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Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 1 sale; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q2 2025

Institutional positions in Definium Therapeutics, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
183
−8 vs. Q1 2025
Shares held
41.8M
+639.6K (+1.6%) vs. Q1 2025
Total value
$271.0M
+$30.5M (+12.7%) vs. Q1 2025
New holders
18
57 more added
Sold out
26
50 more reduced

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 183 institutions
Q1 2021: 8 institutionsQ2 2021: 156 institutionsQ3 2021: 175 institutionsQ4 2021: 176 institutionsQ1 2022: 159 institutionsQ2 2022: 156 institutionsQ3 2022: 101 institutionsQ4 2022: 104 institutionsQ1 2023: 89 institutionsQ2 2023: 84 institutionsQ3 2023: 93 institutionsQ4 2023: 104 institutionsQ1 2024: 135 institutionsQ2 2024: 152 institutionsQ3 2024: 158 institutionsQ4 2024: 174 institutionsQ1 2025: 191 institutionsQ2 2025: 183 institutionsQ3 2025: 196 institutionsQ4 2025: 209 institutionsQ1 2026: 248 institutionsQ2 2026: 362 institutions
Value heldQ2 2025: $271.0M
Q1 2021: $932.0KQ2 2021: $131.0MQ3 2021: $104.8MQ4 2021: $72.0MQ1 2022: $53.6MQ2 2022: $15.1MQ3 2022: $20.5MQ4 2022: $11.1MQ1 2023: $12.6MQ2 2023: $13.9MQ3 2023: $12.1MQ4 2023: $17.9MQ1 2024: $327.2MQ2 2024: $299.3MQ3 2024: $281.6MQ4 2024: $288.9MQ1 2025: $240.5MQ2 2025: $271.0MQ3 2025: $468.6MQ4 2025: $908.7MQ1 2026: $1.47BQ2 2026: $5.35B
Institutions holding DFTX and their total value by quarter
QuarterHoldersValue
Q2 2026362$5.35B
Q1 2026248$1.47B
Q4 2025209$908.7M
Q3 2025196$468.6M
Q2 2025183$271.0M
Q1 2025191$240.5M
Q4 2024174$288.9M
Q3 2024158$281.6M
Q2 2024152$299.3M
Q1 2024135$327.2M
Q4 2023104$17.9M
Q3 202393$12.1M
Q2 202384$13.9M
Q1 202389$12.6M
Q4 2022104$11.1M
Q3 2022101$20.5M
Q2 2022156$15.1M
Q1 2022159$53.6M
Q4 2021176$72.0M
Q3 2021175$104.8M
Q2 2021156$131.0M
Q1 20218$932.0K

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q1 2025.

