Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q1 2026
Institutional positions in Protagonist Therapeutics, Inc as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 322
- +10 vs. Q4 2025
- Shares held
- 78.9M
- +13.3M (+20.3%) vs. Q4 2025
- Total value
- $8.31B
- +$2.61B (+45.7%) vs. Q4 2025
- New holders
- 60
- 111 more added
- Sold out
- 50
- 104 more reduced
7 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Louisiana State Employees Retirement System | 26,100 | $2.75M | 0.05% | −800−3.0% | Reduced |
| Teachers Retirement System of the State of Kentucky | 26,528 | $2.80M | 0.02% | 00.0% | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. | 27,260 | $2.87M | 0.01% | +13,990+105.4% | Added |
| Granahan Investment Management Inc | 27,391 | $2.89M | 0.14% | +27,391 | New |
| EAM Investors, LLC | 27,914 | $2.94M | 0.34% | −50,584−64.4% | Reduced |
| Pathstone Holdings, LLC | 28,252 | $2.98M | 0.01% | +11,811+71.8% | Added |
| Illinois Municipal Retirement Fund | 28,596 | $3.01M | 0.04% | −2,648−8.5% | Reduced |
| Allspring Global Investments Holdings, LLC | 29,916 | $3.10M | 0.01% | +25,931+650.7% | Added |
| Wells Fargo & Company | 30,072 | $3.17M | 0.00% | −41,573−58.0% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 30,604 | $3.21M | 0.00% | −185−0.6% | Reduced |
| State of Wisconsin Investment Board | 30,767 | $3.24M | 0.01% | −4,019−11.6% | Reduced |
| LMR Partners LLP | 30,850 | $3.25M | 0.03% | −9,150−22.9% | Reduced |
| MetLife Investment Management | 31,799 | $3.35M | 0.02% | −641−2.0% | Reduced |
| HighVista Strategies LLC | 33,852 | $3.57M | 0.99% | −39,693−54.0% | Reduced |
| Birchview Capital, LP | 35,000 | $3.69M | 2.10% | −20,000−36.4% | Reduced |
| State of Alaska, Department of Revenue | 37,147 | $3.91M | 0.04% | −952−2.5% | Reduced |
| Elmind Capital, LP | 38,000 | $4.01M | 1.14% | 00.0% | Unchanged |
| Thrivent Financial for Lutherans | 39,225 | $4.13M | 0.01% | −1,155−2.9% | Reduced |
| Russell Investments Group, Ltd. | 40,376 | $4.26M | 0.00% | +34,653+605.5% | Added |
| OrbiMed Advisors LLC | 42,100 | $4.44M | 0.10% | +20,400+94.0% | Added |
| Vanguard Asset Management, Ltd | 46,386 | $4.89M | 0.00% | +46,386 | New |
| Assetmark, Inc | 46,442 | $4.89M | 0.01% | +46,157+16,195.4% | Added |
| Rafferty Asset Management, LLC | 46,752 | $4.93M | 0.02% | −16,909−26.6% | Reduced |
| New York State Teachers Retirement System | 47,424 | $5.00M | 0.01% | −1,926−3.9% | Reduced |
| Great West Life Assurance Co | 47,440 | $5.00M | 0.01% | −2,200−4.4% | Reduced |
| Silvercrest Asset Management Group LLC | 47,931 | $5.05M | 0.04% | −5,286−9.9% | Reduced |
| Creative Planning | 47,971 | $5.06M | 0.00% | +6,717+16.3% | Added |
| Northwestern Mutual Wealth Management Co | 49,020 | $5.17M | 0.00% | +126+0.3% | Added |
| Integral Health Asset Management, LLC | 50,000 | $5.27M | 0.28% | +50,000 | New |
