Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 209
- +20 vs. Q3 2025
- Shares held
- 67.9M
- +28.3M (+71.7%) vs. Q3 2025
- Total value
- $908.7M
- +$442.6M (+95.0%) vs. Q3 2025
- New holders
- 50
- 92 more added
- Sold out
- 30
- 31 more reduced
7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| TSFG, LLC | 6 | $0 | 0.00% | 00.0% | Unchanged |
| Huntington National Bank | 1 | $1 | 0.00% | 00.0% | Unchanged |
| Signaturefd, LLC | 2 | $27 | 0.00% | 00.0% | Unchanged |
| Navalign, LLC | 2 | $27 | 0.00% | +2 | New |
| CoreCap Advisors, LLC | 5 | $67 | 0.00% | 00.0% | Unchanged |
| NBT Bank N A | 6 | $80 | 0.00% | 00.0% | Unchanged |
| SageView Advisory Group, LLC | 6 | $81 | 0.00% | +6 | New |
| Keating Financial Advisory Services, Inc. | 7 | $94 | 0.00% | +7 | New |
| CNB Bank | 10 | $134 | 0.00% | 00.0% | Unchanged |
| Caitong International Asset Management Co., Ltd | 15 | $201 | 0.00% | +15 | New |
| Essential Partners LLC | 21 | $281 | 0.00% | +17+425.0% | Added |
| Pinnacle Wealth Planning Services, Inc. | 25 | $335 | 0.00% | +25 | New |
| Rachor Investment Advisory Services, LLC | 25 | $335 | 0.00% | +25 | New |
| Robbins Farley LLC | 28 | $375 | 0.00% | 00.0% | Unchanged |
| Chesapeake Asset Management LLC | 33 | $441 | 0.00% | 00.0% | Unchanged |
| Sofos Investments, Inc. | 35 | $469 | 0.00% | −13−27.1% | Reduced |
| Plante Moran Financial Advisors, LLC | 36 | $482 | 0.00% | 00.0% | Unchanged |
| Sunbelt Securities, Inc. | 44 | $589 | 0.00% | 00.0% | Unchanged |
| Tradewinds Capital Management, LLC | 53 | $710 | 0.00% | 00.0% | Unchanged |
| MAI Capital Management | 59 | $791 | 0.00% | +49+490.0% | Added |
| Activest Wealth Management | 66 | $884 | 0.00% | 00.0% | Unchanged |
| MH & Associates Securities Management Corp | 66 | $884 | 0.00% | +66 | New |
| Kohmann Bosshard Financial Services, LLC | 66 | $884 | 0.00% | +66 | New |
| Federated Hermes, Inc. | 67 | $897 | 0.00% | +67 | New |
| Reflection Asset Management | 66 | $898 | 0.00% | +66 | New |
| SBI Securities Co., Ltd. | 91 | $1.22K | 0.00% | −14−13.3% | Reduced |
| NBC Securities, Inc. | 100 | $1.34K | 0.00% | 00.0% | Unchanged |
| HighMark Wealth Management LLC | 100 | $1.34K | 0.00% | 00.0% | Unchanged |
| Optiver Holding B.V. | 123 | $1.65K | 0.00% | −95−43.6% | Reduced |
| GWM Advisors LLC | 140 | $1.87K | 0.00% | −2−1.4% | Reduced |
| Allworth Financial LP | 148 | $1.98K | 0.00% | +63+74.1% | Added |
| CIBC Private Wealth Group, LLC | 151 | $2.02K | 0.00% | 00.0% | Unchanged |
| Strategic Wealth Partners, Ltd. | 166 | $2.22K | 0.00% | +166 | New |
| Northwestern Mutual Wealth Management Co | 185 | $2.48K | 0.00% | +19+11.4% | Added |
| Atlantic Edge Private Wealth Management, LLC | 193 | $2.58K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 242 | $3.00K | 0.00% | 00.0% | Unchanged |
| Parallel Advisors, LLC | 232 | $3.12K | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 254 | $3.40K | 0.00% | +150+144.2% | Added |
| Rothschild Investment LLC | 287 | $3.84K | 0.00% | +14+5.1% | Added |
| Rockefeller Capital Management L.P. | 351 | $4.70K | 0.00% | 00.0% | Unchanged |
| NVWM, LLC | 416 | $5.57K | 0.00% | 00.0% | Unchanged |
| Farther Finance Advisors, LLC | 457 | $6.12K | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 479 | $6.41K | 0.00% | +479 | New |
| Atlantic Union Bankshares Corp | 500 | $6.70K | 0.00% | +500 | New |
| Sankala Group LLC | 391 | $6.82K | 0.01% | +391 | New |
| Larson Financial Group LLC | 535 | $7.16K | 0.00% | +535 | New |
| Global Retirement Partners, LLC | 566 | $7.58K | 0.00% | +66+13.2% | Added |
| Massmutual Trust Co FSB | 568 | $7.61K | 0.00% | +136+31.5% | Added |
| First Horizon Corp | 843 | $11.3K | 0.00% | +843 | New |
| UBS Asset Management Americas Inc | 894 | $12.0K | 0.00% | −116,345−99.2% | Reduced |
