Protagonist Therapeutics, Inc
PTGX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001377121
In the last 90 days, Protagonist Therapeutics, Inc insiders filed 0 open-market purchases and 2 sales; 346 institutions reported holding it in 13F filings for Q2 2026, worth $9.30B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q2 2025
Institutional positions in Protagonist Therapeutics, Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 274
- +3 vs. Q1 2025
- Shares held
- 71.0M
- +5.66M (+8.7%) vs. Q1 2025
- Total value
- $3.92B
- +$774.8M (+24.6%) vs. Q1 2025
- New holders
- 52
- 120 more added
- Sold out
- 49
- 76 more reduced
4 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PTGX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 346 | $9.30B |
| Q1 2026 | 322 | $8.31B |
| Q4 2025 | 319 | $6.18B |
| Q3 2025 | 275 | $4.70B |
| Q2 2025 | 274 | $3.92B |
| Q1 2025 | 275 | $3.15B |
| Q4 2024 | 241 | $2.44B |
| Q3 2024 | 240 | $2.78B |
| Q2 2024 | 188 | $2.05B |
| Q1 2024 | 185 | $1.73B |
| Q4 2023 | 157 | $1.32B |
| Q3 2023 | 144 | $945.9M |
| Q2 2023 | 167 | $1.57B |
| Q1 2023 | 138 | $1.22B |
| Q4 2022 | 137 | $533.3M |
| Q3 2022 | 133 | $398.9M |
| Q2 2022 | 131 | $422.1M |
| Q1 2022 | 140 | $1.19B |
| Q4 2021 | 149 | $1.68B |
| Q3 2021 | 132 | $820.8M |
| Q2 2021 | 139 | $2.16B |
| Q1 2021 | 127 | $1.15B |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Protagonist Therapeutics, Inc; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Cerity Partners LLC | 9,722 | $537.3K | 0.00% | +477+5.2% | Added |
| HighTower Advisors, LLC | 9,980 | $551.6K | 0.00% | +3,462+53.1% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,073 | $556.7K | 0.00% | +981+10.8% | Added |
| Cache Advisors, LLC | 10,143 | $560.6K | 0.15% | 00.0% | Unchanged |
| Options Solutions, LLC | 10,226 | $565.2K | 0.20% | +10,226 | New |
| KLP Kapitalforvaltning AS | 10,400 | $574.8K | 0.00% | +1,700+19.5% | Added |
| Franklin Street Advisors Inc | 11,300 | $625.0K | 0.04% | 00.0% | Unchanged |
| Royce & Associates LP | 12,255 | $677.3K | 0.01% | 00.0% | Unchanged |
| Harvest Investment Services, LLC | 13,029 | $720.1K | 0.16% | −2,882−18.1% | Reduced |
| Algert Global LLC | 13,055 | $721.5K | 0.02% | −5,610−30.1% | Reduced |
| Teacher Retirement System of Texas | 13,205 | $729.8K | 0.00% | +1,180+9.8% | Added |
| Natixis Advisors, L.P. | 13,442 | $743.0K | 0.00% | +13,442 | New |
| Police & Firemen's Retirement System of New Jersey | 13,456 | $743.7K | 0.01% | +528+4.1% | Added |
| Erste Asset Management GmbH | 13,500 | $751.8K | 0.01% | 00.0% | Unchanged |
| Oregon Public Employees Retirement Fund | 14,200 | $784.8K | 0.01% | +500+3.6% | Added |
| Arizona State Retirement System | 14,326 | $791.8K | 0.00% | +1,525+11.9% | Added |
| Precision Wealth Strategies, LLC | 14,339 | $792.5K | 0.26% | +14,339 | New |
| UBS Oconnor LLC | 14,523 | $802.7K | 0.02% | +1,183+8.9% | Added |
| Millennium Management LLC | 15,191 | $839.6K | 0.00% | −119,078−88.7% | Reduced |
| ProShare Advisors LLC | 15,376 | $849.8K | 0.00% | −1,382−8.2% | Reduced |
| Mariner, LLC | 15,701 | $867.8K | 0.00% | −930−5.6% | Reduced |
| Moran Wealth Management, LLC | 15,761 | $871.1K | 0.03% | −134−0.8% | Reduced |
