% | +2,082+11.5% | Added |
| Marex Group plc | 20,000 | $267.8K | 0.00% | +20,000 | New |
| ExodusPoint Capital Management, LP | 18,948 | $253.7K | 0.00% | +18,948 | New |
| Rafferty Asset Management, LLC | 18,885 | $252.9K | 0.00% | +6,210+49.0% | Added |
| Gotham Asset Management, LLC | 17,825 | $238.7K | 0.00% | +823+4.8% | Added |
| Sequoia Financial Advisors, LLC | 17,173 | $229.9K | 0.00% | +41+0.2% | Added |
| KLP Kapitalforvaltning AS | 17,000 | $227.6K | 0.00% | +6,600+63.5% | Added |
| Cetera Investment Advisers | 16,600 | $222.3K | 0.00% | +358+2.2% | Added |
| China Universal Asset Management Co., Ltd. | 16,052 | $214.9K | 0.02% | +2,715+20.4% | Added |
| Bay Rivers Group | 16,001 | $214.3K | 0.09% | +2,000+14.3% | Added |
| Voya Investment Management LLC | 15,992 | $214.1K | 0.00% | +1,710+12.0% | Added |
| Caxton Associates LLP | 15,691 | $210.1K | 0.00% | +5,046+47.4% | Added |
| Caxton Corp | 15,688 | $210.1K | 4.91% | −11,323−41.9% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,117 | $202.4K | 0.00% | 00.0% | Unchanged |
| Fore Capital, LLC | 15,000 | $200.8K | 0.27% | −20,000−57.1% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 13,718 | $185.3K | 0.00% | +366+2.7% | Added |
| Commonwealth Equity Services, LLC | 13,611 | $182.3K | 0.00% | −939−6.5% | Reduced |
| Money Concepts Capital Corp | 13,000 | $174.1K | 0.01% | 00.0% | Unchanged |
| SEI Investments Co | 11,836 | $158.5K | 0.00% | +1,421+13.6% | Added |
| Bank of Montreal | 11,802 | $158.0K | 0.00% | +405+3.6% | Added |
| Teacher Retirement System of Texas | 11,797 | $158.0K | 0.00% | −2,897−19.7% | Reduced |
| Brevan Howard Capital Management LP | 11,114 | $148.8K | 0.00% | +11,114 | New |
| Diversify Wealth Management, LLC | 10,000 | $148.7K | 0.01% | 00.0% | Unchanged |
| Twelve Points Wealth Management LLC | 10,645 | $147.3K | 0.03% | +10,645 | New |
| XTX Topco Ltd | 10,994 | $147.2K | 0.00% | +10,994 | New |
| Sanctuary Advisors, LLC | 10,717 | $143.5K | 0.00% | −948−8.1% | Reduced |
| Federation des caisses Desjardins du Quebec | 10,604 | $142.0K | 0.00% | −11,388−51.8% | Reduced |
| Advisor Group Holdings, Inc. | 10,527 | $140.9K | 0.00% | −1,075−9.3% | Reduced |
| Sharpepoint LLC | 10,135 | $135.7K | 0.08% | +10,135 | New |
| King Wealth | 10,000 | $134.0K | 0.02% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 8,865 | $118.7K | 0.00% | −4,838−35.3% | Reduced |
| Flagship Harbor Advisors, LLC | 8,721 | $116.8K | 0.01% | +8,721 | New |
| Ameritas Investment Partners, Inc. | 7,641 | $102.3K | 0.00% | +588+8.3% | Added |
| Hollencrest Capital Management | 7,516 | $100.6K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 7,088 | $94.9K | 0.00% | +7,059+24,341.4% | Added |
| North Star Investment Management Corp. | 6,701 | $89.7K | 0.01% | 00.0% | Unchanged |
| CWM, LLC | 5,352 | $72.0K | 0.00% | +820+18.1% | Added |
| Tower Research Capital LLC (TRC) | 4,334 | $58.0K | 0.00% | +1,884+76.9% | Added |
| Walleye Trading LLC | 4,256 | $57.0K | 0.00% | +3,694+657.3% | Added |
| Sound Income Strategies, LLC | 3,690 | $55.5K | 0.00% | +9+0.2% | Added |
| Sterling Capital Management LLC | 3,915 | $52.4K | 0.00% | +284+7.8% | Added |
| Fifth Third Bancorp | 3,300 | $44.2K | 0.00% | −59−1.8% | Reduced |
| Amalgamated Bank | 2,957 | $40.0K | 0.00% | +176+6.3% | Added |
| Crewe Advisors LLC | 1,999 | $26.8K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,935 | $25.9K | 0.00% | +298+18.2% | Added |
| National Bank of Canada | 1,867 | $25.0K | 0.00% | +276+17.3% | Added |
