Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 3 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Protagonist Therapeutics, Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 322
- +10 vs. Q4 2025
- Shares held
- 78.9M
- +13.3M (+20.3%) vs. Q4 2025
- Total value
- $8.31B
- +$2.61B (+45.7%) vs. Q4 2025
- New holders
- 60
- 111 more added
- Sold out
- 50
- 104 more reduced
7 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Goldman Sachs Group Inc | 778,945 | $82.1M | 0.01% | −182,204−19.0% | Reduced |
| Hood River Capital Management LLC | 829,285 | $87.4M | 0.88% | +829,285 | New |
| ADAR1 Capital Management, LLC | 994,119 | $104.8M | 6.30% | −55,049−5.2% | Reduced |
| Morgan Stanley | 1,018,222 | $107.3M | 0.01% | +139,198+15.8% | Added |
| Jennison Associates LLC | 1,072,011 | $113.0M | 0.08% | +740,847+223.7% | Added |
| Perceptive Advisors LLC | 1,230,879 | $129.7M | 2.56% | −119,546−8.9% | Reduced |
| Bank of America Corp | 1,295,434 | $136.5M | 0.01% | +427,854+49.3% | Added |
| Woodline Partners LP | 1,414,173 | $149.1M | 0.56% | +5,401+0.4% | Added |
| Citadel Advisors LLC | 1,551,900 | $163.6M | 0.12% | +425,213+37.7% | Added |
| Price T Rowe Associates Inc | 1,665,497 | $175.5M | 0.02% | +264,759+18.9% | Added |
| Geode Capital Management, LLC | 1,669,371 | $176.0M | 0.01% | +216,443+14.9% | Added |
| Invesco Ltd. | 2,164,670 | $228.2M | 0.02% | +596,830+38.1% | Added |
| Johnson & Johnson | 2,449,183 | $258.1M | 39.57% | 00.0% | Unchanged |
| Vanguard Capital Management LLC | 2,805,896 | $295.7M | 0.01% | +2,805,896 | New |
| Janus Henderson Group PLC | 2,891,527 | $304.9M | 0.15% | +241,546+9.1% | Added |
| State Street Corp | 3,116,749 | $328.5M | 0.01% | −82,980−2.6% | Reduced |
| Vanguard Portfolio Management LLC | 3,481,211 | $366.9M | 0.02% | +3,481,211 | New |
| Wellington Management Group LLP | 3,599,644 | $379.4M | 0.07% | +428,221+13.5% | Added |
| RTW Investments, LP | 5,059,053 | $533.2M | 5.31% | 00.0% | Unchanged |
| UBS Group AG | 5,177,796 | $545.7M | 0.10% | +2,407,775+86.9% | Added |
| Farallon Capital Management, L.L.C. | 6,348,906 | $669.2M | 3.97% | +204,900+3.3% | Added |
| BlackRock, Inc. | 9,779,369 | $1.03B | 0.02% | +63,370+0.7% | Added |
| Commodore Capital LP | 0 | $0 | 0.00% | −450,000−100.0% | Sold out |
| Skandinaviska Enskilda Banken AB (publ) | 0 | $0 | 0.00% | −205,574−100.0% | Sold out |
| MPM Oncology Impact Management LP | 0 | $0 | 0.00% | −199,471−100.0% | Sold out |
| AIHC Capital Management Ltd | 0 | $0 | 0.00% | −189,823−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −153,876−100.0% | Sold out |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 0 | $0 | 0.00% | −100,000−100.0% | Sold out |
| Quinn Opportunity Partners LLC | 0 | $0 | 0.00% | −55,259−100.0% | Sold out |
| Eversept Partners, LP | 0 | $0 | 0.00% | −52,961−100.0% | Sold out |
| Pentwater Capital Management LP | 0 | $0 | 0.00% | −50,000−100.0% | Sold out |
| SummitTX Capital, L.P. | 0 | $0 | 0.00% | −42,266−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −36,615−100.0% | Sold out |
