Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Tyra Biosciences, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 164
- +32 vs. Q4 2025
- Shares held
- 65.9M
- +10.7M (+19.3%) vs. Q4 2025
- Total value
- $2.52B
- +$1.07B (+73.8%) vs. Q4 2025
- New holders
- 46
- 59 more added
- Sold out
- 14
- 35 more reduced
1 institution that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.52B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $778.4M |
| Q2 2025 | 121 | $541.5M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $748.6M |
| Q1 2024 | 77 | $768.4M |
| Q4 2023 | 62 | $495.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $573.0M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $313.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $494.2M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Vestal Point Capital, LP | 54,000 | $2.07M | 0.06% | −2,371,000−97.8% | Reduced |
| JPMorgan Chase & Co | 66,789 | $2.31M | 0.00% | −4,386−6.2% | Reduced |
| UBS Group AG | 61,561 | $2.36M | 0.00% | +2,705+4.6% | Added |
| Catalio Capital Management, LP | 67,285 | $2.58M | 0.54% | +67,285 | New |
| Russell Investments Group, Ltd. | 70,422 | $2.70M | 0.00% | +57,426+441.9% | Added |
| Bank of New York Mellon Corp | 72,213 | $2.77M | 0.00% | +11,312+18.6% | Added |
| Ensign Peak Advisors, Inc | 74,064 | $2.84M | 0.01% | +74,064 | New |
| Kalehua Capital Management LLC | 74,465 | $2.85M | 2.02% | 00.0% | Unchanged |
| Wellington Management Group LLP | 77,169 | $2.96M | 0.00% | −27,136−26.0% | Reduced |
| Cinctive Capital Management LP | 78,018 | $2.99M | 0.20% | +78,018 | New |
| Schonfeld Strategic Advisors LLC | 79,592 | $3.05M | 0.02% | +79,592 | New |
| XTX Topco Ltd | 83,896 | $3.21M | 0.06% | +53,482+175.8% | Added |
| Oppenheimer & Co Inc | 84,192 | $3.22M | 0.04% | −534−0.6% | Reduced |
| Dimensional Fund Advisors LP | 91,826 | $3.52M | 0.00% | −3,814−4.0% | Reduced |
| Two Sigma Investments, LP | 101,618 | $3.89M | 0.00% | −5,405−5.1% | Reduced |
| Invesco Ltd. | 109,052 | $4.18M | 0.00% | −20,383−15.7% | Reduced |
| Morgan Stanley | 120,485 | $4.61M | 0.00% | +1,587+1.3% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 128,860 | $4.94M | 0.01% | −919−0.7% | Reduced |
| HighVista Strategies LLC | 131,304 | $5.03M | 1.39% | +96,218+274.2% | Added |
| Ameriprise Financial Inc | 144,900 | $5.55M | 0.00% | +90,275+165.3% | Added |
| Trexquant Investment LP | 147,317 | $5.64M | 0.04% | +147,317 | New |
| Vanguard Fiduciary Trust Co | 157,791 | $6.04M | 0.00% | +157,791 | New |
| Jacobs Levy Equity Management, Inc | 162,204 | $6.21M | 0.03% | +32,451+25.0% | Added |
| Algert Global LLC | 188,010 | $7.20M | 0.11% | +141,140+301.1% | Added |
| BNP Paribas Arbitrage, SA | 190,039 | $7.28M | 0.00% | +69,761+58.0% | Added |
| StemPoint Capital LP | 193,177 | $7.40M | 1.42% | +193,177 | New |
| Marshall Wace, LLP | 197,748 | $7.57M | 0.01% | −514,143−72.2% | Reduced |
| Seven Fleet Capital Management LP | 198,585 | $7.61M | 2.39% | +119,025+149.6% | Added |
| Charles Schwab Investment Management Inc | 199,111 | $7.63M | 0.00% | −315−0.2% | Reduced |
| Sofinnova Investments, Inc. | 204,015 | $7.81M | 0.39% | +204,015 | New |
| Bank of America Corp | 209,922 | $8.04M | 0.00% | +171,612+448.0% | Added |
| Northern Trust Corp | 218,508 | $8.37M | 0.00% | +17,552+8.7% | Added |
| Millennium Management LLC | 221,581 | $8.49M | 0.01% | +107,193+93.7% | Added |
| Raymond James Financial Inc | 247,098 | $9.46M | 0.00% | +77,066+45.3% | Added |
