Xenon Pharmaceuticals Inc.
XENE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001582313
In the last 90 days, Xenon Pharmaceuticals Inc. insiders filed 0 open-market purchases and 2 sales; 315 institutions reported holding it in 13F filings for Q2 2026, worth $6.10B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Xenon Pharmaceuticals Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 245
- +28 vs. Q3 2025
- Shares held
- 84.4M
- +294.5K (+0.4%) vs. Q3 2025
- Total value
- $3.78B
- +$405.9M (+12.0%) vs. Q3 2025
- New holders
- 50
- 81 more added
- Sold out
- 22
- 74 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XENE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 315 | $6.10B |
| Q1 2026 | 290 | $5.80B |
| Q4 2025 | 245 | $3.78B |
| Q3 2025 | 219 | $3.39B |
| Q2 2025 | 206 | $2.60B |
| Q1 2025 | 206 | $2.58B |
| Q4 2024 | 209 | $2.99B |
| Q3 2024 | 203 | $2.95B |
| Q2 2024 | 213 | $2.89B |
| Q1 2024 | 220 | $3.16B |
| Q4 2023 | 204 | $3.32B |
| Q3 2023 | 181 | $2.10B |
| Q2 2023 | 175 | $2.36B |
| Q1 2023 | 163 | $2.19B |
| Q4 2022 | 159 | $2.38B |
| Q3 2022 | 154 | $2.09B |
| Q2 2022 | 151 | $1.73B |
| Q1 2022 | 132 | $1.50B |
| Q4 2021 | 130 | $1.49B |
| Q3 2021 | 118 | $521.7M |
| Q2 2021 | 103 | $620.0M |
| Q1 2021 | 91 | $590.0M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Xenon Pharmaceuticals Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Dimensional Fund Advisors LP | 452,147 | $20.3M | 0.00% | −1,876−0.4% | Reduced |
| MPM Oncology Impact Management LP | 485,620 | $21.8M | 2.49% | −17,778−3.5% | Reduced |
| TimesSquare Capital Management, LLC | 532,740 | $23.9M | 0.36% | −24,060−4.3% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 542,020 | $24.3M | 0.31% | 00.0% | Unchanged |
| T. Rowe Price Investment Management, Inc. | 547,613 | $24.5M | 0.02% | −51,500−8.6% | Reduced |
| Caligan Partners LP | 549,665 | $24.6M | 2.26% | +105,100+23.6% | Added |
| Trails Edge Capital Partners, LP | 597,092 | $26.8M | 6.61% | +597,092 | New |
| Vestal Point Capital, LP | 600,000 | $26.9M | 0.99% | −500,000−45.5% | Reduced |
| Barclays PLC | 600,964 | $26.9M | 0.01% | +489,664+439.9% | Added |
| Loomis Sayles & Co L P | 612,032 | $27.4M | 0.03% | −28,594−4.5% | Reduced |
| Pictet Asset Management Holding SA | 625,985 | $28.0M | 0.03% | −636,594−50.4% | Reduced |
| Millennium Management LLC | 635,056 | $28.5M | 0.02% | −748,951−54.1% | Reduced |
| Capital World Investors | 655,737 | $29.4M | 0.00% | 00.0% | Unchanged |
| Vanguard Group Inc | 664,641 | $29.8M | 0.00% | −186,745−21.9% | Reduced |
| Federated Hermes, Inc. | 672,237 | $30.1M | 0.05% | +439,737+189.1% | Added |
| American Century Companies Inc | 680,473 | $30.5M | 0.02% | +21,216+3.2% | Added |
| Adage Capital Partners GP, L.L.C. | 685,100 | $30.7M | 0.05% | −150,000−18.0% | Reduced |
| Fiera Capital Corp | 686,056 | $30.7M | 0.10% | +166,057+31.9% | Added |
| Goldman Sachs Group Inc | 696,047 | $31.2M | 0.00% | −24,612−3.4% | Reduced |
| Standard Life Aberdeen plc | 750,291 | $33.6M | 0.05% | +171,146+29.6% | Added |
| Franklin Resources Inc | 758,059 | $34.0M | 0.01% | +62,159+8.9% | Added |
| Rock Springs Capital Management LP | 787,788 | $35.3M | 1.81% | −63,956−7.5% | Reduced |
| First Turn Management, LLC | 799,743 | $35.8M | 4.10% | 00.0% | Unchanged |
| Siren, L.L.C. | 812,761 | $36.4M | 1.09% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 862,300 | $38.6M | 0.00% | +820,608+1,968.3% | Added |
