Spyre Therapeutics, Inc.
SYRE- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001636282
In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Spyre Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 153
- +16 vs. Q3 2025
- Shares held
- 81.0M
- +16.7M (+25.9%) vs. Q3 2025
- Total value
- $2.65B
- +$1.57B (+146.2%) vs. Q3 2025
- New holders
- 30
- 76 more added
- Sold out
- 14
- 27 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SYRE on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 265 | $8.52B |
| Q1 2026 | 198 | $4.16B |
| Q4 2025 | 153 | $2.65B |
| Q3 2025 | 137 | $1.08B |
| Q2 2025 | 129 | $952.6M |
| Q1 2025 | 129 | $1.00B |
| Q4 2024 | 131 | $1.39B |
| Q3 2024 | 119 | $1.51B |
| Q2 2024 | 107 | $1.18B |
| Q1 2024 | 103 | $1.21B |
| Q4 2023 | 54 | $601.0M |
| Q3 2023 | 29 | $43.9M |
| Q2 2023 | 44 | $31.9M |
| Q1 2023 | 45 | $12.0M |
| Q4 2022 | 51 | $19.2M |
| Q3 2022 | 55 | $23.5M |
| Q2 2022 | 67 | $24.8M |
| Q1 2022 | 84 | $95.4M |
| Q4 2021 | 86 | $189.4M |
| Q3 2021 | 77 | $322.5M |
| Q2 2021 | 78 | $285.8M |
| Q1 2021 | 84 | $328.7M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Spyre Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Manufacturers Life Insurance Company, The | 129,013 | $4.14M | 0.00% | +57,065+79.3% | Added |
| Victory Capital Management Inc | 146,079 | $4.79M | 0.00% | −180,002−55.2% | Reduced |
| TD Asset Management Inc | 149,822 | $4.91M | 0.00% | +77,454+107.0% | Added |
| Patient Square Capital LP | 150,000 | $4.91M | 1.05% | +150,000 | New |
| Invesco Ltd. | 150,934 | $4.94M | 0.00% | +100,232+197.7% | Added |
| Nuveen, LLC | 150,980 | $4.95M | 0.00% | +54,808+57.0% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 171,211 | $5.61M | 0.01% | +60,755+55.0% | Added |
| Barclays PLC | 182,524 | $5.98M | 0.00% | +14,194+8.4% | Added |
| Morgan Stanley | 182,734 | $5.99M | 0.00% | −151,988−45.4% | Reduced |
| Silverarc Capital Management, LLC | 187,737 | $6.15M | 0.89% | +187,737 | New |
| HighVista Strategies LLC | 188,206 | $6.17M | 1.59% | −27,540−12.8% | Reduced |
| Bank of New York Mellon Corp | 192,830 | $6.32M | 0.00% | +56,870+41.8% | Added |
| Armistice Capital, LLC | 196,426 | $6.43M | 0.16% | +40,426+25.9% | Added |
| Capital World Investors | 200,172 | $6.56M | 0.00% | 00.0% | Unchanged |
| Woodline Partners LP | 265,892 | $8.71M | 0.03% | +134,016+101.6% | Added |
| Goldman Sachs Group Inc | 275,065 | $9.01M | 0.00% | −54,468−16.5% | Reduced |
| Emerald Mutual Fund Advisers Trust | 412,371 | $13.5M | 0.66% | +104,159+33.8% | Added |
| Bank of America Corp | 419,727 | $13.8M | 0.00% | +74,924+21.7% | Added |
| Candriam Luxembourg S.C.A. | 425,534 | $13.9M | 0.07% | +21,172+5.2% | Added |
| Blackstone Group Inc. | 500,998 | $16.4M | 0.07% | 00.0% | Unchanged |
| Northern Trust Corp | 561,023 | $18.4M | 0.00% | +118,987+26.9% | Added |
| Charles Schwab Investment Management Inc | 574,622 | $18.8M | 0.00% | +149,277+35.1% | Added |
| Emerald Advisers, LLC | 636,109 | $20.8M | 0.64% | +87,397+15.9% | Added |
| Point72 Asset Management, L.P. | 662,351 | $21.7M | 0.03% | +662,351 | New |
| UBS Group AG | 680,566 | $22.3M | 0.00% | +294,977+76.5% | Added |
| Deerfield Management Company, L.P. (Series C) | 710,626 | $23.3M | 0.30% | +96,961+15.8% | Added |
