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Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q2 2024

Institutional positions in Definium Therapeutics, Inc. as of Jun 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
152
+18 vs. Q1 2024
Shares held
41.5M
+6.72M (+19.3%) vs. Q1 2024
Total value
$299.3M
−$27.9M (−8.5%) vs. Q1 2024
New holders
45
39 more added
Sold out
27
24 more reduced

1 institution that held it in Q1 2024 haven't filed for Q2 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2024: 152 institutions
Q1 2021: 8 institutionsQ2 2021: 156 institutionsQ3 2021: 175 institutionsQ4 2021: 176 institutionsQ1 2022: 159 institutionsQ2 2022: 156 institutionsQ3 2022: 101 institutionsQ4 2022: 104 institutionsQ1 2023: 89 institutionsQ2 2023: 84 institutionsQ3 2023: 93 institutionsQ4 2023: 104 institutionsQ1 2024: 135 institutionsQ2 2024: 152 institutionsQ3 2024: 158 institutionsQ4 2024: 174 institutionsQ1 2025: 191 institutionsQ2 2025: 183 institutionsQ3 2025: 196 institutionsQ4 2025: 209 institutionsQ1 2026: 248 institutionsQ2 2026: 362 institutions
Value heldQ2 2024: $299.3M
Q1 2021: $932.0KQ2 2021: $131.0MQ3 2021: $104.8MQ4 2021: $72.0MQ1 2022: $53.6MQ2 2022: $15.1MQ3 2022: $20.5MQ4 2022: $11.1MQ1 2023: $12.6MQ2 2023: $13.9MQ3 2023: $12.1MQ4 2023: $17.9MQ1 2024: $327.2MQ2 2024: $299.3MQ3 2024: $281.6MQ4 2024: $288.9MQ1 2025: $240.5MQ2 2025: $271.0MQ3 2025: $468.6MQ4 2025: $908.7MQ1 2026: $1.47BQ2 2026: $5.35B
Institutions holding DFTX and their total value by quarter
QuarterHoldersValue
Q2 2026362$5.35B
Q1 2026248$1.47B
Q4 2025209$908.7M
Q3 2025196$468.6M
Q2 2025183$271.0M
Q1 2025191$240.5M
Q4 2024174$288.9M
Q3 2024158$281.6M
Q2 2024152$299.3M
Q1 2024135$327.2M
Q4 2023104$17.9M
Q3 202393$12.1M
Q2 202384$13.9M
Q1 202389$12.6M
Q4 2022104$11.1M
Q3 2022101$20.5M
Q2 2022156$15.1M
Q1 2022159$53.6M
Q4 2021176$72.0M
Q3 2021175$104.8M
Q2 2021156$131.0M
Q1 20218$932.0K

Institutions, Q2 2024

Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q1 2024.