| DekaBank Deutsche Girozentrale | 15,800 | $879.0K | 0.00% | 00.0% | Unchanged |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 15,913 | $879.5K | 0.00% | +1,651+11.6% | Added |
| Polen Capital Management LLC | 15,999 | $884.3K | 0.00% | +15,999 | New |
| State Board of Administration of Florida Retirement System | 16,303 | $901.1K | 0.00% | 00.0% | Unchanged |
| StemPoint Capital LP | 16,770 | $926.8K | 0.30% | −32,471−65.9% | Reduced |
| Handelsbanken Fonder AB | 17,000 | $940.0K | 0.00% | +2,600+18.1% | Added |
| AQR Capital Management LLC | 17,409 | $962.2K | 0.00% | −22,678−56.6% | Reduced |
| Winton Group Ltd | 17,433 | $963.5K | 0.05% | −3,362−16.2% | Reduced |
| Persistent Asset Partners Ltd | 17,520 | $968.3K | 0.85% | +17,520 | New |
| Amalgamated Bank | 17,543 | $970.0K | 0.01% | +605+3.6% | Added |
| Arrowstreet Capital, Limited Partnership | 17,856 | $986.9K | 0.00% | +17,856 | New |
| Maryland State Retirement & Pension System | 18,216 | $1.01M | 0.02% | +818+4.7% | Added |
| Teachers Retirement System of the State of Kentucky | 18,732 | $1.04M | 0.01% | −1,468−7.3% | Reduced |
| China Universal Asset Management Co., Ltd. | 18,908 | $1.05M | 0.10% | +136+0.7% | Added |
| Virginia Retirement Systems Et Al | 19,000 | $1.05M | 0.01% | +1,400+8.0% | Added |
| Profund Advisors LLC | 19,074 | $1.05M | 0.04% | +7,515+65.0% | Added |
| Guggenheim Capital LLC | 19,208 | $1.06M | 0.01% | +303+1.6% | Added |
| Bellevue Group AG | 19,472 | $1.08M | 0.02% | +1,850+10.5% | Added |
| New York State Common Retirement Fund | 19,582 | $1.08M | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 19,600 | $1.08M | 0.00% | +600+3.2% | Added |
| Fieldview Capital Management, LLC | 20,381 | $1.13M | 0.17% | +20,381 | New |
| Comerica Bank | 21,291 | $1.18M | 0.00% | +1,050+5.2% | Added |
| Glenmede Investment Management, LP | 21,434 | $1.18M | 0.01% | +21,434 | New |
| Allianz Asset Management GmbH | 22,300 | $1.23M | 0.00% | +15,900+248.4% | Added |
| Mackenzie Financial Corp | 22,457 | $1.24M | 0.00% | −241−1.1% | Reduced |
| Horizon Investments, LLC | 22,470 | $1.24M | 0.02% | +22,470 | New |
| Artia Global Partners LP | 22,951 | $1.27M | 0.33% | −310,900−93.1% | Reduced |
| Ensign Peak Advisors, Inc | 23,136 | $1.28M | 0.00% | −3,900−14.4% | Reduced |
| Yousif Capital Management, LLC | 23,404 | $1.29M | 0.01% | +1,067+4.8% | Added |
| Toroso Investments, LLC | 23,777 | $1.31M | 0.01% | +4,367+22.5% | Added |
| Envestnet Asset Management Inc | 23,878 | $1.32M | 0.00% | +7,199+43.2% | Added |
| State of Tennessee, Treasury Department | 25,990 | $1.44M | 0.01% | −495−1.9% | Reduced |
| Brevan Howard Capital Management LP | 26,994 | $1.49M | 0.02% | +10,880+67.5% | Added |
| Citadel Advisors LLC | 27,201 | $1.50M | 0.00% | −126,866−82.3% | Reduced |
| Illinois Municipal Retirement Fund | 27,569 | $1.52M | 0.02% | +8,060+41.3% | Added |
| Louisiana State Employees Retirement System | 29,000 | $1.60M | 0.03% | +900+3.2% | Added |
| Creative Planning | 30,204 | $1.67M | 0.00% | +12,871+74.3% | Added |
| Hussman Strategic Advisors, Inc. | 31,500 | $1.74M | 0.40% | −21,000−40.0% | Reduced |