| Deeter Investments LLP | 0 | $0 | 0.00% | −300,000−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −26,792−100.0% | Sold out |
| Parkman Healthcare Partners LLC | 0 | $0 | 0.00% | −25,973−100.0% | Sold out |
| Diadema Partners LP | 0 | $0 | 0.00% | −22,700−100.0% | Sold out |
| Campbell & CO Investment Adviser LLC | 0 | $0 | 0.00% | −21,054−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −17,391−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −12,850−100.0% | Sold out |
| FORA Capital, LLC | 0 | $0 | 0.00% | −9,130−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −8,167−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −7,908−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −7,718−100.0% | Sold out |
| Horizon Investments, LLC | 0 | $0 | 0.00% | −7,461−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −6,654−100.0% | Sold out |
| CAPROCK Group, Inc. | 0 | $0 | 0.00% | −5,991−100.0% | Sold out |
| Fieldview Capital Management, LLC | 0 | $0 | 0.00% | −5,841−100.0% | Sold out |
| Aviva PLC | 0 | $0 | 0.00% | −5,609−100.0% | Sold out |
| DekaBank Deutsche Girozentrale | 0 | $0 | 0.00% | −15,800−100.0% | Sold out |
| Arrowstreet Capital, Limited Partnership | 0 | $0 | 0.00% | −5,076−100.0% | Sold out |
| Jefferies Financial Group Inc. | 0 | $0 | 0.00% | −5,000−100.0% | Sold out |
| Taconic Capital Advisors LP | 0 | $0 | 0.00% | −5,000−100.0% | Sold out |
| Cornerstone Investment Partners, LLC | 0 | $0 | 0.00% | −4,634−100.0% | Sold out |
| New Vernon Capital Holdings II LLC | 0 | $0 | 0.00% | −4,137−100.0% | Sold out |
| Mackenzie Financial Corp | 0 | $0 | 0.00% | −3,648−100.0% | Sold out |
| Camden Capital, LLC | 0 | $0 | 0.00% | −3,251−100.0% | Sold out |
| AlphaGrep UK Ltd | 0 | $0 | 0.00% | −3,070−100.0% | Sold out |
| Highland Capital Management, LLC | 0 | $0 | 0.00% | −2,462−100.0% | Sold out |
| State of Wyoming | 0 | $0 | 0.00% | −2,070−100.0% | Sold out |
| Quest Partners LLC | 0 | $0 | 0.00% | −1,617−100.0% | Sold out |
| Clear Street Markets LLC | 0 | $0 | 0.00% | −500−100.0% | Sold out |
| Greenline Wealth Management LLC | 0 | $0 | 0.00% | −304−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −190−100.0% | Sold out |
| Matrix Trust Co | 0 | $0 | 0.00% | −143−100.0% | Sold out |
| SageView Advisory Group, LLC | 0 | $0 | 0.00% | −106−100.0% | Sold out |
| Danske Bank A/S | 0 | $0 | 0.00% | −100−100.0% | Sold out |
| Elyxium Wealth, LLC | 0 | $0 | 0.00% | −22−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −10−100.0% | Sold out |
| Flagship Harbor Advisors, LLC | 0 | $0 | 0.00% | −6−100.0% | Sold out |
| TD Capital Management LLC | 0 | $0 | 0.00% | −4−100.0% | Sold out |
| Avion Wealth | 0 | $0 | 0.00% | −6−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |
| Keystone Investors Pte Ltd | – | – | – | – | Not filed |
| Comerica Bank | – | – | – | – | Not filed |
| CIBC World Markets Corp | – | – | – | – | Not filed |
| Global Retirement Partners, LLC | – | – | – | – | Not filed |
| ORG Partners LLC | – | – | – | – | Not filed |
| CIBC Private Wealth Group, LLC | – | – | – | – | Not filed |