Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Spyre Therapeutics, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 198
- +47 vs. Q4 2025
- Shares held
- 82.7M
- +5.74M (+7.5%) vs. Q4 2025
- Total value
- $4.16B
- +$1.64B (+65.2%) vs. Q4 2025
- New holders
- 58
- 67 more added
- Sold out
- 11
- 49 more reduced
2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Warren Averett Asset Management, LLC | 25,966 | $1.31M | 0.01% | +120.0% | Added |
| Profund Advisors LLC | 26,043 | $1.31M | 0.05% | +5,450+26.5% | Added |
| State of Wisconsin Investment Board | 26,523 | $1.34M | 0.00% | −729−2.7% | Reduced |
| Cinctive Capital Management LP | 27,430 | $1.38M | 0.09% | −8,505−23.7% | Reduced |
| Virginia Retirement Systems Et Al | 27,550 | $1.39M | 0.01% | +2,600+10.4% | Added |
| Susquehanna International Group, LLP | 28,962 | $1.46M | 0.00% | +22,851+373.9% | Added |
| Vanguard Global Advisers, LLC | 31,141 | $1.57M | 0.00% | +31,141 | New |
| Wells Fargo & Company | 33,208 | $1.68M | 0.00% | −49,208−59.7% | Reduced |
| Vanguard Asset Management, Ltd | 33,232 | $1.68M | 0.00% | +33,232 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 36,323 | $1.81M | 0.00% | +1,179+3.4% | Added |
| MetLife Investment Management | 38,407 | $1.94M | 0.01% | +396+1.0% | Added |
| Legal & General Group Plc | 44,792 | $2.26M | 0.00% | −11,656−20.6% | Reduced |
| Barclays PLC | 45,786 | $2.31M | 0.00% | −136,738−74.9% | Reduced |
| Alliancebernstein L.P. | 70,900 | $2.32M | 0.00% | +3,400+5.0% | Added |
| Dimensional Fund Advisors LP | 47,697 | $2.41M | 0.00% | −29,593−38.3% | Reduced |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $2.68M | 0.04% | 00.0% | Unchanged |
| Voya Investment Management LLC | 53,970 | $2.72M | 0.00% | +26,693+97.9% | Added |
| Balyasny Asset Management LLC | 55,477 | $2.80M | 0.01% | −17,988−24.5% | Reduced |
| Rafferty Asset Management, LLC | 56,920 | $2.87M | 0.01% | +3,510+6.6% | Added |
| Schroder Investment Management Group | 63,684 | $2.89M | 0.00% | +2,110+3.4% | Added |
| California State Teachers Retirement System | 59,242 | $2.99M | 0.00% | +11,204+23.3% | Added |
| Fred Alger Management, LLC | 59,453 | $3.00M | 0.01% | +59,453 | New |
| Prudential Financial Inc | 59,555 | $3.00M | 0.00% | +59,555 | New |
| Alps Advisors Inc | 63,939 | $3.23M | 0.02% | +231+0.4% | Added |
| Rockefeller Capital Management L.P. | 64,002 | $3.23M | 0.01% | +63,453+11,557.9% | Added |
| HealthInvest Partners AB | 62,735 | $3.49M | 1.13% | +62,735 | New |
| Mercer Global Advisors Inc | 71,091 | $3.59M | 0.01% | −35,225−33.1% | Reduced |
| Rhumbline Advisers | 85,121 | $4.29M | 0.00% | +2,165+2.6% | Added |
| ExodusPoint Capital Management, LP | 87,065 | $4.39M | 0.04% | +49,194+129.9% | Added |
| Swiss National Bank | 96,500 | $4.87M | 0.00% | 00.0% | Unchanged |
| F/M Investments LLC | 99,460 | $5.02M | 0.33% | −4,258−4.1% | Reduced |
| Seven Grand Managers, LLC | 100,000 | $5.04M | 0.34% | 00.0% | Unchanged |
| B Group, Inc. | 100,000 | $5.04M | 3.74% | 00.0% | Unchanged |
| Citadel Advisors LLC | 108,135 | $5.45M | 0.00% | +44,231+69.2% | Added |
| Manufacturers Life Insurance Company, The | 112,841 | $5.69M | 0.00% | −16,172−12.5% | Reduced |
| Armistice Capital, LLC | 120,931 | $6.10M | 0.20% | −75,495−38.4% | Reduced |
| Deutsche Bank AG | 129,242 | $6.52M | 0.00% | +7,301+6.0% | Added |
| Invesco Ltd. | 132,390 | $6.68M | 0.00% | −18,544−12.3% | Reduced |
| TD Asset Management Inc | 137,390 | $6.93M | 0.01% | −12,432−8.3% | Reduced |
| Marshall Wace, LLP | 139,259 | $7.02M | 0.01% | +139,259 | New |
| HighVista Strategies LLC | 146,264 | $7.38M | 2.04% | −41,942−22.3% | Reduced |
| Millennium Management LLC | 146,639 | $7.40M | 0.01% | +70,445+92.5% | Added |
| Ensign Peak Advisors, Inc | 148,537 | $7.49M | 0.01% | +148,537 | New |
| Nuveen, LLC | 153,899 | $7.76M | 0.00% | +2,919+1.9% | Added |
| Ameriprise Financial Inc | 159,217 | $8.03M | 0.00% | +120,961+316.2% | Added |
| StemPoint Capital LP | 167,606 | $8.45M | 1.62% | +135,229+417.7% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 170,381 | $8.59M | 0.01% | −830−0.5% | Reduced |
| First Trust Advisors LP | 178,389 | $9.00M | 0.01% | +178,389 | New |
