Definium Therapeutics, Inc.
DFTX- Exchange
- Nasdaq
- Industry
- Medicinal Chemicals & Botanical Products
- SEC CIK
- 0001813814
In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Definium Therapeutics, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 248
- +42 vs. Q4 2025
- Shares held
- 78.1M
- +12.8M (+19.6%) vs. Q4 2025
- Total value
- $1.47B
- +$600.8M (+68.7%) vs. Q4 2025
- New holders
- 69
- 82 more added
- Sold out
- 27
- 53 more reduced
3 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting DFTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 362 | $5.35B |
| Q1 2026 | 248 | $1.47B |
| Q4 2025 | 209 | $908.7M |
| Q3 2025 | 196 | $468.6M |
| Q2 2025 | 183 | $271.0M |
| Q1 2025 | 191 | $240.5M |
| Q4 2024 | 174 | $288.9M |
| Q3 2024 | 158 | $281.6M |
| Q2 2024 | 152 | $299.3M |
| Q1 2024 | 135 | $327.2M |
| Q4 2023 | 104 | $17.9M |
| Q3 2023 | 93 | $12.1M |
| Q2 2023 | 84 | $13.9M |
| Q1 2023 | 89 | $12.6M |
| Q4 2022 | 104 | $11.1M |
| Q3 2022 | 101 | $20.5M |
| Q2 2022 | 156 | $15.1M |
| Q1 2022 | 159 | $53.6M |
| Q4 2021 | 176 | $72.0M |
| Q3 2021 | 175 | $104.8M |
| Q2 2021 | 156 | $131.0M |
| Q1 2021 | 8 | $932.0K |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Definium Therapeutics, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Simplex Trading, LLC | 41,156 | $777.8K | 0.02% | −7,070−14.7% | Reduced |
| Scotia Capital Inc. | 40,548 | $766.4K | 0.00% | −9,129−18.4% | Reduced |
| Wells Fargo & Company | 39,973 | $755.5K | 0.00% | −67,084−62.7% | Reduced |
| Quantinno Capital Management LP | 39,958 | $755.2K | 0.00% | +634+1.6% | Added |
| Jennison Associates LLC | 39,957 | $755.2K | 0.00% | −13,828−25.7% | Reduced |
| Barclays PLC | 39,683 | $750.0K | 0.00% | −143,940−78.4% | Reduced |
| Palumbo Wealth Management LLC | 37,966 | $717.6K | 0.18% | −1,036−2.7% | Reduced |
| Caxton Associates LLP | 37,255 | $704.1K | 0.02% | +21,564+137.4% | Added |
| Walleye Capital LLC | 35,485 | $670.7K | 0.00% | +35,485 | New |
| Mariner, LLC | 34,851 | $658.6K | 0.00% | +14,685+72.8% | Added |
| PSP Research LLC | 34,800 | $657.7K | 0.47% | −41−0.1% | Reduced |
| Caption Management, LLC | 33,758 | $638.0K | 0.03% | +33,758 | New |
| Cetera Investment Advisers | 31,824 | $601.5K | 0.00% | +15,224+91.7% | Added |
| Rathbone Brothers plc | 30,200 | $570.8K | 0.00% | 00.0% | Unchanged |
| Engineers Gate Manager LP | 29,767 | $562.6K | 0.01% | +29,767 | New |
| New York State Common Retirement Fund | 29,600 | $559.4K | 0.00% | 00.0% | Unchanged |
| SEI Investments Co | 28,117 | $531.4K | 0.00% | +16,281+137.6% | Added |
| State of New Jersey Common Pension Fund D | 27,441 | $518.6K | 0.00% | +27,441 | New |
| Police & Firemen's Retirement System of New Jersey | 27,361 | $517.1K | 0.00% | +2,154+8.5% | Added |
| Kingswood Wealth Advisors, LLC | 26,591 | $502.6K | 0.02% | +26,591 | New |
| Citigroup Inc | 26,486 | $500.6K | 0.00% | −14,977−36.1% | Reduced |
| Manufacturers Life Insurance Company, The | 26,404 | $499.0K | 0.00% | −1,918−6.8% | Reduced |
