Definium Therapeutics, Inc.

DFTX

Exchange: Nasdaq
Industry: Medicinal Chemicals & Botanical Products
SEC CIK: 0001813814

SEC filings (opens in a new tab)

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

Q4 2025 vs. Q3 2025

How the institutions holding Definium Therapeutics, Inc. changed between Q3 2025 and Q4 2025.

All holders in Q4 2025 All holders in Q3 2025

13F holders of DFTX: Q3 2025 compared with Q4 2025
Measure	Q3 2025	Of which not filed for Q4 2025	Q4 2025	Change
Holders	196	7	209	+20
Shares	39.7M	207.7K	67.9M	+28.3M (+71.7%)
Value	$468.6M	$2.46M	$908.7M	+$442.6M (+95.0%)

7 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (50)

Institutions that held Definium Therapeutics, Inc. at the end of Q4 2025 but not at the end of Q3 2025.

Institutions new to DFTX in Q4 2025
Institution	Shares	Value	% of portfolio
Avoro Capital Advisors LLC	5,000,000	$67.0M	0.66%
Trails Edge Capital Partners, LP	2,568,110	$34.4M	8.50%
Balyasny Asset Management LLC	1,308,115	$17.5M	0.03%
Candriam Luxembourg S.C.A.	971,218	$13.0M	0.06%
Siren, L.L.C.	800,000	$10.7M	0.32%
Vestal Point Capital, LP	637,000	$8.53M	0.31%
Ameriprise Financial Inc	504,241	$6.75M	0.00%
Superstring Capital Management LP	425,202	$5.69M	3.05%
Integral Health Asset Management, LLC	350,000	$4.69M	0.24%
RTW Investments, LP	300,000	$4.02M	0.04%
Universal- Beteiligungs- und Servicegesellschaft mbH	278,720	$3.73M	0.01%
Ensign Peak Advisors, Inc	262,000	$3.51M	0.01%
Seven Grand Managers, LLC	225,000	$3.01M	0.23%
Woodline Partners LP	150,570	$2.02M	0.01%
Soviero Asset Management, LP	150,000	$2.01M	1.05%
Verition Fund Management LLC	132,263	$1.77M	0.01%
Burkehill Global Management, LP	100,000	$1.34M	0.09%
Platinum Investment Management Ltd	70,000	$937.3K	0.22%
State of Wisconsin Investment Board	58,602	$784.7K	0.00%
Jennison Associates LLC	53,785	$720.2K	0.00%
Squarepoint Ops LLC	45,402	$607.9K	0.00%
PSP Research LLC	34,841	$466.5K	0.41%
Dark Forest Capital Management LP	30,661	$410.6K	0.02%
Concurrent Investment Advisors, LLC	20,397	$273.1K	0.00%
EntryPoint Capital, LLC	20,219	$270.7K	0.11%
Marex Group plc	20,000	$267.8K	0.00%
ExodusPoint Capital Management, LP	18,948	$253.7K	0.00%
Brevan Howard Capital Management LP	11,114	$148.8K	0.00%
Twelve Points Wealth Management LLC	10,645	$147.3K	0.03%
XTX Topco Ltd	10,994	$147.2K	0.00%
Sharpepoint LLC	10,135	$135.7K	0.08%
Flagship Harbor Advisors, LLC	8,721	$116.8K	0.01%
Quantbot Technologies LP	1,649	$22.1K	0.00%
High Note Wealth, LLC	1,500	$20.1K	0.00%
First Horizon Corp	843	$11.3K	0.00%
Larson Financial Group LLC	535	$7.16K	0.00%
Sankala Group LLC	391	$6.82K	0.01%
Atlantic Union Bankshares Corp	500	$6.70K	0.00%
SRS Capital Advisors, Inc.	479	$6.41K	0.00%
Strategic Wealth Partners, Ltd.	166	$2.22K	0.00%
Reflection Asset Management	66	$898	0.00%
Federated Hermes, Inc.	67	$897	0.00%
MH & Associates Securities Management Corp	66	$884	0.00%
Kohmann Bosshard Financial Services, LLC	66	$884	0.00%
Pinnacle Wealth Planning Services, Inc.	25	$335	0.00%
Rachor Investment Advisory Services, LLC	25	$335	0.00%
Caitong International Asset Management Co., Ltd	15	$201	0.00%
Keating Financial Advisory Services, Inc.	7	$94	0.00%
SageView Advisory Group, LLC	6	$81	0.00%
Navalign, LLC	2	$27	0.00%

Sold out (30)

Institutions that held Definium Therapeutics, Inc. at the end of Q3 2025 and filed for Q4 2025 without it.

Institutions that sold out of DFTX in Q4 2025
Institution	Shares, Q3 2025	Value, Q3 2025
Tang Capital Management LLC	600,200	$7.08M
Ally Bridge Group (NY) LLC	361,444	$4.26M
Diadema Partners LP	105,891	$1.25M
StemPoint Capital LP	76,875	$906.4K
PFM Health Sciences, LP	75,138	$885.9K
Boothbay Fund Management, LLC	67,984	$801.5K
Cerity Partners LLC	49,650	$585.4K
Virtu Financial LLC	32,184	$379.0K
Blair William & Co	31,905	$376.2K
DRW Securities, LLC	30,727	$360.9K
Sender Co & Partners, Inc.	25,906	$305.4K
Persistent Asset Partners Ltd	24,282	$286.3K
Omers Administration Corp	16,600	$195.7K
Axq Capital, LP	15,585	$183.7K
HighTower Advisors, LLC	12,643	$149.1K
Creative Planning	11,909	$140.4K
Stoneridge Investment Partners LLC	11,563	$136.0K
FNY Investment Advisers, LLC	9,094	$107.0K
Walleye Capital LLC	5,737	$67.6K
Ameritas Advisory Services, LLC	3,250	$38.3K
Mirae Asset Global Investments Co., Ltd.	2,942	$34.7K
BIT Capital GmbH	2,245	$26.5K
Advisory Services Network, LLC	656	$7.74K
Harbour Investments, Inc.	556	$6.55K
Tortoise Investment Management, LLC	400	$4.72K
Principal Securities, Inc.	58	$684
Louisbourg Investments Inc.	52	$613
Anfield Capital Management, LLC	36	$424
Strategic Investment Solutions, Inc.	6	$71
Grey Fox Wealth Advisors, LLC	6	$71

Not filed for Q4 2025 yet (7)

Institutions that held Definium Therapeutics, Inc. at the end of Q3 2025 and haven't filed a 13F for Q4 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding DFTX in Q3 2025 that haven't filed for Q4 2025
Institution	Shares, Q3 2025	Value, Q3 2025
Cubist Systematic Strategies, LLC	108,214	$1.28M
Wolverine Trading, LLC	60,250	$725.4K
Moloney Securities Asset Management, LLC	23,511	$277.2K
Point72 Asia (Singapore) Pte. Ltd.	10,222	$120.5K
Point72 (DIFC) Ltd	4,578	$54.0K
Point72 Europe (London) LLP	815	$9.61K
Guerra Advisors Inc	66	$778