| Vanguard Portfolio Management LLC | 247,270 | $9.47M | 0.00% | +247,270 | New |
| Affinity Asset Advisors, LLC | 257,512 | $9.86M | 0.58% | +257,512 | New |
| Boothbay Fund Management, LLC | 273,274 | $10.5M | 0.25% | +52,097+23.6% | Added |
| Woodline Partners LP | 301,040 | $11.5M | 0.04% | +301,040 | New |
| Elmind Capital, LP | 350,000 | $13.4M | 3.81% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 351,479 | $13.5M | 0.03% | −466,847−57.0% | Reduced |
| Deerfield Management Company, L.P. (Series C) | 549,000 | $21.0M | 0.25% | +549,000 | New |
| Goldman Sachs Group Inc | 550,334 | $21.1M | 0.00% | +367,947+201.7% | Added |
| Sio Capital Management, LLC | 605,439 | $23.2M | 3.34% | +79,437+15.1% | Added |
| Jennison Associates LLC | 632,432 | $24.2M | 0.02% | +632,432 | New |
| Geode Capital Management, LLC | 658,482 | $25.2M | 0.00% | +726+0.1% | Added |
| Canaan Partners XI LLC | 750,000 | $28.7M | 37.76% | −2,624,329−77.8% | Reduced |
| Barclays PLC | 833,399 | $31.9M | 0.01% | +757,090+992.1% | Added |
| Logos Global Management LP | 850,000 | $32.6M | 1.68% | +640,000+304.8% | Added |
| Price T Rowe Associates Inc | 986,061 | $37.8M | 0.00% | +971,629+6,732.5% | Added |
| 5AM Venture Management, LLC | 1,029,298 | $39.4M | 10.94% | 00.0% | Unchanged |
| Vanguard Capital Management LLC | 1,125,970 | $43.1M | 0.00% | +1,125,970 | New |
| State Street Corp | 1,216,078 | $46.6M | 0.00% | +466,615+62.3% | Added |
| Caligan Partners LP | 1,276,968 | $48.9M | 3.46% | +332,711+35.2% | Added |
| BVF Inc | 1,976,196 | $75.7M | 2.41% | −151,469−7.1% | Reduced |
| Paradigm Biocapital Advisors LP | 2,054,991 | $78.7M | 1.61% | +2,054,991 | New |
| BlackRock, Inc. | 2,217,929 | $84.9M | 0.00% | +131,506+6.3% | Added |
| Commodore Capital LP | 2,475,000 | $94.8M | 5.48% | −900,000−26.7% | Reduced |
| TCG Crossover Management, LLC | 3,248,980 | $124.4M | 3.56% | +350,877+12.1% | Added |
| Farallon Capital Management, L.L.C. | 3,580,818 | $137.1M | 0.81% | +1,514,000+73.3% | Added |
| Alta Partners Management Company, L.P. | 3,823,425 | $146.4M | 96.97% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 3,890,589 | $148.9M | 0.07% | +955,147+32.5% | Added |
| Nextech Invest, Ltd. | 4,055,861 | $155.3M | 10.93% | 00.0% | Unchanged |
| FMR LLC | 7,747,648 | $296.7M | 0.02% | +7,735,085+61,570.4% | Added |
| Ra Capital Management, L.P. | 12,198,625 | $467.2M | 4.95% | 00.0% | Unchanged |
| Kynam Capital Management, LP | 0 | $0 | 0.00% | −1,564,492−100.0% | Sold out |
| Trails Edge Capital Partners, LP | 0 | $0 | 0.00% | −700,000−100.0% | Sold out |
| Boone Capital Management LLC | 0 | $0 | 0.00% | −398,482−100.0% | Sold out |
| Investment Counsel Co of Nevada | 0 | $0 | 0.00% | −85,020−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −58,900−100.0% | Sold out |
| Superstring Capital Management LP | 0 | $0 | 0.00% | −58,677−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −45,942−100.0% | Sold out |
| Bank of Nova Scotia | 0 | $0 | 0.00% | −11,100−100.0% | Sold out |
| VARCOV Co. | 0 | $0 | 0.00% | −9,708−100.0% | Sold out |
| Bellevue Group AG | 0 | $0 | 0.00% | −3,143−100.0% | Sold out |
| Quest Partners LLC | 0 | $0 | 0.00% | −2,139−100.0% | Sold out |
| Amalgamated Bank | 0 | $0 | 0.00% | −814−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −173−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −3−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |