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Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q2 2025

Institutional positions in Definium Therapeutics, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
183
−8 vs. Q1 2025
Shares held
41.8M
+639.6K (+1.6%) vs. Q1 2025
Total value
$271.0M
+$30.5M (+12.7%) vs. Q1 2025
New holders
18
57 more added
Sold out
26
50 more reduced

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 183 institutions
Q1 2021: 8 institutionsQ2 2021: 156 institutionsQ3 2021: 175 institutionsQ4 2021: 176 institutionsQ1 2022: 159 institutionsQ2 2022: 156 institutionsQ3 2022: 101 institutionsQ4 2022: 104 institutionsQ1 2023: 89 institutionsQ2 2023: 84 institutionsQ3 2023: 93 institutionsQ4 2023: 104 institutionsQ1 2024: 135 institutionsQ2 2024: 152 institutionsQ3 2024: 158 institutionsQ4 2024: 174 institutionsQ1 2025: 191 institutionsQ2 2025: 183 institutionsQ3 2025: 196 institutionsQ4 2025: 209 institutionsQ1 2026: 248 institutionsQ2 2026: 362 institutions
Value heldQ2 2025: $271.0M
Q1 2021: $932.0KQ2 2021: $131.0MQ3 2021: $104.8MQ4 2021: $72.0MQ1 2022: $53.6MQ2 2022: $15.1MQ3 2022: $20.5MQ4 2022: $11.1MQ1 2023: $12.6MQ2 2023: $13.9MQ3 2023: $12.1MQ4 2023: $17.9MQ1 2024: $327.2MQ2 2024: $299.3MQ3 2024: $281.6MQ4 2024: $288.9MQ1 2025: $240.5MQ2 2025: $271.0MQ3 2025: $468.6MQ4 2025: $908.7MQ1 2026: $1.47BQ2 2026: $5.35B
Institutions holding DFTX and their total value by quarter
QuarterHoldersValue
Q2 2026362$5.35B
Q1 2026248$1.47B
Q4 2025209$908.7M
Q3 2025196$468.6M
Q2 2025183$271.0M
Q1 2025191$240.5M
Q4 2024174$288.9M
Q3 2024158$281.6M
Q2 2024152$299.3M
Q1 2024135$327.2M
Q4 2023104$17.9M
Q3 202393$12.1M
Q2 202384$13.9M
Q1 202389$12.6M
Q4 2022104$11.1M
Q3 2022101$20.5M
Q2 2022156$15.1M
Q1 2022159$53.6M
Q4 2021176$72.0M
Q3 2021175$104.8M
Q2 2021156$131.0M
Q1 20218$932.0K

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q1 2025.

