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Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q4 2024

Institutional positions in Definium Therapeutics, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
174
+18 vs. Q3 2024
Shares held
41.5M
−7.96M (−16.1%) vs. Q3 2024
Total value
$288.9M
+$7.36M (+2.6%) vs. Q3 2024
New holders
37
60 more added
Sold out
19
33 more reduced

2 institutions that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2024: 174 institutions
Q1 2021: 8 institutionsQ2 2021: 156 institutionsQ3 2021: 175 institutionsQ4 2021: 176 institutionsQ1 2022: 159 institutionsQ2 2022: 156 institutionsQ3 2022: 101 institutionsQ4 2022: 104 institutionsQ1 2023: 89 institutionsQ2 2023: 84 institutionsQ3 2023: 93 institutionsQ4 2023: 104 institutionsQ1 2024: 135 institutionsQ2 2024: 152 institutionsQ3 2024: 158 institutionsQ4 2024: 174 institutionsQ1 2025: 191 institutionsQ2 2025: 183 institutionsQ3 2025: 196 institutionsQ4 2025: 209 institutionsQ1 2026: 248 institutionsQ2 2026: 362 institutions
Value heldQ4 2024: $288.9M
Q1 2021: $932.0KQ2 2021: $131.0MQ3 2021: $104.8MQ4 2021: $72.0MQ1 2022: $53.6MQ2 2022: $15.1MQ3 2022: $20.5MQ4 2022: $11.1MQ1 2023: $12.6MQ2 2023: $13.9MQ3 2023: $12.1MQ4 2023: $17.9MQ1 2024: $327.2MQ2 2024: $299.3MQ3 2024: $281.6MQ4 2024: $288.9MQ1 2025: $240.5MQ2 2025: $271.0MQ3 2025: $468.6MQ4 2025: $908.7MQ1 2026: $1.47BQ2 2026: $5.35B
Institutions holding DFTX and their total value by quarter
QuarterHoldersValue
Q2 2026362$5.35B
Q1 2026248$1.47B
Q4 2025209$908.7M
Q3 2025196$468.6M
Q2 2025183$271.0M
Q1 2025191$240.5M
Q4 2024174$288.9M
Q3 2024158$281.6M
Q2 2024152$299.3M
Q1 2024135$327.2M
Q4 2023104$17.9M
Q3 202393$12.1M
Q2 202384$13.9M
Q1 202389$12.6M
Q4 2022104$11.1M
Q3 2022101$20.5M
Q2 2022156$15.1M
Q1 2022159$53.6M
Q4 2021176$72.0M
Q3 2021175$104.8M
Q2 2021156$131.0M
Q1 20218$932.0K

Institutions, Q4 2024

Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q3 2024.