| Polar Capital Holdings Plc | 740,326 | $24.3M | 0.11% | −48,462−6.1% | Reduced |
| Siren, L.L.C. | 818,598 | $26.8M | 0.80% | +450,000+122.1% | Added |
| Pictet Asset Management Holding SA | 913,960 | $29.9M | 0.03% | −122,258−11.8% | Reduced |
| Baker Bros. Advisors LP | 1,000,000 | $32.8M | 0.19% | 00.0% | Unchanged |
| Franklin Resources Inc | 1,109,274 | $36.3M | 0.01% | +313,999+39.5% | Added |
| Affinity Asset Advisors, LLC | 1,432,591 | $46.9M | 3.37% | +13,292+0.9% | Added |
| Remedium Capital Partners, LLC | 1,456,231 | $47.7M | 28.03% | +1,456,231 | New |
| Paradigm Biocapital Advisors LP | 1,467,266 | $48.1M | 1.29% | 00.0% | Unchanged |
| Wellington Management Group LLP | 1,549,284 | $50.8M | 0.01% | −91,028−5.5% | Reduced |
| Price T Rowe Associates Inc | 1,601,882 | $52.5M | 0.01% | +981,262+158.1% | Added |
| Ra Capital Management, L.P. | 1,621,620 | $53.1M | 0.54% | +1,621,620 | New |
| Braidwell LP | 1,634,615 | $53.5M | 1.71% | −943,789−36.6% | Reduced |
| Geode Capital Management, LLC | 1,659,140 | $54.4M | 0.00% | +433,987+35.4% | Added |
| Janus Henderson Group PLC | 1,829,009 | $59.9M | 0.03% | +1,816,009+13,969.3% | Added |
| Tang Capital Management LLC | 1,892,200 | $62.0M | 3.06% | −1,307,800−40.9% | Reduced |
| TCG Crossover Management, LLC | 1,900,582 | $62.3M | 2.06% | +800,000+72.7% | Added |
| State Street Corp | 2,262,839 | $74.1M | 0.00% | +477,633+26.8% | Added |
| Commodore Capital LP | 2,388,245 | $78.2M | 5.21% | +400,161+20.1% | Added |
| Driehaus Capital Management LLC | 2,882,420 | $94.4M | 0.64% | +822,045+39.9% | Added |
| Perceptive Advisors LLC | 3,069,225 | $100.5M | 1.84% | +1,839,780+149.6% | Added |
| Capital International Investors | 3,492,541 | $114.4M | 0.02% | +1,100,000+46.0% | Added |
| VR Adviser, LLC | 3,685,448 | $120.7M | 5.96% | +1,000,000+37.2% | Added |
| Fairmount Funds Management LLC | 4,018,101 | $131.6M | 10.02% | 00.0% | Unchanged |
| Vanguard Group Inc | 4,035,074 | $132.2M | 0.00% | +984,344+32.3% | Added |
| RTW Investments, LP | 4,171,996 | $136.7M | 1.37% | +550,000+15.2% | Added |
| BlackRock, Inc. | 5,522,101 | $180.9M | 0.00% | +1,539,357+38.7% | Added |
| FMR LLC | 11,638,819 | $381.3M | 0.02% | +2,578,675+28.5% | Added |
| Jefferies Financial Group Inc. | 0 | $0 | 0.00% | −1,388,854−100.0% | Sold out |
| Voloridge Investment Management, LLC | 0 | $0 | 0.00% | −264,317−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −96,057−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −81,474−100.0% | Sold out |
| Opaleye Management Inc. | 0 | $0 | 0.00% | −65,000−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −48,496−100.0% | Sold out |
| DLD Asset Management, LP | 0 | $0 | 0.00% | −30,000−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −27,100−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −20,232−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −19,366−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −14,733−100.0% | Sold out |
| DRW Securities, LLC | 0 | $0 | 0.00% | −11,475−100.0% | Sold out |
| Huntington National Bank | 0 | $0 | 0.00% | −1,470−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −121−100.0% | Sold out |