Institutions holding DFTX in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
HighTower Advisors, LLC12,675$82.3K0.00%−10.0%Reduced
Diametric Capital, LP12,433$80.7K0.04%−937−7.0%Reduced
Mariner, LLC12,043$78.2K0.00%+12,043New
Bank of Montreal11,919$77.4K0.00%−3,186−21.1%Reduced
Sanctuary Advisors, LLC11,661$75.7K0.00%+329+2.9%Added
Bay Rivers Group11,618$75.4K0.03%+11,618New
Avantax Advisory Services, Inc.11,138$72.3K0.00%−459−4.0%Reduced
PEAK6 LLC10,915$70.8K0.00%−2,087−16.1%Reduced
Stoneridge Investment Partners LLC10,759$70.0K0.05%00.0%Unchanged
SEI Investments Co10,415$67.6K0.00%00.0%Unchanged
KLP Kapitalforvaltning AS10,400$67.5K0.00%00.0%Unchanged
Sharpepoint LLC10,165$66.0K0.07%00.0%Unchanged
King Wealth10,000$65.0K0.01%00.0%Unchanged
Tower Research Capital LLC (TRC)8,856$57.5K0.00%−2,512−22.1%Reduced
BNP Paribas Arbitrage, SA8,417$54.6K0.00%+3,020+56.0%Added
Hollencrest Capital Management7,216$46.8K0.00%00.0%Unchanged
Ameritas Investment Partners, Inc.7,053$45.8K0.00%00.0%Unchanged
North Star Investment Management Corp.6,701$43.5K0.00%−2,700−28.7%Reduced
TD Waterhouse Canada Inc.5,657$37.7K0.00%+661+13.2%Added
Capital Advisors Inc50,000$37.5K0.00%00.0%Unchanged
CWM, LLC4,459$29.0K0.00%+1,796+67.4%Added
Russell Investments Group, Ltd.3,817$24.8K0.00%+2,003+110.4%Added
Nisa Investment Advisors, LLC3,378$21.9K0.00%+945+38.8%Added
Ameritas Advisory Services, LLC3,250$21.1K0.00%+3,250New
Clear Street Markets LLC3,096$20.1K0.01%−10,815−77.7%Reduced
Larson Financial Group LLC2,932$19.0K0.00%00.0%Unchanged
Mirae Asset Global Investments Co., Ltd.2,919$18.9K0.00%+465+18.9%Added
Amalgamated Bank2,781$18.0K0.00%00.0%Unchanged
Crewe Advisors LLC1,999$13.0K0.00%00.0%Unchanged
GF Fund Management Co. Ltd.1,877$12.2K0.00%00.0%Unchanged
Sterling Capital Management LLC1,456$9.45K0.00%+1,369+1,573.6%Added
National Bank of Canada1,421$9.22K0.00%00.0%Unchanged
Bullock Wealth Management Group1,194$7.98K0.00%00.0%Unchanged
GAMMA Investing LLC1,108$7.19K0.00%+415+59.9%Added
Stone House Investment Management, LLC1,000$6.49K0.00%00.0%Unchanged
Steward Partners Investment Advisory, LLC1,000$6.49K0.00%00.0%Unchanged
Northwestern Mutual Wealth Management Co633$4.11K0.00%+533+533.0%Added
BNP PARIBAS ASSET MANAGEMENT Holding S.A.678$4.00K0.00%+678New
Harbour Investments, Inc.556$3.61K0.00%+200+56.2%Added
Skopos Labs, Inc.519$3.37K0.00%+137+35.9%Added
SRS Capital Advisors, Inc.501$3.25K0.00%+237+89.8%Added
CIBC Private Wealth Group, LLC484$3.14K0.00%+61+14.4%Added
NBC Securities, Inc.600$3.00K0.00%00.0%Unchanged
Farther Finance Advisors, LLC457$2.97K0.00%−537−54.0%Reduced
IFP Advisors, Inc0$2.82K0.00%−984−100.0%Reduced
Massmutual Trust Co FSB432$2.80K0.00%−135−23.8%Reduced
NVWM, LLC416$2.70K0.00%00.0%Unchanged
Tortoise Investment Management, LLC400$2.60K0.00%00.0%Unchanged
SBI Securities Co., Ltd.382$2.48K0.00%+76+24.8%Added
Caitong International Asset Management Co., Ltd341$2.21K0.00%−218−39.0%Reduced
CarsonAllaria Wealth Management, Ltd.325$2.11K0.00%00.0%Unchanged
Daiwa Securities Group Inc.242$2.00K0.00%00.0%Unchanged
Rothschild Investment LLC273$1.77K0.00%+270+9,000.0%Added
Parallel Advisors, LLC252$1.63K0.00%+233+1,226.3%Added
Atlantic Edge Private Wealth Management, LLC193$1.25K0.00%00.0%Unchanged
GWM Advisors LLC142$9210.00%00.0%Unchanged
Pandora Wealth, Inc.131$8500.00%00.0%Unchanged
First Pacific Financial102$6620.00%+102New
HighMark Wealth Management LLC100$6490.00%00.0%Unchanged
EverSource Wealth Advisors, LLC90$5840.00%+34+60.7%Added
Allworth Financial LP85$5520.00%+16+23.2%Added
Activest Wealth Management66$4280.00%00.0%Unchanged
Fifth Third Bancorp59$3830.00%00.0%Unchanged
Principal Securities, Inc.58$3760.00%+58New
Tradewinds Capital Management, LLC53$3440.00%00.0%Unchanged
Louisbourg Investments Inc.52$3370.00%00.0%Unchanged
Plante Moran Financial Advisors, LLC36$2340.00%00.0%Unchanged
Anfield Capital Management, LLC36$2340.00%00.0%Unchanged
Chesapeake Asset Management LLC33$2140.00%00.0%Unchanged
TruNorth Capital Management, LLC33$2140.00%00.0%Unchanged
Robbins Farley LLC28$1820.00%00.0%Unchanged
Total Investment Management Inc20$1300.00%+20New
The PNC Financial Services Group, Inc.17$1100.00%+17New
MAI Capital Management10$650.00%00.0%Unchanged
CNB Bank10$650.00%00.0%Unchanged
NBT Bank N A6$390.00%00.0%Unchanged
Belmont Capital, LLC6$390.00%00.0%Unchanged
Strategic Investment Solutions, Inc.6$390.00%00.0%Unchanged
CoreCap Advisors, LLC5$320.00%00.0%Unchanged
Essential Partners LLC4$260.00%+4New
Signaturefd, LLC2$130.00%00.0%Unchanged
Huntington National Bank1$10.00%00.0%Unchanged
TSFG, LLC6$00.00%−18−75.0%Reduced
Corebridge Financial, Inc.0$00.00%−35,986−100.0%Sold out
Janney Montgomery Scott LLC0$00.00%−34,685−100.0%Sold out
Clough Capital Partners L P0$00.00%−33,900−100.0%Sold out
Virtu Financial LLC0$00.00%−32,836−100.0%Sold out
Algert Global LLC0$00.00%−24,770−100.0%Sold out
Massar Capital Management, LP0$00.00%−24,583−100.0%Sold out
EntryPoint Capital, LLC0$00.00%−22,708−100.0%Sold out
Gruss & Co., LLC0$00.00%−16,939−100.0%Sold out
HRT Financial LP0$00.00%−16,703−100.0%Sold out
CIBC World Markets Corp0$00.00%−16,299−100.0%Sold out
Ameriprise Financial Inc0$00.00%−15,048−100.0%Sold out
Wolverine Trading, LLC0$00.00%−13,236−100.0%Sold out
Rafferty Asset Management, LLC0$00.00%−13,773−100.0%Sold out
Change Path, LLC0$00.00%−11,455−100.0%Sold out
Black Swift Group, LLC0$00.00%−10,713−100.0%Sold out
Walleye Trading LLC0$00.00%−2,910−100.0%Sold out
Kestra Advisory Services, LLC0$00.00%−2,532−100.0%Sold out