| Massachusetts Financial Services Co | 32,123 | $1.78M | 0.00% | +397+1.3% | Added |
| State of Wisconsin Investment Board | 32,988 | $1.82M | 0.00% | −20,752−38.6% | Reduced |
| Intech Investment Management LLC | 33,953 | $1.88M | 0.02% | +2,971+9.6% | Added |
| Man Group plc | 34,013 | $1.88M | 0.00% | −94,593−73.6% | Reduced |
| MetLife Investment Management | 34,770 | $1.92M | 0.01% | −20−0.1% | Reduced |
| J. Goldman & Co LP | 35,828 | $1.98M | 0.06% | −29,416−45.1% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 35,841 | $1.98M | 0.00% | −1,562−4.2% | Reduced |
| Trexquant Investment LP | 36,018 | $1.99M | 0.02% | −67,965−65.4% | Reduced |
| State of Alaska, Department of Revenue | 36,906 | $2.04M | 0.02% | +3,883+11.8% | Added |
| Gotham Asset Management, LLC | 37,287 | $2.06M | 0.01% | +14,215+61.6% | Added |
| Alps Advisors Inc | 40,220 | $2.22M | 0.01% | −12,754−24.1% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 40,484 | $2.24M | 0.00% | +36,288+864.8% | Added |
| State of New Jersey Common Pension Fund D | 41,025 | $2.27M | 0.01% | −12,711−23.7% | Reduced |
| Wells Fargo & Company | 41,687 | $2.30M | 0.00% | +1,878+4.7% | Added |
| Aquatic Capital Management LLC | 42,000 | $2.32M | 0.05% | +26,893+178.0% | Added |
| Natixis | 42,040 | $2.32M | 0.01% | +42,040 | New |
| SEI Investments Co | 44,932 | $2.48M | 0.00% | +7,404+19.7% | Added |
| Thrivent Financial for Lutherans | 45,576 | $2.52M | 0.01% | +1,800+4.1% | Added |
| Exchange Traded Concepts, LLC | 47,391 | $2.62M | 0.03% | +19,999+73.0% | Added |
| Birchview Capital, LP | 48,000 | $2.65M | 2.63% | −20.0% | Reduced |
| Capital Fund Management S.A. | 49,805 | $2.75M | 0.03% | +49,805 | New |
| Great West Life Assurance Co | 50,242 | $2.78M | 0.00% | −713−1.4% | Reduced |
| California State Teachers Retirement System | 51,195 | $2.83M | 0.00% | +9,339+22.3% | Added |
| Axiom Investors LLC | 51,233 | $2.83M | 0.02% | +11,264+28.2% | Added |
| Silvercrest Asset Management Group LLC | 54,723 | $3.02M | 0.02% | 00.0% | Unchanged |
| New York State Teachers Retirement System | 55,713 | $3.08M | 0.01% | +8,858+18.9% | Added |
| HighVista Strategies LLC | 57,851 | $3.20M | 1.17% | −20,601−26.3% | Reduced |
| Boxer Capital Management, LLC | 60,000 | $3.32M | 1.67% | +60,000 | New |
| Parkman Healthcare Partners LLC | 61,596 | $3.40M | 0.39% | +61,596 | New |
| Alliancebernstein L.P. | 67,900 | $3.75M | 0.00% | 00.0% | Unchanged |
| Qube Research & Technologies Ltd | 68,983 | $3.81M | 0.01% | −274,428−79.9% | Reduced |
| EAM Global Investors LLC | 69,726 | $3.85M | 1.00% | −240.0% | Reduced |
| Susquehanna International Group, LLP | 71,241 | $3.94M | 0.01% | −120,998−62.9% | Reduced |
| EAM Investors, LLC | 71,971 | $3.98M | 0.60% | +2,790+4.0% | Added |
| Royal Bank of Canada | 74,734 | $4.13M | 0.00% | +64,770+650.0% | Added |
| Diadema Partners LP | 76,185 | $4.21M | 2.62% | +76,185 | New |
| Schonfeld Strategic Advisors LLC | 77,068 | $4.26M | 0.03% | −210,233−73.2% | Reduced |
| Prudential Financial Inc | 77,408 | $4.28M | 0.01% | +19,050+32.6% | Added |
| Citigroup Inc | 77,951 | $4.31M | 0.00% | −43,893−36.0% | Reduced |
| Northwestern Mutual Wealth Management Co | 78,894 | $4.36M | 0.00% | 00.0% | Unchanged |