| Geode Capital Management, LLC | 952,679 | $42.7M | 0.00% | −24,756−2.5% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,060,221 | $47.5M | 0.05% | +389,964+58.2% | Added |
| Westfield Capital Management Co LP | 1,226,771 | $55.0M | 0.23% | +20,705+1.7% | Added |
| Affinity Asset Advisors, LLC | 1,250,000 | $56.0M | 4.03% | −150,000−10.7% | Reduced |
| Holocene Advisors, LP | 1,282,081 | $57.5M | 0.12% | −694,472−35.1% | Reduced |
| Jennison Associates LLC | 1,292,055 | $57.9M | 0.03% | +156,820+13.8% | Added |
| Citadel Advisors LLC | 1,321,213 | $59.2M | 0.04% | +362,115+37.8% | Added |
| State Street Corp | 1,492,550 | $66.9M | 0.00% | +26,083+1.8% | Added |
| JPMorgan Chase & Co | 1,494,032 | $67.0M | 0.00% | +94,999+6.8% | Added |
| Alliancebernstein L.P. | 1,593,814 | $71.4M | 0.02% | −60,603−3.7% | Reduced |
| Commodore Capital LP | 1,800,000 | $80.7M | 5.37% | −900,000−33.3% | Reduced |
| Braidwell LP | 1,825,076 | $81.8M | 2.62% | −1,779,953−49.4% | Reduced |
| Polar Capital Holdings Plc | 2,465,694 | $110.5M | 0.51% | −81,072−3.2% | Reduced |
| Capital International Investors | 3,414,959 | $153.1M | 0.02% | +233,466+7.3% | Added |
| Janus Henderson Group PLC | 4,084,034 | $183.1M | 0.08% | +140,149+3.6% | Added |
| Driehaus Capital Management LLC | 4,538,691 | $203.4M | 1.38% | +369,577+8.9% | Added |
| Wellington Management Group LLP | 4,764,779 | $213.6M | 0.04% | +1,154,922+32.0% | Added |
| BlackRock, Inc. | 5,100,284 | $228.6M | 0.00% | +329,333+6.9% | Added |
| Avoro Capital Advisors LLC | 5,424,444 | $243.1M | 2.39% | +24,444+0.5% | Added |
| FMR LLC | 8,920,250 | $399.8M | 0.02% | +1,3430.0% | Added |
| Saturn V Capital Management LLC | 0 | $0 | 0.00% | −503,701−100.0% | Sold out |
| Tri Locum Partners LP | 0 | $0 | 0.00% | −366,102−100.0% | Sold out |
| Great Point Partners LLC | 0 | $0 | 0.00% | −200,000−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −89,879−100.0% | Sold out |
| HighVista Strategies LLC | 0 | $0 | 0.00% | −82,190−100.0% | Sold out |
| Avidity Partners Management LP | 0 | $0 | 0.00% | −53,400−100.0% | Sold out |
| NJ State Employees Deferred Compensation Plan | 0 | $0 | 0.00% | −25,000−100.0% | Sold out |
| Sanders Morris Harris LLC | 0 | $0 | 0.00% | −21,500−100.0% | Sold out |
| Natixis Advisors, L.P. | 0 | $0 | 0.00% | −17,564−100.0% | Sold out |
| CenterBook Partners LP | 0 | $0 | 0.00% | −14,770−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −12,652−100.0% | Sold out |
| DRW Securities, LLC | 0 | $0 | 0.00% | −9,273−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −8,850−100.0% | Sold out |
| Freestone Grove Partners LP | 0 | $0 | 0.00% | −6,748−100.0% | Sold out |
| Inceptionr LLC | 0 | $0 | 0.00% | −6,322−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −5,200−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −3,556−100.0% | Sold out |
| Quarry LP | 0 | $0 | 0.00% | −2,500−100.0% | Sold out |
| United Community Bank | 0 | $0 | 0.00% | −200−100.0% | Sold out |
| Principal Securities, Inc. | 0 | $0 | 0.00% | −68−100.0% | Sold out |
| American National Bank | 0 | $0 | 0.00% | −5−100.0% | Sold out |
| Tortoise Investment Management, LLC | 0 | $0 | 0.00% | −2−100.0% | Sold out |
| AXA Investment Managers S.A. | – | – | – | – | Not filed |
| CIBC Bancorp USA Inc. | – | – | – | – | Not filed |