| EFG International AG | 50,086 | $5.28M | 0.11% | −22,537−31.0% | Reduced |
| Nordea Investment Management AB | 51,821 | $5.33M | 0.00% | +51,821 | New |
| KVP Capital Advisors, LP | 53,000 | $5.59M | 4.17% | 00.0% | Unchanged |
| Moody Aldrich Partners LLC | 53,893 | $5.68M | 1.02% | −26,730−33.2% | Reduced |
| Bessemer Group Inc | 54,178 | $5.71M | 0.01% | +160.0% | Added |
| California State Teachers Retirement System | 58,677 | $6.18M | 0.01% | +10,644+22.2% | Added |
| Alliancebernstein L.P. | 73,790 | $6.44M | 0.00% | +568+0.8% | Added |
| Atika Capital Management LLC | 62,100 | $6.55M | 1.03% | −23,900−27.8% | Reduced |
| Knott David M Jr | 63,000 | $6.64M | 3.95% | −10,000−13.7% | Reduced |
| Great Lakes Advisors, LLC | 71,043 | $7.49M | 0.06% | −2,923−4.0% | Reduced |
| StemPoint Capital LP | 72,577 | $7.65M | 1.47% | +13,147+22.1% | Added |
| Algert Global LLC | 78,470 | $8.27M | 0.12% | +73,380+1,441.7% | Added |
| SEI Investments Co | 83,197 | $8.77M | 0.01% | +45,851+122.8% | Added |
| Victory Capital Management Inc | 83,544 | $8.81M | 0.01% | +2,973+3.7% | Added |
| Axiom Investors LLC | 85,475 | $9.01M | 0.10% | −3,993−4.5% | Reduced |
| First Trust Advisors LP | 87,858 | $9.26M | 0.01% | +41,404+89.1% | Added |
| Schroder Investment Management Group | 100,166 | $10.0M | 0.01% | +100,166 | New |
| Prudential Financial Inc | 95,235 | $10.0M | 0.01% | −15,125−13.7% | Reduced |
| Swiss National Bank | 98,900 | $10.4M | 0.01% | +700+0.7% | Added |
| Opaleye Management Inc. | 100,000 | $10.5M | 1.39% | −5,000−4.8% | Reduced |
| Balyasny Asset Management LLC | 101,299 | $10.7M | 0.02% | +101,299 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 105,514 | $11.1M | 0.02% | −8,522−7.5% | Reduced |
| UBS Asset Management Americas Inc | 107,437 | $11.3M | 0.00% | +2,909+2.8% | Added |
| Panagora Asset Management Inc | 116,609 | $12.3M | 0.05% | −8,775−7.0% | Reduced |
| Deutsche Bank AG | 125,451 | $13.2M | 0.00% | +19,991+19.0% | Added |
| Manufacturers Life Insurance Company, The | 127,818 | $13.5M | 0.01% | +14,478+12.8% | Added |
| Nuveen, LLC | 127,914 | $13.5M | 0.00% | +2,053+1.6% | Added |
| Legal & General Group Plc | 135,367 | $14.3M | 0.00% | −13,797−9.2% | Reduced |
| Kennedy Capital Management, Inc. | 137,099 | $14.5M | 0.31% | −84,345−38.1% | Reduced |
| Franklin Resources Inc | 137,871 | $14.5M | 0.00% | +61,429+80.4% | Added |
| Neuberger Berman Group LLC | 141,441 | $14.9M | 0.01% | +42,968+43.6% | Added |
| Ameriprise Financial Inc | 145,690 | $15.4M | 0.00% | −23,828−14.1% | Reduced |
| Rhumbline Advisers | 157,413 | $16.6M | 0.01% | +2,463+1.6% | Added |
| Citigroup Inc | 158,711 | $16.7M | 0.01% | +63,802+67.2% | Added |
| Duquesne Family Office LLCSuperinvestorDuquesne Family Office | 159,700 | $16.8M | 0.57% | 00.0% | Unchanged |
| Nan Fung Trinity (HK) Ltd | 160,670 | $16.9M | 1.86% | −20,000−11.1% | Reduced |