| Bay Rivers Group | 26,346 | $497.9K | 0.21% | +10,345+64.7% | Added |
| Intech Investment Management LLC | 24,990 | $472.3K | 0.00% | −4,665−15.7% | Reduced |
| Campbell & CO Investment Adviser LLC | 24,755 | $467.9K | 0.03% | +24,755 | New |
| Raymond James Financial Inc | 23,713 | $448.2K | 0.00% | +2,592+12.3% | Added |
| BNP Paribas Arbitrage, SA | 23,356 | $441.4K | 0.00% | +973+4.3% | Added |
| Arizona State Retirement System | 22,054 | $416.8K | 0.00% | −188−0.8% | Reduced |
| Virtus Investment Advisers, Inc. | 21,727 | $410.6K | 0.11% | +529+2.5% | Added |
| Concurrent Investment Advisors, LLC | 21,285 | $402.3K | 0.00% | +888+4.4% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,868 | $394.4K | 0.00% | +5,751+38.0% | Added |
| Vanguard Investments Australia, Ltd. | 20,467 | $386.8K | 0.00% | +20,467 | New |
| China Universal Asset Management Co., Ltd. | 20,192 | $381.6K | 0.03% | +4,140+25.8% | Added |
| Marex Group plc | 20,000 | $378.0K | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 19,300 | $364.8K | 0.00% | +19,300 | New |
| ProShare Advisors LLC | 18,731 | $354.0K | 0.00% | −2,808−13.0% | Reduced |
| HighTower Advisors, LLC | 18,559 | $350.8K | 0.00% | +18,559 | New |
| Gsa Capital Partners LLP | 18,155 | $343.0K | 0.02% | −34,100−65.3% | Reduced |
| Sequoia Financial Advisors, LLC | 17,245 | $325.9K | 0.00% | +72+0.4% | Added |
| KLP Kapitalforvaltning AS | 17,000 | $321.3K | 0.00% | 00.0% | Unchanged |
| Voya Investment Management LLC | 16,384 | $309.7K | 0.00% | +392+2.5% | Added |
| Persistent Asset Partners Ltd | 15,861 | $299.8K | 0.12% | +15,861 | New |
| Virtu Financial LLC | 14,460 | $273.0K | 0.01% | +14,460 | New |
| Heritage Wealth Management, Inc. | 14,375 | $271.7K | 0.15% | +14,375 | New |
| Profund Advisors LLC | 14,196 | $268.3K | 0.01% | −7,793−35.4% | Reduced |
| Amundi | 14,136 | $267.2K | 0.00% | +14,136 | New |
| Boothbay Fund Management, LLC | 14,096 | $266.4K | 0.01% | +14,096 | New |
| Fox Run Management, L.L.C. | 14,557 | $254.7K | 0.04% | −16,151−52.6% | Reduced |
| Pictet Asset Management Holding SA | 13,295 | $251.3K | 0.00% | +13,295 | New |
| Steward Partners Investment Advisory, LLC | 13,240 | $250.2K | 0.00% | +12,240+1,224.0% | Added |
| Magnetar Financial LLC | 13,178 | $249.1K | 0.00% | +13,178 | New |
| Money Concepts Capital Corp | 13,000 | $245.7K | 0.01% | 00.0% | Unchanged |
| Summit Trail Advisors, LLC | 13,000 | $245.7K | 0.00% | +13,000 | New |
| Federation des caisses Desjardins du Quebec | 12,644 | $239.0K | 0.00% | +2,040+19.2% | Added |
| Stifel Financial Corp | 12,626 | $238.6K | 0.00% | +12,626 | New |
| Cinctive Capital Management LP | 12,551 | $237.2K | 0.02% | +12,551 | New |
| Twelve Points Wealth Management LLC | 12,245 | $231.4K | 0.05% | +1,600+15.0% | Added |
| Bank of Montreal | 12,136 | $229.4K | 0.00% | +334+2.8% | Added |
| Diversify Wealth Management, LLC | 11,000 | $225.4K | 0.00% | +1,000+10.0% | Added |
| Sanctuary Advisors, LLC | 11,466 | $216.7K | 0.00% | +749+7.0% | Added |
| Chicago Partners Investment Group LLC | 9,307 | $214.8K | 0.00% | +9,307 | New |
