Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Spyre Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 265
- +69 vs. Q1 2026
- Shares held
- 95.8M
- +14.8M (+18.3%) vs. Q1 2026
- Total value
- $8.52B
- +$4.44B (+108.8%) vs. Q1 2026
- New holders
- 91
- 105 more added
- Sold out
- 22
- 55 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 147,000 | $13.1M | 0.45% | +147,000 | New |
| Balyasny Asset Management LLC | 147,042 | $13.1M | 0.02% | +91,565+165.1% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 172,923 | $15.4M | 0.02% | +2,542+1.5% | Added |
| Deutsche Bank AG | 174,459 | $15.5M | 0.00% | +45,217+35.0% | Added |
| Neuberger Berman Group LLC | 180,884 | $16.1M | 0.01% | +180,884 | New |
| Nuveen, LLC | 181,105 | $16.1M | 0.00% | +27,206+17.7% | Added |
| Frontier Capital Management Co LLC | 182,931 | $16.2M | 0.15% | +182,931 | New |
| OrbiMed Advisors LLC | 186,145 | $16.5M | 0.31% | +186,145 | New |
| Millennium Management LLC | 196,712 | $17.5M | 0.01% | +50,073+34.1% | Added |
| Eventide Asset Management, LLC | 201,616 | $17.9M | 0.24% | +201,616 | New |
| Seven Grand Managers, LLC | 225,000 | $20.0M | 0.80% | +125,000+125.0% | Added |
| Cormorant Asset Management, LP | 225,000 | $20.0M | 1.02% | +225,000 | New |
| Bellevue Group AG | 229,931 | $20.4M | 0.43% | +229,931 | New |
| Bank of New York Mellon Corp | 245,193 | $21.8M | 0.00% | +53,798+28.1% | Added |
| BNP Paribas Arbitrage, SA | 259,923 | $23.1M | 0.01% | +241,293+1,295.2% | Added |
| ADAR1 Capital Management, LLC | 283,982 | $25.2M | 1.19% | −54,341−16.1% | Reduced |
| Jennison Associates LLC | 303,180 | $26.9M | 0.02% | +303,180 | New |
| Woodline Partners LP | 306,049 | $27.2M | 0.08% | +40,157+15.1% | Added |
| Integral Health Asset Management, LLC | 325,000 | $28.9M | 1.18% | +325,000 | New |
| Ameriprise Financial Inc | 356,082 | $31.6M | 0.01% | +196,865+123.6% | Added |
| Samlyn Capital, LLC | 400,075 | $35.5M | 0.59% | +3,414+0.9% | Added |
| Emerald Mutual Fund Advisers Trust | 401,271 | $35.6M | 1.25% | −6,842−1.7% | Reduced |
| Voya Investment Management LLC | 431,694 | $38.3M | 0.03% | +377,724+699.9% | Added |
| Morgan Stanley | 499,963 | $44.4M | 0.00% | +253,244+102.6% | Added |
| UBS Asset Management Americas Inc | 522,071 | $46.3M | 0.01% | +314,757+151.8% | Added |
| Candriam Luxembourg S.C.A. | 546,312 | $48.5M | 0.22% | −63,970−10.5% | Reduced |
| Vanguard Fiduciary Trust Co | 551,389 | $49.0M | 0.01% | +86,738+18.7% | Added |
| Victory Capital Management Inc | 553,980 | $49.2M | 0.03% | +261,854+89.6% | Added |
| Emerald Advisers, LLC | 567,430 | $50.4M | 1.19% | −45,935−7.5% | Reduced |
| Pictet Asset Management Holding SA | 628,138 | $55.8M | 0.05% | +136,489+27.8% | Added |
| Charles Schwab Investment Management Inc | 652,958 | $58.0M | 0.01% | +90,305+16.0% | Added |
| Northern Trust Corp | 674,529 | $59.9M | 0.01% | +95,622+16.5% | Added |
| UBS Group AG | 843,071 | $74.8M | 0.01% | +171,836+25.6% | Added |
| Commodore Capital LP | 846,786 | $75.2M | 4.48% | −1,065,594−55.7% | Reduced |
| Braidwell LP | 879,467 | $78.1M | 2.89% | −53,356−5.7% | Reduced |
| Capital International Investors | 955,196 | $84.8M | 0.02% | −790,933−45.3% | Reduced |
| Siren, L.L.C. | 968,598 | $86.0M | 1.75% | +150,000+18.3% | Added |
| Polar Capital Holdings Plc | 988,009 | $87.7M | 0.25% | +195,162+24.6% | Added |
| Marshall Wace, LLP | 991,693 | $88.0M | 0.07% | +852,434+612.1% | Added |
| Holocene Advisors, LP | 1,015,170 | $90.1M | 0.21% | +1,015,170 | New |
| JPMorgan Chase & Co | 1,093,026 | $98.9M | 0.01% | +113,727+11.6% | Added |
