Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Protagonist Therapeutics, Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 275
- +3 vs. Q2 2025
- Shares held
- 70.7M
- −267.3K (−0.4%) vs. Q2 2025
- Total value
- $4.70B
- +$772.8M (+19.7%) vs. Q2 2025
- New holders
- 42
- 84 more added
- Sold out
- 39
- 109 more reduced
2 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Brinker Capital Investments, LLC | 6,928 | $460.2K | 0.00% | +328+5.0% | Added |
| CWM Advisors, LLC | 6,938 | $460.9K | 0.04% | −346−4.8% | Reduced |
| New Vernon Capital Holdings II LLC | 7,198 | $478.2K | 0.22% | 00.0% | Unchanged |
| XTX Topco Ltd | 7,260 | $482.3K | 0.03% | −72−1.0% | Reduced |
| Brevan Howard Capital Management LP | 7,598 | $504.7K | 0.01% | −19,396−71.9% | Reduced |
| Capstone Investment Advisors, LLC | 7,676 | $509.9K | 0.00% | +689+9.9% | Added |
| Aviva PLC | 7,792 | $517.6K | 0.00% | −1,643−17.4% | Reduced |
| Maryland State Retirement & Pension System | 8,407 | $558.5K | 0.01% | −9,809−53.8% | Reduced |
| AQR Capital Management LLC | 8,570 | $569.3K | 0.00% | −8,839−50.8% | Reduced |
| HighTower Advisors, LLC | 8,613 | $572.2K | 0.00% | −1,367−13.7% | Reduced |
| Cerity Partners LLC | 8,618 | $572.5K | 0.00% | −1,104−11.4% | Reduced |
| Resona Asset Management Co.,Ltd. | 8,731 | $580.0K | 0.00% | +8,731 | New |
| Toroso Investments, LLC | 8,945 | $594.2K | 0.00% | −14,832−62.4% | Reduced |
| HRT Financial LP | 9,470 | $629.0K | 0.00% | +9,470 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,073 | $669.1K | 0.00% | 00.0% | Unchanged |
| Cache Advisors, LLC | 10,143 | $673.8K | 0.12% | 00.0% | Unchanged |
| KLP Kapitalforvaltning AS | 10,400 | $690.9K | 0.00% | 00.0% | Unchanged |
| Cambria Investment Management, L.P. | 10,944 | $727.0K | 0.04% | +2,187+25.0% | Added |
| Ensign Peak Advisors, Inc | 10,986 | $729.8K | 0.00% | −12,150−52.5% | Reduced |
| Franklin Street Advisors Inc | 11,300 | $750.7K | 0.04% | 00.0% | Unchanged |
| Persistent Asset Partners Ltd | 11,780 | $782.5K | 0.57% | −5,740−32.8% | Reduced |
| Teacher Retirement System of Texas | 12,106 | $804.2K | 0.00% | −1,099−8.3% | Reduced |
| BNP Paribas Arbitrage, SA | 13,137 | $872.7K | 0.00% | +3,998+43.7% | Added |
| ProShare Advisors LLC | 13,187 | $876.0K | 0.00% | −2,189−14.2% | Reduced |
| Oregon Public Employees Retirement Fund | 13,200 | $876.9K | 0.01% | −1,000−7.0% | Reduced |
| Erste Asset Management GmbH | 13,500 | $879.4K | 0.01% | 00.0% | Unchanged |
| Pathstone Holdings, LLC | 13,362 | $887.7K | 0.00% | +5,167+63.1% | Added |
| Mariner, LLC | 13,551 | $900.2K | 0.00% | −2,150−13.7% | Reduced |
| Weiss Asset Management LP | 14,310 | $950.6K | 0.01% | +14,310 | New |
| Arizona State Retirement System | 14,669 | $974.5K | 0.01% | +343+2.4% | Added |