Institutions holding DFTX in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
TSFG, LLC6$00.00%−18−75.0%Reduced
Huntington National Bank1$10.00%00.0%Unchanged
Signaturefd, LLC2$130.00%00.0%Unchanged
Essential Partners LLC4$260.00%+4New
CoreCap Advisors, LLC5$320.00%00.0%Unchanged
NBT Bank N A6$390.00%00.0%Unchanged
Belmont Capital, LLC6$390.00%00.0%Unchanged
Strategic Investment Solutions, Inc.6$390.00%00.0%Unchanged
MAI Capital Management10$650.00%00.0%Unchanged
CNB Bank10$650.00%00.0%Unchanged
The PNC Financial Services Group, Inc.17$1100.00%+17New
Total Investment Management Inc20$1300.00%+20New
Robbins Farley LLC28$1820.00%00.0%Unchanged
Chesapeake Asset Management LLC33$2140.00%00.0%Unchanged
TruNorth Capital Management, LLC33$2140.00%00.0%Unchanged
Plante Moran Financial Advisors, LLC36$2340.00%00.0%Unchanged
Anfield Capital Management, LLC36$2340.00%00.0%Unchanged
Louisbourg Investments Inc.52$3370.00%00.0%Unchanged
Tradewinds Capital Management, LLC53$3440.00%00.0%Unchanged
Principal Securities, Inc.58$3760.00%+58New
Fifth Third Bancorp59$3830.00%00.0%Unchanged
Activest Wealth Management66$4280.00%00.0%Unchanged
Allworth Financial LP85$5520.00%+16+23.2%Added
EverSource Wealth Advisors, LLC90$5840.00%+34+60.7%Added
HighMark Wealth Management LLC100$6490.00%00.0%Unchanged
First Pacific Financial102$6620.00%+102New
Pandora Wealth, Inc.131$8500.00%00.0%Unchanged
GWM Advisors LLC142$9210.00%00.0%Unchanged
Atlantic Edge Private Wealth Management, LLC193$1.25K0.00%00.0%Unchanged
Parallel Advisors, LLC252$1.63K0.00%+233+1,226.3%Added
Rothschild Investment LLC273$1.77K0.00%+270+9,000.0%Added
Daiwa Securities Group Inc.242$2.00K0.00%00.0%Unchanged
CarsonAllaria Wealth Management, Ltd.325$2.11K0.00%00.0%Unchanged
Caitong International Asset Management Co., Ltd341$2.21K0.00%−218−39.0%Reduced
SBI Securities Co., Ltd.382$2.48K0.00%+76+24.8%Added
Tortoise Investment Management, LLC400$2.60K0.00%00.0%Unchanged
NVWM, LLC416$2.70K0.00%00.0%Unchanged
Massmutual Trust Co FSB432$2.80K0.00%−135−23.8%Reduced
IFP Advisors, Inc0$2.82K0.00%−984−100.0%Reduced
Farther Finance Advisors, LLC457$2.97K0.00%−537−54.0%Reduced
NBC Securities, Inc.600$3.00K0.00%00.0%Unchanged
CIBC Private Wealth Group, LLC484$3.14K0.00%+61+14.4%Added
SRS Capital Advisors, Inc.501$3.25K0.00%+237+89.8%Added
Skopos Labs, Inc.519$3.37K0.00%+137+35.9%Added
Harbour Investments, Inc.556$3.61K0.00%+200+56.2%Added
BNP PARIBAS ASSET MANAGEMENT Holding S.A.678$4.00K0.00%+678New
Northwestern Mutual Wealth Management Co633$4.11K0.00%+533+533.0%Added
Stone House Investment Management, LLC1,000$6.49K0.00%00.0%Unchanged
Steward Partners Investment Advisory, LLC1,000$6.49K0.00%00.0%Unchanged
GAMMA Investing LLC1,108$7.19K0.00%+415+59.9%Added
Bullock Wealth Management Group1,194$7.98K0.00%00.0%Unchanged
National Bank of Canada1,421$9.22K0.00%00.0%Unchanged
Sterling Capital Management LLC1,456$9.45K0.00%+1,369+1,573.6%Added
GF Fund Management Co. Ltd.1,877$12.2K0.00%00.0%Unchanged
Crewe Advisors LLC1,999$13.0K0.00%00.0%Unchanged
Amalgamated Bank2,781$18.0K0.00%00.0%Unchanged
Mirae Asset Global Investments Co., Ltd.2,919$18.9K0.00%+465+18.9%Added
Larson Financial Group LLC2,932$19.0K0.00%00.0%Unchanged
Clear Street Markets LLC3,096$20.1K0.01%−10,815−77.7%Reduced
Ameritas Advisory Services, LLC3,250$21.1K0.00%+3,250New
Nisa Investment Advisors, LLC3,378$21.9K0.00%+945+38.8%Added
Russell Investments Group, Ltd.3,817$24.8K0.00%+2,003+110.4%Added
CWM, LLC4,459$29.0K0.00%+1,796+67.4%Added
Capital Advisors Inc50,000$37.5K0.00%00.0%Unchanged
TD Waterhouse Canada Inc.5,657$37.7K0.00%+661+13.2%Added
North Star Investment Management Corp.6,701$43.5K0.00%−2,700−28.7%Reduced
Ameritas Investment Partners, Inc.7,053$45.8K0.00%00.0%Unchanged
Hollencrest Capital Management7,216$46.8K0.00%00.0%Unchanged
BNP Paribas Arbitrage, SA8,417$54.6K0.00%+3,020+56.0%Added
Tower Research Capital LLC (TRC)8,856$57.5K0.00%−2,512−22.1%Reduced
King Wealth10,000$65.0K0.01%00.0%Unchanged
Sharpepoint LLC10,165$66.0K0.07%00.0%Unchanged
KLP Kapitalforvaltning AS10,400$67.5K0.00%00.0%Unchanged
SEI Investments Co10,415$67.6K0.00%00.0%Unchanged
Stoneridge Investment Partners LLC10,759$70.0K0.05%00.0%Unchanged
PEAK6 LLC10,915$70.8K0.00%−2,087−16.1%Reduced
Avantax Advisory Services, Inc.11,138$72.3K0.00%−459−4.0%Reduced
Bay Rivers Group11,618$75.4K0.03%+11,618New
Sanctuary Advisors, LLC11,661$75.7K0.00%+329+2.9%Added
Bank of Montreal11,919$77.4K0.00%−3,186−21.1%Reduced
Mariner, LLC12,043$78.2K0.00%+12,043New
Diametric Capital, LP12,433$80.7K0.04%−937−7.0%Reduced
HighTower Advisors, LLC12,675$82.3K0.00%−10.0%Reduced
Virtus Investment Advisers, Inc.12,881$83.6K0.03%−10,507−44.9%Reduced
Profund Advisors LLC13,707$89.0K0.00%−3,802−21.7%Reduced
FMR LLC13,787$89.5K0.00%−625−4.3%Reduced
Gotham Asset Management, LLC14,078$91.4K0.00%+14,078New
Bailard, Inc.14,600$94.8K0.00%00.0%Unchanged
Dynamic Technology Lab Private Ltd14,623$95.0K0.01%+14,623New
Wealth Enhancement Advisory Services, LLC13,436$96.3K0.00%−102−0.8%Reduced
China Universal Asset Management Co., Ltd.15,175$98.5K0.01%+466+3.2%Added
Zurcher Kantonalbank (Zurich Cantonalbank)15,602$101.3K0.00%−13,265−46.0%Reduced
Diversify Wealth Management, LLC10,000$101.5K0.01%00.0%Unchanged
Teacher Retirement System of Texas16,260$105.5K0.00%+1,400+9.4%Added
Commonwealth Equity Services, LLC16,455$107.0K0.00%−1,837−10.0%Reduced
Sequoia Financial Advisors, LLC16,579$107.6K0.00%00.0%Unchanged
Raymond James Financial Inc17,029$110.5K0.00%−1,450−7.8%Reduced
New York State Common Retirement Fund17,100$111.0K0.00%00.0%Unchanged
Quantinno Capital Management LP17,154$111.3K0.00%+17,154New
Advisor Group Holdings, Inc.17,451$113.2K0.00%−72−0.4%Reduced