| Silverarc Capital Management, LLC | 186,618 | $9.41M | 1.11% | −1,119−0.6% | Reduced |
| Bank of New York Mellon Corp | 191,395 | $9.65M | 0.00% | −1,435−0.7% | Reduced |
| Boothbay Fund Management, LLC | 193,031 | $9.74M | 0.23% | +193,031 | New |
| UBS Asset Management Americas Inc | 207,314 | $10.5M | 0.00% | +145,098+233.2% | Added |
| Morgan Stanley | 246,719 | $12.4M | 0.00% | +63,985+35.0% | Added |
| Woodline Partners LP | 265,892 | $13.4M | 0.05% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 269,938 | $13.6M | 0.00% | −5,127−1.9% | Reduced |
| Victory Capital Management Inc | 292,126 | $14.7M | 0.01% | +146,047+100.0% | Added |
| Blackstone Group Inc. | 292,847 | $14.8M | 0.06% | −208,151−41.5% | Reduced |
| ADAR1 Capital Management, LLC | 338,323 | $17.1M | 1.03% | +304,272+893.6% | Added |
| Samlyn Capital, LLC | 396,661 | $20.0M | 0.34% | +396,661 | New |
| Emerald Mutual Fund Advisers Trust | 408,113 | $20.6M | 1.00% | −4,258−1.0% | Reduced |
| Vanguard Fiduciary Trust Co | 464,651 | $23.4M | 0.01% | +464,651 | New |
| Pictet Asset Management Holding SA | 491,649 | $24.8M | 0.03% | −422,311−46.2% | Reduced |
| Charles Schwab Investment Management Inc | 562,653 | $28.4M | 0.00% | −11,969−2.1% | Reduced |
| Northern Trust Corp | 578,907 | $29.2M | 0.00% | +17,884+3.2% | Added |
| Vanguard Portfolio Management LLC | 585,130 | $29.5M | 0.00% | +585,130 | New |
| Candriam Luxembourg S.C.A. | 610,282 | $30.8M | 0.16% | +184,748+43.4% | Added |
| Emerald Advisers, LLC | 613,365 | $30.9M | 0.98% | −22,744−3.6% | Reduced |
| Capital World Investors | 666,564 | $33.6M | 0.00% | +466,392+233.0% | Added |
| UBS Group AG | 671,235 | $33.9M | 0.01% | −9,331−1.4% | Reduced |
| Polar Capital Holdings Plc | 792,847 | $40.0M | 0.17% | +52,521+7.1% | Added |
| Siren, L.L.C. | 818,598 | $41.3M | 1.14% | 00.0% | Unchanged |
| Caligan Partners LP | 878,127 | $44.3M | 3.13% | +878,127 | New |
| JPMorgan Chase & Co | 979,299 | $44.5M | 0.00% | +916,348+1,455.7% | Added |
| Franklin Resources Inc | 882,833 | $44.5M | 0.01% | −226,441−20.4% | Reduced |
| Braidwell LP | 932,823 | $47.1M | 1.57% | −701,792−42.9% | Reduced |
| Baker Bros. Advisors LP | 1,000,000 | $50.4M | 0.29% | 00.0% | Unchanged |
| Bank of America Corp | 1,228,093 | $61.9M | 0.00% | +808,366+192.6% | Added |
| Affinity Asset Advisors, LLC | 1,279,134 | $64.5M | 3.78% | −153,457−10.7% | Reduced |
| Remedium Capital Partners, LLC | 1,456,231 | $73.5M | 26.13% | 00.0% | Unchanged |
| Price T Rowe Associates Inc | 1,598,730 | $80.6M | 0.01% | −3,152−0.2% | Reduced |
| Ra Capital Management, L.P. | 1,621,620 | $81.8M | 0.87% | 00.0% | Unchanged |
| Janus Henderson Group PLC | 1,656,164 | $83.6M | 0.04% | −172,845−9.5% | Reduced |
| Geode Capital Management, LLC | 1,720,912 | $86.8M | 0.01% | +61,772+3.7% | Added |
| Capital International Investors | 1,746,129 | $88.1M | 0.02% | −1,746,412−50.0% | Reduced |
| Wellington Management Group LLP | 1,824,811 | $92.0M | 0.02% | +275,527+17.8% | Added |
| Tang Capital Management LLC | 1,892,200 | $95.4M | 4.85% | 00.0% | Unchanged |
| TCG Crossover Management, LLC | 1,900,582 | $95.9M | 2.74% | 00.0% | Unchanged |
| Commodore Capital LP | 1,912,380 | $96.5M | 5.58% | −475,865−19.9% | Reduced |
| Paradigm Biocapital Advisors LP | 1,957,266 | $98.7M | 2.02% | +490,000+33.4% | Added |
| State Street Corp | 2,607,031 | $131.5M | 0.00% | +344,192+15.2% | Added |
| Driehaus Capital Management LLC | 2,790,785 | $140.8M | 1.03% | −91,635−3.2% | Reduced |
| Vanguard Capital Management LLC | 3,057,401 | $154.2M | 0.00% | +3,057,401 | New |
| VR Adviser, LLC | 3,685,448 | $185.9M | 6.94% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 3,783,225 | $190.8M | 3.77% | +714,000+23.3% | Added |
| Fairmount Funds Management LLC | 4,018,101 | $202.7M | 14.64% | 00.0% | Unchanged |
| RTW Investments, LP | 4,171,996 | $210.4M | 2.09% | 00.0% | Unchanged |
| BlackRock, Inc. | 5,521,221 | $278.5M | 0.00% | −8800.0% | Reduced |
| FMR LLC | 11,781,024 | $594.2M | 0.03% | +142,205+1.2% | Added |
| Deerfield Management Company, L.P. (Series C) | 0 | $0 | 0.00% | −710,626−100.0% | Sold out |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −662,351−100.0% | Sold out |