| Jain Global LLC | 14,850 | $986.5K | 0.01% | +14,850 | New |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 14,893 | $989.3K | 0.00% | −1,020−6.4% | Reduced |
| DekaBank Deutsche Girozentrale | 15,800 | $1.03M | 0.00% | 00.0% | Unchanged |
| Virginia Retirement Systems Et Al | 15,600 | $1.04M | 0.01% | −3,400−17.9% | Reduced |
| China Universal Asset Management Co., Ltd. | 15,905 | $1.06M | 0.09% | −3,003−15.9% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 16,119 | $1.07M | 0.01% | +2,663+19.8% | Added |
| Moran Wealth Management, LLC | 16,212 | $1.08M | 0.03% | +451+2.9% | Added |
| State Board of Administration of Florida Retirement System | 16,303 | $1.08M | 0.00% | 00.0% | Unchanged |
| Comerica Bank | 16,395 | $1.09M | 0.00% | −4,896−23.0% | Reduced |
| Amalgamated Bank | 16,826 | $1.12M | 0.01% | −717−4.1% | Reduced |
| Natixis Advisors, L.P. | 16,855 | $1.12M | 0.00% | +3,413+25.4% | Added |
| Royce & Associates LP | 16,989 | $1.13M | 0.01% | +4,734+38.6% | Added |
| Teachers Retirement System of the State of Kentucky | 17,296 | $1.15M | 0.01% | −1,436−7.7% | Reduced |
| STRS Ohio | 17,800 | $1.18M | 0.00% | −1,800−9.2% | Reduced |
| Glenmede Investment Management, LP | 18,000 | $1.20M | 0.01% | −3,434−16.0% | Reduced |
| J. Goldman & Co LP | 18,068 | $1.20M | 0.05% | −17,760−49.6% | Reduced |
| Profund Advisors LLC | 18,157 | $1.21M | 0.04% | −917−4.8% | Reduced |
| Yousif Capital Management, LLC | 18,426 | $1.22M | 0.01% | −4,978−21.3% | Reduced |
| Winton Group Ltd | 18,561 | $1.23M | 0.05% | +1,128+6.5% | Added |
| Guggenheim Capital LLC | 18,583 | $1.23M | 0.01% | −625−3.3% | Reduced |
| Handelsbanken Fonder AB | 18,900 | $1.26M | 0.00% | +1,900+11.2% | Added |
| New York State Common Retirement Fund | 19,582 | $1.30M | 0.00% | 00.0% | Unchanged |
| Allianz Asset Management GmbH | 19,678 | $1.31M | 0.00% | −2,622−11.8% | Reduced |
| Polen Capital Management LLC | 20,325 | $1.35M | 0.00% | +4,326+27.0% | Added |
| Capital Fund Management S.A. | 20,348 | $1.35M | 0.01% | −29,457−59.1% | Reduced |
| Superstring Capital Management LP | 20,358 | $1.35M | 1.33% | +20,358 | New |
| Bellevue Group AG | 20,581 | $1.37M | 0.03% | +1,109+5.7% | Added |
| Hussman Strategic Advisors, Inc. | 21,000 | $1.40M | 0.30% | −10,500−33.3% | Reduced |
| Intech Investment Management LLC | 21,643 | $1.44M | 0.01% | −12,310−36.3% | Reduced |
| Gotham Asset Management, LLC | 22,198 | $1.47M | 0.01% | −15,089−40.5% | Reduced |
| Artia Global Partners LP | 22,951 | $1.52M | 0.27% | 00.0% | Unchanged |
| Envestnet Asset Management Inc | 24,258 | $1.61M | 0.00% | +380+1.6% | Added |
| State of Tennessee, Treasury Department | 26,490 | $1.76M | 0.01% | +500+1.9% | Added |
| Louisiana State Employees Retirement System | 26,900 | $1.79M | 0.03% | −2,100−7.2% | Reduced |
| Alps Advisors Inc | 29,203 | $1.94M | 0.01% | −11,017−27.4% | Reduced |
