Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Definium Therapeutics, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 183
- −8 vs. Q1 2025
- Shares held
- 41.8M
- +639.6K (+1.6%) vs. Q1 2025
- Total value
- $271.0M
- +$30.5M (+12.7%) vs. Q1 2025
- New holders
- 18
- 57 more added
- Sold out
- 26
- 50 more reduced
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 5,802,139 | $37.7M | 0.00% | +86,426+1.5% | Added |
| Commodore Capital LP | 5,000,000 | $32.5M | 2.29% | +475,000+10.5% | Added |
| Blackstone Group Inc. | 3,587,479 | $23.3M | 0.10% | 00.0% | Unchanged |
| Marshall Wace, LLP | 3,421,224 | $22.2M | 0.03% | +828,067+31.9% | Added |
| Driehaus Capital Management LLC | 3,092,658 | $20.1M | 0.16% | −258,747−7.7% | Reduced |
| Deep Track Capital, LP | 2,500,000 | $16.2M | 0.52% | 00.0% | Unchanged |
| Octagon Capital Advisors LP | 2,130,000 | $13.8M | 3.04% | −888,000−29.4% | Reduced |
| Vanguard Group Inc | 1,813,996 | $11.8M | 0.00% | +47,449+2.7% | Added |
| State Street Corp | 1,805,893 | $11.7M | 0.00% | −36,321−2.0% | Reduced |
| Geode Capital Management, LLC | 1,733,454 | $11.3M | 0.00% | +66,663+4.0% | Added |
| AWM Investment Company, Inc. | 1,215,662 | $7.89M | 0.88% | +7,500+0.6% | Added |
| Ally Bridge Group (NY) LLC | 726,172 | $4.71M | 3.92% | +336,029+86.1% | Added |
| Morgan Stanley | 688,531 | $4.47M | 0.00% | +28,639+4.3% | Added |
| Tang Capital Management LLC | 600,200 | $3.90M | 0.20% | +200,000+50.0% | Added |
| Northern Trust Corp | 599,242 | $3.89M | 0.00% | −43,541−6.8% | Reduced |
| Charles Schwab Investment Management Inc | 598,212 | $3.88M | 0.00% | +34,908+6.2% | Added |
| UBS Group AG | 514,445 | $3.34M | 0.00% | +406,419+376.2% | Added |
| Woodline Partners LP | 502,198 | $3.26M | 0.02% | −503,000−50.0% | Reduced |
| Rosalind Advisors, Inc. | 420,000 | $2.73M | 1.32% | 00.0% | Unchanged |
| Wellington Management Group LLP | 261,953 | $1.70M | 0.00% | +36,025+15.9% | Added |
| Bank of New York Mellon Corp | 240,739 | $1.56M | 0.00% | +40,542+20.3% | Added |
| Nuveen, LLC | 239,842 | $1.56M | 0.00% | −26,209−9.9% | Reduced |
| Millennium Management LLC | 183,400 | $1.19M | 0.00% | +183,400 | New |
| Citadel Advisors LLC | 178,604 | $1.16M | 0.00% | −234,786−56.8% | Reduced |
| Barclays PLC | 175,233 | $1.14M | 0.00% | +55,660+46.5% | Added |
| Susquehanna International Group, LLP | 169,325 | $1.10M | 0.00% | −175,879−50.9% | Reduced |
| Diadema Partners LP | 158,536 | $1.03M | 0.64% | +158,536 | New |
| Jane Street Group, LLC | 128,315 | $832.8K | 0.00% | +54,326+73.4% | Added |
| Bank of America Corp | 119,214 | $773.7K | 0.00% | +30,992+35.1% | Added |
| Rhumbline Advisers | 115,296 | $748.3K | 0.00% | +6,839+6.3% | Added |
| Swiss National Bank | 115,100 | $747.0K | 0.00% | +8,500+8.0% | Added |
| AdvisorShares Investments LLC | 109,593 | $711.3K | 0.13% | −10,000−8.4% | Reduced |
| Goldman Sachs Group Inc | 102,847 | $667.5K | 0.00% | −89,348−46.5% | Reduced |
| Data Collective IV GP, LLC | 100,350 | $651.3K | 0.50% | 00.0% | Unchanged |
| Oppenheimer & Co Inc | 98,336 | $638.2K | 0.01% | +27,221+38.3% | Added |
| Royal Bank of Canada | 97,129 | $629.0K | 0.00% | +31,892+48.9% | Added |
| StemPoint Capital LP | 90,852 | $589.6K | 0.19% | +90,852 | New |
| Simplex Trading, LLC | 87,951 | $570.0K | 0.02% | +40,095+83.8% | Added |
| Alliancebernstein L.P. | 74,830 | $485.6K | 0.00% | −750−1.0% | Reduced |
| DRW Securities, LLC | 69,426 | $450.6K | 0.03% | +19,426+38.9% | Added |
| LPL Financial LLC | 68,489 | $444.5K | 0.00% | +1,056+1.6% | Added |
| Creative Planning | 66,097 | $429.0K | 0.00% | +1,655+2.6% | Added |
| Ikarian Capital, LLC | 62,691 | $406.9K | 0.13% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 58,764 | $381.4K | 0.00% | −4,485−7.1% | Reduced |
| California State Teachers Retirement System | 57,288 | $371.8K | 0.00% | −1,210−2.1% | Reduced |
| Legal & General Group Plc | 56,703 | $368.0K | 0.00% | −590−1.0% | Reduced |
| Two Sigma Investments, LP | 56,478 | $366.5K | 0.00% | −2,744−4.6% | Reduced |
| Scotia Capital Inc. | 53,931 | $350.2K | 0.00% | −44−0.1% | Reduced |