| Quantbot Technologies LP | 1,649 | $22.1K | 0.00% | +1,649 | New |
| TD Waterhouse Canada Inc. | 1,532 | $20.5K | 0.00% | −4,062−72.6% | Reduced |
| High Note Wealth, LLC | 1,500 | $20.1K | 0.00% | +1,500 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,379 | $18.0K | 0.00% | +587+74.1% | Added |
| Bullock Wealth Management Group | 1,194 | $16.0K | 0.01% | 00.0% | Unchanged |
| GAMMA Investing LLC | 1,030 | $13.8K | 0.00% | +111+12.1% | Added |
| Stone House Investment Management, LLC | 1,000 | $13.4K | 0.00% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 1,000 | $13.4K | 0.00% | 00.0% | Unchanged |
| UBS Asset Management Americas Inc | 894 | $12.0K | 0.00% | −116,345−99.2% | Reduced |
| First Horizon Corp | 843 | $11.3K | 0.00% | +843 | New |
| Massmutual Trust Co FSB | 568 | $7.61K | 0.00% | +136+31.5% | Added |
| Global Retirement Partners, LLC | 566 | $7.58K | 0.00% | +66+13.2% | Added |
| Larson Financial Group LLC | 535 | $7.16K | 0.00% | +535 | New |
| Sankala Group LLC | 391 | $6.82K | 0.01% | +391 | New |
| Atlantic Union Bankshares Corp | 500 | $6.70K | 0.00% | +500 | New |
| SRS Capital Advisors, Inc. | 479 | $6.41K | 0.00% | +479 | New |
| Farther Finance Advisors, LLC | 457 | $6.12K | 0.00% | 00.0% | Unchanged |
| NVWM, LLC | 416 | $5.57K | 0.00% | 00.0% | Unchanged |
| Rockefeller Capital Management L.P. | 351 | $4.70K | 0.00% | 00.0% | Unchanged |
| Rothschild Investment LLC | 287 | $3.84K | 0.00% | +14+5.1% | Added |
| EverSource Wealth Advisors, LLC | 254 | $3.40K | 0.00% | +150+144.2% | Added |
| Parallel Advisors, LLC | 232 | $3.12K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 242 | $3.00K | 0.00% | 00.0% | Unchanged |
| Atlantic Edge Private Wealth Management, LLC | 193 | $2.58K | 0.00% | 00.0% | Unchanged |
| Northwestern Mutual Wealth Management Co | 185 | $2.48K | 0.00% | +19+11.4% | Added |
| Strategic Wealth Partners, Ltd. | 166 | $2.22K | 0.00% | +166 | New |
| CIBC Private Wealth Group, LLC | 151 | $2.02K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 148 | $1.98K | 0.00% | +63+74.1% | Added |
| GWM Advisors LLC | 140 | $1.87K | 0.00% | −2−1.4% | Reduced |
| Optiver Holding B.V. | 123 | $1.65K | 0.00% | −95−43.6% | Reduced |
| NBC Securities, Inc. | 100 | $1.34K | 0.00% | 00.0% | Unchanged |
| HighMark Wealth Management LLC | 100 | $1.34K | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 91 | $1.22K | 0.00% | −14−13.3% | Reduced |
| Reflection Asset Management | 66 | $898 | 0.00% | +66 | New |
| Federated Hermes, Inc. | 67 | $897 | 0.00% | +67 | New |
| Activest Wealth Management | 66 | $884 | 0.00% | 00.0% | Unchanged |
| MH & Associates Securities Management Corp | 66 | $884 | 0.00% | +66 | New |
| Kohmann Bosshard Financial Services, LLC | 66 | $884 | 0.00% | +66 | New |
| MAI Capital Management | 59 | $791 | 0.00% | +49+490.0% | Added |
| Tradewinds Capital Management, LLC | 53 | $710 | 0.00% | 00.0% | Unchanged |
| Sunbelt Securities, Inc. | 44 | $589 | 0.00% | 00.0% | Unchanged |
| Plante Moran Financial Advisors, LLC | 36 | $482 | 0.00% | 00.0% | Unchanged |
| Sofos Investments, Inc. | 35 | $469 | 0.00% | −13−27.1% | Reduced |
| Chesapeake Asset Management LLC | 33 | $441 | 0.00% | 00.0% | Unchanged |
| Robbins Farley LLC | 28 | $375 | 0.00% | 00.0% | Unchanged |
| Pinnacle Wealth Planning Services, Inc. | 25 | $335 | 0.00% | +25 | New |
| Rachor Investment Advisory Services, LLC | 25 | $335 | 0.00% | +25 | New |
| Essential Partners LLC | 21 | $281 | 0.00% | +17+425.0% | Added |
| Caitong International Asset Management Co., Ltd | 15 | $201 | 0.00% | +15 | New |