| Lord, Abbett & Co. LLC | 163,459 | $17.2M | 0.06% | +163,459 | New |
| JPMorgan Chase & Co | 172,990 | $17.3M | 0.00% | +17,690+11.4% | Added |
| Susquehanna International Group, LLP | 167,576 | $17.7M | 0.02% | +155,814+1,324.7% | Added |
| Raymond James Financial Inc | 177,361 | $17.8M | 0.01% | −4,142−2.3% | Reduced |
| Boxer Capital Management, LLC | 170,000 | $17.9M | 2.35% | 00.0% | Unchanged |
| Affinity Asset Advisors, LLC | 172,125 | $18.1M | 1.06% | 00.0% | Unchanged |
| Fisher Asset Management, LLC | 173,971 | $18.3M | 0.01% | +108,857+167.2% | Added |
| Eagle Health Investments LP | 179,322 | $18.9M | 3.97% | +122,022+213.0% | Added |
| TD Asset Management Inc | 183,700 | $19.4M | 0.02% | +24,970+15.7% | Added |
| BNP Paribas Arbitrage, SA | 194,530 | $20.5M | 0.01% | +96,766+99.0% | Added |
| Holocene Advisors, LP | 209,916 | $22.1M | 0.05% | −1030.0% | Reduced |
| Public Sector Pension Investment Board | 210,280 | $22.2M | 0.07% | +6,854+3.4% | Added |
| Segall Bryant & Hamill, LLC | 212,714 | $22.4M | 0.32% | +83,654+64.8% | Added |
| NEXTBio Capital Management LP | 229,619 | $24.2M | 11.24% | 00.0% | Unchanged |
| SEB Asset Management AB | 232,416 | $24.5M | 0.10% | +232,416 | New |
| Adage Capital Partners GP, L.L.C. | 282,436 | $29.8M | 0.05% | +49,600+21.3% | Added |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 306,037 | $32.3M | 0.04% | −24,767−7.5% | Reduced |
| Vestal Point Capital, LP | 326,159 | $34.4M | 0.96% | +326,159 | New |
| Bank of New York Mellon Corp | 341,465 | $36.0M | 0.01% | −8,923−2.5% | Reduced |
| 683 Capital Management, LLC | 355,000 | $37.4M | 3.47% | −25,669−6.7% | Reduced |
| Principal Financial Group Inc | 367,822 | $38.8M | 0.02% | +19,890+5.7% | Added |
| Vanguard Fiduciary Trust Co | 412,730 | $43.5M | 0.01% | +412,730 | New |
| Rubric Capital Management LP | 427,998 | $45.1M | 0.55% | +427,998 | New |
| Voya Investment Management LLC | 454,383 | $47.9M | 0.05% | +88,218+24.1% | Added |
| Dimensional Fund Advisors LP | 508,103 | $53.5M | 0.01% | +93,688+22.6% | Added |
| American Century Companies Inc | 537,320 | $56.6M | 0.03% | +1,897+0.4% | Added |
| Charles Schwab Investment Management Inc | 552,956 | $58.3M | 0.01% | −3,806−0.7% | Reduced |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 571,825 | $60.3M | 5.11% | 00.0% | Unchanged |
| Pictet Asset Management Holding SA | 581,083 | $61.2M | 0.06% | +51,452+9.7% | Added |
| Northern Trust Corp | 587,968 | $62.0M | 0.01% | +12,850+2.2% | Added |
| Alyeska Investment Group, L.P. | 593,197 | $62.5M | 0.18% | +393,674+197.3% | Added |
| Clearbridge Investments, LLC | 621,820 | $65.5M | 0.06% | +131,978+26.9% | Added |
| Marshall Wace, LLP | 628,075 | $66.2M | 0.07% | −396,850−38.7% | Reduced |
| FMR LLC | 661,997 | $69.8M | 0.00% | +122,119+22.6% | Added |
| Driehaus Capital Management LLC | 720,928 | $76.0M | 0.56% | −378,242−34.4% | Reduced |