| State of Alaska, Department of Revenue | 29,425 | $1.95M | 0.02% | −7,481−20.3% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 30,871 | $2.05M | 0.00% | −4,970−13.9% | Reduced |
| SummitTX Capital, L.P. | 31,490 | $2.09M | 0.09% | +31,490 | New |
| Illinois Municipal Retirement Fund | 33,183 | $2.20M | 0.03% | +5,614+20.4% | Added |
| Exchange Traded Concepts, LLC | 33,552 | $2.23M | 0.02% | −13,839−29.2% | Reduced |
| MetLife Investment Management | 33,846 | $2.25M | 0.01% | −924−2.7% | Reduced |
| Creative Planning | 36,214 | $2.41M | 0.00% | +6,010+19.9% | Added |
| State of New Jersey Common Pension Fund D | 37,956 | $2.52M | 0.01% | −3,069−7.5% | Reduced |
| State of Wisconsin Investment Board | 40,906 | $2.72M | 0.01% | +7,918+24.0% | Added |
| SG Americas Securities, LLC | 41,246 | $2.74M | 0.01% | +39,322+2,043.8% | Added |
| Thrivent Financial for Lutherans | 42,188 | $2.80M | 0.01% | −3,388−7.4% | Reduced |
| SEI Investments Co | 44,011 | $2.92M | 0.00% | −921−2.0% | Reduced |
| Jane Street Group, LLC | 44,339 | $2.95M | 0.00% | +44,339 | New |
| Great West Life Assurance Co | 48,407 | $3.15M | 0.00% | −1,835−3.7% | Reduced |
| California State Teachers Retirement System | 47,437 | $3.15M | 0.00% | −3,758−7.3% | Reduced |
| Wells Fargo & Company | 47,794 | $3.17M | 0.00% | +6,107+14.6% | Added |
| StemPoint Capital LP | 47,954 | $3.19M | 0.64% | +31,184+186.0% | Added |
| Birchview Capital, LP | 48,000 | $3.19M | 2.41% | 00.0% | Unchanged |
| New York State Teachers Retirement System | 49,550 | $3.29M | 0.01% | −6,163−11.1% | Reduced |
| Diadema Partners LP | 51,185 | $3.40M | 2.37% | −25,000−32.8% | Reduced |
| Silvercrest Asset Management Group LLC | 53,217 | $3.54M | 0.02% | −1,506−2.8% | Reduced |
| Northwestern Mutual Wealth Management Co | 58,894 | $3.91M | 0.00% | −20,000−25.4% | Reduced |
| Parkman Healthcare Partners LLC | 61,849 | $4.11M | 0.45% | +253+0.4% | Added |
| First Trust Advisors LP | 62,724 | $4.17M | 0.00% | −51,183−44.9% | Reduced |
| Susquehanna International Group, LLP | 63,188 | $4.20M | 0.01% | −8,053−11.3% | Reduced |
| Assenagon Asset Management S.A. | 65,756 | $4.37M | 0.01% | −26,119−28.4% | Reduced |
| Royal Bank of Canada | 69,996 | $4.65M | 0.00% | −4,738−6.3% | Reduced |
| Rafferty Asset Management, LLC | 74,827 | $4.97M | 0.02% | −5,716−7.1% | Reduced |
| EAM Investors, LLC | 80,067 | $5.23M | 0.60% | +8,096+11.2% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 78,796 | $5.23M | 0.02% | −3,954−4.8% | Reduced |
| Axiom Investors LLC | 80,113 | $5.32M | 0.04% | +28,880+56.4% | Added |
| EFG Asset Management (North America) Corp. | 82,639 | $5.49M | 0.71% | +913+1.1% | Added |
| Franklin Resources Inc | 82,918 | $5.51M | 0.00% | +339+0.4% | Added |
| Knott David M Jr | 83,000 | $5.51M | 2.31% | +3,000+3.8% | Added |
| Atika Capital Management LLC | 83,000 | $5.51M | 0.47% | +83,000 | New |