Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Protagonist Therapeutics, Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 275
- +3 vs. Q2 2025
- Shares held
- 70.7M
- −267.3K (−0.4%) vs. Q2 2025
- Total value
- $4.70B
- +$772.8M (+19.7%) vs. Q2 2025
- New holders
- 42
- 84 more added
- Sold out
- 39
- 109 more reduced
2 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Victory Capital Management Inc | 85,494 | $5.68M | 0.00% | −5,438−6.0% | Reduced |
| Great Lakes Advisors, LLC | 89,171 | $5.92M | 0.05% | −50,220−36.0% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 90,317 | $6.00M | 0.01% | +49,833+123.1% | Added |
| Schonfeld Strategic Advisors LLC | 95,190 | $6.32M | 0.04% | +18,122+23.5% | Added |
| Swiss National Bank | 96,100 | $6.38M | 0.00% | +2,300+2.5% | Added |
| Opaleye Management Inc. | 105,000 | $6.98M | 0.99% | 00.0% | Unchanged |
| Boxer Capital Management, LLC | 110,000 | $7.31M | 2.33% | +50,000+83.3% | Added |
| UBS Asset Management Americas Inc | 110,229 | $7.32M | 0.00% | −133,144−54.7% | Reduced |
| Deutsche Bank AG | 117,212 | $7.79M | 0.00% | +6,048+5.4% | Added |
| HighVista Strategies LLC | 121,682 | $8.08M | 1.98% | +63,831+110.3% | Added |
| Segall Bryant & Hamill, LLC | 123,125 | $8.18M | 0.11% | +2,966+2.5% | Added |
| Neuberger Berman Group LLC | 123,377 | $8.20M | 0.01% | +29,795+31.8% | Added |
| ExodusPoint Capital Management, LP | 124,929 | $8.30M | 0.12% | +124,929 | New |
| Prudential Financial Inc | 126,403 | $8.40M | 0.01% | +48,995+63.3% | Added |
| Millennium Management LLC | 127,560 | $8.47M | 0.01% | +112,369+739.7% | Added |
| Nuveen, LLC | 128,384 | $8.53M | 0.00% | −1,127−0.9% | Reduced |
| Manufacturers Life Insurance Company, The | 135,096 | $8.97M | 0.01% | +40,295+42.5% | Added |
| Moody Aldrich Partners LLC | 143,060 | $9.50M | 1.80% | −27,510−16.1% | Reduced |
| Nan Fung Trinity (HK) Ltd | 144,892 | $9.63M | 0.96% | +9,842+7.3% | Added |
| Panagora Asset Management Inc | 148,729 | $9.88M | 0.04% | −610.0% | Reduced |
| TD Asset Management Inc | 150,428 | $9.99M | 0.01% | +34,096+29.3% | Added |
| Citigroup Inc | 152,580 | $10.1M | 0.01% | +74,629+95.7% | Added |
| Ameriprise Financial Inc | 153,191 | $10.2M | 0.00% | −15,180−9.0% | Reduced |
| Legal & General Group Plc | 155,829 | $10.4M | 0.00% | −10,352−6.2% | Reduced |
| Duquesne Family Office LLCSuperinvestorDuquesne Family Office | 159,700 | $10.6M | 0.27% | +159,700 | New |
| Rhumbline Advisers | 163,980 | $10.9M | 0.01% | −9,048−5.2% | Reduced |
| Barclays PLC | 171,406 | $11.4M | 0.00% | −40,706−19.2% | Reduced |
| Kennedy Capital Management, Inc. | 208,437 | $13.8M | 0.31% | +73,547+54.5% | Added |
| Affinity Asset Advisors, LLC | 220,600 | $14.7M | 1.36% | −219,400−49.9% | Reduced |
| Public Sector Pension Investment Board | 228,146 | $15.2M | 0.06% | +16,865+8.0% | Added |
| Citadel Advisors LLC | 237,881 | $15.8M | 0.01% | +210,680+774.5% | Added |
| JPMorgan Chase & Co | 252,400 | $16.8M | 0.00% | −193,292−43.4% | Reduced |
| Alliancebernstein L.P. | 260,854 | $17.3M | 0.01% | +192,954+284.2% | Added |
| Raymond James Financial Inc | 294,296 | $19.6M | 0.01% | −17,690−5.7% | Reduced |
| Logos Global Management LP | 300,000 | $19.9M | 1.97% | +300,000 | New |
| Voya Investment Management LLC | 305,419 | $20.3M | 0.02% | +25,065+8.9% | Added |
| Principal Financial Group Inc | 326,088 | $21.7M | 0.01% | −4,046−1.2% | Reduced |
| Bank of New York Mellon Corp | 363,261 | $24.1M | 0.00% | −24,821−6.4% | Reduced |
| 683 Capital Management, LLC | 407,500 | $27.1M | 2.46% | −37,500−8.4% | Reduced |
| Dimensional Fund Advisors LP | 438,515 | $29.1M | 0.01% | +258,465+143.6% | Added |
| Toronto Dominion Bank | 445,440 | $29.6M | 0.06% | 00.0% | Unchanged |
| Colony Group, LLC | 448,988 | $29.8M | 0.05% | +448,988 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 451,766 | $30.0M | 0.08% | +5,740+1.3% | Added |
| Mangrove Partners | 478,413 | $31.8M | 2.64% | +83,030+21.0% | Added |
| FMR LLC | 520,664 | $34.6M | 0.00% | −17,768−3.3% | Reduced |
| Charles Schwab Investment Management Inc | 552,877 | $36.7M | 0.01% | −22,487−3.9% | Reduced |