Institutions holding DFTX in Q2 2024
InstitutionSharesValue% of portfolioChange in sharesAction
Commodore Capital LP7,145,888$51.5M3.52%+1,312,555+22.5%Added
Deep Track Capital, LP6,103,817$44.0M1.31%−562,850−8.4%Reduced
BlackRock Inc.5,384,030$38.8M0.00%+4,589,718+577.8%Added
Driehaus Capital Management LLC2,538,410$18.3M0.18%−9,135−0.4%Reduced
Marshall Wace, LLP2,160,203$15.6M0.02%+161,659+8.1%Added
Octagon Capital Advisors LP2,153,000$15.5M2.56%00.0%Unchanged
Blackstone Group Inc.1,898,325$13.7M0.06%+648,450+51.9%Added
State Street Corp1,805,047$13.0M0.00%+1,686,143+1,418.1%Added
Vanguard Group Inc1,741,403$12.6M0.00%+1,178,482+209.4%Added
Geode Capital Management, LLC1,514,769$10.9M0.00%+1,125,365+289.0%Added
Artal Group S.A.1,007,875$7.27M0.19%+1,007,875New
Woodline Partners LP1,001,250$7.22M0.07%+671+0.1%Added
Ally Bridge Group (NY) LLC965,426$6.96M4.15%−36,026−3.6%Reduced
AWM Investment Company, Inc.833,000$6.01M0.81%00.0%Unchanged
Two Sigma Investments, LP683,687$4.93M0.01%−28,551−4.0%Reduced
Charles Schwab Investment Management Inc556,357$4.01M0.00%+359,143+182.1%Added
Tri Locum Partners LP382,055$2.75M0.70%+2,459+0.6%Added
Bank of New York Mellon Corp246,208$1.78M0.00%+203,216+472.7%Added
Nuveen Asset Management, LLC204,140$1.47M0.00%+204,140New
Northern Trust Corp183,914$1.33M0.00%+118,365+180.6%Added
Ikarian Capital, LLC162,481$1.17M0.37%−135,000−45.4%Reduced
Morgan Stanley157,981$1.14M0.00%+47,019+42.4%Added
Moloney Securities Asset Management, LLC135,311$975.6K0.14%−26,650−16.5%Reduced
AdvisorShares Investments LLC124,166$877.9K0.15%+14,659+13.4%Added
Swiss National Bank110,900$799.6K0.00%+110,900New
Data Collective IV GP, LLC100,350$723.5K0.51%00.0%Unchanged
Rhumbline Advisers94,116$678.6K0.00%+94,116New
Two Sigma Advisers, LP85,017$613.0K0.00%+63,100+287.9%Added
Jane Street Group, LLC78,273$564.3K0.00%−294,186−79.0%Reduced
UBS Asset Management Americas Inc78,079$562.9K0.00%+78,079New
Wellington Management Group LLP76,570$552.1K0.00%+21,505+39.1%Added
Bank of America Corp75,758$546.2K0.00%+49,576+189.4%Added
Alliancebernstein L.P.75,330$543.1K0.00%+75,330New
Goldman Sachs Group Inc69,514$501.2K0.00%−338,486−83.0%Reduced
Alpine Global Management, LLC68,176$491.5K0.09%+68,176New
Royal Bank of Canada66,898$483.0K0.00%+26,279+64.7%Added
UBS Group AG56,488$407.3K0.00%+32,104+131.7%Added
California State Teachers Retirement System56,300$405.9K0.00%+56,300New
Scotia Capital Inc.53,951$389.7K0.00%00.0%Unchanged
Legal & General Group Plc53,233$383.8K0.00%+53,233New
Kestra Private Wealth Services, LLC51,339$370.2K0.01%00.0%Unchanged
LPL Financial LLC46,265$333.6K0.00%+2,538+5.8%Added
Boothbay Fund Management, LLC46,221$333.3K0.01%−38,403−45.4%Reduced
Barclays PLC44,827$323.2K0.00%+35,680+390.1%Added
Group One Trading, L.P.44,365$319.9K0.01%+8,007+22.0%Added
Corebridge Financial, Inc.38,733$279.7K0.00%+38,733New
Deutsche Bank AG36,690$264.5K0.00%+31,077+553.7%Added
Invesco Ltd.36,441$262.7K0.00%+36,441New
Cubist Systematic Strategies, LLC35,508$256.0K0.00%+6,890+24.1%Added
JPMorgan Chase & Co34,198$246.6K0.00%+30,682+872.6%Added
Bank of Montreal33,133$240.2K0.00%+33,133New
Man Group plc32,062$231.2K0.00%−80,115−71.4%Reduced
Caxton Corp30,383$219.1K1.11%+1,318+4.5%Added
New York State Common Retirement Fund29,100$209.8K0.00%+29,100New
Janus Henderson Group PLC28,000$202.2K0.00%−927,678−97.1%Reduced
GTS Securities LLC27,785$200.3K0.00%+2,864+11.5%Added
Manufacturers Life Insurance Company, The27,344$197.2K0.00%+27,344New
Voloridge Investment Management, LLC26,847$193.6K0.00%+26,847New
Citigroup Inc25,905$186.8K0.00%−85,161−76.7%Reduced
PEAK6 Investments LLC25,700$185.3K0.01%+10,246+66.3%Added
Wells Fargo & Company25,370$182.9K0.00%+22,787+882.2%Added
Commonwealth Equity Services, LLC24,966$180.0K0.00%+114+0.5%Added
Voya Investment Management LLC24,208$174.5K0.00%+24,208New
Rathbone Brothers plc24,200$174.5K0.00%00.0%Unchanged
Bailard, Inc.24,100$173.8K0.00%00.0%Unchanged
Profund Advisors LLC20,846$150.3K0.01%+20,846New
Mitchell McLeod Pugh & Williams Inc20,000$144.2K0.03%00.0%Unchanged
Walleye Capital LLC18,487$133.3K0.00%+18,487New
Zurcher Kantonalbank (Zurich Cantonalbank)18,147$130.8K0.00%+18,147New
Balyasny Asset Management LLC17,663$127.3K0.00%+17,663New
Citadel Advisors LLC17,580$126.8K0.00%−39,740−69.3%Reduced
Rafferty Asset Management, LLC17,299$124.7K0.00%+17,299New
Wolverine Trading, LLC17,274$124.5K0.00%−24,022−58.2%Reduced
Federation des caisses Desjardins du Quebec17,216$124.1K0.00%+3,095+21.9%Added
Change Path, LLC16,844$121.0K0.01%+16,844New
Sequoia Financial Advisors, LLC16,688$120.3K0.00%−1,224−6.8%Reduced
Arizona State Retirement System15,789$113.8K0.00%+15,789New
Fore Capital, LLC15,000$108.2K0.16%+15,000New
Mercer Global Advisors Inc14,520$104.7K0.00%−408−2.7%Reduced
HighTower Advisors, LLC14,530$104.0K0.00%+14,530New
Raymond James Financial Services Advisors, Inc.12,789$92.2K0.00%−973−7.1%Reduced
Teacher Retirement System of Texas12,389$89.0K0.00%+12,389New
FMR LLC11,728$84.6K0.00%−12,849−52.3%Reduced
Blair William & Co11,268$81.2K0.00%−73−0.6%Reduced
Wealth Alliance11,000$79.3K0.01%+11,000New
Diversify Wealth Management, LLC10,000$74.7K0.01%+10,000New
Bridgewealth Advisory Group, LLC10,000$72.1K0.03%+10,000New
Thrivent Financial for Lutherans10,027$72.0K0.00%00.0%Unchanged
Simplex Trading, LLC8,841$63.0K0.00%−46,007−83.9%Reduced
Ameritas Investment Partners, Inc.7,053$50.9K0.00%+7,053New
Aquatic Capital Management LLC6,600$47.6K0.00%+6,600New
TD Waterhouse Canada Inc.4,498$32.0K0.00%−39−0.9%Reduced
Advisor Group Holdings, Inc.4,234$30.5K0.00%+493+13.2%Added
Tower Research Capital LLC (TRC)3,018$21.8K0.00%−2,745−47.6%Reduced
North Star Investment Management Corp.2,500$18.0K0.00%+350+16.3%Added
Amalgamated Bank2,491$18.0K0.00%+2,491New
IFP Advisors, Inc2,000$14.4K0.00%+1,970+6,566.7%Added
Crewe Advisors LLC1,999$14.4K0.00%00.0%Unchanged
National Bank of Canada1,742$12.3K0.00%00.0%Unchanged
Quantbot Technologies LP1,577$11.4K0.00%+1,577New