Skip to main content
Livermore
Livermore
ZHEN

Definium Therapeutics, Inc.

DFTX
Exchange
Nasdaq
Industry
Medicinal Chemicals & Botanical Products
SEC CIK
0001813814

In the last 90 days, Definium Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 362 institutions reported holding it in 13F filings for Q2 2026, worth $5.35B in total; Duquesne Family Office is the only superinvestor holding it.

Q1 2026 vs. Q4 2025

How the institutions holding Definium Therapeutics, Inc. changed between Q4 2025 and Q1 2026.

All holders in Q1 2026All holders in Q4 2025

13F holders of DFTX: Q4 2025 compared with Q1 2026
MeasureQ4 2025Of which not filed for Q1 2026Q1 2026Change
Holders2093248+42
Shares67.9M2.59M78.1M+12.8M (+19.6%)
Value$908.7M$34.7M$1.47B+$600.8M (+68.7%)

3 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so the changes leave them out.

New holders (69)

Institutions that held Definium Therapeutics, Inc. at the end of Q1 2026 but not at the end of Q4 2025.

Institutions new to DFTX in Q1 2026
InstitutionSharesValue% of portfolio
ArrowMark Colorado Holdings LLC1,594,717$30.1M0.80%
Vanguard Capital Management LLC1,096,978$20.7M0.00%
Holocene Advisors, LP1,091,967$20.6M0.05%
Catalio Capital Management, LP1,037,984$19.6M4.10%
Vanguard Portfolio Management LLC872,665$16.5M0.00%
Eventide Asset Management, LLC686,162$13.0M0.21%
Vanguard Fiduciary Trust Co575,937$10.9M0.00%
Qube Research & Technologies Ltd426,055$8.05M0.01%
Tri Locum Partners LP369,588$6.99M0.98%
Sofinnova Investments, Inc.344,166$6.50M0.33%
Patient Square Capital LP331,000$6.26M1.11%
StemPoint Capital LP325,483$6.15M1.18%
BIT Capital GmbH277,511$5.24M0.29%
PFM Health Sciences, LP205,317$3.88M0.41%
Polygon Management Ltd.199,994$3.78M0.74%
HighVista Strategies LLC185,856$3.51M0.97%
Eversept Partners, LP160,723$3.04M0.20%
Neuberger Berman Group LLC133,369$2.52M0.00%
Seven Fleet Capital Management LP99,887$1.89M0.59%
Fred Alger Management, LLC92,165$1.74M0.01%
Group One Trading, L.P.87,832$1.66M0.05%
Vanguard Asset Management, Ltd54,018$1.02M0.00%
Blair William & Co53,695$1.01M0.00%
Vanguard Global Advisers, LLC48,044$908.0K0.00%
Allstate Corp45,366$857.4K0.01%
Twinbeech Capital LP42,100$795.7K0.08%
Walleye Capital LLC35,485$670.7K0.00%
Caption Management, LLC33,758$638.0K0.03%
Engineers Gate Manager LP29,767$562.6K0.01%
State of New Jersey Common Pension Fund D27,441$518.6K0.00%
Kingswood Wealth Advisors, LLC26,591$502.6K0.02%
Campbell & CO Investment Adviser LLC24,755$467.9K0.03%
Vanguard Investments Australia, Ltd.20,467$386.8K0.00%
STRS Ohio19,300$364.8K0.00%
HighTower Advisors, LLC18,559$350.8K0.00%
Persistent Asset Partners Ltd15,861$299.8K0.12%
Virtu Financial LLC14,460$273.0K0.01%
Heritage Wealth Management, Inc.14,375$271.7K0.15%
Amundi14,136$267.2K0.00%
Boothbay Fund Management, LLC14,096$266.4K0.01%
Pictet Asset Management Holding SA13,295$251.3K0.00%
Magnetar Financial LLC13,178$249.1K0.00%
Summit Trail Advisors, LLC13,000$245.7K0.00%
Stifel Financial Corp12,626$238.6K0.00%
Cinctive Capital Management LP12,551$237.2K0.02%
Chicago Partners Investment Group LLC9,307$214.8K0.00%
RPS Advisory Solutions LLC11,355$214.6K0.12%
SG Americas Securities, LLC10,493$198.0K0.00%
CIBC World Markets Inc.10,049$189.9K0.00%
Swiss Life Asset Management Ltd17,745$187.0K0.00%
Mirae Asset Global Investments Co., Ltd.5,200$98.3K0.00%
Advisory Services Network, LLC2,659$50.3K0.00%
KBC Group NV2,172$41.0K0.00%
Opal Wealth Advisors, LLC1,101$20.8K0.00%
Kemnay Advisory Services Inc.806$15.2K0.00%
Los Angeles Capital Management LLC618$11.7K0.00%
Harbour Investments, Inc.556$10.5K0.00%
Private Wealth Management Group, LLC450$8.51K0.00%
Meeder Asset Management Inc353$6.67K0.00%
Western Pacific Wealth Management, LP333$6.29K0.01%
Ancora Advisors, LLC251$4.74K0.00%
Smartleaf Asset Management LLC215$3.76K0.00%
Jones Financial Companies LLLP180$3.22K0.00%
Salem Investment Counselors Inc150$2.83K0.00%
Louisbourg Investments Inc.52$9830.00%
Anfield Capital Management, LLC36$6800.00%
RMG Wealth Management LLC30$6420.00%
Benson Wealth Management INC30$5670.00%
Vanguard National Trust Co27$5100.00%

Sold out (27)

Institutions that held Definium Therapeutics, Inc. at the end of Q4 2025 and filed for Q1 2026 without it.

Institutions that sold out of DFTX in Q1 2026
InstitutionShares, Q4 2025Value, Q4 2025
Vestal Point Capital, LP637,000$8.53M
Universal- Beteiligungs- und Servicegesellschaft mbH278,720$3.73M
Two Sigma Advisers, LP65,281$874.1K
California State Teachers Retirement System58,383$781.7K
Scientech Research LLC31,699$424.4K
Dark Forest Capital Management LP30,661$410.6K
Mercer Global Advisors Inc20,392$273.0K
EntryPoint Capital, LLC20,219$270.7K
Rafferty Asset Management, LLC18,885$252.9K
Gotham Asset Management, LLC17,825$238.7K
Caxton Corp15,688$210.1K
Fore Capital, LLC15,000$200.8K
Wealth Enhancement Advisory Services, LLC13,718$185.3K
XTX Topco Ltd10,994$147.2K
Flagship Harbor Advisors, LLC8,721$116.8K
Amalgamated Bank2,957$40.0K
Quantbot Technologies LP1,649$22.1K
Atlantic Union Bankshares Corp500$6.70K
Daiwa Securities Group Inc.242$3.00K
Reflection Asset Management66$898
Kohmann Bosshard Financial Services, LLC66$884
Tradewinds Capital Management, LLC53$710
CNB Bank10$134
SageView Advisory Group, LLC6$81
NBT Bank N A6$80
Signaturefd, LLC2$27
Navalign, LLC2$27

Not filed for Q1 2026 yet (3)

Institutions that held Definium Therapeutics, Inc. at the end of Q4 2025 and haven't filed a 13F for Q1 2026. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding DFTX in Q4 2025 that haven't filed for Q1 2026
InstitutionShares, Q4 2025Value, Q4 2025
Vanguard Group Inc2,591,901$34.7M
Global Retirement Partners, LLC566$7.58K
CIBC Private Wealth Group, LLC151$2.02K