| American Century Companies Inc | 600,047 | $39.9M | 0.02% | −213,948−26.3% | Reduced |
| Northern Trust Corp | 603,222 | $40.1M | 0.01% | −11,844−1.9% | Reduced |
| Lynx1 Capital Management LP | 700,014 | $46.5M | 9.47% | −33,000−4.5% | Reduced |
| Adage Capital Partners GP, L.L.C. | 718,202 | $47.7M | 0.08% | −374,060−34.2% | Reduced |
| Morgan Stanley | 768,359 | $51.0M | 0.00% | −100,604−11.6% | Reduced |
| Goldman Sachs Group Inc | 781,711 | $51.9M | 0.01% | +4,404+0.6% | Added |
| Jefferies Financial Group Inc. | 821,503 | $54.6M | 0.50% | −2,516−0.3% | Reduced |
| Pictet Asset Management Holding SA | 822,212 | $54.6M | 0.05% | +70,235+9.3% | Added |
| Bank of America Corp | 829,877 | $55.1M | 0.00% | −21,955−2.6% | Reduced |
| ADAR1 Capital Management, LLC | 989,182 | $65.7M | 6.51% | +41,113+4.3% | Added |
| Invesco Ltd. | 1,003,706 | $66.7M | 0.01% | +282,026+39.1% | Added |
| Commodore Capital LP | 1,025,000 | $68.1M | 3.32% | −50,000−4.7% | Reduced |
| Perceptive Advisors LLC | 1,030,134 | $68.4M | 1.98% | −44,314−4.1% | Reduced |
| Marshall Wace, LLP | 1,085,564 | $72.1M | 0.08% | +1,085,564 | New |
| Janus Henderson Group PLC | 1,100,821 | $73.2M | 0.03% | +653,993+146.4% | Added |
| Driehaus Capital Management LLC | 1,139,854 | $75.7M | 0.54% | +382,144+50.4% | Added |
| Price T Rowe Associates Inc | 1,220,436 | $81.1M | 0.01% | +283,733+30.3% | Added |
| Geode Capital Management, LLC | 1,416,646 | $94.1M | 0.01% | −27,584−1.9% | Reduced |
| Woodline Partners LP | 1,438,247 | $95.5M | 0.45% | +491,363+51.9% | Added |
| Deep Track Capital, LP | 1,715,691 | $114.0M | 3.18% | −1,530,208−47.1% | Reduced |
| UBS Group AG | 1,896,008 | $126.0M | 0.02% | −605,243−24.2% | Reduced |
| Wellington Management Group LLP | 1,908,446 | $126.8M | 0.02% | +870,708+83.9% | Added |
| Johnson & Johnson | 2,449,183 | $162.7M | 32.29% | 00.0% | Unchanged |
| BVF Inc | 2,560,916 | $170.1M | 6.90% | −650,125−20.2% | Reduced |
| State Street Corp | 3,165,795 | $210.3M | 0.01% | −41,748−1.3% | Reduced |
| Vanguard Group Inc | 4,257,229 | $282.8M | 0.00% | −101,366−2.3% | Reduced |
| RTW Investments, LP | 5,756,277 | $382.4M | 4.71% | 00.0% | Unchanged |
| Farallon Capital Management, L.L.C. | 6,196,006 | $411.6M | 2.33% | +24,000+0.4% | Added |
| BlackRock, Inc. | 9,404,232 | $624.7M | 0.01% | −226,109−2.3% | Reduced |
| Holocene Advisors, LP | 0 | $0 | 0.00% | −530,326−100.0% | Sold out |
| Jupiter Asset Management Ltd | 0 | $0 | 0.00% | −405,644−100.0% | Sold out |
| Eversept Partners, LP | 0 | $0 | 0.00% | −277,316−100.0% | Sold out |
| Renaissance Technologies LLC | 0 | $0 | 0.00% | −173,134−100.0% | Sold out |
| Capitolis Liquid Global Markets LLC | 0 | $0 | 0.00% | −116,100−100.0% | Sold out |
| Checkpoint Capital L.P. | 0 | $0 | 0.00% | −81,311−100.0% | Sold out |
| EAM Global Investors LLC | 0 | $0 | 0.00% | −69,726−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −68,983−100.0% | Sold out |
| Natixis | 0 | $0 | 0.00% | −42,040−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −42,000−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −36,018−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −34,013−100.0% | Sold out |
| Massachusetts Financial Services Co | 0 | $0 | 0.00% | −32,123−100.0% | Sold out |
| Horizon Investments, LLC | 0 | $0 | 0.00% | −22,470−100.0% | Sold out |
| Fieldview Capital Management, LLC | 0 | $0 | 0.00% | −20,381−100.0% | Sold out |
| Arrowstreet Capital, Limited Partnership | 0 | $0 | 0.00% | −17,856−100.0% | Sold out |
| UBS Oconnor LLC | 0 | $0 | 0.00% | −14,523−100.0% | Sold out |
| Precision Wealth Strategies, LLC | 0 | $0 | 0.00% | −14,339−100.0% | Sold out |
| Algert Global LLC | 0 | $0 | 0.00% | −13,055−100.0% | Sold out |
| Harvest Investment Services, LLC | 0 | $0 | 0.00% | −13,029−100.0% | Sold out |
| Options Solutions, LLC | 0 | $0 | 0.00% | −10,226−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −9,452−100.0% | Sold out |
| Nomura Holdings Inc | 0 | $0 | 0.00% | −7,416−100.0% | Sold out |
| Bryce Point Capital, LLC | 0 | $0 | 0.00% | −6,200−100.0% | Sold out |
| Mitsubishi UFJ Trust & Banking Corp | 0 | $0 | 0.00% | −5,975−100.0% | Sold out |