| Kestra Private Wealth Services, LLC | 50,140 | $325.4K | 0.00% | −66−0.1% | Reduced |
| Cerity Partners LLC | 49,650 | $322.2K | 0.00% | +1,165+2.4% | Added |
| MetLife Investment Management | 49,196 | $319.3K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 48,487 | $314.7K | 0.00% | +2,342+5.1% | Added |
| Deutsche Bank AG | 47,989 | $311.4K | 0.00% | −11,237−19.0% | Reduced |
| Wells Fargo & Company | 47,717 | $309.7K | 0.00% | +10,301+27.5% | Added |
| UBS Asset Management Americas Inc | 42,129 | $273.4K | 0.00% | −3,492−7.7% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 41,261 | $267.8K | 0.00% | −2,289−5.3% | Reduced |
| Balyasny Asset Management LLC | 38,937 | $252.7K | 0.00% | −130,621−77.0% | Reduced |
| Invesco Ltd. | 38,463 | $249.6K | 0.00% | −637−1.6% | Reduced |
| Intech Investment Management LLC | 37,686 | $244.6K | 0.00% | −17,304−31.5% | Reduced |
| Citigroup Inc | 37,333 | $242.3K | 0.00% | −33,842−47.5% | Reduced |
| Persistent Asset Partners Ltd | 36,642 | $237.8K | 0.21% | +36,642 | New |
| Price T Rowe Associates Inc | 36,331 | $236.0K | 0.00% | +5,386+17.4% | Added |
| Fore Capital, LLC | 35,000 | $227.2K | 0.45% | −5,000−12.5% | Reduced |
| Caxton Corp | 34,073 | $221.1K | 2.24% | 00.0% | Unchanged |
| XTX Topco Ltd | 32,402 | $210.3K | 0.01% | +2,858+9.7% | Added |
| Moloney Securities Asset Management, LLC | 31,511 | $204.5K | 0.03% | −4,500−12.5% | Reduced |
| Polar Asset Management Partners Inc. | 29,300 | $190.2K | 0.00% | +29,300 | New |
| Rathbone Brothers plc | 28,200 | $183.0K | 0.00% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 28,000 | $181.9K | 0.00% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 27,568 | $178.9K | 0.00% | +204+0.7% | Added |
| Palumbo Wealth Management LLC | 24,043 | $156.0K | 0.05% | +1,415+6.3% | Added |
| Blair William & Co | 22,218 | $144.2K | 0.00% | +9,718+77.7% | Added |
| Federation des caisses Desjardins du Quebec | 21,422 | $139.0K | 0.00% | −1,000−4.5% | Reduced |
| Voya Investment Management LLC | 21,261 | $138.0K | 0.00% | +146+0.7% | Added |
| Mitchell McLeod Pugh & Williams Inc | 20,000 | $129.8K | 0.02% | 00.0% | Unchanged |
| Mercer Global Advisors Inc | 19,852 | $128.8K | 0.00% | +272+1.4% | Added |
| AQR Capital Management LLC | 19,758 | $128.2K | 0.00% | +7,508+61.3% | Added |
| Squarepoint Ops LLC | 19,684 | $127.7K | 0.00% | −3,787−16.1% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 18,554 | $120.4K | 0.00% | 00.0% | Unchanged |
| ProShare Advisors LLC | 18,268 | $118.6K | 0.00% | −941−4.9% | Reduced |
| Boothbay Fund Management, LLC | 17,984 | $116.7K | 0.00% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 17,877 | $116.0K | 0.00% | +17,877 | New |
| Arizona State Retirement System | 17,581 | $114.1K | 0.00% | +1,805+11.4% | Added |
| Advisor Group Holdings, Inc. | 17,451 | $113.2K | 0.00% | −72−0.4% | Reduced |
| Quantinno Capital Management LP | 17,154 | $111.3K | 0.00% | +17,154 | New |
| New York State Common Retirement Fund | 17,100 | $111.0K | 0.00% | 00.0% | Unchanged |
| Raymond James Financial Inc | 17,029 | $110.5K | 0.00% | −1,450−7.8% | Reduced |
| Sequoia Financial Advisors, LLC | 16,579 | $107.6K | 0.00% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 16,455 | $107.0K | 0.00% | −1,837−10.0% | Reduced |
| Teacher Retirement System of Texas | 16,260 | $105.5K | 0.00% | +1,400+9.4% | Added |
| Diversify Wealth Management, LLC | 10,000 | $101.5K | 0.01% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,602 | $101.3K | 0.00% | −13,265−46.0% | Reduced |
| China Universal Asset Management Co., Ltd. | 15,175 | $98.5K | 0.01% | +466+3.2% | Added |
| Wealth Enhancement Advisory Services, LLC | 13,436 | $96.3K | 0.00% | −102−0.8% | Reduced |
| Dynamic Technology Lab Private Ltd | 14,623 | $95.0K | 0.01% | +14,623 | New |
| Bailard, Inc. | 14,600 | $94.8K | 0.00% | 00.0% | Unchanged |
| Gotham Asset Management, LLC | 14,078 | $91.4K | 0.00% | +14,078 | New |
| FMR LLC | 13,787 | $89.5K | 0.00% | −625−4.3% | Reduced |
| Profund Advisors LLC | 13,707 | $89.0K | 0.00% | −3,802−21.7% | Reduced |
| Virtus Investment Advisers, Inc. | 12,881 | $83.6K | 0.03% | −10,507−44.9% | Reduced |