Institutions holding DFTX in Q4 2024
InstitutionSharesValue% of portfolioChange in sharesAction
SEI Investments Co10,415$72.5K0.00%00.0%Unchanged
KLP Kapitalforvaltning AS10,400$72.4K0.00%+10,400New
Advisor Group Holdings, Inc.10,246$71.2K0.00%+2,270+28.5%Added
Simplex Trading, LLC10,228$71.0K0.00%+10,228New
Sharpepoint LLC10,165$70.7K0.06%+10,165New
Virtus ETF Advisers LLC10,127$70.5K0.03%+10,127New
King Wealth10,000$70.0K0.01%+10,000New
Diversify Wealth Management, LLC10,000$69.3K0.01%00.0%Unchanged
North Star Investment Management Corp.9,401$65.4K0.00%00.0%Unchanged
PEAK6 LLC8,095$56.3K0.00%+8,095New
Militia Capital Partners, LP7,400$51.5K0.02%+7,400New
Hollencrest Capital Management7,216$50.2K0.00%+7,150+10,833.3%Added
Ameritas Investment Partners, Inc.7,053$49.1K0.00%00.0%Unchanged
Diadema Partners LP4,710$32.8K0.04%+4,710New
TD Waterhouse Canada Inc.4,335$30.1K0.00%00.0%Unchanged
EMC Capital Management2,575$18.0K0.01%+2,575New
Amalgamated Bank2,491$17.0K0.00%00.0%Unchanged
Mirae Asset Global Investments Co., Ltd.2,444$16.7K0.00%+2,444New
Russell Investments Group, Ltd.2,166$15.1K0.00%+1,354+166.7%Added
Tower Research Capital LLC (TRC)2,150$15.0K0.00%−1,895−46.8%Reduced
Crewe Advisors LLC1,999$13.9K0.00%00.0%Unchanged
National Bank of Canada1,547$10.8K0.00%+77+5.2%Added
GF Fund Management Co. Ltd.1,540$10.7K0.00%+1,540New
CWM, LLC1,468$10.0K0.00%−37−2.5%Reduced
Bullock Wealth Management Group1,194$8.31K0.00%00.0%Unchanged
Spire Wealth Management1,040$7.24K0.00%+1,040New
Farther Finance Advisors, LLC901$6.27K0.00%−20−2.2%Reduced
Steward Partners Investment Advisory, LLC900$6.26K0.00%+400+80.0%Added
Venturi Wealth Management, LLC721$5.02K0.00%00.0%Unchanged
Nelson, Van Denburg & Campbell Wealth Management Group, LLC533$3.71K0.00%+135+33.9%Added
Northwestern Mutual Wealth Management Co468$3.26K0.00%+69+17.3%Added
R Squared Ltd450$3.13K0.00%+450New
CIBC Private Wealth Group, LLC423$2.99K0.00%00.0%Unchanged
NVWM, LLC416$2.90K0.00%00.0%Unchanged
Tortoise Investment Management, LLC400$2.78K0.00%00.0%Unchanged
Harbour Investments, Inc.356$2.48K0.00%−100−21.9%Reduced
Daiwa Securities Group Inc.242$2.00K0.00%+242New
SRS Capital Advisors, Inc.276$1.92K0.00%+248+885.7%Added
Continuum Advisory, LLC239$1.66K0.00%00.0%Unchanged
Nisa Investment Advisors, LLC204$1.42K0.00%+204New
SBI Securities Co., Ltd.196$1.36K0.00%+196New
GWM Advisors LLC148$1.03K0.00%00.0%Unchanged
GAMMA Investing LLC106$7380.00%−77−42.1%Reduced
HighMark Wealth Management LLC100$6960.00%+22+28.2%Added
Cornerstone Planning Group LLC77$5310.00%00.0%Unchanged
Sterling Capital Management LLC74$5150.00%00.0%Unchanged
Allworth Financial LP69$4840.00%+3+4.5%Added
Activest Wealth Management66$4590.00%00.0%Unchanged
Kohmann Bosshard Financial Services, LLC66$4590.00%+66New
Fifth Third Bancorp59$4110.00%00.0%Unchanged
Tradewinds Capital Management, LLC53$3690.00%00.0%Unchanged
Louisbourg Investments Inc.52$3620.00%00.0%Unchanged
Plante Moran Financial Advisors, LLC36$2510.00%00.0%Unchanged
Anfield Capital Management, LLC36$2510.00%00.0%Unchanged
TruNorth Capital Management, LLC33$2300.00%00.0%Unchanged
Chesapeake Asset Management LLC33$2290.00%00.0%Unchanged
Robbins Farley LLC28$1950.00%00.0%Unchanged
Parallel Advisors, LLC19$1320.00%−700−97.4%Reduced
IFP Advisors, Inc0$1110.00%−1,000−100.0%Reduced
EverSource Wealth Advisors, LLC13$900.00%+13New
Ameriflex Group, Inc.13$880.00%+13New
CNB Bank10$700.00%00.0%Unchanged
MAI Capital Management10$700.00%+10New
NBT Bank N A6$420.00%00.0%Unchanged
Belmont Capital, LLC6$420.00%00.0%Unchanged
Strategic Investment Solutions, Inc.6$420.00%00.0%Unchanged
Glen Eagle Advisors, LLC6$420.00%00.0%Unchanged
CoreCap Advisors, LLC5$350.00%−10−66.7%Reduced
Hexagon Capital Partners LLC4$280.00%00.0%Unchanged
Rothschild Investment LLC3$210.00%00.0%Unchanged
Signaturefd, LLC2$140.00%00.0%Unchanged
Coppell Advisory Solutions LLC1$70.00%00.0%Unchanged
Huntington National Bank1$10.00%00.0%Unchanged
TSFG, LLC24$00.00%00.0%Unchanged
Alyeska Investment Group, L.P.0$00.00%−66,694−100.0%Sold out
Balyasny Asset Management LLC0$00.00%−26,386−100.0%Sold out
GTS Securities LLC0$00.00%−21,567−100.0%Sold out
Rafferty Asset Management, LLC0$00.00%−18,658−100.0%Sold out
Sherbrooke Park Advisers LLC0$00.00%−13,827−100.0%Sold out
Change Path, LLC0$00.00%−12,462−100.0%Sold out
Voloridge Investment Management, LLC0$00.00%−11,198−100.0%Sold out
Blair William & Co0$00.00%−11,000−100.0%Sold out
Wealth Alliance0$00.00%−11,000−100.0%Sold out
Jaffetilchin Investment Partners, LLC0$00.00%−2,389−100.0%Sold out
NBC Securities, Inc.0$00.00%−600−100.0%Sold out
Albion Financial Group0$00.00%−132−100.0%Sold out
Tower View Investment Management & Research LLC0$00.00%−100−100.0%Sold out
Capital Performance Advisors LLP0$00.00%−80−100.0%Sold out
Arrow Financial Corp0$00.00%−66−100.0%Sold out
Westside Investment Management, Inc.0$00.00%−66−100.0%Sold out
True Wealth Design, LLC0$00.00%−19−100.0%Sold out
SJS Investment Consulting Inc.0$00.00%−12−100.0%Sold out
Motco0$00.00%−10−100.0%Sold out
Raymond James Financial Services Advisors, Inc.––––Not filed
PEAK6 Investments LLC––––Not filed