Karyopharm Therapeutics Inc.
KPTI- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001503802
In the last 90 days, Karyopharm Therapeutics Inc. insiders filed 0 open-market purchases and 2 sales; 96 institutions reported holding it in 13F filings for Q2 2026, worth $206.8M in total; no superinvestor holds it.
13F holders, Q2 2024
Institutional positions in Karyopharm Therapeutics Inc. as of Jun 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 114
- 0 vs. Q1 2024
- Shares held
- 67.6M
- −7.22M (−9.7%) vs. Q1 2024
- Total value
- $58.6M
- −$54.3M (−48.1%) vs. Q1 2024
- New holders
- 27
- 24 more added
- Sold out
- 27
- 33 more reduced
Compare with Q1 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting KPTI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 96 | $206.8M |
| Q1 2026 | 77 | $98.4M |
| Q4 2025 | 68 | $69.6M |
| Q3 2025 | 52 | $19.5M |
| Q2 2025 | 50 | $19.0M |
| Q1 2025 | 50 | $13.7M |
| Q4 2024 | 87 | $41.2M |
| Q3 2024 | 91 | $49.2M |
| Q2 2024 | 114 | $58.6M |
| Q1 2024 | 114 | $113.0M |
| Q4 2023 | 120 | $63.5M |
| Q3 2023 | 120 | $102.8M |
| Q2 2023 | 138 | $145.0M |
| Q1 2023 | 132 | $340.1M |
| Q4 2022 | 155 | $334.4M |
| Q3 2022 | 147 | $364.1M |
| Q2 2022 | 150 | $302.8M |
| Q1 2022 | 139 | $501.8M |
| Q4 2021 | 143 | $347.5M |
| Q3 2021 | 134 | $334.4M |
| Q2 2021 | 154 | $608.7M |
| Q1 2021 | 171 | $637.1M |
Institutions, Q2 2024
Shares, value and share of portfolio for each institution holding Karyopharm Therapeutics Inc.; share changes are against Q1 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Opaleye Management Inc. | 1,425,000 | $1.24M | 0.28% | +1,425,000 | New |
| C WorldWide Group Holding A/S | 1,500,000 | $1.30M | 0.01% | 00.0% | Unchanged |
| Jane Street Group, LLC | 1,549,976 | $1.34M | 0.00% | +1,378,326+803.0% | Added |
| Avidity Partners Management LP | 2,018,500 | $1.75M | 0.07% | −6,280,070−75.7% | Reduced |
| Millennium Management LLC | 2,092,426 | $1.82M | 0.00% | +906,547+76.4% | Added |
| BNP Paribas Arbitrage, SA | 2,274,195 | $1.97M | 0.00% | +500,437+28.2% | Added |
| Goldman Sachs Group Inc | 2,290,434 | $1.99M | 0.00% | +782,172+51.9% | Added |
| Marshall Wace, LLP | 2,580,863 | $2.25M | 0.00% | −14,736−0.6% | Reduced |
| Citadel Advisors LLC | 3,101,399 | $2.69M | 0.00% | −3,670−0.1% | Reduced |
| BlackRock Inc. | 4,169,788 | $3.62M | 0.00% | −5,277,890−55.9% | Reduced |
| Adage Capital Partners GP, L.L.C. | 4,319,842 | $3.75M | 0.01% | +819,842+23.4% | Added |
| Eversept Partners, LP | 4,987,180 | $4.33M | 0.33% | −29,140−0.6% | Reduced |
| Palo Alto Investors LP | 5,102,193 | $4.43M | 0.51% | 00.0% | Unchanged |
| Vanguard Group Inc | 7,654,482 | $6.64M | 0.00% | −683,919−8.2% | Reduced |
| Nuveen Asset Management, LLC | 0 | $0 | 0.00% | −492,365−100.0% | Sold out |
| Panagora Asset Management Inc | 0 | $0 | 0.00% | −229,924−100.0% | Sold out |
| Alliancebernstein L.P. | 0 | $0 | 0.00% | −192,810−100.0% | Sold out |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | $0 | 0.00% | −76,317−100.0% | Sold out |
| State Board of Administration of Florida Retirement System | 0 | $0 | 0.00% | −27,015−100.0% | Sold out |
| MetLife Investment Management | 0 | $0 | 0.00% | −60,551−100.0% | Sold out |
| American International Group, Inc. | 0 | $0 | 0.00% | −55,816−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −55,985−100.0% | Sold out |
| Voya Investment Management LLC | 0 | $0 | 0.00% | −38,802−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −37,132−100.0% | Sold out |
| Manufacturers Life Insurance Company, The | 0 | $0 | 0.00% | −35,868−100.0% | Sold out |
| Principal Financial Group Inc | 0 | $0 | 0.00% | −33,165−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −23,500−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −19,615−100.0% | Sold out |
| Diversified Trust Co | 0 | $0 | 0.00% | −18,580−100.0% | Sold out |
| Legal & General Group Plc | 0 | $0 | 0.00% | −13,735−100.0% | Sold out |
| California State Teachers Retirement System | 0 | $0 | 0.00% | −11,387−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −10,208−100.0% | Sold out |
| Metropolitan Life Insurance Co | 0 | $0 | 0.00% | −6,231−100.0% | Sold out |
| Ameritas Investment Partners, Inc. | 0 | $0 | 0.00% | −6,194−100.0% | Sold out |
| Amalgamated Bank | 0 | $0 | 0.00% | −2,478−100.0% | Sold out |
| ADAR1 Capital Management, LLC | 0 | $0 | 0.00% | −1,479−100.0% | Sold out |
| Headlands Technologies LLC | 0 | $0 | 0.00% | −1,242−100.0% | Sold out |
| Sofos Investments, Inc. | 0 | $0 | 0.00% | −147−100.0% | Sold out |
| Nelson, Van Denburg & Campbell Wealth Management Group, LLC | 0 | $0 | 0.00% | −22−100.0% | Sold out |
| Farther Finance Advisors, LLC | 0 | $0 | 0.00% | −13−100.0% | Sold out |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | $0 | 0.00% | −6−100.0% | Sold out |