Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Protagonist Therapeutics, Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 274
- +3 vs. Q1 2025
- Shares held
- 71.0M
- +5.66M (+8.7%) vs. Q1 2025
- Total value
- $3.92B
- +$774.8M (+24.6%) vs. Q1 2025
- New holders
- 52
- 120 more added
- Sold out
- 49
- 76 more reduced
4 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Knott David M Jr | 80,000 | $4.42M | 2.00% | +4,000+5.3% | Added |
| Rafferty Asset Management, LLC | 80,543 | $4.45M | 0.01% | +36,286+82.0% | Added |
| Checkpoint Capital L.P. | 81,311 | $4.49M | 2.09% | −93,873−53.6% | Reduced |
| EFG Asset Management (North America) Corp. | 81,726 | $4.52M | 0.64% | +10,592+14.9% | Added |
| Franklin Resources Inc | 82,579 | $4.56M | 0.00% | +3,535+4.5% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 82,750 | $4.57M | 0.02% | −166,200−66.8% | Reduced |
| Victory Capital Management Inc | 90,932 | $5.03M | 0.00% | −11,479−11.2% | Reduced |
| Assenagon Asset Management S.A. | 91,875 | $5.08M | 0.01% | +47,003+104.7% | Added |
| Neuberger Berman Group LLC | 93,582 | $5.17M | 0.00% | +93,582 | New |
| Swiss National Bank | 93,800 | $5.18M | 0.00% | +6,900+7.9% | Added |
| Manufacturers Life Insurance Company, The | 94,801 | $5.24M | 0.00% | −26,049−21.6% | Reduced |
| Opaleye Management Inc. | 105,000 | $5.80M | 1.17% | 00.0% | Unchanged |
| Deutsche Bank AG | 111,164 | $6.14M | 0.00% | +45,469+69.2% | Added |
| First Trust Advisors LP | 113,907 | $6.30M | 0.01% | +32,221+39.4% | Added |
| Capitolis Liquid Global Markets LLC | 116,100 | $6.42M | 0.05% | +116,100 | New |
| TD Asset Management Inc | 116,332 | $6.43M | 0.01% | −53,600−31.5% | Reduced |
| Segall Bryant & Hamill, LLC | 120,159 | $6.64M | 0.09% | +120,159 | New |
| Nuveen, LLC | 129,511 | $7.16M | 0.00% | −23,260−15.2% | Reduced |
| Kennedy Capital Management, Inc. | 134,890 | $7.46M | 0.18% | −2,614−1.9% | Reduced |
| Nan Fung Trinity (HK) Ltd | 135,050 | $7.46M | 0.89% | +135,050 | New |
| Great Lakes Advisors, LLC | 139,391 | $7.70M | 0.06% | −12,927−8.5% | Reduced |
| Panagora Asset Management Inc | 148,790 | $8.22M | 0.04% | −1,118−0.7% | Reduced |
| Legal & General Group Plc | 166,181 | $9.18M | 0.00% | +18,074+12.2% | Added |
| Ameriprise Financial Inc | 168,371 | $9.31M | 0.00% | +31,529+23.0% | Added |
| Moody Aldrich Partners LLC | 170,570 | $9.43M | 1.82% | +7,087+4.3% | Added |
| Rhumbline Advisers | 173,028 | $9.56M | 0.01% | +10,963+6.8% | Added |
| Renaissance Technologies LLC | 173,134 | $9.57M | 0.01% | −150,433−46.5% | Reduced |
| Dimensional Fund Advisors LP | 180,050 | $9.95M | 0.00% | +58,496+48.1% | Added |
| Public Sector Pension Investment Board | 211,281 | $11.7M | 0.05% | +22,250+11.8% | Added |
| Barclays PLC | 212,112 | $11.7M | 0.00% | +100,680+90.4% | Added |
| UBS Asset Management Americas Inc | 243,373 | $13.5M | 0.00% | +34,617+16.6% | Added |
| Eversept Partners, LP | 277,316 | $15.3M | 1.54% | −269,800−49.3% | Reduced |
| Voya Investment Management LLC | 280,354 | $15.5M | 0.02% | +220,676+369.8% | Added |
| Raymond James Financial Inc | 311,986 | $17.2M | 0.01% | +13,159+4.4% | Added |
| Principal Financial Group Inc | 330,134 | $18.2M | 0.01% | −16,961−4.9% | Reduced |
| Bank of New York Mellon Corp | 388,082 | $21.4M | 0.00% | +11,219+3.0% | Added |
| Mangrove Partners | 395,383 | $21.9M | 2.35% | 00.0% | Unchanged |
| Jupiter Asset Management Ltd | 405,644 | $22.4M | 0.19% | +237,581+141.4% | Added |
| Affinity Asset Advisors, LLC | 440,000 | $24.3M | 3.60% | +40,000+10.0% | Added |
| 683 Capital Management, LLC | 445,000 | $24.6M | 2.49% | −55,000−11.0% | Reduced |
| Toronto Dominion Bank | 445,440 | $24.6M | 0.05% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 445,692 | $24.6M | 0.00% | −23,207−4.9% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 446,026 | $24.7M | 0.06% | +66,377+17.5% | Added |
| Janus Henderson Group PLC | 446,828 | $24.7M | 0.01% | +425,374+1,982.7% | Added |
| Holocene Advisors, LP | 530,326 | $29.3M | 0.07% | +530,326 | New |
| FMR LLC | 538,432 | $29.8M | 0.00% | +60,089+12.6% | Added |