| Stone House Investment Management, LLC | 1,000 | $13.4K | 0.00% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 1,000 | $13.4K | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 1,030 | $13.8K | 0.00% | +111+12.1% | Added |
| Bullock Wealth Management Group | 1,194 | $16.0K | 0.01% | 00.0% | Unchanged |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,379 | $18.0K | 0.00% | +587+74.1% | Added |
| High Note Wealth, LLC | 1,500 | $20.1K | 0.00% | +1,500 | New |
| TD Waterhouse Canada Inc. | 1,532 | $20.5K | 0.00% | −4,062−72.6% | Reduced |
| Quantbot Technologies LP | 1,649 | $22.1K | 0.00% | +1,649 | New |
| National Bank of Canada | 1,867 | $25.0K | 0.00% | +276+17.3% | Added |
| GF Fund Management Co. Ltd. | 1,935 | $25.9K | 0.00% | +298+18.2% | Added |
| Crewe Advisors LLC | 1,999 | $26.8K | 0.00% | 00.0% | Unchanged |
| Amalgamated Bank | 2,957 | $40.0K | 0.00% | +176+6.3% | Added |
| Fifth Third Bancorp | 3,300 | $44.2K | 0.00% | −59−1.8% | Reduced |
| Sterling Capital Management LLC | 3,915 | $52.4K | 0.00% | +284+7.8% | Added |
| Sound Income Strategies, LLC | 3,690 | $55.5K | 0.00% | +9+0.2% | Added |
| Walleye Trading LLC | 4,256 | $57.0K | 0.00% | +3,694+657.3% | Added |
| Tower Research Capital LLC (TRC) | 4,334 | $58.0K | 0.00% | +1,884+76.9% | Added |
| CWM, LLC | 5,352 | $72.0K | 0.00% | +820+18.1% | Added |
| North Star Investment Management Corp. | 6,701 | $89.7K | 0.01% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 7,088 | $94.9K | 0.00% | +7,059+24,341.4% | Added |
| Hollencrest Capital Management | 7,516 | $100.6K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 7,641 | $102.3K | 0.00% | +588+8.3% | Added |
| Flagship Harbor Advisors, LLC | 8,721 | $116.8K | 0.01% | +8,721 | New |
| Russell Investments Group, Ltd. | 8,865 | $118.7K | 0.00% | −4,838−35.3% | Reduced |
| King Wealth | 10,000 | $134.0K | 0.02% | 00.0% | Unchanged |
| Sharpepoint LLC | 10,135 | $135.7K | 0.08% | +10,135 | New |
| Advisor Group Holdings, Inc. | 10,527 | $140.9K | 0.00% | −1,075−9.3% | Reduced |
| Federation des caisses Desjardins du Quebec | 10,604 | $142.0K | 0.00% | −11,388−51.8% | Reduced |
| Sanctuary Advisors, LLC | 10,717 | $143.5K | 0.00% | −948−8.1% | Reduced |
| XTX Topco Ltd | 10,994 | $147.2K | 0.00% | +10,994 | New |
| Twelve Points Wealth Management LLC | 10,645 | $147.3K | 0.03% | +10,645 | New |
| Diversify Wealth Management, LLC | 10,000 | $148.7K | 0.01% | 00.0% | Unchanged |
| Brevan Howard Capital Management LP | 11,114 | $148.8K | 0.00% | +11,114 | New |
| Teacher Retirement System of Texas | 11,797 | $158.0K | 0.00% | −2,897−19.7% | Reduced |
| Bank of Montreal | 11,802 | $158.0K | 0.00% | +405+3.6% | Added |
| SEI Investments Co | 11,836 | $158.5K | 0.00% | +1,421+13.6% | Added |
| Money Concepts Capital Corp | 13,000 | $174.1K | 0.01% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 13,611 | $182.3K | 0.00% | −939−6.5% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 13,718 | $185.3K | 0.00% | +366+2.7% | Added |
| Fore Capital, LLC | 15,000 | $200.8K | 0.27% | −20,000−57.1% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,117 | $202.4K | 0.00% | 00.0% | Unchanged |
| Caxton Corp | 15,688 | $210.1K | 4.91% | −11,323−41.9% | Reduced |
| Caxton Associates LLP | 15,691 | $210.1K | 0.00% | +5,046+47.4% | Added |
| Voya Investment Management LLC | 15,992 | $214.1K | 0.00% | +1,710+12.0% | Added |
| Bay Rivers Group | 16,001 | $214.3K | 0.09% | +2,000+14.3% | Added |
| China Universal Asset Management Co., Ltd. | 16,052 | $214.9K | 0.02% | +2,715+20.4% | Added |
| Cetera Investment Advisers | 16,600 | $222.3K | 0.00% | +358+2.2% | Added |
| KLP Kapitalforvaltning AS | 17,000 | $227.6K | 0.00% | +6,600+63.5% | Added |
| Sequoia Financial Advisors, LLC | 17,173 | $229.9K | 0.00% | +41+0.2% | Added |
| Gotham Asset Management, LLC | 17,825 | $238.7K | 0.00% | +823+4.8% | Added |