| Affinity Asset Advisors, LLC | 1,279,134 | $113.6M | 5.55% | 00.0% | Unchanged |
| Remedium Capital Partners, LLC | 1,464,169 | $130.0M | 28.78% | +7,938+0.5% | Added |
| Franklin Resources Inc | 1,472,943 | $130.8M | 0.03% | +590,110+66.8% | Added |
| Goldman Sachs Group Inc | 1,478,059 | $131.2M | 0.01% | +1,208,121+447.6% | Added |
| Wellington Management Group LLP | 1,581,505 | $140.4M | 0.02% | −243,306−13.3% | Reduced |
| Adage Capital Partners GP, L.L.C. | 1,722,300 | $152.9M | 0.21% | +1,722,300 | New |
| Bank of America Corp | 1,777,854 | $157.8M | 0.01% | +549,761+44.8% | Added |
| Tang Capital Management LLC | 1,892,200 | $168.0M | 7.63% | 00.0% | Unchanged |
| TCG Crossover Management, LLC | 1,900,582 | $168.7M | 4.06% | 00.0% | Unchanged |
| Jupiter Topco LLC | 2,206,936 | $195.9M | 0.08% | +2,206,936 | New |
| Capital World Investors | 2,315,553 | $205.6M | 0.02% | +1,648,989+247.4% | Added |
| Vanguard Portfolio Management LLC | 2,330,098 | $206.9M | 0.01% | +1,744,968+298.2% | Added |
| Geode Capital Management, LLC | 2,562,265 | $239.3M | 0.01% | +841,353+48.9% | Added |
| Driehaus Capital Management LLC | 2,799,166 | $248.5M | 1.44% | +8,381+0.3% | Added |
| Price T Rowe Associates Inc | 2,960,855 | $262.9M | 0.03% | +1,362,125+85.2% | Added |
| VR Adviser, LLC | 2,985,448 | $265.0M | 8.04% | −700,000−19.0% | Reduced |
| State Street Corp | 3,057,416 | $271.4M | 0.01% | +450,385+17.3% | Added |
| Vanguard Capital Management LLC | 3,448,681 | $306.2M | 0.01% | +391,280+12.8% | Added |
| Paradigm Biocapital Advisors LP | 3,840,778 | $341.0M | 6.38% | +1,883,512+96.2% | Added |
| RTW Investments, LP | 4,251,996 | $377.5M | 3.22% | +80,000+1.9% | Added |
| Perceptive Advisors LLC | 4,319,496 | $383.5M | 5.95% | +536,271+14.2% | Added |
| BlackRock, Inc. | 6,506,605 | $577.7M | 0.01% | +985,384+17.8% | Added |
| FMR LLC | 13,026,187 | $1.16B | 0.05% | +1,245,163+10.6% | Added |
| ABS Investment Management LLC | 89 | – | – | +89 | New |
| Massmutual Trust Co FSB | 0 | $0 | 0.00% | −3−100.0% | Sold out |
| Fairmount Funds Management LLC | 0 | $0 | 0.00% | −4,018,101−100.0% | Sold out |
| Ra Capital Management, L.P. | 0 | $0 | 0.00% | −1,621,620−100.0% | Sold out |
| Baker Bros. Advisors LP | 0 | $0 | 0.00% | −1,000,000−100.0% | Sold out |
| Caligan Partners LP | 0 | $0 | 0.00% | −878,127−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −87,065−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −63,939−100.0% | Sold out |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −18,647−100.0% | Sold out |
| Carlyle Group Inc. | 0 | $0 | 0.00% | −9,620−100.0% | Sold out |
| RWC Asset Management LLP | 0 | $0 | 0.00% | −8,166−100.0% | Sold out |
| Capstone Investment Advisors, LLC | 0 | $0 | 0.00% | −7,537−100.0% | Sold out |
| Scientech Research LLC | 0 | $0 | 0.00% | −7,088−100.0% | Sold out |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | $0 | 0.00% | −6,140−100.0% | Sold out |
| DeepCurrents Investment Group LLC | 0 | $0 | 0.00% | −4,740−100.0% | Sold out |
| ABS Direct Equity Fund LLC | 0 | $0 | 0.00% | −2,800−100.0% | Sold out |
| Patient Square Capital LP | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −901−100.0% | Sold out |
| Clear Street Markets LLC | 0 | $0 | 0.00% | −562−100.0% | Sold out |
| Delos Wealth Advisors, LLC | 0 | $0 | 0.00% | −250−100.0% | Sold out |
| Quadrant Capital Group LLC | 0 | $0 | 0.00% | −146−100.0% | Sold out |
| MAI Capital Management | 0 | $0 | 0.00% | −13−100.0% | Sold out |
| Twin Peaks Wealth Advisors, LLC | 0 | $0 | 0.00% | −3−100.0% | Sold out |
| Janus Henderson Group PLC | – | – | – | – | Not filed |
| CWM, LLC | – | – | – | – | Not filed |