| Charles Schwab Investment Management Inc | 575,364 | $31.8M | 0.01% | +17,646+3.2% | Added |
| Northern Trust Corp | 615,066 | $34.0M | 0.00% | −24,441−3.8% | Reduced |
| Invesco Ltd. | 721,680 | $39.9M | 0.01% | −137,968−16.0% | Reduced |
| Lynx1 Capital Management LP | 733,014 | $40.5M | 11.70% | 00.0% | Unchanged |
| Pictet Asset Management Holding SA | 751,977 | $41.6M | 0.04% | +456,384+154.4% | Added |
| Driehaus Capital Management LLC | 757,710 | $41.9M | 0.34% | +522,637+222.3% | Added |
| Goldman Sachs Group Inc | 777,307 | $43.0M | 0.01% | +221,756+39.9% | Added |
| American Century Companies Inc | 813,995 | $45.0M | 0.02% | +128,171+18.7% | Added |
| Jefferies Financial Group Inc. | 824,019 | $45.5M | 0.75% | +192,126+30.4% | Added |
| Bank of America Corp | 851,832 | $47.1M | 0.00% | +380,087+80.6% | Added |
| Morgan Stanley | 868,963 | $48.0M | 0.00% | +371,858+74.8% | Added |
| Price T Rowe Associates Inc | 936,703 | $51.8M | 0.01% | −385,303−29.1% | Reduced |
| Woodline Partners LP | 946,884 | $52.3M | 0.28% | +49,185+5.5% | Added |
| ADAR1 Capital Management, LLC | 948,069 | $52.4M | 8.51% | +8,400+0.9% | Added |
| Wellington Management Group LLP | 1,037,738 | $57.4M | 0.01% | +50,368+5.1% | Added |
| Perceptive Advisors LLC | 1,074,448 | $59.4M | 2.23% | −16,823−1.5% | Reduced |
| Commodore Capital LP | 1,075,000 | $59.4M | 4.19% | +1,075,000 | New |
| Adage Capital Partners GP, L.L.C. | 1,092,262 | $60.4M | 0.10% | +748,758+218.0% | Added |
| Geode Capital Management, LLC | 1,444,230 | $79.8M | 0.01% | +20,671+1.5% | Added |
| Johnson & Johnson | 2,449,183 | $136.4M | 40.83% | 00.0% | Unchanged |
| UBS Group AG | 2,501,251 | $138.2M | 0.03% | +2,148,380+608.8% | Added |
| State Street Corp | 3,207,543 | $177.3M | 0.01% | +500,924+18.5% | Added |
| BVF Inc | 3,211,041 | $177.5M | 6.34% | +636,026+24.7% | Added |
| Deep Track Capital, LP | 3,245,899 | $179.4M | 5.77% | +245,899+8.2% | Added |
| Vanguard Group Inc | 4,358,595 | $240.9M | 0.00% | +81,377+1.9% | Added |
| RTW Investments, LP | 5,756,277 | $318.1M | 4.53% | +36,862+0.6% | Added |
| Farallon Capital Management, L.L.C. | 6,172,006 | $341.1M | 1.56% | +65,000+1.1% | Added |
| BlackRock, Inc. | 9,630,341 | $532.3M | 0.01% | −106,426−1.1% | Reduced |
| Colony Group, LLC | 0 | $0 | 0.00% | −435,097−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −193,300−100.0% | Sold out |
| Soleus Capital Management, L.P. | 0 | $0 | 0.00% | −169,000−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −128,654−100.0% | Sold out |
| Nan Fung Group Holdings Ltd | 0 | $0 | 0.00% | −121,400−100.0% | Sold out |
| Empowered Funds, LLC | 0 | $0 | 0.00% | −102,532−100.0% | Sold out |
| Lazard Asset Management LLC | 0 | $0 | 0.00% | −96,420−100.0% | Sold out |
| Aquilo Capital Management, LLC | 0 | $0 | 0.00% | −81,692−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −69,242−100.0% | Sold out |
| BCJ Capital Management, LLC | 0 | $0 | 0.00% | −58,413−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −56,780−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −47,361−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −42,583−100.0% | Sold out |
| Corebridge Financial, Inc. | 0 | $0 | 0.00% | −31,020−100.0% | Sold out |
| Hennion & Walsh Asset Management, Inc. | 0 | $0 | 0.00% | −26,066−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −26,061−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −24,867−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −20,169−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −19,847−100.0% | Sold out |
| Coppell Advisory Solutions LLC | 0 | $0 | 0.00% | −20,765−100.0% | Sold out |
| Campbell & CO Investment Adviser LLC | 0 | $0 | 0.00% | −19,015−100.0% | Sold out |
| Jennison Associates LLC | 0 | $0 | 0.00% | −18,317−100.0% | Sold out |
| Scientech Research LLC | 0 | $0 | 0.00% | −18,271−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −15,327−100.0% | Sold out |
| Springhill Fund Asset Management (HK) Co Ltd | 0 | $0 | 0.00% | −12,859−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −11,963−100.0% | Sold out |