| RPS Advisory Solutions LLC | 11,355 | $214.6K | 0.12% | +11,355 | New |
| Dynamic Technology Lab Private Ltd | 10,880 | $205.6K | 0.03% | −12,084−52.6% | Reduced |
| Advisor Group Holdings, Inc. | 10,559 | $199.6K | 0.00% | +32+0.3% | Added |
| SG Americas Securities, LLC | 10,493 | $198.0K | 0.00% | +10,493 | New |
| Schonfeld Strategic Advisors LLC | 10,412 | $196.8K | 0.00% | −20,044−65.8% | Reduced |
| Verition Fund Management LLC | 10,384 | $196.3K | 0.00% | −121,879−92.1% | Reduced |
| Teacher Retirement System of Texas | 10,300 | $194.7K | 0.00% | −1,497−12.7% | Reduced |
| Commonwealth Equity Services, LLC | 10,251 | $193.7K | 0.00% | −3,360−24.7% | Reduced |
| CIBC World Markets Inc. | 10,049 | $189.9K | 0.00% | +10,049 | New |
| Sharpepoint LLC | 10,000 | $189.0K | 0.11% | −135−1.3% | Reduced |
| King Wealth | 10,000 | $189.0K | 0.02% | 00.0% | Unchanged |
| Swiss Life Asset Management Ltd | 17,745 | $187.0K | 0.00% | +17,745 | New |
| Ameritas Investment Partners, Inc. | 7,641 | $144.4K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 7,620 | $144.0K | 0.00% | +532+7.5% | Added |
| North Star Investment Management Corp. | 7,571 | $143.1K | 0.01% | +870+13.0% | Added |
| Hollencrest Capital Management | 7,386 | $139.6K | 0.01% | −130−1.7% | Reduced |
| Tower Research Capital LLC (TRC) | 7,305 | $138.1K | 0.00% | +2,971+68.6% | Added |
| CWM, LLC | 5,600 | $105.8K | 0.00% | +248+4.6% | Added |
| Walleye Trading LLC | 5,414 | $102.3K | 0.00% | +1,158+27.2% | Added |
| Mirae Asset Global Investments Co., Ltd. | 5,200 | $98.3K | 0.00% | +5,200 | New |
| Caitong International Asset Management Co., Ltd | 4,036 | $76.3K | 0.01% | +4,021+26,806.7% | Added |
| Sound Income Strategies, LLC | 3,690 | $76.0K | 0.00% | 00.0% | Unchanged |
| Fifth Third Bancorp | 3,300 | $62.4K | 0.00% | 00.0% | Unchanged |
| Advisory Services Network, LLC | 2,659 | $50.3K | 0.00% | +2,659 | New |
| Sterling Capital Management LLC | 2,443 | $46.2K | 0.00% | −1,472−37.6% | Reduced |
| UBS Asset Management Americas Inc | 2,413 | $45.6K | 0.00% | +1,519+169.9% | Added |
| GF Fund Management Co. Ltd. | 2,213 | $41.8K | 0.00% | +278+14.4% | Added |
| KBC Group NV | 2,172 | $41.0K | 0.00% | +2,172 | New |
| Crewe Advisors LLC | 1,999 | $37.8K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 1,802 | $37.1K | 0.00% | +270+17.6% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,812 | $34.2K | 0.00% | +433+31.4% | Added |
| National Bank of Canada | 1,708 | $32.3K | 0.00% | −159−8.5% | Reduced |
| High Note Wealth, LLC | 1,500 | $28.4K | 0.01% | 00.0% | Unchanged |
| GAMMA Investing LLC | 1,111 | $21.0K | 0.00% | +81+7.9% | Added |
| Opal Wealth Advisors, LLC | 1,101 | $20.8K | 0.00% | +1,101 | New |
| Stone House Investment Management, LLC | 1,000 | $18.9K | 0.00% | 00.0% | Unchanged |
| Bullock Wealth Management Group | 907 | $18.7K | 0.01% | −287−24.0% | Reduced |
| First Horizon Corp | 962 | $18.2K | 0.00% | +119+14.1% | Added |
| Kemnay Advisory Services Inc. | 806 | $15.2K | 0.00% | +806 | New |